KR107_HUMAN
ID KR107_HUMAN Reviewed; 370 AA.
AC P60409; Q0VDJ8; Q70LJ2;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-DEC-2018, sequence version 3.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Keratin-associated protein 10-7;
DE AltName: Full=High sulfur keratin-associated protein 10.7;
DE AltName: Full=Keratin-associated protein 10.7;
DE AltName: Full=Keratin-associated protein 18-7;
DE AltName: Full=Keratin-associated protein 18.7;
GN Name=KRTAP10-7; Synonyms=KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Hair root;
RX PubMed=15028290; DOI=10.1016/j.ygeno.2003.09.024;
RA Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.;
RT "A cluster of 21 keratin-associated protein genes within introns of another
RT gene on human chromosome 21q22.3.";
RL Genomics 83:679-693(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 318-370, AND TISSUE SPECIFICITY.
RC TISSUE=Scalp;
RX PubMed=14962103; DOI=10.1046/j.0022-202x.2003.22128.x;
RA Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S.,
RA Schweizer J.;
RT "Hair keratin associated proteins: characterization of a second high sulfur
RT KAP gene domain on human chromosome 21.";
RL J. Invest. Dermatol. 122:147-158(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC P60409; P01023: A2M; NbExp=3; IntAct=EBI-10172290, EBI-640741;
CC P60409; Q8WTP8: AEN; NbExp=3; IntAct=EBI-10172290, EBI-8637627;
CC P60409; P43353: ALDH3B1; NbExp=3; IntAct=EBI-10172290, EBI-2558314;
CC P60409; Q96IX9: ANKRD36BP1; NbExp=3; IntAct=EBI-10172290, EBI-744859;
CC P60409; Q9BXS5: AP1M1; NbExp=6; IntAct=EBI-10172290, EBI-541426;
CC P60409; P29972: AQP1; NbExp=3; IntAct=EBI-10172290, EBI-745213;
CC P60409; Q5T686: AVPI1; NbExp=3; IntAct=EBI-10172290, EBI-8640233;
CC P60409; Q9UBV7: B4GALT7; NbExp=3; IntAct=EBI-10172290, EBI-10319970;
CC P60409; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-10172290, EBI-742750;
CC P60409; A8KA13: BCL6B; NbExp=4; IntAct=EBI-10172290, EBI-10174813;
CC P60409; A8K571: BMP7; NbExp=3; IntAct=EBI-10172290, EBI-10174327;
CC P60409; Q0VDD7: BRME1; NbExp=3; IntAct=EBI-10172290, EBI-741210;
CC P60409; P41223: BUD31; NbExp=6; IntAct=EBI-10172290, EBI-3904603;
CC P60409; Q13895: BYSL; NbExp=5; IntAct=EBI-10172290, EBI-358049;
CC P60409; Q9H7E9: C8orf33; NbExp=3; IntAct=EBI-10172290, EBI-715389;
CC P60409; Q9Y2V2: CARHSP1; NbExp=3; IntAct=EBI-10172290, EBI-718719;
CC P60409; Q7Z7H3: CATIP; NbExp=3; IntAct=EBI-10172290, EBI-10258233;
CC P60409; Q14781: CBX2; NbExp=3; IntAct=EBI-10172290, EBI-745934;
CC P60409; Q8N715: CCDC185; NbExp=3; IntAct=EBI-10172290, EBI-740814;
CC P60409; Q8TAB7: CCDC26; NbExp=3; IntAct=EBI-10172290, EBI-10271580;
CC P60409; P51959: CCNG1; NbExp=3; IntAct=EBI-10172290, EBI-3905829;
CC P60409; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-10172290, EBI-5278764;
CC P60409; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-10172290, EBI-741528;
CC P60409; Q9H2X0: CHRD; NbExp=6; IntAct=EBI-10172290, EBI-947551;
CC P60409; P07510: CHRNG; NbExp=4; IntAct=EBI-10172290, EBI-9008836;
CC P60409; P07510-2: CHRNG; NbExp=3; IntAct=EBI-10172290, EBI-11979451;
CC P60409; P49759: CLK1; NbExp=3; IntAct=EBI-10172290, EBI-473775;
CC P60409; P49759-3: CLK1; NbExp=3; IntAct=EBI-10172290, EBI-11981867;
CC P60409; Q9HAZ1: CLK4; NbExp=6; IntAct=EBI-10172290, EBI-633400;
