ID   KPTA_AERPE              Reviewed;         220 AA.
AC   Q9YFP5;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   30-APR-2003, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Probable RNA 2'-phosphotransferase;
DE            EC=2.7.1.-;
GN   Name=kptA; OrderedLocusNames=APE_0204.1;
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS   K1).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA   Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA   Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT   Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- FUNCTION: Removes the 2'-phosphate from RNA via an intermediate in
CC       which the phosphate is ADP-ribosylated by NAD followed by a presumed
CC       transesterification to release the RNA and generate ADP-ribose 1''-2''-
CC       cyclic phosphate (APPR>P). May function as an ADP-ribosylase (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the KptA/TPT1 family. {ECO:0000305}.
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DR   EMBL; BA000002; BAA79116.2; -; Genomic_DNA.
DR   PIR; B72777; B72777.
DR   PDB; 1WFX; X-ray; 2.80 A; A=35-220.
DR   PDBsum; 1WFX; -.
DR   AlphaFoldDB; Q9YFP5; -.
DR   SMR; Q9YFP5; -.
DR   STRING; 272557.APE_0204.1; -.
DR   EnsemblBacteria; BAA79116; BAA79116; APE_0204.1.
DR   KEGG; ape:APE_0204.1; -.
DR   PATRIC; fig|272557.25.peg.146; -.
DR   eggNOG; arCOG04063; Archaea.
DR   OMA; TEEPVHC; -.
DR   BRENDA; 2.7.1.160; 171.
DR   EvolutionaryTrace; Q9YFP5; -.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:InterPro.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:UniProtKB-UniRule.
DR   GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.970; -; 1.
DR   Gene3D; 3.20.170.30; -; 1.
DR   HAMAP; MF_00299; KptA; 1.
DR   InterPro; IPR002745; Ptrans_KptA/Tpt1.
DR   InterPro; IPR042081; RNA_2'-PTrans_C.
DR   InterPro; IPR022928; RNA_2'-PTrans_KptA.
DR   InterPro; IPR042080; RNA_2'-PTrans_N.
DR   PANTHER; PTHR12684; PTHR12684; 1.
DR   Pfam; PF01885; PTS_2-RNA; 1.
PE   1: Evidence at protein level;
KW   3D-structure; NAD; Reference proteome; Transferase.
FT   CHAIN           1..220
FT                   /note="Probable RNA 2'-phosphotransferase"
FT                   /id="PRO_0000157484"
FT   HELIX           39..48
FT                   /evidence="ECO:0007829|PDB:1WFX"
FT   HELIX           52..54
FT                   /evidence="ECO:0007829|PDB:1WFX"
FT   HELIX           66..75
FT                   /evidence="ECO:0007829|PDB:1WFX"
FT   HELIX           83..92
FT                   /evidence="ECO:0007829|PDB:1WFX"
FT   STRAND          98..101
FT                   /evidence="ECO:0007829|PDB:1WFX"
FT   STRAND          104..109
FT                   /evidence="ECO:0007829|PDB:1WFX"
FT   STRAND          126..130
FT                   /evidence="ECO:0007829|PDB:1WFX"
FT   HELIX           134..136
FT                   /evidence="ECO:0007829|PDB:1WFX"
FT   HELIX           137..143
FT                   /evidence="ECO:0007829|PDB:1WFX"
FT   STRAND          149..157
FT                   /evidence="ECO:0007829|PDB:1WFX"
FT   HELIX           159..166
FT                   /evidence="ECO:0007829|PDB:1WFX"
FT   STRAND          169..179
FT                   /evidence="ECO:0007829|PDB:1WFX"
FT   HELIX           180..185
FT                   /evidence="ECO:0007829|PDB:1WFX"
FT   STRAND          194..201
FT                   /evidence="ECO:0007829|PDB:1WFX"
FT   HELIX           205..207
FT                   /evidence="ECO:0007829|PDB:1WFX"
FT   STRAND          208..213
FT                   /evidence="ECO:0007829|PDB:1WFX"
SQ   SEQUENCE   220 AA;  24703 MW;  57DA42C6A4159156 CRC64;
     MAEELPELAL CCDGTVVEGR SNCRCKARAV LPGGMRVRLS KTLAGILRHH PGRYGVRLTR
     EGWARVSEVV EGLRKAGWSW VEEWHIVGVA LHDPKGRYEL RNGEIRARYG HSIPVNVEPL
     PGEPPPILYH GTTEEALPLI MERGIMRGRR LKVHLTSSLE DAVSTGRRHG NLVAVLLVDV
     ECLRRRGLKV ERMSKTVYTV DWVPPECIAE VRRESLGRSL