KR105_HUMAN
ID KR105_HUMAN Reviewed; 271 AA.
AC P60370; Q0VAR7; Q0VAR8; Q70LJ3;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Keratin-associated protein 10-5;
DE AltName: Full=High sulfur keratin-associated protein 10.5;
DE AltName: Full=Keratin-associated protein 10.5;
DE AltName: Full=Keratin-associated protein 18-5;
DE AltName: Full=Keratin-associated protein 18.5;
GN Name=KRTAP10-5; Synonyms=KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANTS PHE-183 AND
RP VAL-235.
RC TISSUE=Hair root;
RX PubMed=15028290; DOI=10.1016/j.ygeno.2003.09.024;
RA Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.;
RT "A cluster of 21 keratin-associated protein genes within introns of another
RT gene on human chromosome 21q22.3.";
RL Genomics 83:679-693(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ASN-20; PHE-183;
RP VAL-235 AND ARG-268.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 261-271, VARIANT ARG-268, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Scalp;
RX PubMed=14962103; DOI=10.1046/j.0022-202x.2003.22128.x;
RA Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S.,
RA Schweizer J.;
RT "Hair keratin associated proteins: characterization of a second high sulfur
RT KAP gene domain on human chromosome 21.";
RL J. Invest. Dermatol. 122:147-158(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC P60370; Q6UY14-3: ADAMTSL4; NbExp=6; IntAct=EBI-10172150, EBI-10173507;
CC P60370; Q8WTP8: AEN; NbExp=3; IntAct=EBI-10172150, EBI-8637627;
CC P60370; P43353: ALDH3B1; NbExp=3; IntAct=EBI-10172150, EBI-2558314;
CC P60370; Q9Y2J4-4: AMOTL2; NbExp=3; IntAct=EBI-10172150, EBI-10187270;
CC P60370; A8KA13: BCL6B; NbExp=3; IntAct=EBI-10172150, EBI-10174813;
CC P60370; A8K571: BMP7; NbExp=3; IntAct=EBI-10172150, EBI-10174327;
CC P60370; Q13895: BYSL; NbExp=5; IntAct=EBI-10172150, EBI-358049;
CC P60370; Q6NUJ2: C11orf87; NbExp=3; IntAct=EBI-10172150, EBI-6660291;
CC P60370; Q8WW18: C17orf50; NbExp=3; IntAct=EBI-10172150, EBI-12877892;
CC P60370; Q9H257: CARD9; NbExp=3; IntAct=EBI-10172150, EBI-751319;
CC P60370; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-10172150, EBI-744545;
CC P60370; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-10172150, EBI-947551;
CC P60370; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-10172150, EBI-741032;
CC P60370; Q02930-3: CREB5; NbExp=6; IntAct=EBI-10172150, EBI-10192698;
CC P60370; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10172150, EBI-3867333;
CC P60370; Q6P158: DHX57; NbExp=3; IntAct=EBI-10172150, EBI-1051531;
CC P60370; P42892: ECE1; NbExp=3; IntAct=EBI-10172150, EBI-2859983;
CC P60370; O60573: EIF4E2; NbExp=3; IntAct=EBI-10172150, EBI-398610;
CC P60370; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-10172150, EBI-744099;
CC P60370; Q5TZK3: FAM74A6; NbExp=3; IntAct=EBI-10172150, EBI-10247271;
CC P60370; Q5HYJ3: FAM76B; NbExp=5; IntAct=EBI-10172150, EBI-751192;
CC P60370; Q5HYJ3-3: FAM76B; NbExp=3; IntAct=EBI-10172150, EBI-11956087;
CC P60370; O95363: FARS2; NbExp=3; IntAct=EBI-10172150, EBI-2513774;
CC P60370; Q9NWN3: FBXO34; NbExp=3; IntAct=EBI-10172150, EBI-719816;
CC P60370; A0A0C3SFZ9: FCHO1; NbExp=3; IntAct=EBI-10172150, EBI-11977403;
