ID   ARBH_VARV               Reviewed;         237 AA.
AC   Q85365;
DT   28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   29-SEP-2021, entry version 53.
DE   RecName: Full=Apoptosis regulator Bcl-2 homolog;
DE            Short=vBcl-2;
DE   AltName: Full=F1L homolog;
GN   Name=C5L;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 39-201, INTERACTION WITH HOST
RP   BID; BAX AND BAK1, AND FUNCTION.
RX   PubMed=25766319; DOI=10.1038/cddis.2015.52;
RA   Marshall B., Puthalakath H., Caria S., Chugh S., Doerflinger M.,
RA   Colman P.M., Kvansakul M.;
RT   "Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus
RT   counterpart inhibits apoptosis independent of Bim.";
RL   Cell Death Dis. 6:E1680-E1680(2015).
CC   -!- FUNCTION: Plays a role in the inhibition of host apoptosis. Interacts
CC       with host BAX and thereby inhibits its activity.
CC       {ECO:0000269|PubMed:25766319}.
CC   -!- SUBUNIT: Interacts with host BAK1, BAX and BID.
CC       {ECO:0000269|PubMed:25766319}.
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DR   EMBL; L22579; AAA60773.1; -; Genomic_DNA.
DR   PIR; T28463; T28463.
DR   PDB; 5AJJ; X-ray; 1.75 A; A=39-201.
DR   PDB; 5AJK; X-ray; 2.55 A; A/C/E/G/I/K=39-201.
DR   PDBsum; 5AJJ; -.
DR   PDBsum; 5AJK; -.
DR   SMR; Q85365; -.
DR   MEROPS; I91.001; -.
DR   Proteomes; UP000119805; Genome.
DR   GO; GO:0019050; P:suppression by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.437.10; -; 1.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR011207; Orthopox_F1.
DR   InterPro; IPR021119; Poxvirus_F1/C10.
DR   Pfam; PF11099; M11L; 1.
DR   PIRSF; PIRSF015971; VAC_F1L; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Host-virus interaction;
KW   Inhibition of host apoptosis by viral BCL2-like protein;
KW   Modulation of host cell apoptosis by virus.
FT   CHAIN           1..237
FT                   /note="Apoptosis regulator Bcl-2 homolog"
FT                   /id="PRO_0000443227"
FT   HELIX           66..69
FT                   /evidence="ECO:0007829|PDB:5AJJ"
FT   HELIX           73..96
FT                   /evidence="ECO:0007829|PDB:5AJJ"
FT   HELIX           99..118
FT                   /evidence="ECO:0007829|PDB:5AJJ"
FT   HELIX           120..132
FT                   /evidence="ECO:0007829|PDB:5AJJ"
FT   HELIX           137..150
FT                   /evidence="ECO:0007829|PDB:5AJJ"
FT   HELIX           155..169
FT                   /evidence="ECO:0007829|PDB:5AJJ"
FT   HELIX           174..188
FT                   /evidence="ECO:0007829|PDB:5AJJ"
FT   HELIX           191..200
FT                   /evidence="ECO:0007829|PDB:5AJJ"
SQ   SEQUENCE   237 AA;  27716 MW;  20A79E111C37D266 CRC64;
     MYNSMLPMFM CNNIVDDIDD IDDIDDIDDI DDIDDIDDKA SNNDDHNYVY PLPENMVYRF
     NKSTNILDYL STERDHVMMA VQYYMSKQRL DDLYRQLPTK TRSYIDIINM YCDKVNNDYN
     RDMNIMYDMA STESFTVYDI NNEVNTILMD NKGLGVRLAT ISFITELGKR CMNPVETIKM
     FTLLSHTICD DCFIDYITDI SPPDNTIPNI STREYLKLIG ITAIMFATYK TLKYMIG