ID   KPSE1_ECOLX             Reviewed;         382 AA.
AC   P42501;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Capsule polysaccharide export inner-membrane protein KpsE;
GN   Name=kpsE;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K1;
RX   PubMed=8253690; DOI=10.1128/jb.175.24.8018-8023.1993;
RA   Cieslewicz M.J., Steenbergen S.M., Vimr E.R.;
RT   "Cloning, sequencing, expression, and complementation analysis of the
RT   Escherichia coli K1 kps region 1 gene, kpsE, and identification of an
RT   upstream open reading frame encoding a protein with homology to GutQ.";
RL   J. Bacteriol. 175:8018-8023(1993).
CC   -!- FUNCTION: Involved in the translocation of the polysialic acid capsule.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BexC/CtrB/KpsE family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB51624.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L19929; AAB51624.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; P42501; -.
DR   SMR; P42501; -.
DR   DIP; DIP-17000N; -.
DR   IntAct; P42501; 1.
DR   TCDB; 8.A.4.1.1; the cytoplasmic membrane-periplasmic auxiliary-2 (mpa2) family.
DR   GO; GO:0009276; C:Gram-negative-bacterium-type cell wall; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005351; F:carbohydrate:proton symporter activity; IEA:InterPro.
DR   GO; GO:0015774; P:polysaccharide transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005705; BexC_CtrB_KpsE_VexD.
DR   TIGRFAMs; TIGR01010; BexC_CtrB_KpsE; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Cell inner membrane; Cell membrane;
KW   Membrane; Polysaccharide transport; Sugar transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..382
FT                   /note="Capsule polysaccharide export inner-membrane protein
FT                   KpsE"
FT                   /id="PRO_0000084316"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   382 AA;  43050 MW;  05D25E12BD86F4B5 CRC64;
     MLIKVKSAVS WMRARLSAIS LADIQKHLAK IIILAPMAML LIYLAIFSQP RYMSESKVAI
     KRSDDLNSGS LNFGLLLGAS NPSSAEDALY LKEYINSPDM LAALDKQLNF REAFSHSGLD
     FLNHLSKDET AEGFLKYYKD RINVSYDDKT GLLNIQTTGF SPEFALKFNQ TVLKESERFI
     NEMSHRIARD QLAFAETEME KARQRLDASK AELLSYQDNN NVLDPQAQAQ AASTLVNTLM
     GQKIQMEADL RNLLTYLRED APQVVSARNA IQSLQAQIDE EQSKITAPQG DKLNRMAVDF
     EEIKSKVEFN TELYKLTLTS IEKTRVEAAR KLKVLSVISS PQLPQESSFP NIPYLIACWL
     LVCCLLFGTL KLLLAVIEDH RD