CC P60370; P15976: GATA1; NbExp=3; IntAct=EBI-10172150, EBI-3909284;
CC P60370; O76003: GLRX3; NbExp=6; IntAct=EBI-10172150, EBI-374781;
CC P60370; Q9Y223: GNE; NbExp=3; IntAct=EBI-10172150, EBI-4291090;
CC P60370; Q0D2H9: GOLGA8DP; NbExp=3; IntAct=EBI-10172150, EBI-10181276;
CC P60370; Q03014: HHEX; NbExp=3; IntAct=EBI-10172150, EBI-747421;
CC P60370; P49639: HOXA1; NbExp=6; IntAct=EBI-10172150, EBI-740785;
CC P60370; P37235: HPCAL1; NbExp=3; IntAct=EBI-10172150, EBI-749311;
CC P60370; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10172150, EBI-11749135;
CC P60370; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-10172150, EBI-10172150;
CC P60370; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-10172150, EBI-12012928;
CC P60370; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10172150, EBI-10172290;
CC P60370; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10172150, EBI-10171774;
CC P60370; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-10172150, EBI-1052037;
CC P60370; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-10172150, EBI-10210845;
CC P60370; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-10172150, EBI-10176379;
CC P60370; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-10172150, EBI-11953846;
CC P60370; P0C7H8: KRTAP2-3; NbExp=3; IntAct=EBI-10172150, EBI-10196781;
CC P60370; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-10172150, EBI-3957672;
CC P60370; Q9BYR7: KRTAP3-2; NbExp=6; IntAct=EBI-10172150, EBI-751260;
CC P60370; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-10172150, EBI-739863;
CC P60370; Q9BYR5: KRTAP4-2; NbExp=8; IntAct=EBI-10172150, EBI-10172511;
CC P60370; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-10172150, EBI-11958132;
CC P60370; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-10172150, EBI-10250562;
CC P60370; P26371: KRTAP5-9; NbExp=8; IntAct=EBI-10172150, EBI-3958099;
CC P60370; Q9BYQ4: KRTAP9-2; NbExp=5; IntAct=EBI-10172150, EBI-1044640;
CC P60370; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-10172150, EBI-1043191;
CC P60370; Q9BYQ2: KRTAP9-4; NbExp=5; IntAct=EBI-10172150, EBI-10185730;
CC P60370; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-10172150, EBI-11958364;
CC P60370; Q5T7P3: LCE1B; NbExp=10; IntAct=EBI-10172150, EBI-10245913;
CC P60370; Q5T751: LCE1C; NbExp=5; IntAct=EBI-10172150, EBI-12224199;
CC P60370; Q5T752: LCE1D; NbExp=3; IntAct=EBI-10172150, EBI-11741311;
CC P60370; Q5T753: LCE1E; NbExp=3; IntAct=EBI-10172150, EBI-11955335;
CC P60370; Q5TA79: LCE2A; NbExp=6; IntAct=EBI-10172150, EBI-10246607;
CC P60370; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-10172150, EBI-11973993;
CC P60370; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-10172150, EBI-10246750;
CC P60370; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-10172150, EBI-11974495;
CC P60370; Q5T5A8: LCE3C; NbExp=7; IntAct=EBI-10172150, EBI-10245291;
CC P60370; Q9BYE3: LCE3D; NbExp=6; IntAct=EBI-10172150, EBI-6658837;
CC P60370; Q5T5B0: LCE3E; NbExp=8; IntAct=EBI-10172150, EBI-10245456;
CC P60370; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-10172150, EBI-10246358;