CC P60409; Q8NE01: CNNM3; NbExp=5; IntAct=EBI-10172290, EBI-741032;
CC P60409; P27658: COL8A1; NbExp=3; IntAct=EBI-10172290, EBI-747133;
CC P60409; Q9UGL9: CRCT1; NbExp=6; IntAct=EBI-10172290, EBI-713677;
CC P60409; Q02930-3: CREB5; NbExp=4; IntAct=EBI-10172290, EBI-10192698;
CC P60409; Q49AN0: CRY2; NbExp=3; IntAct=EBI-10172290, EBI-2212355;
CC P60409; Q9HCP0: CSNK1G1; NbExp=3; IntAct=EBI-10172290, EBI-1383814;
CC P60409; P78368: CSNK1G2; NbExp=3; IntAct=EBI-10172290, EBI-748380;
CC P60409; Q9NSA3: CTNNBIP1; NbExp=3; IntAct=EBI-10172290, EBI-747082;
CC P60409; Q99895: CTRC; NbExp=3; IntAct=EBI-10172290, EBI-10295404;
CC P60409; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10172290, EBI-3867333;
CC P60409; Q9GZP9: DERL2; NbExp=3; IntAct=EBI-10172290, EBI-7962814;
CC P60409; Q6P158: DHX57; NbExp=6; IntAct=EBI-10172290, EBI-1051531;
CC P60409; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-10172290, EBI-9679045;
CC P60409; Q92608: DOCK2; NbExp=5; IntAct=EBI-10172290, EBI-448771;
CC P60409; O75461: E2F6; NbExp=3; IntAct=EBI-10172290, EBI-749694;
CC P60409; H3BUJ7: E4F1; NbExp=3; IntAct=EBI-10172290, EBI-10178160;
CC P60409; Q08426: EHHADH; NbExp=3; IntAct=EBI-10172290, EBI-2339219;
CC P60409; Q8N9I5: FADS6; NbExp=3; IntAct=EBI-10172290, EBI-3943864;
CC P60409; Q9H5Z6: FAM124B; NbExp=3; IntAct=EBI-10172290, EBI-741626;
CC P60409; Q3B820: FAM161A; NbExp=3; IntAct=EBI-10172290, EBI-719941;
CC P60409; Q08E93: FAM27E3; NbExp=3; IntAct=EBI-10172290, EBI-2602739;
CC P60409; Q5TZK3: FAM74A6; NbExp=3; IntAct=EBI-10172290, EBI-10247271;
CC P60409; Q5HYJ3: FAM76B; NbExp=3; IntAct=EBI-10172290, EBI-751192;
CC P60409; O95363: FARS2; NbExp=6; IntAct=EBI-10172290, EBI-2513774;
CC P60409; Q9H0R8: GABARAPL1; NbExp=3; IntAct=EBI-10172290, EBI-746969;
CC P60409; P60520: GABARAPL2; NbExp=6; IntAct=EBI-10172290, EBI-720116;
CC P60409; P55040: GEM; NbExp=6; IntAct=EBI-10172290, EBI-744104;
CC P60409; P43220: GLP1R; NbExp=3; IntAct=EBI-10172290, EBI-7466542;
CC P60409; Q9Y223: GNE; NbExp=3; IntAct=EBI-10172290, EBI-4291090;
CC P60409; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-10172290, EBI-11975289;
CC P60409; Q0D2H9: GOLGA8DP; NbExp=3; IntAct=EBI-10172290, EBI-10181276;
CC P60409; P28799: GRN; NbExp=3; IntAct=EBI-10172290, EBI-747754;
CC P60409; P09211: GSTP1; NbExp=6; IntAct=EBI-10172290, EBI-353467;
CC P60409; Q96NT3: GUCD1; NbExp=3; IntAct=EBI-10172290, EBI-8293751;
CC P60409; P02008: HBZ; NbExp=3; IntAct=EBI-10172290, EBI-719843;
CC P60409; P08631-2: HCK; NbExp=3; IntAct=EBI-10172290, EBI-9834454;
CC P60409; Q03014: HHEX; NbExp=3; IntAct=EBI-10172290, EBI-747421;
CC P60409; P49639: HOXA1; NbExp=5; IntAct=EBI-10172290, EBI-740785;
CC P60409; P31273: HOXC8; NbExp=3; IntAct=EBI-10172290, EBI-1752118;
CC P60409; P37235: HPCAL1; NbExp=3; IntAct=EBI-10172290, EBI-749311;
CC P60409; O75506: HSBP1; NbExp=3; IntAct=EBI-10172290, EBI-748664;
CC P60409; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-10172290, EBI-3918847;
CC P60409; P42858: HTT; NbExp=9; IntAct=EBI-10172290, EBI-466029;
CC P60409; Q969P0: IGSF8; NbExp=6; IntAct=EBI-10172290, EBI-8293590;
CC P60409; Q8WYH8: ING5; NbExp=3; IntAct=EBI-10172290, EBI-488533;
CC P60409; Q92835: INPP5D; NbExp=3; IntAct=EBI-10172290, EBI-1380477;
CC P60409; Q8NA54: IQUB; NbExp=3; IntAct=EBI-10172290, EBI-10220600;
