ID   KPBA_CAEEL              Reviewed;        1226 AA.
AC   P34335;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 3.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=Probable phosphorylase b kinase regulatory subunit alpha;
DE            Short=Phosphorylase kinase subunit alpha;
GN   ORFNames=C14B9.8;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Phosphorylase b kinase catalyzes the phosphorylation of
CC       serine in certain substrates, including troponin I. The alpha chain may
CC       bind calmodulin (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Glycan biosynthesis; glycogen metabolism.
CC   -!- SIMILARITY: Belongs to the phosphorylase b kinase regulatory chain
CC       family. {ECO:0000305}.
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DR   EMBL; FO080531; CCD64441.1; -; Genomic_DNA.
DR   PIR; S44754; S44754.
DR   RefSeq; NP_498777.2; NM_066376.5.
DR   AlphaFoldDB; P34335; -.
DR   SMR; P34335; -.
DR   BioGRID; 41355; 1.
DR   STRING; 6239.C14B9.8; -.
DR   iPTMnet; P34335; -.
DR   EPD; P34335; -.
DR   PaxDb; P34335; -.
DR   PeptideAtlas; P34335; -.
DR   PRIDE; P34335; -.
DR   EnsemblMetazoa; C14B9.8a.1; C14B9.8a.1; WBGene00015754.
DR   GeneID; 176149; -.
DR   KEGG; cel:CELE_C14B9.8; -.
DR   UCSC; C14B9.8; c. elegans.
DR   CTD; 176149; -.
DR   WormBase; C14B9.8a; CE38273; WBGene00015754; -.
DR   eggNOG; KOG3635; Eukaryota.
DR   GeneTree; ENSGT00950000183118; -.
DR   HOGENOM; CLU_004177_0_1_1; -.
DR   InParanoid; P34335; -.
DR   OMA; QFEHIEC; -.
DR   PhylomeDB; P34335; -.
DR   BRENDA; 2.7.11.19; 1045.
DR   Reactome; R-CEL-70221; Glycogen breakdown (glycogenolysis).
DR   UniPathway; UPA00163; -.
DR   PRO; PR:P34335; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00015754; Expressed in germ line (C elegans) and 4 other tissues.
DR   ExpressionAtlas; P34335; baseline and differential.
DR   GO; GO:0005964; C:phosphorylase kinase complex; IBA:GO_Central.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.50.10.10; -; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR011613; GH15-like.
DR   InterPro; IPR045583; KPBA/B_C.
DR   InterPro; IPR008734; PHK_A/B_su.
DR   PANTHER; PTHR10749; PTHR10749; 1.
DR   Pfam; PF00723; Glyco_hydro_15; 1.
DR   Pfam; PF19292; KPBB_C; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
PE   3: Inferred from homology;
KW   Calmodulin-binding; Carbohydrate metabolism; Glycogen metabolism;
KW   Reference proteome.
FT   CHAIN           1..1226
FT                   /note="Probable phosphorylase b kinase regulatory subunit
FT                   alpha"
FT                   /id="PRO_0000057734"
FT   REGION          666..688
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1226 AA;  139451 MW;  899A757F6B6F9E6D CRC64;
     MRSRSGSGVR LDRILFMVEQ TICSHQNPIT ALFANQKDFP GHAWVRDNVY IAQALWALYR
     AYMKCADFDE DLTKAKELGF TCVKMMQSIL ECLMRQAEKV ELFKKYQRPL DALHSKFAVG
     TKGTVCGDAD WGHLQMDAIS LYLLTLAQIT ASGLQVVRNF DEVAFIQNLV YYIETGYRTP
     DYGVWERGDK TNQGIRELNA SSIGMVKAAL QALNDVGDLF VDGSRGSVVH VLPDEIEQCS
     AVLSSMLPRE SFSKETDAAL LGIISYPAFC VEDPELVSQT RETITQRLLG KYGCRRFMRD
     GYKTVLEDAS RLYYNKSELQ QFEDIECEWP IFLCYLILDA MYSKDDDAVE AYWRQLESVL
     VLSDKGFRLV PELYVVLKEH VSAEKAHPGT QDRVPGGATP FLWAQSLYVI ICLLYEGFLL
     PAELDPLSRR LSVYEKRPPC EVQVTVLAES LDVQRELRAH DIHVQCVDEI DPVFTILPAS
     ALGQLLAKIG ESKKLNLSGR PLDRPIGLLS TSRLYQIGNK FVIFTPQFMD SRRSHLMYDI
     RILTDEWSSE LQYIYASWNS VSISGRPLVV LVITQGMLST EGLSHFSNIH LNRHMKSTVI
     GAIKKINTGY LSGARVVMKD LSDFFRTTAV SKMEFRDKSA EDTLRSVAAE KVQFTLLTED
     ATEAKNEKIT TPRGPRTLRR GESVKDRSAY TAVHKASMRH RSIALDSNDA DLMKLRLAYK
     SRPRDLQDMD STYQSPPPTQ TPLGLVKEHS SGELRQQLLK TTRRGAENET THRDLTAEQM
     NEMKADDLLD LVNETTVLEE QISIVHCLWM KFGPDYDTEL GCQHITVRML MEEVHTKACE
     AREWALVRLT AGLLKKQLEE LSKAVTHLLV RQKQITVGIA SKKEEVITCP KTNEELEKIM
     NRAYGDDANS FTLAQEIIVY LGSLVRTEPK LFLEMFRLRI GLIIQVLASE LSRLRNISGA
     EAAETLLTVS PFELKSMIFS LLSGRLLEEY AEDGIHYSDT IRETRTGIGS FRRQIEERKS
     LRKSTRSVGG LEIPKEEDED EEADEDDFQF GIWLRHRRID GALNRVPNGF YAILWDTVHK
     MPHGVKINDT VLHWGLTQEM TRKEIKFALE SEEALNRIAE PEYRELVVET LWLLGRLEKL
     VLLEQPNIPR DRPLDVDHIL HVANQIFVDH NKHLETIVME CCASSNPNNT RCDGARNICK
     HFYDSAPAGE YGTSHYIIRA LMQLYS