CC P60370; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-10172150, EBI-11955689;
CC P60370; Q5T871: LELP1; NbExp=3; IntAct=EBI-10172150, EBI-18115868;
CC P60370; Q7Z4I7-5: LIMS2; NbExp=3; IntAct=EBI-10172150, EBI-10257651;
CC P60370; Q9P127: LUZP4; NbExp=3; IntAct=EBI-10172150, EBI-10198848;
CC P60370; P50222: MEOX2; NbExp=3; IntAct=EBI-10172150, EBI-748397;
CC P60370; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-10172150, EBI-16439278;
CC P60370; Q13875: MOBP; NbExp=3; IntAct=EBI-10172150, EBI-10230628;
CC P60370; A1L3X4: MT1DP; NbExp=3; IntAct=EBI-10172150, EBI-10172129;
CC P60370; P50539-3: MXI1; NbExp=3; IntAct=EBI-10172150, EBI-10211940;
CC P60370; P41227: NAA10; NbExp=3; IntAct=EBI-10172150, EBI-747693;
CC P60370; Q92692: NECTIN2; NbExp=3; IntAct=EBI-10172150, EBI-718419;
CC P60370; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10172150, EBI-945833;
CC P60370; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10172150, EBI-22310682;
CC P60370; Q9NQX5: NPDC1; NbExp=3; IntAct=EBI-10172150, EBI-748927;
CC P60370; P22736: NR4A1; NbExp=3; IntAct=EBI-10172150, EBI-721550;
CC P60370; Q92570: NR4A3; NbExp=5; IntAct=EBI-10172150, EBI-13644623;
CC P60370; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-10172150, EBI-741158;
CC P60370; Q7Z417: NUFIP2; NbExp=6; IntAct=EBI-10172150, EBI-1210753;
CC P60370; P32242: OTX1; NbExp=6; IntAct=EBI-10172150, EBI-740446;
CC P60370; Q12837: POU4F2; NbExp=3; IntAct=EBI-10172150, EBI-17236143;
CC P60370; O43741: PRKAB2; NbExp=3; IntAct=EBI-10172150, EBI-1053424;
CC P60370; P54619: PRKAG1; NbExp=3; IntAct=EBI-10172150, EBI-1181439;
CC P60370; Q9NZ81: PRR13; NbExp=3; IntAct=EBI-10172150, EBI-740924;
CC P60370; P10745: RBP3; NbExp=3; IntAct=EBI-10172150, EBI-12806054;
CC P60370; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-10172150, EBI-748391;
CC P60370; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-10172150, EBI-10313866;
CC P60370; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-10172150, EBI-11955083;
CC P60370; Q9UHI7: SLC23A1; NbExp=3; IntAct=EBI-10172150, EBI-1759386;
CC P60370; Q9NP91: SLC6A20; NbExp=3; IntAct=EBI-10172150, EBI-10311198;
CC P60370; P49901: SMCP; NbExp=3; IntAct=EBI-10172150, EBI-750494;
CC P60370; Q96E40: SPACA9; NbExp=3; IntAct=EBI-10172150, EBI-722584;
CC P60370; O43609: SPRY1; NbExp=3; IntAct=EBI-10172150, EBI-3866665;
CC P60370; O43597: SPRY2; NbExp=3; IntAct=EBI-10172150, EBI-742487;
CC P60370; O75716: STK16; NbExp=3; IntAct=EBI-10172150, EBI-749295;
CC P60370; Q9P2Z0: THAP10; NbExp=3; IntAct=EBI-10172150, EBI-745404;
CC P60370; Q4VB56: TNP2; NbExp=3; IntAct=EBI-10172150, EBI-10241829;
CC P60370; Q63HR2: TNS2; NbExp=3; IntAct=EBI-10172150, EBI-949753;
CC P60370; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-10172150, EBI-5235829;
CC P60370; Q9Y260: TRPV6; NbExp=3; IntAct=EBI-10172150, EBI-750052;
CC P60370; O75386: TULP3; NbExp=3; IntAct=EBI-10172150, EBI-5357290;
CC P60370; Q86UY0: TXNDC5; NbExp=3; IntAct=EBI-10172150, EBI-2825190;
CC P60370; Q8TAI1: TYMSOS; NbExp=3; IntAct=EBI-10172150, EBI-742060;
CC P60370; Q9BRU9: UTP23; NbExp=3; IntAct=EBI-10172150, EBI-5457544;
CC P60370; Q06250: WT1-AS; NbExp=3; IntAct=EBI-10172150, EBI-10223946;