CC P60409; P16144-2: ITGB4; NbExp=3; IntAct=EBI-10172290, EBI-11051601;
CC P60409; P18084: ITGB5; NbExp=3; IntAct=EBI-10172290, EBI-1223434;
CC P60409; Q2WGJ6: KLHL38; NbExp=6; IntAct=EBI-10172290, EBI-6426443;
CC P60409; P35900: KRT20; NbExp=3; IntAct=EBI-10172290, EBI-742094;
CC P60409; P78385: KRT83; NbExp=3; IntAct=EBI-10172290, EBI-10221390;
CC P60409; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-10172290, EBI-10172150;
CC P60409; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10172290, EBI-10172290;
CC P60409; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-10172290, EBI-10171774;
CC P60409; P60411: KRTAP10-9; NbExp=6; IntAct=EBI-10172290, EBI-10172052;
CC P60409; P59990: KRTAP12-1; NbExp=6; IntAct=EBI-10172290, EBI-10210845;
CC P60409; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10172290, EBI-11953334;
CC P60409; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-10172290, EBI-3957672;
CC P60409; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-10172290, EBI-10172511;
CC P60409; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-10172290, EBI-11993254;
CC P60409; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-10172290, EBI-11993296;
CC P60409; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-10172290, EBI-11958178;
CC P60409; Q6L8G9: KRTAP5-6; NbExp=6; IntAct=EBI-10172290, EBI-10250562;
CC P60409; P26371: KRTAP5-9; NbExp=5; IntAct=EBI-10172290, EBI-3958099;
CC P60409; Q9BYQ4: KRTAP9-2; NbExp=6; IntAct=EBI-10172290, EBI-1044640;
CC P60409; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-10172290, EBI-1043191;
CC P60409; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-10172290, EBI-11958364;
CC P60409; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-10172290, EBI-11962058;
CC P60409; Q5T7P3: LCE1B; NbExp=9; IntAct=EBI-10172290, EBI-10245913;
CC P60409; Q5T752: LCE1D; NbExp=3; IntAct=EBI-10172290, EBI-11741311;
CC P60409; Q5T754: LCE1F; NbExp=5; IntAct=EBI-10172290, EBI-11958008;
CC P60409; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-10172290, EBI-10246607;
CC P60409; O14633: LCE2B; NbExp=5; IntAct=EBI-10172290, EBI-11478468;
CC P60409; Q5TA81: LCE2C; NbExp=5; IntAct=EBI-10172290, EBI-11973993;
CC P60409; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-10172290, EBI-9394625;
CC P60409; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-10172290, EBI-11974495;
CC P60409; Q5T5A8: LCE3C; NbExp=3; IntAct=EBI-10172290, EBI-10245291;
CC P60409; Q9BYE3: LCE3D; NbExp=5; IntAct=EBI-10172290, EBI-6658837;
CC P60409; Q5T5B0: LCE3E; NbExp=8; IntAct=EBI-10172290, EBI-10245456;
CC P60409; Q5TA78: LCE4A; NbExp=8; IntAct=EBI-10172290, EBI-10246358;
CC P60409; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-10172290, EBI-11955689;
CC P60409; Q7Z4I7-5: LIMS2; NbExp=3; IntAct=EBI-10172290, EBI-10257651;
CC P60409; Q5T6M2: LINC00242; NbExp=3; IntAct=EBI-10172290, EBI-10245897;
CC P60409; P02545: LMNA; NbExp=3; IntAct=EBI-10172290, EBI-351935;
CC P60409; P25791: LMO2; NbExp=3; IntAct=EBI-10172290, EBI-739696;
CC P60409; O75427: LRCH4; NbExp=3; IntAct=EBI-10172290, EBI-718707;
CC P60409; O60336: MAPKBP1; NbExp=6; IntAct=EBI-10172290, EBI-947402;
CC P60409; B1AHB0: MCM5; NbExp=3; IntAct=EBI-10172290, EBI-10175425;
CC P60409; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-10172290, EBI-348259;
