ARBH_ASFK5
ID ARBH_ASFK5 Reviewed; 179 AA.
AC P0C8H4;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 29.
DE RecName: Full=Apoptosis regulator Bcl-2 homolog;
GN OrderedLocusNames=Ken-053;
OS African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Asfuvirales; Asfarviridae; Asfivirus.
OX NCBI_TaxID=561445;
OH NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Kutish G.F., Rock D.L.;
RT "African swine fever virus genomes.";
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Suppresses apoptosis in host cell to promote the viral
CC replication (By similarity). Has the ability to potentially bind to all
CC the members of the proapoptotic Bcl-2 family (By similarity). Inhibits
CC autophagy by interacting with host Beclin 1 (BECN1) (By similarity).
CC {ECO:0000250|UniProtKB:P42485}.
CC -!- SUBUNIT: Interacts with host BECN1 (via BH3 homology domain); this
CC interaction allows the virus to inhibit BECN1, and thus autophagy (By
CC similarity). Interacts with host BID (By similarity). Interacts with
CC host BAX (By similarity). {ECO:0000250|UniProtKB:P42485}.
CC -!- SUBCELLULAR LOCATION: Host mitochondrion
CC {ECO:0000250|UniProtKB:P42485}. Host endoplasmic reticulum
CC {ECO:0000250|UniProtKB:P42485}.
CC -!- INDUCTION: Expressed in the early phase of the viral replicative cycle
CC (By similarity). Expressed in the late phase of the viral replicative
CC cycle (By similarity). {ECO:0000250|UniProtKB:P42485,
CC ECO:0000250|UniProtKB:Q07819}.
CC -!- SIMILARITY: Belongs to the Bcl-2 family. {ECO:0000305}.
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DR EMBL; AY261360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; P0C8H4; -.
DR Proteomes; UP000000861; Genome.
DR GO; GO:0044165; C:host cell endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0019050; P:suppression by virus of host apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0039521; P:suppression by virus of host autophagy; IEA:UniProtKB-KW.
DR Gene3D; 1.10.437.10; -; 1.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR046371; Bcl-2_BH1-3.
DR InterPro; IPR026298; Bcl-2_fam.
DR InterPro; IPR002475; Bcl2-like.
DR InterPro; IPR020717; Bcl2_BH1_motif_CS.
DR InterPro; IPR020726; Bcl2_BH2_motif_CS.
DR PANTHER; PTHR11256; PTHR11256; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR PRINTS; PR01862; BCL2FAMILY.
DR SMART; SM00337; BCL; 1.
DR SUPFAM; SSF56854; SSF56854; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
DR PROSITE; PS01080; BH1; 1.
DR PROSITE; PS01258; BH2; 1.
PE 3: Inferred from homology;
KW Early protein; Host endoplasmic reticulum; Host mitochondrion;
KW Host-virus interaction;
KW Inhibition of host apoptosis by viral BCL2-like protein;
KW Inhibition of host autophagy by virus; Late protein;
KW Modulation of host cell apoptosis by virus.
FT CHAIN 1..179
FT /note="Apoptosis regulator Bcl-2 homolog"
FT /id="PRO_0000355216"
FT MOTIF 76..95
FT /note="BH1"
FT /evidence="ECO:0000255"
FT MOTIF 126..141
FT /note="BH2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 179 AA; 21080 MW; DE10792A2E21E633 CRC64;
MEGEELIYHN IINEILVGYI KYYMNDISEH ELSPYQQQIK KILTYYDDCL NKQVTITFSL
TSAQEIKTQF TEVVTELFKD LINWGRICGF IVFSARMAKY CKDANNHLES TVITTAYNFM
KHNLLPWMIS HGGQEEFLAF SLHSDIYSVI FNIKYFLSKF CNHMFLKSCV HLLRNCNLI