CC P60370; P25490: YY1; NbExp=3; IntAct=EBI-10172150, EBI-765538;
CC P60370; O43167: ZBTB24; NbExp=3; IntAct=EBI-10172150, EBI-744471;
CC P60370; P10074: ZBTB48; NbExp=3; IntAct=EBI-10172150, EBI-744864;
CC P60370; Q9BQ24: ZFYVE21; NbExp=3; IntAct=EBI-10172150, EBI-2849569;
CC P60370; Q15973: ZNF124; NbExp=3; IntAct=EBI-10172150, EBI-2555767;
CC P60370; P17024: ZNF20; NbExp=3; IntAct=EBI-10172150, EBI-717634;
CC P60370; Q14C61: ZNF264; NbExp=3; IntAct=EBI-10172150, EBI-2826570;
CC P60370; Q14593: ZNF273; NbExp=3; IntAct=EBI-10172150, EBI-3922471;
CC P60370; Q9HBT8-2: ZNF286A; NbExp=3; IntAct=EBI-10172150, EBI-10310244;
CC P60370; P17041: ZNF32; NbExp=3; IntAct=EBI-10172150, EBI-1965483;
CC P60370; A2RRD8: ZNF320; NbExp=3; IntAct=EBI-10172150, EBI-10173019;
CC P60370; Q86UD4: ZNF329; NbExp=3; IntAct=EBI-10172150, EBI-7233259;
CC P60370; Q8IZ26: ZNF34; NbExp=3; IntAct=EBI-10172150, EBI-10264496;
CC P60370; Q8TAU3: ZNF417; NbExp=5; IntAct=EBI-10172150, EBI-740727;
CC P60370; Q8N7K0: ZNF433; NbExp=3; IntAct=EBI-10172150, EBI-10267553;
CC P60370; Q8NDP4: ZNF439; NbExp=3; IntAct=EBI-10172150, EBI-747580;
CC P60370; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-10172150, EBI-726439;
CC P60370; Q9BR84: ZNF559; NbExp=4; IntAct=EBI-10172150, EBI-746605;
CC P60370; Q7Z3I7: ZNF572; NbExp=3; IntAct=EBI-10172150, EBI-10172590;
CC P60370; Q96N58: ZNF578; NbExp=3; IntAct=EBI-10172150, EBI-11955189;
CC P60370; Q96SQ5: ZNF587; NbExp=6; IntAct=EBI-10172150, EBI-6427977;
CC P60370; Q9BS34: ZNF670; NbExp=3; IntAct=EBI-10172150, EBI-745276;
CC P60370; Q8IYX0: ZNF679; NbExp=3; IntAct=EBI-10172150, EBI-745567;
CC P60370; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-10172150, EBI-11090299;
CC P60370; Q8N508: ZNF697; NbExp=3; IntAct=EBI-10172150, EBI-10265733;
CC P60370; Q96C28: ZNF707; NbExp=3; IntAct=EBI-10172150, EBI-748111;
CC P60370; A8K8V0: ZNF785; NbExp=3; IntAct=EBI-10172150, EBI-3925400;
CC P60370; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-10172150, EBI-10240849;
CC P60370; Q9Y5A6: ZSCAN21; NbExp=3; IntAct=EBI-10172150, EBI-10281938;
CC P60370; Q16670: ZSCAN26; NbExp=3; IntAct=EBI-10172150, EBI-3920053;
CC P60370; Q5BKY6; NbExp=3; IntAct=EBI-10172150, EBI-10243533;
CC P60370; Q5XG85; NbExp=3; IntAct=EBI-10172150, EBI-10248413;
CC P60370; Q9NWL9; NbExp=3; IntAct=EBI-10172150, EBI-10315054;
CC -!- TISSUE SPECIFICITY: Restricted to a narrow region of the hair fiber
CC cuticle, lying approximately 20 cell layers above the apex of the
CC dermal papilla of the hair root; not detected in any other tissues.
CC {ECO:0000269|PubMed:14962103, ECO:0000269|PubMed:15028290}.
CC -!- SIMILARITY: Belongs to the KRTAP type 10 family. {ECO:0000305}.
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DR EMBL; AB076352; BAD01539.1; -; mRNA.
DR EMBL; AP001067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC120949; AAI20950.1; -; mRNA.
DR EMBL; BC120950; AAI20951.1; -; mRNA.
DR EMBL; AJ566384; CAD97464.1; -; mRNA.
DR CCDS; CCDS42958.1; -.
DR AlphaFoldDB; P60370; -.
DR IntAct; P60370; 140.
DR STRING; 9606.ENSP00000383223; -.
DR BioMuta; KRTAP10-5; -.
DR DMDM; 215274018; -.
DR MassIVE; P60370; -.
DR PaxDb; P60370; -.
