ID   KOZA_XENLA              Reviewed;         213 AA.
AC   Q9W7E8;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Homeobox protein koza;
DE   AltName: Full=Homeodomain transcription factor koza;
GN   Name=koza {ECO:0000312|EMBL:AAD38901.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAD38901.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP   STAGE, AND INDUCTION.
RC   TISSUE=Tadpole {ECO:0000269|PubMed:12454933};
RX   PubMed=12454933; DOI=10.1002/dvdy.10186;
RA   Newman C.S., Krieg P.A.;
RT   "Xenopus bagpipe-related gene, koza, may play a role in regulation of cell
RT   proliferation.";
RL   Dev. Dyn. 225:571-580(2002).
CC   -!- FUNCTION: May regulate cell proliferation in a tissue-specific manner.
CC       {ECO:0000269|PubMed:12454933}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the muscle layer of embryonic somites.
CC       In tailbud embryos, expressed throughout the entire myotome but at the
CC       mid-tailbud stage (stage 32), expression becomes restricted to the
CC       outer periphery of the somite so that by the tadpole stage only the
CC       outer, type I cells show expression. Also expressed in the dorsal
CC       cement gland and in the myocardial layer of the developing heart. In
CC       all tissues, expression begins after terminal differentiation.
CC       {ECO:0000269|PubMed:12454933}.
CC   -!- DEVELOPMENTAL STAGE: First detectable at low levels at the late
CC       gastrula/early neurula embryo (stage 14). Levels remain approximately
CC       constant throughout subsequent embryonic development, before declining
CC       in the tadpole. {ECO:0000269|PubMed:12454933}.
CC   -!- INDUCTION: By ihh/bhh. {ECO:0000269|PubMed:12454933}.
CC   -!- MISCELLANEOUS: Based on similarity to Drosophila 'bagpipe/bap', the
CC       name 'koza' was chosen after a Polish musical instrument related to the
CC       Scottish bagpipe. {ECO:0000269|PubMed:12454933}.
CC   -!- SIMILARITY: Belongs to the NK-3 homeobox family. {ECO:0000255}.
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DR   EMBL; AF127225; AAD38901.1; -; mRNA.
DR   RefSeq; NP_001079169.1; NM_001085700.1.
DR   AlphaFoldDB; Q9W7E8; -.
DR   SMR; Q9W7E8; -.
DR   GeneID; 373737; -.
DR   KEGG; xla:373737; -.
DR   CTD; 373737; -.
DR   Xenbase; XB-GENE-6252708; nkx3-1.S.
DR   OrthoDB; 1398668at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 373737; Expressed in neurula embryo and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IMP:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..213
FT                   /note="Homeobox protein koza"
FT                   /id="PRO_0000271785"
FT   DNA_BIND        102..161
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          24..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..59
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   213 AA;  24723 MW;  23C18B85EF91AFA5 CRC64;
     MSKLRTEDMS HPVKPLRSFL IQDILSHMGP GSKEKSLGFP KTDQDQDSSL RDTEEKYASE
     KLQSSSQPAE IHHSHMEADE NLELDTAQPI TAVENKLAKQ QQKRSRAAFS HSQVIELERK
     FSSQKYLSAP ERAQLAKSLK LTETQVKIWF QNRRYKTKRK QLATDMEEVE KSSAHPAQCR
     DTNISRTSLL SFYQNYQRYP YLYYLAGWPA PLW