ID   KPRB_XENTR              Reviewed;         358 AA.
AC   Q28DH0;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Phosphoribosyl pyrophosphate synthase-associated protein 2;
DE            Short=PRPP synthase-associated protein 2;
GN   Name=prpsap2; ORFNames=TEgg105n03.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Seems to play a negative regulatory role in 5-phosphoribose
CC       1-diphosphate synthesis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase family.
CC       {ECO:0000305}.
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DR   EMBL; CR855518; CAJ81381.1; -; mRNA.
DR   EMBL; BC121509; AAI21510.1; -; mRNA.
DR   RefSeq; NP_001017337.1; NM_001017337.3.
DR   RefSeq; XP_012825932.1; XM_012970478.2.
DR   RefSeq; XP_012825933.1; XM_012970479.1.
DR   RefSeq; XP_012825934.1; XM_012970480.1.
DR   RefSeq; XP_017952621.1; XM_018097132.1.
DR   AlphaFoldDB; Q28DH0; -.
DR   SMR; Q28DH0; -.
DR   DNASU; 550091; -.
DR   GeneID; 550091; -.
DR   KEGG; xtr:550091; -.
DR   CTD; 5636; -.
DR   Xenbase; XB-GENE-981784; prpsap2.
DR   InParanoid; Q28DH0; -.
DR   OrthoDB; 1043963at2759; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000041223; Expressed in skeletal muscle tissue and 12 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0002189; C:ribose phosphate diphosphokinase complex; IBA:GO_Central.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0004749; F:ribose phosphate diphosphokinase activity; IBA:GO_Central.
DR   GO; GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.2020; -; 2.
DR   InterPro; IPR029099; Pribosyltran_N.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR005946; Rib-P_diPkinase.
DR   PANTHER; PTHR10210; PTHR10210; 1.
DR   Pfam; PF14572; Pribosyl_synth; 1.
DR   Pfam; PF13793; Pribosyltran_N; 1.
DR   SUPFAM; SSF53271; SSF53271; 2.
DR   TIGRFAMs; TIGR01251; ribP_PPkin; 1.
PE   2: Evidence at transcript level;
KW   Nucleotide biosynthesis; Reference proteome.
FT   CHAIN           1..358
FT                   /note="Phosphoribosyl pyrophosphate synthase-associated
FT                   protein 2"
FT                   /id="PRO_0000366928"
SQ   SEQUENCE   358 AA;  39628 MW;  056A6569E0DC44B6 CRC64;
     MNVTKGGLVL FSANSNASCV ELAKRIAERL GVELGKVQVY QEPNRETRVQ IQESVRGKDV
     FIIQTVSKDV NTTIMELLIM VYACRTSCAK TISGVIPYFP YSKQCKMRKR GSIVSKLLAS
     MMCKAGLTHF ITMDLHQKEI QGFFNIPVDN LRASPFLLQY IQEEIPDYRN AVIVAKSPSS
     AKRAQSFAER LRLGLAVIHG EAQDAESDMV DGRHSPPVVK NIGAAMHPSL EIPLMFPKEK
     PPITVVGDVG GRIAIIVDDI IDDVDSFVAA ADTLKERGAY KIFVMATHGL LSSEAPRLIE
     ESTIDEVVVT NTIPHEIQKL QCPKIKTVDI SMILSEAIRR IHNGESMSYL FRNIGVDD