KPRP_HUMAN
ID KPRP_HUMAN Reviewed; 579 AA.
AC Q5T749;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Keratinocyte proline-rich protein;
DE Short=hKPRP;
GN Name=KPRP; Synonyms=C1orf45;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP INDUCTION.
RX PubMed=16297201; DOI=10.1111/j.0022-202x.2005.23887.x;
RA Lee W.-H., Jang S., Lee J.-S., Lee Y., Seo E.-Y., You K.-H., Lee S.-C.,
RA Nam K.I., Kim J.-M., Kee S.-H., Yang J.-M., Seo Y.-J., Park J.-K.,
RA Kim C.D., Lee J.-H.;
RT "Molecular cloning and expression of human keratinocyte proline-rich
RT protein (hKPRP), an epidermal marker isolated from calcium-induced
RT differentiating keratinocytes.";
RL J. Invest. Dermatol. 125:995-1000(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- INTERACTION:
CC Q5T749; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-10981970, EBI-357530;
CC Q5T749; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-10981970, EBI-11954519;
CC Q5T749; Q7Z3C6-3: ATG9A; NbExp=5; IntAct=EBI-10981970, EBI-12006308;
CC Q5T749; P35070: BTC; NbExp=3; IntAct=EBI-10981970, EBI-6590057;
CC Q5T749; Q5BKX5-3: C19orf54; NbExp=3; IntAct=EBI-10981970, EBI-11976299;
CC Q5T749; Q8NEC5: CATSPER1; NbExp=5; IntAct=EBI-10981970, EBI-744545;
CC Q5T749; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-10981970, EBI-10961624;
CC Q5T749; P23141-3: CES1; NbExp=3; IntAct=EBI-10981970, EBI-12360993;
CC Q5T749; P61024: CKS1B; NbExp=3; IntAct=EBI-10981970, EBI-456371;
CC Q5T749; P51800-3: CLCNKA; NbExp=3; IntAct=EBI-10981970, EBI-11980535;
CC Q5T749; Q9BYD5: CNFN; NbExp=3; IntAct=EBI-10981970, EBI-12819063;
CC Q5T749; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-10981970, EBI-741032;
CC Q5T749; P27658: COL8A1; NbExp=3; IntAct=EBI-10981970, EBI-747133;
CC Q5T749; Q02930-3: CREB5; NbExp=5; IntAct=EBI-10981970, EBI-10192698;
CC Q5T749; A8MQ03: CYSRT1; NbExp=7; IntAct=EBI-10981970, EBI-3867333;
CC Q5T749; Q9NQL9: DMRT3; NbExp=5; IntAct=EBI-10981970, EBI-9679045;
CC Q5T749; Q13627: DYRK1A; NbExp=3; IntAct=EBI-10981970, EBI-1053596;
CC Q5T749; P60228: EIF3E; NbExp=3; IntAct=EBI-10981970, EBI-347740;
CC Q5T749; Q92731-3: ESR2; NbExp=3; IntAct=EBI-10981970, EBI-12259414;
CC Q5T749; A6H8Z2: FAM221B; NbExp=3; IntAct=EBI-10981970, EBI-12006844;
CC Q5T749; Q86X60-2: FAM72B; NbExp=3; IntAct=EBI-10981970, EBI-12886238;
CC Q5T749; Q96EF6: FBXO17; NbExp=3; IntAct=EBI-10981970, EBI-2510157;
CC Q5T749; A0A0C3SFZ9: FCHO1; NbExp=3; IntAct=EBI-10981970, EBI-11977403;
CC Q5T749; Q14192: FHL2; NbExp=3; IntAct=EBI-10981970, EBI-701903;
CC Q5T749; Q13643: FHL3; NbExp=4; IntAct=EBI-10981970, EBI-741101;
CC Q5T749; O43559: FRS3; NbExp=5; IntAct=EBI-10981970, EBI-725515;
CC Q5T749; O76003: GLRX3; NbExp=3; IntAct=EBI-10981970, EBI-374781;
CC Q5T749; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-10981970, EBI-11975289;
CC Q5T749; O75791: GRAP2; NbExp=3; IntAct=EBI-10981970, EBI-740418;
CC Q5T749; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-10981970, EBI-11978177;
CC Q5T749; P08631-2: HCK; NbExp=3; IntAct=EBI-10981970, EBI-9834454;
CC Q5T749; Q96MH2: HEXIM2; NbExp=3; IntAct=EBI-10981970, EBI-5460660;
CC Q5T749; P52597: HNRNPF; NbExp=3; IntAct=EBI-10981970, EBI-352986;
CC Q5T749; P49639: HOXA1; NbExp=8; IntAct=EBI-10981970, EBI-740785;
CC Q5T749; P31273: HOXC8; NbExp=3; IntAct=EBI-10981970, EBI-1752118;
