ID   KPRB_BOVIN              Reviewed;         369 AA.
AC   A2VDS0;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Phosphoribosyl pyrophosphate synthase-associated protein 2;
DE            Short=PRPP synthase-associated protein 2;
GN   Name=PRPSAP2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Seems to play a negative regulatory role in 5-phosphoribose
CC       1-diphosphate synthesis. {ECO:0000250}.
CC   -!- SUBUNIT: Binds to PRPS1 and PRPS2. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase family.
CC       {ECO:0000305}.
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DR   EMBL; BC133374; AAI33375.1; -; mRNA.
DR   RefSeq; NP_001074982.1; NM_001081513.1.
DR   AlphaFoldDB; A2VDS0; -.
DR   SMR; A2VDS0; -.
DR   STRING; 9913.ENSBTAP00000019786; -.
DR   PaxDb; A2VDS0; -.
DR   PeptideAtlas; A2VDS0; -.
DR   PRIDE; A2VDS0; -.
DR   Ensembl; ENSBTAT00000019786; ENSBTAP00000019786; ENSBTAG00000014858.
DR   GeneID; 506111; -.
DR   KEGG; bta:506111; -.
DR   CTD; 5636; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014858; -.
DR   VGNC; VGNC:33387; PRPSAP2.
DR   eggNOG; KOG1503; Eukaryota.
DR   GeneTree; ENSGT00950000182803; -.
DR   HOGENOM; CLU_033546_0_0_1; -.
DR   InParanoid; A2VDS0; -.
DR   OMA; HYAYARS; -.
DR   OrthoDB; 1043963at2759; -.
DR   TreeFam; TF106367; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000014858; Expressed in retropharyngeal lymph node and 108 other tissues.
DR   ExpressionAtlas; A2VDS0; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0002189; C:ribose phosphate diphosphokinase complex; IBA:GO_Central.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0004749; F:ribose phosphate diphosphokinase activity; IBA:GO_Central.
DR   GO; GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IBA:GO_Central.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 2.
DR   InterPro; IPR029099; Pribosyltran_N.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR005946; Rib-P_diPkinase.
DR   PANTHER; PTHR10210; PTHR10210; 1.
DR   Pfam; PF14572; Pribosyl_synth; 1.
DR   Pfam; PF13793; Pribosyltran_N; 1.
DR   SUPFAM; SSF53271; SSF53271; 2.
DR   TIGRFAMs; TIGR01251; ribP_PPkin; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Nucleotide biosynthesis; Phosphoprotein; Reference proteome.
FT   CHAIN           1..369
FT                   /note="Phosphoribosyl pyrophosphate synthase-associated
FT                   protein 2"
FT                   /id="PRO_0000284956"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:O60256"
FT   MOD_RES         219
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O60256"
FT   MOD_RES         227
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O60256"
FT   MOD_RES         233
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O60256"
SQ   SEQUENCE   369 AA;  40714 MW;  3DDBD04E24C9B057 CRC64;
     MFCVAPPESE AKMNITKGGL VLFSANSNSS CMELSKKIAE RLGVEMGKVQ VYQEPDRETR
     VQIQESVRGK DVFIIQTVSK DVNTTIMELL IMVYACKTSC AKSIIGVVPY FPYSKQCKMR
     KRGSIVSKLL ASMMCKAGLT HLITMDLHQK EIQGFFNIPV DNLRASPFLL QYIQEEIPDY
     RNAVIVAKSP ASAKRAQSFA ERLRLGIAVI HGEAQDAESD LVDGRHSPPM VRSAAAIHPS
     LEIPMLIPKE KPPITVVGDV GGRIAIIVDD IIDDVDSFLA AAETLKERGA YKIFVMATHG
     LLSSDAPLLI EESAIDEVVV TNTIPHEIQK LQCPKIKTVD ISMTLSEAIR RIHNGESMSY
     LFRNIGLDD