ID   KPRS1_ORYSJ             Reviewed;         396 AA.
AC   Q6Z2L5; Q0E4B1; Q6Z2L6;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 2.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Ribose-phosphate pyrophosphokinase 1, chloroplastic;
DE            EC=2.7.6.1;
DE   AltName: Full=Phosphoribosyl pyrophosphate synthase 1;
DE   Flags: Precursor;
GN   OrderedLocusNames=Os02g0127700, LOC_Os02g03540;
GN   ORFNames=P0482F12.28-1, P0482F12.28-2, P0576F08.1-1, P0576F08.1-2;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-
CC         diphosphate + AMP + H(+); Xref=Rhea:RHEA:15609, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58017, ChEBI:CHEBI:78346,
CC         ChEBI:CHEBI:456215; EC=2.7.6.1;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6Z2L5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6Z2L5-2; Sequence=VSP_013703;
CC   -!- SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase family.
CC       {ECO:0000305}.
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DR   EMBL; AP004886; BAD07971.1; -; Genomic_DNA.
DR   EMBL; AP004886; BAD07972.1; -; Genomic_DNA.
DR   EMBL; AP005311; BAD08028.1; -; Genomic_DNA.
DR   EMBL; AP005311; BAD08029.1; -; Genomic_DNA.
DR   EMBL; AP008208; BAF07677.1; -; Genomic_DNA.
DR   EMBL; AP014958; BAS76781.1; -; Genomic_DNA.
DR   EMBL; AK060422; BAG87440.1; -; mRNA.
DR   EMBL; AK072096; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AK099092; BAG93919.1; -; mRNA.
DR   RefSeq; XP_015623376.1; XM_015767890.1. [Q6Z2L5-1]
DR   AlphaFoldDB; Q6Z2L5; -.
DR   SMR; Q6Z2L5; -.
DR   STRING; 4530.OS02T0127700-02; -.
DR   PaxDb; Q6Z2L5; -.
DR   PRIDE; Q6Z2L5; -.
DR   EnsemblPlants; Os02t0127700-02; Os02t0127700-02; Os02g0127700. [Q6Z2L5-1]
DR   GeneID; 4328168; -.
DR   Gramene; Os02t0127700-02; Os02t0127700-02; Os02g0127700. [Q6Z2L5-1]
DR   KEGG; osa:4328168; -.
DR   eggNOG; KOG1448; Eukaryota.
DR   HOGENOM; CLU_033546_7_0_1; -.
DR   InParanoid; Q6Z2L5; -.
DR   OMA; FGWARQD; -.
DR   OrthoDB; 1043963at2759; -.
DR   PlantReactome; R-OSA-1119278; PRPP biosynthesis I.
DR   Proteomes; UP000000763; Chromosome 2.
DR   Proteomes; UP000059680; Chromosome 2.
DR   ExpressionAtlas; Q6Z2L5; baseline and differential.
DR   Genevisible; Q6Z2L5; OS.
DR   GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0002189; C:ribose phosphate diphosphokinase complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0004749; F:ribose phosphate diphosphokinase activity; IBA:GO_Central.
DR   GO; GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IBA:GO_Central.
DR   GO; GO:0009156; P:ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 2.
DR   HAMAP; MF_00583_B; RibP_PPkinase_B; 1.
DR   InterPro; IPR000842; PRib_PP_synth_CS.
DR   InterPro; IPR029099; Pribosyltran_N.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR005946; Rib-P_diPkinase.
DR   InterPro; IPR037515; Rib-P_diPkinase_bac.
DR   PANTHER; PTHR10210; PTHR10210; 1.
DR   Pfam; PF14572; Pribosyl_synth; 1.
DR   Pfam; PF13793; Pribosyltran_N; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
DR   TIGRFAMs; TIGR01251; ribP_PPkin; 1.
DR   PROSITE; PS00114; PRPP_SYNTHASE; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; ATP-binding; Chloroplast; Kinase; Magnesium;
KW   Metal-binding; Nucleotide biosynthesis; Nucleotide-binding; Plastid;
KW   Reference proteome; Transferase; Transit peptide.
FT   TRANSIT         1..36
FT                   /note="Chloroplast"
FT                   /evidence="ECO:0000255"
FT   CHAIN           37..396
FT                   /note="Ribose-phosphate pyrophosphokinase 1, chloroplastic"
FT                   /id="PRO_0000141097"
FT   REGION          290..305
FT                   /note="Binding of phosphoribosylpyrophosphate"
FT                   /evidence="ECO:0000255"
FT   BINDING         204
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         206
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         215
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         219
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         194..224
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12869764"
FT                   /id="VSP_013703"
SQ   SEQUENCE   396 AA;  42926 MW;  C9B788A6A8DD341A CRC64;
     MPLSYSAAAA AAPSPLAARS RGLLRRPPRS SPVVVRCKKI DQLRAVNGIP PYAPVSNRSL
     LSPVTLPIIR DANIKNDTRL RIFSGTANPS LSQEIASYLG LELGKINIKR FADGEIYVQL
     QESVRGCDVF LVQPTCPPAN ENLMELLIMI DACRRASAKN ITAVIPYFGY ARADRKSQGR
     ESIAAKLVAN MITEAGANRV LVCDLHSSQA MGYFDIPVDH VYGQPVILDY LASKTICSDD
     LVVVSPDVGG VARARAFAKK LSDAPLAIVD KRRHGHNVAE VMNLIGDVRG KVAVMMDDMI
     DTAGTIAKGA ELLHQEGARE VYACCTHAVF SPPAIERLSS GLFQEVIITN TIPLKEDKSF
     PQLTILSVAN LLGETIWRVH DDCSVGHEPY SSLDID