CC Q5T749; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-10981970, EBI-3918847;
CC Q5T749; P16144-2: ITGB4; NbExp=3; IntAct=EBI-10981970, EBI-11051601;
CC Q5T749; Q6UXX5: ITIH6; NbExp=3; IntAct=EBI-10981970, EBI-11028396;
CC Q5T749; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10981970, EBI-11749135;
CC Q5T749; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-10981970, EBI-11741292;
CC Q5T749; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10981970, EBI-10171774;
CC Q5T749; P60328: KRTAP12-3; NbExp=6; IntAct=EBI-10981970, EBI-11953334;
CC Q5T749; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-10981970, EBI-11953846;
CC Q5T749; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-10981970, EBI-10241252;
CC Q5T749; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-10981970, EBI-11992140;
CC Q5T749; Q8IUB9: KRTAP19-1; NbExp=3; IntAct=EBI-10981970, EBI-12811111;
CC Q5T749; Q3LHN2: KRTAP19-2; NbExp=3; IntAct=EBI-10981970, EBI-12196745;
CC Q5T749; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-10981970, EBI-1048945;
CC Q5T749; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-10981970, EBI-12805508;
CC Q5T749; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-10981970, EBI-10241353;
CC Q5T749; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-10981970, EBI-751260;
CC Q5T749; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-10981970, EBI-10172511;
CC Q5T749; Q9BYR2: KRTAP4-5; NbExp=5; IntAct=EBI-10981970, EBI-11993254;
CC Q5T749; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-10981970, EBI-11974251;
CC Q5T749; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-10981970, EBI-11987425;
CC Q5T749; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-10981970, EBI-3958099;
CC Q5T749; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-10981970, EBI-12111050;
CC Q5T749; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-10981970, EBI-11962084;
CC Q5T749; Q5T5A8: LCE3C; NbExp=5; IntAct=EBI-10981970, EBI-10245291;
CC Q5T749; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-10981970, EBI-6658837;
CC Q5T749; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-10981970, EBI-10245456;
CC Q5T749; P48059-3: LIMS1; NbExp=3; IntAct=EBI-10981970, EBI-12864460;
CC Q5T749; P25791-3: LMO2; NbExp=3; IntAct=EBI-10981970, EBI-11959475;
CC Q5T749; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-10981970, EBI-739832;
CC Q5T749; O60336: MAPKBP1; NbExp=5; IntAct=EBI-10981970, EBI-947402;
CC Q5T749; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-10981970, EBI-16439278;
CC Q5T749; Q5JXC2: MIIP; NbExp=3; IntAct=EBI-10981970, EBI-2801965;
CC Q5T749; P40692: MLH1; NbExp=3; IntAct=EBI-10981970, EBI-744248;
CC Q5T749; O43639: NCK2; NbExp=3; IntAct=EBI-10981970, EBI-713635;
CC Q5T749; Q8IV28: NID2; NbExp=3; IntAct=EBI-10981970, EBI-10261509;
CC Q5T749; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10981970, EBI-22310682;
CC Q5T749; P48146: NPBWR2; NbExp=3; IntAct=EBI-10981970, EBI-10210114;
CC Q5T749; Q92570: NR4A3; NbExp=3; IntAct=EBI-10981970, EBI-13644623;
CC Q5T749; Q9HB63: NTN4; NbExp=3; IntAct=EBI-10981970, EBI-743459;
CC Q5T749; Q7Z417: NUFIP2; NbExp=5; IntAct=EBI-10981970, EBI-1210753;
CC Q5T749; P32242: OTX1; NbExp=6; IntAct=EBI-10981970, EBI-740446;