DR PeptideAtlas; P60370; -.
DR PRIDE; P60370; -.
DR ProteomicsDB; 57199; -.
DR Ensembl; ENST00000400372.1; ENSP00000383223.1; ENSG00000241123.1.
DR MANE-Select; ENST00000400372.1; ENSP00000383223.1; NM_198694.3; NP_941967.3.
DR UCSC; uc002zfl.2; human.
DR GeneCards; KRTAP10-5; -.
DR HGNC; HGNC:22969; KRTAP10-5.
DR HPA; ENSG00000241123; Tissue enriched (skin).
DR neXtProt; NX_P60370; -.
DR OpenTargets; ENSG00000241123; -.
DR PharmGKB; PA134950015; -.
DR VEuPathDB; HostDB:ENSG00000241123; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000158579; -.
DR HOGENOM; CLU_062832_0_0_1; -.
DR InParanoid; P60370; -.
DR PhylomeDB; P60370; -.
DR TreeFam; TF351356; -.
DR PathwayCommons; P60370; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; P60370; -.
DR Pharos; P60370; Tdark.
DR PRO; PR:P60370; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; P60370; protein.
DR Bgee; ENSG00000241123; Expressed in skin of abdomen and 6 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 4.
DR Pfam; PF13885; Keratin_B2_2; 3.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..271
FT /note="Keratin-associated protein 10-5"
FT /id="PRO_0000185213"
FT REPEAT 26..30
FT /note="1"
FT REPEAT 51..55
FT /note="2"
FT REPEAT 73..77
FT /note="3"
FT REPEAT 78..82
FT /note="4"
FT REPEAT 88..92
FT /note="5"
FT REPEAT 93..97
FT /note="6"
FT REPEAT 98..102
FT /note="7"
FT REPEAT 110..114
FT /note="8"
FT REPEAT 120..124
FT /note="9"
FT REPEAT 130..134
FT /note="10"
FT REPEAT 135..139
FT /note="11"
FT REPEAT 140..144
FT /note="12"
FT REPEAT 152..156
FT /note="13"
FT REPEAT 162..166
FT /note="14"
FT REPEAT 177..181
FT /note="15"
FT REPEAT 187..191
FT /note="16"
FT REPEAT 199..203
FT /note="17"
FT REPEAT 209..213
FT /note="18"
FT REPEAT 214..218
FT /note="19"
FT REPEAT 233..237
FT /note="20"
FT REPEAT 240..244
FT /note="21"
FT REPEAT 251..255
FT /note="22"
FT REGION 26..255
FT /note="22 X 5 AA repeats of C-C-X(3)"
FT VARIANT 4
FT /note="C -> S (in dbSNP:rs5017208)"
FT /id="VAR_062113"
FT VARIANT 20
FT /note="D -> N (in dbSNP:rs2020221)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_017696"
FT VARIANT 183
FT /note="C -> F (in dbSNP:rs380585)"
FT /evidence="ECO:0000269|PubMed:15028290,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_047505"
FT VARIANT 235
FT /note="L -> V (in dbSNP:rs464424)"
FT /evidence="ECO:0000269|PubMed:15028290,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_017697"
FT VARIANT 247
FT /note="Y -> C (in dbSNP:rs7509970)"
FT /id="VAR_047506"
FT VARIANT 268
FT /note="P -> R (in dbSNP:rs464391)"
FT /evidence="ECO:0000269|PubMed:14962103,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_047507"
SQ SEQUENCE 271 AA; 27537 MW; 25B628E2236F3D0D CRC64;
MAACTMSVCS SACSDSWRVD DCPESCCEPP CGTAPCLTLV CTPVSCVSSP CCQAACEPSP
CQSGCTSSCT PSCCQPACCA SSPCQQACCV PVCCKPVCCL PTCSKDSSSC CQQSSCQPTC
CASSSCQQSC CVPVCCKPVC CVPTCSEDSS SCCQHSSCQP TCCTSSPCQQ SCYVPVCCKP
VCCKPICCVP VCSGASTSCC QQSSCQPACC TTSCCRPSSS VSLLCRPICR PACCLPISSC
CAPASSYQAS CCRPASCVSL LCRPACSPLA C
