KPTN_CHICK
ID KPTN_CHICK Reviewed; 430 AA.
AC A0A1D5PJB7;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2016, sequence version 1.
DT 03-AUG-2022, entry version 25.
DE RecName: Full=KICSTOR complex protein kaptin {ECO:0000303|PubMed:10099934};
DE AltName: Full=Actin-associated protein 2E4 {ECO:0000303|PubMed:10099934};
GN Name=KPTN {ECO:0000303|PubMed:10099934};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red jungle fowl;
RX PubMed=15592404; DOI=10.1038/nature03154;
RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA Wilson R.K.;
RT "Sequence and comparative analysis of the chicken genome provide unique
RT perspectives on vertebrate evolution.";
RL Nature 432:695-716(2004).
RN [2]
RP SUBCELLULAR LOCATION.
RX PubMed=10099934; DOI=10.1016/s0171-9335(99)80013-2;
RA Bearer E.L., Abraham M.T.;
RT "2E4 (kaptin): a novel actin-associated protein from human blood platelets
RT found in lamellipodia and the tips of the stereocilia of the inner ear.";
RL Eur. J. Cell Biol. 78:117-126(1999).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=11409409; DOI=10.1046/j.1469-1809.2000.6430189.x;
RA Bearer E.L., Chen A.F., Chen A.H., Li Z., Mark H.-F., Smith R.J.H.,
RA Jackson C.L.;
RT "2E4/Kaptin (KPTN) - a candidate gene for the hearing loss loci, DFNA4.";
RL Ann. Hum. Genet. 64:189-196(2000).
CC -!- FUNCTION: As part of the KICSTOR complex may function in the amino
CC acid-sensing branch of the TORC1 signaling pathway.
CC {ECO:0000250|UniProtKB:Q9Y664}.
CC -!- SUBUNIT: May be part of the KICSTOR complex.
CC {ECO:0000250|UniProtKB:Q9Y664}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9Y664}.
CC Cell projection, lamellipodium {ECO:0000269|PubMed:10099934}. Cell
CC projection, stereocilium {ECO:0000269|PubMed:10099934,
CC ECO:0000269|PubMed:11409409}. Note=Localization to lysosomes is amino
CC acid-independent (By similarity). Colocalizes with F-actin (By
CC similarity). {ECO:0000250|UniProtKB:Q9Y664}.
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DR EMBL; AADN04000872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015127970.1; XM_015272484.1.
DR AlphaFoldDB; A0A1D5PJB7; -.
DR GeneID; 101752009; -.
DR KEGG; gga:101752009; -.
DR CTD; 11133; -.
DR VEuPathDB; HostDB:geneid_101752009; -.
DR PRO; PR:A0A1D5PJB7; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:InterPro.
DR GO; GO:0140007; C:KICSTOR complex; ISS:UniProtKB.
DR GO; GO:0030027; C:lamellipodium; IDA:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032420; C:stereocilium; IDA:UniProtKB.
DR GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR GO; GO:0034198; P:cellular response to amino acid starvation; ISS:UniProtKB.
DR GO; GO:0042149; P:cellular response to glucose starvation; ISS:UniProtKB.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; ISS:UniProtKB.
DR GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR InterPro; IPR029982; Kptn.
DR PANTHER; PTHR15435; PTHR15435; 1.
PE 3: Inferred from homology;
KW Actin-binding; Cell projection; Lysosome; Membrane; Reference proteome.
FT CHAIN 1..430
FT /note="KICSTOR complex protein kaptin"
FT /id="PRO_0000440328"
FT REGION 256..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 430 AA; 46980 MW; 8DD6C9EAA3C15B1F CRC64;
MAGPCPLVED SCSRLPSQSN VYGLAALPGA GGLLAATLKG KVLHFRYQHL RHKLRPVARE
LQFTYIPVDA EIVSIGCFQK SAPKRGLVVG ITFIKDSGDK PSPFLNIYCD YEPGCEFDLD
SVAQSCLNLE LRFTPLQLCH AEVHIGDRCD TVFLLSGTDP GIHLYRENEG LHQFEEQPLH
ELFPELQELP SSALWLDVCT VPSSRRRLTA VGCQSGYVRV AHVDQDTRAV LQSWSIQQDG
PISTVLLFPL EEPDDDGDVA GGHRGADDVG PSAPGPEPTP HYSLLVASTI EMSVVYRDVL
SRGLTEQLSL PGSDHHDAVL CAMLACTALD GGREVLLGTY GQELLCYAYR GRRCGFQLLW
TRRFPGPVLA LCGADLTGDG LREVAVGCLQ GLHVLQHSLE PTAQRLKERL RREVARRAQQ
RGGEGTGTPK