CC Q5T749; P09619: PDGFRB; NbExp=3; IntAct=EBI-10981970, EBI-641237;
CC Q5T749; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-10981970, EBI-14084211;
CC Q5T749; O15496: PLA2G10; NbExp=3; IntAct=EBI-10981970, EBI-726466;
CC Q5T749; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-10981970, EBI-769257;
CC Q5T749; Q12837: POU4F2; NbExp=5; IntAct=EBI-10981970, EBI-17236143;
CC Q5T749; Q9Y3C6: PPIL1; NbExp=3; IntAct=EBI-10981970, EBI-2557649;
CC Q5T749; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-10981970, EBI-12000762;
CC Q5T749; P10745: RBP3; NbExp=3; IntAct=EBI-10981970, EBI-12806054;
CC Q5T749; O15211: RGL2; NbExp=3; IntAct=EBI-10981970, EBI-712355;
CC Q5T749; Q9H0F5: RNF38; NbExp=3; IntAct=EBI-10981970, EBI-2341200;
CC Q5T749; Q13214-2: SEMA3B; NbExp=3; IntAct=EBI-10981970, EBI-11017428;
CC Q5T749; Q96B97: SH3KBP1; NbExp=5; IntAct=EBI-10981970, EBI-346595;
CC Q5T749; Q16348: SLC15A2; NbExp=3; IntAct=EBI-10981970, EBI-12806032;
CC Q5T749; Q7Z698: SPRED2; NbExp=3; IntAct=EBI-10981970, EBI-7082156;
CC Q5T749; O43609: SPRY1; NbExp=3; IntAct=EBI-10981970, EBI-3866665;
CC Q5T749; O43610: SPRY3; NbExp=3; IntAct=EBI-10981970, EBI-12290641;
CC Q5T749; O75716: STK16; NbExp=3; IntAct=EBI-10981970, EBI-749295;
CC Q5T749; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-10981970, EBI-750487;
CC Q5T749; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-10981970, EBI-11952651;
CC Q5T749; Q63HR2: TNS2; NbExp=5; IntAct=EBI-10981970, EBI-949753;
CC Q5T749; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-10981970, EBI-5235829;
CC Q5T749; Q15654: TRIP6; NbExp=3; IntAct=EBI-10981970, EBI-742327;
CC Q5T749; P57075-2: UBASH3A; NbExp=5; IntAct=EBI-10981970, EBI-7353612;
CC Q5T749; Q8TF42: UBASH3B; NbExp=5; IntAct=EBI-10981970, EBI-1380492;
CC Q5T749; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-10981970, EBI-11957216;
CC Q5T749; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-10981970, EBI-11957238;
CC Q5T749; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-10981970, EBI-6427977;
CC Q5T749; A0A384ME25; NbExp=3; IntAct=EBI-10981970, EBI-10211777;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in the upper layer of epidermis and
CC psoriasis (at protein level). Expressed in the upper layer of epidermis
CC and psoriasis. {ECO:0000269|PubMed:16297201}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the periderm of fetal skin from 16th
CC week gestational age and in the granular and horny layers of the
CC epidermis at 24th week gestational age and thereafter (at protein
CC level). {ECO:0000269|PubMed:16297201}.
CC -!- INDUCTION: By calcium and in psoriatic lesions.
CC {ECO:0000269|PubMed:16297201}.
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DR EMBL; AY960854; AAX59055.1; -; mRNA.
DR EMBL; AL353779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS30862.1; -.
DR RefSeq; NP_001020402.1; NM_001025231.1.
DR RefSeq; XP_011507873.1; XM_011509571.1.
DR AlphaFoldDB; Q5T749; -.
DR BioGRID; 138665; 275.
DR IntAct; Q5T749; 134.
DR MINT; Q5T749; -.
DR STRING; 9606.ENSP00000475216; -.
DR iPTMnet; Q5T749; -.
DR PhosphoSitePlus; Q5T749; -.
DR BioMuta; KPRP; -.
DR DMDM; 74745319; -.
DR EPD; Q5T749; -.
DR jPOST; Q5T749; -.
DR MassIVE; Q5T749; -.
DR MaxQB; Q5T749; -.
DR PaxDb; Q5T749; -.
DR PeptideAtlas; Q5T749; -.
DR PRIDE; Q5T749; -.
