ID   KPPR_SYNY3              Reviewed;         332 AA.
AC   P37101; P74363;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Phosphoribulokinase;
DE            Short=PRK;
DE            Short=PRKase;
DE            EC=2.7.1.19;
DE   AltName: Full=Phosphopentokinase;
GN   Name=prk; Synonyms=ptk; OrderedLocusNames=sll1525;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1660882; DOI=10.1016/s0021-9258(18)54340-4;
RA   Su X., Bogorad L.;
RT   "A residue substitution in phosphoribulokinase of Synechocystis PCC 6803
RT   renders the mutant light-sensitive.";
RL   J. Biol. Chem. 266:23698-23705(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
RN   [3]
RP   INDUCTION.
RX   PubMed=9484476; DOI=10.1023/a:1005935819038;
RA   van Thor J.J., Hellingwerf K.J., Matthijs H.C.P.;
RT   "Characterization and transcriptional regulation of the Synechocystis PCC
RT   6803 petH gene, encoding ferredoxin-NADP+ oxidoreductase: involvement of a
RT   novel type of divergent operator.";
RL   Plant Mol. Biol. 36:353-363(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-
CC         bisphosphate + H(+); Xref=Rhea:RHEA:19365, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:57870, ChEBI:CHEBI:58121,
CC         ChEBI:CHEBI:456216; EC=2.7.1.19;
CC   -!- PATHWAY: Carbohydrate biosynthesis; Calvin cycle.
CC   -!- INDUCTION: By light. {ECO:0000269|PubMed:9484476}.
CC   -!- SIMILARITY: Belongs to the phosphoribulokinase family. {ECO:0000305}.
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DR   EMBL; M77134; AAA27293.1; -; Genomic_DNA.
DR   EMBL; BA000022; BAA18458.1; -; Genomic_DNA.
DR   PIR; JC1336; JC1336.
DR   AlphaFoldDB; P37101; -.
DR   SMR; P37101; -.
DR   IntAct; P37101; 6.
DR   STRING; 1148.1653545; -.
DR   PaxDb; P37101; -.
DR   EnsemblBacteria; BAA18458; BAA18458; BAA18458.
DR   KEGG; syn:sll1525; -.
DR   eggNOG; COG0572; Bacteria.
DR   InParanoid; P37101; -.
DR   OMA; GLKMRAT; -.
DR   PhylomeDB; P37101; -.
DR   UniPathway; UPA00116; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008974; F:phosphoribulokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0019253; P:reductive pentose-phosphate cycle; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR006082; PRK.
DR   InterPro; IPR006083; PRK/URK.
DR   Pfam; PF00485; PRK; 1.
DR   PRINTS; PR00478; PHRIBLKINASE.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00567; PHOSPHORIBULOKINASE; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Calvin cycle; Kinase; Nucleotide-binding; Photosynthesis;
KW   Reference proteome; Transferase.
FT   CHAIN           1..332
FT                   /note="Phosphoribulokinase"
FT                   /id="PRO_0000201959"
FT   VARIANT         222
FT                   /note="S -> Y (in a light-sensitive mutant with reduced
FT                   activity)"
FT   CONFLICT        317
FT                   /note="K -> E (in Ref. 2; BAA18458)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   332 AA;  37913 MW;  00B8EF288A7ABE54 CRC64;
     MTTQLDRVVL IGVAGDSGCG KSTFLRRLTD LFGEEFMTVI CLDDYHSLDR QGRKAAGVTA
     LDPRANNFDL MYEQIKTLKS GQSIMKPIYN HETGLLDPPE KVEPNKVVVI EGLHPLYDER
     VRELVDFGVY LDISEEVKIN WKIQRDMAER GHTYEDILAS INARKPDFTA YIEPQKQYAD
     VVIQVLPTRL IEDKESKLLR VRLVQKEGVK FFEPAYLFDE GSTIDWRPCG RKLTCTYPGI
     KMYYGPDNFM GNEVSLLEVD GRFENLEEMV YVENHLSKTG TKYYGEMTEL LLKHKDYPGT
     DNGTGLFQVL VGLKMRKVYE QLTAEAKVPA SV