ID   ARAR_GEOSE              Reviewed;         364 AA.
AC   Q9S470;
DT   03-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Arabinose metabolism transcriptional repressor;
GN   Name=araR;
OS   Geobacillus stearothermophilus (Bacillus stearothermophilus).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=1422;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=T-6 / NCIMB 40222;
RA   Gilead-Gropper S., Shoham Y.;
RT   "The L-arabinose utilization gene cluster from Bacillus stearothermophilus
RT   T-6.";
RL   Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor of the arabinose utilization genes.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
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DR   EMBL; AF160811; AAD45715.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9S470; -.
DR   SMR; Q9S470; -.
DR   PRIDE; Q9S470; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd01541; PBP1_AraR; 1.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR033532; AraR_ligand_bind_dom.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00392; GntR; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..364
FT                   /note="Arabinose metabolism transcriptional repressor"
FT                   /id="PRO_0000050619"
FT   DOMAIN          6..74
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        34..53
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   364 AA;  41945 MW;  EE87DCF065655168 CRC64;
     MKEKTLPKYL QLKQEILSWI ISGQMKPDEK IPTEHEIANQ FQLSRHTVRQ ALGELEKEGW
     LYKIQGSGTF VSRPKPKEQV DTKTIGIVTT YISDYIFPHI VRGAEETLRE KGYRLLLAST
     NNDKQREKEQ LEEMIREPLS GLIIEPTKSA QGNPNMGYYL SLNNLHIPYV MINARYLEVS
     CPCVKMDDEQ GGFLLTDHLI RLGHRRIAGF FKTDDLQGVD RLRGFIRAHQ QHEVPVATEY
     LLSYATEEKW TKPLEVAREF LQRPKEERPT AFVCYNDELA ILLLEVIRQQ GLSVPDDISI
     VGFDDFTFAT ATEVKLTTIR HPKTEMGVQA AEMLIQMIEQ RSVDKIGDII YRPELIVRNS
     TKEI