ID   KPTA_ECOL5              Reviewed;         184 AA.
AC   Q0T8X6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Probable RNA 2'-phosphotransferase {ECO:0000255|HAMAP-Rule:MF_00299};
DE            EC=2.7.1.- {ECO:0000255|HAMAP-Rule:MF_00299};
GN   Name=kptA {ECO:0000255|HAMAP-Rule:MF_00299}; OrderedLocusNames=ECP_4667;
OS   Escherichia coli O6:K15:H31 (strain 536 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=362663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=536 / UPEC;
RX   PubMed=16879640; DOI=10.1111/j.1365-2958.2006.05255.x;
RA   Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U.,
RA   Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.;
RT   "Role of pathogenicity island-associated integrases in the genome
RT   plasticity of uropathogenic Escherichia coli strain 536.";
RL   Mol. Microbiol. 61:584-595(2006).
CC   -!- FUNCTION: Removes the 2'-phosphate from RNA via an intermediate in
CC       which the phosphate is ADP-ribosylated by NAD followed by a presumed
CC       transesterification to release the RNA and generate ADP-ribose 1''-2''-
CC       cyclic phosphate (APPR>P). May function as an ADP-ribosylase.
CC       {ECO:0000255|HAMAP-Rule:MF_00299}.
CC   -!- SIMILARITY: Belongs to the KptA/TPT1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00299}.
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DR   EMBL; CP000247; ABG72603.1; -; Genomic_DNA.
DR   RefSeq; WP_001151841.1; NC_008253.1.
DR   AlphaFoldDB; Q0T8X6; -.
DR   SMR; Q0T8X6; -.
DR   STRING; 362663.ECP_4667; -.
DR   EnsemblBacteria; ABG72603; ABG72603; ECP_4667.
DR   KEGG; ecp:ECP_4667; -.
DR   HOGENOM; CLU_052998_4_0_6; -.
DR   OMA; YLYHGTV; -.
DR   Proteomes; UP000009182; Chromosome.
DR   GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:InterPro.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:UniProtKB-UniRule.
DR   GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.970; -; 1.
DR   Gene3D; 3.20.170.30; -; 1.
DR   HAMAP; MF_00299; KptA; 1.
DR   InterPro; IPR002745; Ptrans_KptA/Tpt1.
DR   InterPro; IPR042081; RNA_2'-PTrans_C.
DR   InterPro; IPR022928; RNA_2'-PTrans_KptA.
DR   InterPro; IPR042080; RNA_2'-PTrans_N.
DR   PANTHER; PTHR12684; PTHR12684; 1.
DR   Pfam; PF01885; PTS_2-RNA; 1.
PE   3: Inferred from homology;
KW   NAD; Transferase.
FT   CHAIN           1..184
FT                   /note="Probable RNA 2'-phosphotransferase"
FT                   /id="PRO_1000022015"
SQ   SEQUENCE   184 AA;  20501 MW;  F68A86F739BCED85 CRC64;
     MAKYNDKELA ETSKFLSFVL RHKPEAIGIV LDREGWADID KLILCAQKAG KRLTRALLDT
     VVATSDKKRF SYSSDGTCIR AVQGHSTSQV AIAFIEKTPP QFLYHGTASR FLDEIKKQGL
     IAGERHYVHL SADEATARKV GARHGSPVIL TVKAQEMAKR GIPFWQAENG VWLTSTVAVE
     FLEW