ID   KPRA_BOVIN              Reviewed;         356 AA.
AC   Q08DW2;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Phosphoribosyl pyrophosphate synthase-associated protein 1;
DE            Short=PRPP synthase-associated protein 1;
GN   Name=PRPSAP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Seems to play a negative regulatory role in 5-phosphoribose
CC       1-diphosphate synthesis. {ECO:0000250}.
CC   -!- SUBUNIT: Binds to PRPS1 and PRPS2. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase family.
CC       {ECO:0000305}.
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DR   EMBL; BC123542; AAI23543.1; -; mRNA.
DR   RefSeq; NP_001070325.1; NM_001076857.2.
DR   AlphaFoldDB; Q08DW2; -.
DR   SMR; Q08DW2; -.
DR   STRING; 9913.ENSBTAP00000040198; -.
DR   PaxDb; Q08DW2; -.
DR   PRIDE; Q08DW2; -.
DR   Ensembl; ENSBTAT00000042563; ENSBTAP00000040198; ENSBTAG00000030172.
DR   GeneID; 789409; -.
DR   KEGG; bta:789409; -.
DR   CTD; 5635; -.
DR   VEuPathDB; HostDB:ENSBTAG00000030172; -.
DR   VGNC; VGNC:33386; PRPSAP1.
DR   eggNOG; KOG1503; Eukaryota.
DR   GeneTree; ENSGT00950000182803; -.
DR   HOGENOM; CLU_033546_0_0_1; -.
DR   InParanoid; Q08DW2; -.
DR   OMA; CHELKIF; -.
DR   OrthoDB; 1043963at2759; -.
DR   TreeFam; TF106367; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000030172; Expressed in caput epididymis and 103 other tissues.
DR   ExpressionAtlas; Q08DW2; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0002189; C:ribose phosphate diphosphokinase complex; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0004749; F:ribose phosphate diphosphokinase activity; IBA:GO_Central.
DR   GO; GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.2020; -; 2.
DR   InterPro; IPR029099; Pribosyltran_N.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR005946; Rib-P_diPkinase.
DR   PANTHER; PTHR10210; PTHR10210; 1.
DR   Pfam; PF14572; Pribosyl_synth; 1.
DR   Pfam; PF13793; Pribosyltran_N; 1.
DR   SUPFAM; SSF53271; SSF53271; 2.
DR   TIGRFAMs; TIGR01251; ribP_PPkin; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Nucleotide biosynthesis; Phosphoprotein; Reference proteome.
FT   CHAIN           1..356
FT                   /note="Phosphoribosyl pyrophosphate synthase-associated
FT                   protein 1"
FT                   /id="PRO_0000284955"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q14558"
FT   MOD_RES         177
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q14558"
FT   MOD_RES         215
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q14558"
SQ   SEQUENCE   356 AA;  39424 MW;  E62EC576A263236D CRC64;
     MNAARTGYRV FSANSTAACT ELAKRITERL GAELGKSVVY QETNGETRVE IQESVRGQDI
     FIIQTIPRDV NTAVMELLIM AYALKTACAR NIIGVIPYFP YSKQSKMRKR GSIVCKLLAS
     MLAKAGLTHI ITMDLHQKEI QGFFSFPVDN LRASPFLLQY IQEEIPNYRN AVIVAKSPDA
     AKRAQSYAER LRLGLAVIHG EAQCAEMDMD DGRHSPPMVK NATVHPGLEL PLMMAKEKPP
     ITVVGDVGGR IAIIVDDIID DVESFVAAAE ILKERGAYRI YVMATHGILS AEAPRLIEES
     SIDEVVVTNT VPHEVQKLQC PKIKTVDISL ILSEAIRRIH NGESMAYLFR NITVDD