KR106_HUMAN
ID KR106_HUMAN Reviewed; 365 AA.
AC P60371;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 3.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Keratin-associated protein 10-6;
DE AltName: Full=High sulfur keratin-associated protein 10.6;
DE AltName: Full=Keratin-associated protein 10.6;
DE AltName: Full=Keratin-associated protein 18-6;
DE AltName: Full=Keratin-associated protein 18.6;
GN Name=KRTAP10-6; Synonyms=KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT
RP PRO-SER-CYS-CYS-ALA-81 INS.
RC TISSUE=Hair root;
RX PubMed=15028290; DOI=10.1016/j.ygeno.2003.09.024;
RA Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.;
RT "A cluster of 21 keratin-associated protein genes within introns of another
RT gene on human chromosome 21q22.3.";
RL Genomics 83:679-693(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=14962103; DOI=10.1046/j.0022-202x.2003.22128.x;
RA Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S.,
RA Schweizer J.;
RT "Hair keratin associated proteins: characterization of a second high sulfur
RT KAP gene domain on human chromosome 21.";
RL J. Invest. Dermatol. 122:147-158(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC P60371; P82987: ADAMTSL3; NbExp=3; IntAct=EBI-12012928, EBI-10221726;
CC P60371; Q5T686: AVPI1; NbExp=3; IntAct=EBI-12012928, EBI-8640233;
CC P60371; P49759-3: CLK1; NbExp=3; IntAct=EBI-12012928, EBI-11981867;
CC P60371; Q9HAZ1: CLK4; NbExp=3; IntAct=EBI-12012928, EBI-633400;
CC P60371; Q6P158: DHX57; NbExp=3; IntAct=EBI-12012928, EBI-1051531;
CC P60371; Q9UBU2: DKK2; NbExp=3; IntAct=EBI-12012928, EBI-13274770;
CC P60371; Q12950: FOXD4; NbExp=3; IntAct=EBI-12012928, EBI-11317801;
CC P60371; O96004: HAND1; NbExp=3; IntAct=EBI-12012928, EBI-11320290;
CC P60371; Q03014: HHEX; NbExp=3; IntAct=EBI-12012928, EBI-747421;
CC P60371; P09067: HOXB5; NbExp=3; IntAct=EBI-12012928, EBI-3893317;
CC P60371; A0A384DVV8: KIAA0040; NbExp=3; IntAct=EBI-12012928, EBI-20764875;
CC P60371; Q9HAQ2: KIF9; NbExp=3; IntAct=EBI-12012928, EBI-8472129;
CC P60371; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-12012928, EBI-10172150;
CC P60371; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-12012928, EBI-10172511;
CC P60371; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-12012928, EBI-11958132;
CC P60371; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-12012928, EBI-11993254;
CC P60371; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-12012928, EBI-11993296;
CC P60371; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-12012928, EBI-11958178;
CC P60371; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-12012928, EBI-3958099;
CC P60371; Q5T753: LCE1E; NbExp=3; IntAct=EBI-12012928, EBI-11955335;
CC P60371; Q5T754: LCE1F; NbExp=3; IntAct=EBI-12012928, EBI-11958008;
CC P60371; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-12012928, EBI-11973993;
CC P60371; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-12012928, EBI-10246750;
CC P60371; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-12012928, EBI-11974495;
CC P60371; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-12012928, EBI-10245456;
CC P60371; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-12012928, EBI-10246358;
CC P60371; Q96ES6: MFSD3; NbExp=3; IntAct=EBI-12012928, EBI-745345;
CC P60371; Q13875-3: MOBP; NbExp=3; IntAct=EBI-12012928, EBI-12013470;
CC P60371; P07438: MT1B; NbExp=3; IntAct=EBI-12012928, EBI-12015462;
CC P60371; P41227: NAA10; NbExp=3; IntAct=EBI-12012928, EBI-747693;
CC P60371; Q8IW45: NAXD; NbExp=3; IntAct=EBI-12012928, EBI-8650724;
CC P60371; Q969G9: NKD1; NbExp=3; IntAct=EBI-12012928, EBI-1538217;
