ID   KPRB_PONAB              Reviewed;         369 AA.
AC   Q5RBA8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Phosphoribosyl pyrophosphate synthase-associated protein 2;
DE            Short=PRPP synthase-associated protein 2;
GN   Name=PRPSAP2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Seems to play a negative regulatory role in 5-phosphoribose
CC       1-diphosphate synthesis. {ECO:0000250}.
CC   -!- SUBUNIT: Binds to PRPS1 and PRPS2. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR858743; CAH90952.1; -; mRNA.
DR   RefSeq; NP_001127355.1; NM_001133883.1.
DR   AlphaFoldDB; Q5RBA8; -.
DR   SMR; Q5RBA8; -.
DR   STRING; 9601.ENSPPYP00000009060; -.
DR   GeneID; 100174419; -.
DR   KEGG; pon:100174419; -.
DR   CTD; 5636; -.
DR   eggNOG; KOG1503; Eukaryota.
DR   InParanoid; Q5RBA8; -.
DR   OrthoDB; 1043963at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0004749; F:ribose phosphate diphosphokinase activity; IEA:InterPro.
DR   GO; GO:0009165; P:nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 2.
DR   InterPro; IPR029099; Pribosyltran_N.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR005946; Rib-P_diPkinase.
DR   PANTHER; PTHR10210; PTHR10210; 1.
DR   Pfam; PF14572; Pribosyl_synth; 1.
DR   Pfam; PF13793; Pribosyltran_N; 1.
DR   SUPFAM; SSF53271; SSF53271; 2.
DR   TIGRFAMs; TIGR01251; ribP_PPkin; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Nucleotide biosynthesis; Phosphoprotein; Reference proteome.
FT   CHAIN           1..369
FT                   /note="Phosphoribosyl pyrophosphate synthase-associated
FT                   protein 2"
FT                   /id="PRO_0000366926"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:O60256"
FT   MOD_RES         5
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O60256"
FT   MOD_RES         219
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O60256"
FT   MOD_RES         227
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O60256"
FT   MOD_RES         233
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O60256"
SQ   SEQUENCE   369 AA;  40897 MW;  C24FD6BF79E4647B CRC64;
     MFCVTPPELE TKMNITKGGL VLFSANSNSS CMELSKKIAE RLGVEMGKVQ VYQEPNRETR
     VQIQESVRGK DVFIIQTISK DVNTTIMELL IMVYACKTSC AKSIIGVIPY FPYSKQCKMR
     KRGSIVSKLL ASMMCKAGLT HLITMDLHQK EIQGFFNIPV DNLRASPFLL QYIQEEIPDY
     RNAVIVAKSP ASAKRAQSFA ERLRLGIAVI HGEAQDAESD LVDGRHSPPM VRSVAAIHPS
     LEIPMLIPKE KPPITVVGDV GGRIAIIVDD IIDDVDSFLA AAETLKERGA YKIFVMATHG
     LLSSDAPRLI EESAIDEVVV TNTIPHEVQK LQCPKIKTVD ISMILSEAIR RIHNGESMSY
     LFRNIGLDD