ID   ARBH_CNPV               Reviewed;         175 AA.
AC   Q6VZT9;
DT   28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Apoptosis regulator Bcl-2 homolog;
DE            Short=vBcl-2;
GN   Name=CNPV058;
OS   Canarypox virus (CNPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Avipoxvirus.
OX   NCBI_TaxID=44088;
OH   NCBI_TaxID=9134; Serinus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14671117; DOI=10.1128/jvi.78.1.353-366.2004;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Kutish G.F., Rock D.L.;
RT   "The genome of canarypox virus.";
RL   J. Virol. 78:353-366(2004).
RN   [2]
RP   FUNCTION, AND INTERACTION WITH HOST BAK1 AND BAX.
RX   PubMed=29053589; DOI=10.3390/v9100305;
RA   Anasir M.I., Baxter A.A., Poon I.K.H., Hulett M.D., Kvansakul M.;
RT   "Structural and functional insight into canarypox virus CNP058 mediated
RT   regulation of apoptosis.";
RL   Viruses 9:0-0(2017).
CC   -!- FUNCTION: Plays a role in the inhibition of host apoptosis. Interacts
CC       with host proapoptotic factors BAK1 and BAX to supposedly prevent their
CC       activation. {ECO:0000269|PubMed:29053589}.
CC   -!- SUBUNIT: Interacts with host BAK1 and BAX as well as other BH3-
CC       containing proteins including BIM, BID or PUMA.
CC       {ECO:0000269|PubMed:29053589}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
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DR   EMBL; AY318871; AAR83404.1; -; Genomic_DNA.
DR   RefSeq; NP_955081.1; NC_005309.1.
DR   PDB; 5WOS; X-ray; 2.45 A; A=1-143.
DR   PDBsum; 5WOS; -.
DR   SMR; Q6VZT9; -.
DR   GeneID; 2700183; -.
DR   KEGG; vg:2700183; -.
DR   Proteomes; UP000168164; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019050; P:suppression by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.437.10; -; 1.
DR   InterPro; IPR013281; Apop_reg_Mc1.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR046371; Bcl-2_BH1-3.
DR   InterPro; IPR026298; Bcl-2_fam.
DR   InterPro; IPR002475; Bcl2-like.
DR   PANTHER; PTHR11256; PTHR11256; 1.
DR   PANTHER; PTHR11256:SF46; PTHR11256:SF46; 1.
DR   Pfam; PF00452; Bcl-2; 1.
DR   SUPFAM; SSF56854; SSF56854; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Host membrane; Host-virus interaction;
KW   Inhibition of host apoptosis by viral BCL2-like protein; Membrane;
KW   Modulation of host cell apoptosis by virus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..175
FT                   /note="Apoptosis regulator Bcl-2 homolog"
FT                   /id="PRO_0000443228"
FT   TRANSMEM        152..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   HELIX           9..27
FT                   /evidence="ECO:0007829|PDB:5WOS"
FT   TURN            32..34
FT                   /evidence="ECO:0007829|PDB:5WOS"
FT   HELIX           38..64
FT                   /evidence="ECO:0007829|PDB:5WOS"
FT   HELIX           70..72
FT                   /evidence="ECO:0007829|PDB:5WOS"
FT   HELIX           73..81
FT                   /evidence="ECO:0007829|PDB:5WOS"
FT   HELIX           87..107
FT                   /evidence="ECO:0007829|PDB:5WOS"
FT   TURN            110..115
FT                   /evidence="ECO:0007829|PDB:5WOS"
FT   HELIX           116..133
FT                   /evidence="ECO:0007829|PDB:5WOS"
FT   TURN            134..136
FT                   /evidence="ECO:0007829|PDB:5WOS"
FT   HELIX           137..141
FT                   /evidence="ECO:0007829|PDB:5WOS"
SQ   SEQUENCE   175 AA;  20745 MW;  486BED45D42C90C4 CRC64;
     MDPSVKKDEI YYTILNIIQN YFIEYCTGKN RNFHVEDENT YIIVKNMCDI ILRDNIVEFR
     KDIDRCSDIE NEIPEIVYDT IHDKITWGRV ISIIAFGAYV TKVFKEKGRD NVVDLMPDII
     TESLLSRCRS WLSDQNCWDG LKAYVYNNKK FYYVTRYFRV AAFIITSLAV INLFL