CC P60371; P48645: NMU; NbExp=3; IntAct=EBI-12012928, EBI-10210351;
CC P60371; Q9UGY1: NOL12; NbExp=3; IntAct=EBI-12012928, EBI-716098;
CC P60371; Q9NQX5: NPDC1; NbExp=3; IntAct=EBI-12012928, EBI-748927;
CC P60371; Q96AQ6: PBXIP1; NbExp=3; IntAct=EBI-12012928, EBI-740845;
CC P60371; Q13526: PIN1; NbExp=3; IntAct=EBI-12012928, EBI-714158;
CC P60371; Q6UXX9-2: RSPO2; NbExp=3; IntAct=EBI-12012928, EBI-12009390;
CC P60371; Q8TAD8: SNIP1; NbExp=3; IntAct=EBI-12012928, EBI-749336;
CC P60371; A0A024R4B0: SPATA3; NbExp=3; IntAct=EBI-12012928, EBI-14123856;
CC P60371; Q9BX79-6: STRA6; NbExp=3; IntAct=EBI-12012928, EBI-12140683;
CC P60371; Q6EMK4: VASN; NbExp=3; IntAct=EBI-12012928, EBI-10249550;
CC P60371; P19544-6: WT1; NbExp=3; IntAct=EBI-12012928, EBI-11745701;
CC P60371; Q96MU7: YTHDC1; NbExp=3; IntAct=EBI-12012928, EBI-2849854;
CC P60371; O43167: ZBTB24; NbExp=3; IntAct=EBI-12012928, EBI-744471;
CC P60371; Q7Z2W4: ZC3HAV1; NbExp=3; IntAct=EBI-12012928, EBI-922540;
CC P60371; Q9NZV7: ZIM2; NbExp=3; IntAct=EBI-12012928, EBI-11962760;
CC P60371; Q8NC26: ZNF114; NbExp=3; IntAct=EBI-12012928, EBI-10265237;
CC P60371; P52744: ZNF138; NbExp=3; IntAct=EBI-12012928, EBI-10746567;
CC P60371; Q12901: ZNF155; NbExp=3; IntAct=EBI-12012928, EBI-10747670;
CC P60371; Q14929: ZNF169; NbExp=3; IntAct=EBI-12012928, EBI-10234472;
CC P60371; Q9UK13: ZNF221; NbExp=3; IntAct=EBI-12012928, EBI-14513896;
CC P60371; Q16600: ZNF239; NbExp=3; IntAct=EBI-12012928, EBI-8787052;
CC P60371; O43296: ZNF264; NbExp=3; IntAct=EBI-12012928, EBI-4395808;
CC P60371; Q8ND82: ZNF280C; NbExp=3; IntAct=EBI-12012928, EBI-8831272;
CC P60371; Q9NR11-2: ZNF302; NbExp=3; IntAct=EBI-12012928, EBI-12988373;
CC P60371; Q9P2F9: ZNF319; NbExp=3; IntAct=EBI-12012928, EBI-11993110;
CC P60371; Q8TF45: ZNF418; NbExp=3; IntAct=EBI-12012928, EBI-3446851;
CC P60371; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-12012928, EBI-726439;
CC P60371; Q96JC4: ZNF479; NbExp=3; IntAct=EBI-12012928, EBI-10820574;
CC P60371; Q9ULM2: ZNF490; NbExp=3; IntAct=EBI-12012928, EBI-1105370;
CC P60371; Q08ER8: ZNF543; NbExp=3; IntAct=EBI-12012928, EBI-10226133;
CC P60371; Q8TA94: ZNF563; NbExp=3; IntAct=EBI-12012928, EBI-11792334;
CC P60371; Q8IYB9: ZNF595; NbExp=3; IntAct=EBI-12012928, EBI-2682172;
CC P60371; Q6ZNG1: ZNF600; NbExp=3; IntAct=EBI-12012928, EBI-3444696;
CC P60371; Q96BR6: ZNF669; NbExp=3; IntAct=EBI-12012928, EBI-12006574;
CC P60371; Q499Z4: ZNF672; NbExp=3; IntAct=EBI-12012928, EBI-12146251;
CC P60371; Q8IYX0: ZNF679; NbExp=3; IntAct=EBI-12012928, EBI-745567;
CC P60371; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-12012928, EBI-11090299;
CC P60371; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-12012928, EBI-10251462;
CC P60371; Q68DI1: ZNF776; NbExp=3; IntAct=EBI-12012928, EBI-12878746;
CC P60371; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-12012928, EBI-10240849;
CC P60371; O43257: ZNHIT1; NbExp=3; IntAct=EBI-12012928, EBI-347522;
CC -!- TISSUE SPECIFICITY: Restricted to a narrow region of the hair fiber
CC cuticle, lying approximately 20 cell layers above the apex of the
CC dermal papilla of the hair root; not detected in any other tissues.
CC {ECO:0000269|PubMed:14962103, ECO:0000269|PubMed:15028290}.
CC -!- SIMILARITY: Belongs to the KRTAP type 10 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB076353; BAD01540.1; -; mRNA.
DR EMBL; AL773602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS42959.1; -.
DR RefSeq; NP_941961.3; NM_198688.3.
DR AlphaFoldDB; P60371; -.
DR BioGRID; 132125; 73.
DR IntAct; P60371; 73.
DR STRING; 9606.ENSP00000383219; -.
DR iPTMnet; P60371; -.
DR PhosphoSitePlus; P60371; -.
DR BioMuta; KRTAP10-6; -.
DR DMDM; 288558812; -.