DR ProteomicsDB; 64636; -.
DR Antibodypedia; 50318; 33 antibodies from 11 providers.
DR DNASU; 448834; -.
DR Ensembl; ENST00000606109.1; ENSP00000475216.1; ENSG00000203786.6.
DR GeneID; 448834; -.
DR KEGG; hsa:448834; -.
DR MANE-Select; ENST00000606109.2; ENSP00000475216.1; NM_001025231.3; NP_001020402.1.
DR UCSC; uc057lai.1; human.
DR CTD; 448834; -.
DR DisGeNET; 448834; -.
DR GeneCards; KPRP; -.
DR HGNC; HGNC:31823; KPRP.
DR HPA; ENSG00000203786; Tissue enriched (skin).
DR MIM; 613260; gene.
DR neXtProt; NX_Q5T749; -.
DR OpenTargets; ENSG00000203786; -.
DR PharmGKB; PA162393640; -.
DR VEuPathDB; HostDB:ENSG00000203786; -.
DR eggNOG; ENOG502S65C; Eukaryota.
DR GeneTree; ENSGT00730000111554; -.
DR HOGENOM; CLU_024690_0_0_1; -.
DR InParanoid; Q5T749; -.
DR OMA; KPQGCTS; -.
DR OrthoDB; 1260706at2759; -.
DR PhylomeDB; Q5T749; -.
DR TreeFam; TF351578; -.
DR PathwayCommons; Q5T749; -.
DR SignaLink; Q5T749; -.
DR BioGRID-ORCS; 448834; 13 hits in 1063 CRISPR screens.
DR GenomeRNAi; 448834; -.
DR Pharos; Q5T749; Tdark.
DR PRO; PR:Q5T749; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T749; protein.
DR Bgee; ENSG00000203786; Expressed in skin of leg and 54 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
PE 1: Evidence at protein level;
KW Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..579
FT /note="Keratinocyte proline-rich protein"
FT /id="PRO_0000271008"
FT REGION 526..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 394
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT VARIANT 14
FT /note="Q -> H (in dbSNP:rs17612167)"
FT /id="VAR_029840"
FT VARIANT 37
FT /note="V -> A (in dbSNP:rs944683)"
FT /id="VAR_029841"
FT VARIANT 113
FT /note="C -> R (in dbSNP:rs16834457)"
FT /id="VAR_029842"
FT VARIANT 168
FT /note="R -> H (in dbSNP:rs16834461)"
FT /id="VAR_029843"
FT VARIANT 413
FT /note="C -> S (in dbSNP:rs4329520)"
FT /id="VAR_029844"
FT VARIANT 532
FT /note="P -> T (in dbSNP:rs6703294)"
FT /id="VAR_029845"
SQ SEQUENCE 579 AA; 64136 MW; AB29AE2276D15A04 CRC64;
MCDQQQIQCR LPLQQCCVKG PSFCSSQSPF AQSQVVVQAP CEMQIVDCPA SCPVQVCQVS
DQAPCQSQTT QVKCQSKTKQ VKGQAQCQSK TTQVKGQAAS QSQTSSVQSQ APCQSEVSYV
QCEASQPVQT CFVECAPVCY TETCYVECPV QNYVPCPAPQ PVQMYRGRPA VCQPQGRFST
QCQYQGSYSS CGPQFQSRAT CNNYTPQFQL RPSYSSCFPQ YRSRTSFSPC VPQCQTQGSY
GSFTEQHRSR STSRCLPPPR RLQLFPRSCS PPRRFEPCSS SYLPLRPSEG FPNYCTPPRR
SEPIYNSRCP RRPISSCSQR RGPKCRIEIS SPCCPRQVPP QRCPVEIPPI RRRSQSCGPQ
PSWGASCPEL RPHVEPRPLP SFCPPRRLDQ CPESPLQRCP PPAPRPRLRP EPCISLEPRP
RPLPRQLSEP CLYPEPLPAL RPTPRPVPLP RPGQCEIPEP RPCLQPCEHP EPCPRPEPIP
LPAPCPSPEP CRETWRSPSP CWGPNPVPYP GDLGCHESSP HRLDTEAPYC GPSSYNQGQE
SGAGCGPGDV FPERRGQDGH GDQGNAFAGV KGEAKSAYF
