ID   KPRP_RAT                Reviewed;         699 AA.
AC   Q7TQM5;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Keratinocyte proline-rich protein;
GN   Name=Kprp;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RC   STRAIN=Sprague-Dawley; TISSUE=Fetal skin;
RX   PubMed=12668678; DOI=10.1074/jbc.m210488200;
RA   Kong W., Longaker M.T., Lorenz H.P.;
RT   "Molecular cloning and expression of keratinocyte proline-rich protein, a
RT   novel squamous epithelial marker isolated during skin development.";
RL   J. Biol. Chem. 278:22781-22786(2003).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12668678}.
CC   -!- TISSUE SPECIFICITY: Expressed in the stratified squamous epithelial
CC       layers of the skin, esophagus and tongue.
CC       {ECO:0000269|PubMed:12668678}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in skin and hair germ cells at 19, 20
CC       and 21 dpc. {ECO:0000269|PubMed:12668678}.
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DR   EMBL; AF548002; AAP74957.1; -; mRNA.
DR   RefSeq; NP_001002290.1; NM_001002290.1.
DR   AlphaFoldDB; Q7TQM5; -.
DR   STRING; 10116.ENSRNOP00000040866; -.
DR   PaxDb; Q7TQM5; -.
DR   PRIDE; Q7TQM5; -.
DR   GeneID; 432393; -.
DR   KEGG; rno:432393; -.
DR   UCSC; RGD:1303244; rat.
DR   CTD; 448834; -.
DR   RGD; 1303244; Kprp.
DR   eggNOG; ENOG502S65C; Eukaryota.
DR   InParanoid; Q7TQM5; -.
DR   OrthoDB; 1260706at2759; -.
DR   PhylomeDB; Q7TQM5; -.
DR   PRO; PR:Q7TQM5; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..699
FT                   /note="Keratinocyte proline-rich protein"
FT                   /id="PRO_0000271009"
FT   REGION          448..533
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        448..471
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        472..516
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        517..533
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         436
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5T749"
SQ   SEQUENCE   699 AA;  76358 MW;  CD86DE65F59425A6 CRC64;
     MCDQQEIQCC GPIPQCCVKG SSFGPSQFPY ANNQVLVEAP CEMQFLECAA PCPIQVSQTP
     CQSSTTEVKG QAPCKTTNVK CQTKTTQVKC QPKTTEIKCQ APCQAQVSCV QCQAPCQSQV
     SYVQVPQPPQ TYYVECAPVY YTETRFVEYP VSNYVPVPAP QPGYTYVECP SLGQGQGQGS
     FSTRYQYQGS YGSCTSQSQS RGSYSSCGPQ HQSQASYSYC EPQFQSRPSY TNCGTQRQSQ
     ASFGSCTSQL QSRASYSNCS SQRRSGTSFS TCAPQCQGQG TYGSFTAQRK SQSASRCLPS
     RRLQPSYRSC SPPRHSEPCY SSCLPSRCSS GSYNYCTPPR RSEPIYGSHC SPRGRPSGCS
     QRCGPKCRIE ISSPCCPRQV PPQRCPVQIP PIRGRSRSCP RQPSWGVSCP DLRPCAEPHA
     FPRPCRPQRL DRSPESSWRR CPVPAPRPYP RPEPCPSPEP RPCPRPRPRP EPCPSPEPRP
     RPRPDPCPSP ELRPRPRPEP CPSPEPRPRP RPDPCPSPEP RPRPCPEPCP SPEPRPCPPL
     RRFSEPCLYP EPCSVSKPVP CPVPCPAPHP RPVHCETPGR RPQPSPRSQP CPHPEPMPRP
     VPCSSPVPCG DPIHCPSPCS GHNPVPYSQE LGCHESNPCR LDTEGPSSYS FSQGQESNGC
     CVSGGVFSGS RGLSGCGDQG NTYRGMNCGA CGGTQGAYF