DR MassIVE; P60371; -.
DR PaxDb; P60371; -.
DR PeptideAtlas; P60371; -.
DR PRIDE; P60371; -.
DR Antibodypedia; 78046; 1 antibodies from 1 providers.
DR DNASU; 386674; -.
DR Ensembl; ENST00000400368.1; ENSP00000383219.1; ENSG00000188155.11.
DR GeneID; 386674; -.
DR KEGG; hsa:386674; -.
DR MANE-Select; ENST00000400368.1; ENSP00000383219.1; NM_198688.3; NP_941961.3.
DR UCSC; uc032qbq.1; human.
DR CTD; 386674; -.
DR GeneCards; KRTAP10-6; -.
DR HGNC; HGNC:20523; KRTAP10-6.
DR HPA; ENSG00000188155; Tissue enriched (skin).
DR neXtProt; NX_P60371; -.
DR PharmGKB; PA134871340; -.
DR VEuPathDB; HostDB:ENSG00000188155; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000164049; -.
DR InParanoid; P60371; -.
DR OrthoDB; 1629708at2759; -.
DR PhylomeDB; P60371; -.
DR PathwayCommons; P60371; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; P60371; -.
DR BioGRID-ORCS; 386674; 27 hits in 978 CRISPR screens.
DR GenomeRNAi; 386674; -.
DR Pharos; P60371; Tdark.
DR PRO; PR:P60371; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; P60371; protein.
DR Bgee; ENSG00000188155; Expressed in skin of abdomen and 7 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 5.
DR Pfam; PF13885; Keratin_B2_2; 4.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..365
FT /note="Keratin-associated protein 10-6"
FT /id="PRO_0000185214"
FT REPEAT 41..45
FT /note="1"
FT REPEAT 46..50
FT /note="2"
FT REPEAT 67..71
FT /note="3"
FT REPEAT 89..93
FT /note="4"
FT REPEAT 99..103
FT /note="5"
FT REPEAT 109..113
FT /note="6"
FT REPEAT 114..118
FT /note="7"
FT REPEAT 119..123
FT /note="8"
FT REPEAT 124..128
FT /note="9"
FT REPEAT 129..133
FT /note="10"
FT REPEAT 135..139
FT /note="11"
FT REPEAT 145..149
FT /note="12"
FT REPEAT 155..159
FT /note="13"
FT REPEAT 160..164
FT /note="14"
FT REPEAT 172..176
FT /note="15"
FT REPEAT 186..190
FT /note="16"
FT REPEAT 208..212
FT /note="17"
FT REPEAT 218..222
FT /note="18"
FT REPEAT 228..232
FT /note="19"
FT REPEAT 233..237
FT /note="20"
FT REPEAT 238..242
FT /note="21"
FT REPEAT 250..254
FT /note="22"
FT REPEAT 260..264
FT /note="23"
FT REPEAT 270..274
FT /note="24"
FT REPEAT 282..286
FT /note="25"
FT REPEAT 292..296
FT /note="26"
FT REPEAT 297..301
FT /note="27"
FT REPEAT 316..320
FT /note="28"
FT REPEAT 334..338
FT /note="29"
FT REGION 41..338
FT /note="29 X 5 AA repeats of C-C-X(3)"
FT VARIANT 68
FT /note="C -> S (in dbSNP:rs13051409)"
FT /id="VAR_060049"
FT VARIANT 74
FT /note="P -> S (in dbSNP:rs13050443)"
FT /id="VAR_060050"
FT VARIANT 81
FT /note="C -> CPSCCA"
FT /id="VAR_017699"
FT VARIANT 159
FT /note="V -> I (in dbSNP:rs233306)"
FT /id="VAR_057649"
FT VARIANT 300
FT /note="S -> P (in dbSNP:rs465279)"
FT /id="VAR_062533"
SQ SEQUENCE 365 AA; 36781 MW; 480DC12200716EA2 CRC64;
MAASTMSVCS SDLSYGSRVC LPGSCDSCSD SWQVDDCPES CCEPPCCAPA PCLSLVCTPV
SRVSSPCCPV TCEPSPCQSG CTSSCTPSCC QQSSCQLACC ASSPCQQACC VPVCCKTVCC
KPVCCVSVCC GDSSCCQQSS CQSACCTSSP CQQACCVPVC CKPVCSGISS SCCQQSSCVS
CVSSPCCQAV CEPSPCQSGC TSSCTPSCCQ QSSCQPTCCT SSPCQQACCV PVCCVPVCCV
PTCSEDSSSC CQQSSCQPAC CTSSPCQHAC CVPVCSGAST SCCQQSSCQP ACCTASCCRS
SSSVSLLCHP VCKSTCCVPV PSCGASASSC QPSCCRTASC VSLLCRPMCS RPACYSLCSG
QKSSC
