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ARAR_ALKHC
ID   ARAR_ALKHC              Reviewed;         375 AA.
AC   Q9KBQ0;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Arabinose metabolism transcriptional repressor;
GN   Name=araR; OrderedLocusNames=BH1875;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: Transcriptional repressor of the arabinose utilization genes.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
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DR   EMBL; BA000004; BAB05594.1; -; Genomic_DNA.
DR   PIR; C83884; C83884.
DR   RefSeq; WP_010898036.1; NC_002570.2.
DR   AlphaFoldDB; Q9KBQ0; -.
DR   SMR; Q9KBQ0; -.
DR   STRING; 272558.10174493; -.
DR   PRIDE; Q9KBQ0; -.
DR   EnsemblBacteria; BAB05594; BAB05594; BAB05594.
DR   KEGG; bha:BH1875; -.
DR   eggNOG; COG1609; Bacteria.
DR   HOGENOM; CLU_037628_15_0_9; -.
DR   OMA; DYIFPRI; -.
DR   OrthoDB; 1796334at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd01541; PBP1_AraR; 1.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR033532; AraR_ligand_bind_dom.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00392; GntR; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..375
FT                   /note="Arabinose metabolism transcriptional repressor"
FT                   /id="PRO_0000050618"
FT   DOMAIN          1..70
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        30..49
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   375 AA;  42747 MW;  4D20C954C6A95867 CRC64;
     METKYNFVKQ QIKSKILEGI VLPHGKIGSE NELMKEYNVS RHTVRKAIDE LVNEGWVYRK
     QGAGTFCADR TDQKNPIGKA QRKNIALITT YLSEYIFPSI IRGAESILSE HGYQVTIFST
     NNNHEQEKRA LEAVLSQRFD GLIVEPTKSS IPNPNINYYL NLERQGIPYV MINAYYEELE
     PYFLGMDDVK GGYTQTKHLL DLGHEQIVGL FKNDDLQGAK RLKGFIKAHR ERGIALNPQH
     IITYTTEQKN AKPLEELHRI FKDRSHRPTG IVCYNDELAL KLLDVIREFD IRVPEELSVV
     GYDDSFLSVA SEVKLTTIQH PKVEMGIDAA KLIISCIEQE RKDRSADGEQ SIIYEPKLVV
     RHSTAEAKSE KGVAK
 
 
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