KPRP_MOUSE
ID KPRP_MOUSE Reviewed; 657 AA.
AC B2RUR4; Q9D1P8;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Keratinocyte proline-rich protein {ECO:0000312|EMBL:AAI41373.1};
GN Name=Kprp {ECO:0000312|EMBL:AAI41373.1, ECO:0000312|MGI:MGI:1920981};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:EDL00676.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:AAI41373.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3] {ECO:0000305, ECO:0000312|EMBL:BAB22669.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 551-657.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB22669.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:BAB22669.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7TQM5}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB22669.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CH466656; EDL00676.1; -; Genomic_DNA.
DR EMBL; BC141372; AAI41373.1; -; mRNA.
DR EMBL; AK003253; BAB22669.1; ALT_INIT; mRNA.
DR CCDS; CCDS38517.1; -.
DR RefSeq; NP_082905.1; NM_028629.1.
DR AlphaFoldDB; B2RUR4; -.
DR BioGRID; 241339; 1.
DR STRING; 10090.ENSMUSP00000072200; -.
DR iPTMnet; B2RUR4; -.
DR PhosphoSitePlus; B2RUR4; -.
DR PaxDb; B2RUR4; -.
DR PRIDE; B2RUR4; -.
DR ProteomicsDB; 263451; -.
DR Antibodypedia; 50318; 33 antibodies from 11 providers.
DR Ensembl; ENSMUST00000072363; ENSMUSP00000072200; ENSMUSG00000059832.
DR GeneID; 433619; -.
DR KEGG; mmu:433619; -.
DR UCSC; uc008qes.1; mouse.
DR CTD; 448834; -.
DR MGI; MGI:1920981; Kprp.
DR VEuPathDB; HostDB:ENSMUSG00000059832; -.
DR eggNOG; ENOG502S65C; Eukaryota.
DR GeneTree; ENSGT00730000111554; -.
DR HOGENOM; CLU_024690_0_0_1; -.
DR InParanoid; B2RUR4; -.
DR OMA; KPQGCTS; -.
DR OrthoDB; 1260706at2759; -.
DR PhylomeDB; B2RUR4; -.
DR TreeFam; TF351578; -.
DR BioGRID-ORCS; 433619; 3 hits in 72 CRISPR screens.
DR PRO; PR:B2RUR4; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; B2RUR4; protein.
DR Bgee; ENSMUSG00000059832; Expressed in tail skin and 39 other tissues.
DR Genevisible; B2RUR4; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
PE 2: Evidence at transcript level;
KW Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..657
FT /note="Keratinocyte proline-rich protein"
FT /id="PRO_0000364006"
FT REGION 285..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..442
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..493
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 442
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5T749"
SQ SEQUENCE 657 AA; 71740 MW; 7ABA3C866874F35C CRC64;
MCDQQPIQCC VPIPQCCVKG SSFGPSQFSY ANNQVLVEAP CEMKVLECAA PCPVQVSQTA
CQSSTTEVKG QAPCKTTKGK CQAPCQSKTT QVKYQPKTTE IKCQAPCQTQ VSCVQCQAPC
QSQVSYVQIP QPPQTYYVEC PPVYYTETRY VEYPVSTYMP APALQPGYTY VECPAVGQGQ
GQGQGGFSTQ YQYQGSYGSC TPQSQSRRSY SSCGPQNQSQ ASYSYCEPQF QSGPSYTNCG
PQRQSQASYG NCTSQLQSRA SYSNCSSQRR SGATFSTCAP RCQSQGTYGS YTSQRRSQST
SRCLPPRRLQ PSYRSCSPPR HSEPCYSSCL PSRCSSGSYN YCTPPRRSEP IYGSHCPPRG
RPSGCSQRCG PKCRVEISSP CCPRQVPPQR CPVQIPPFRG RSQSCPRQPS WGVSCPDLRP
RADPHPFPRS CRPQHLDRSP ESSRQRCPVP APRPYPRPQP CPSPEPRPYP RPQPCPSPEP
RPRPCPQPCP SPEPRPCPPL RRFSEPCLYP EPCSAPQPVP HPAPRPVPRP RPVHCENPGP
RPQPCPLPHP EPMPRPAPCS SPEPCGQPVR CPSPCSGPNP VPYRQELGCH ESNPCRLDTE
GPRCGSYNFT QRQESNGSCE SGDVFSGSHG LSGCGDQGNT CGGMNCGAYG GAKGAYF