CC P60409; Q13875: MOBP; NbExp=3; IntAct=EBI-10172290, EBI-10230628;
CC P60409; Q13875-3: MOBP; NbExp=3; IntAct=EBI-10172290, EBI-12013470;
CC P60409; Q9NV56: MRGBP; NbExp=6; IntAct=EBI-10172290, EBI-399076;
CC P60409; Q9BW11: MXD3; NbExp=3; IntAct=EBI-10172290, EBI-741574;
CC P60409; P50539-3: MXI1; NbExp=3; IntAct=EBI-10172290, EBI-10211940;
CC P60409; Q86VE0: MYPOP; NbExp=3; IntAct=EBI-10172290, EBI-2858213;
CC P60409; P41227: NAA10; NbExp=3; IntAct=EBI-10172290, EBI-747693;
CC P60409; Q8IW45: NAXD; NbExp=6; IntAct=EBI-10172290, EBI-8650724;
CC P60409; Q92692: NECTIN2; NbExp=3; IntAct=EBI-10172290, EBI-718419;
CC P60409; Q9NQS3: NECTIN3; NbExp=3; IntAct=EBI-10172290, EBI-2826725;
CC P60409; Q969G9: NKD1; NbExp=5; IntAct=EBI-10172290, EBI-1538217;
CC P60409; Q9UGY1: NOL12; NbExp=3; IntAct=EBI-10172290, EBI-716098;
CC P60409; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10172290, EBI-945833;
CC P60409; P48146: NPBWR2; NbExp=3; IntAct=EBI-10172290, EBI-10210114;
CC P60409; Q9NQX5: NPDC1; NbExp=6; IntAct=EBI-10172290, EBI-748927;
CC P60409; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-10172290, EBI-741158;
CC P60409; Q9Y5Y2: NUBP2; NbExp=3; IntAct=EBI-10172290, EBI-1048886;
CC P60409; Q7Z417: NUFIP2; NbExp=6; IntAct=EBI-10172290, EBI-1210753;
CC P60409; P32242: OTX1; NbExp=5; IntAct=EBI-10172290, EBI-740446;
CC P60409; Q15077: P2RY6; NbExp=3; IntAct=EBI-10172290, EBI-10235794;
CC P60409; Q9H1Q7: PCED1A; NbExp=3; IntAct=EBI-10172290, EBI-748452;
CC P60409; Q92824: PCSK5; NbExp=3; IntAct=EBI-10172290, EBI-751290;
CC P60409; O76083-2: PDE9A; NbExp=3; IntAct=EBI-10172290, EBI-11524542;
CC P60409; Q14554: PDIA5; NbExp=3; IntAct=EBI-10172290, EBI-953879;
CC P60409; Q96HC4: PDLIM5; NbExp=3; IntAct=EBI-10172290, EBI-751267;
CC P60409; P17858: PFKL; NbExp=3; IntAct=EBI-10172290, EBI-487243;
CC P60409; Q9HCN3: PGAP6; NbExp=3; IntAct=EBI-10172290, EBI-10310808;
CC P60409; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-10172290, EBI-14084211;
CC P60409; Q13526: PIN1; NbExp=6; IntAct=EBI-10172290, EBI-714158;
CC P60409; Q9UGP5-2: POLL; NbExp=3; IntAct=EBI-10172290, EBI-10320765;
CC P60409; Q03181-2: PPARD; NbExp=3; IntAct=EBI-10172290, EBI-10223258;
CC P60409; O43741: PRKAB2; NbExp=8; IntAct=EBI-10172290, EBI-1053424;
CC P60409; P04554: PRM2; NbExp=3; IntAct=EBI-10172290, EBI-9681663;
CC P60409; Q1LZN1: PRM2; NbExp=3; IntAct=EBI-10172290, EBI-10239098;
CC P60409; Q9NZ81: PRR13; NbExp=3; IntAct=EBI-10172290, EBI-740924;
CC P60409; P0CG20: PRR35; NbExp=3; IntAct=EBI-10172290, EBI-11986293;
CC P60409; P41222: PTGDS; NbExp=3; IntAct=EBI-10172290, EBI-948821;
CC P60409; P43115-12: PTGER3; NbExp=3; IntAct=EBI-10172290, EBI-10234038;
CC P60409; Q8WUK0: PTPMT1; NbExp=6; IntAct=EBI-10172290, EBI-7199479;
CC P60409; P15151: PVR; NbExp=3; IntAct=EBI-10172290, EBI-3919694;
CC P60409; Q9Y2K5: R3HDM2; NbExp=3; IntAct=EBI-10172290, EBI-948428;
CC P60409; Q8N4F7: RNF175; NbExp=3; IntAct=EBI-10172290, EBI-10265447;
CC P60409; Q9H9Y2: RPF1; NbExp=4; IntAct=EBI-10172290, EBI-9996007;
CC P60409; P62913: RPL11; NbExp=3; IntAct=EBI-10172290, EBI-354380;
CC P60409; Q969Q0: RPL36AL; NbExp=3; IntAct=EBI-10172290, EBI-2877705;
CC P60409; P62857: RPS28; NbExp=3; IntAct=EBI-10172290, EBI-353027;
CC P60409; Q6P087: RPUSD3; NbExp=3; IntAct=EBI-10172290, EBI-5458784;
CC P60409; Q6UXX9: RSPO2; NbExp=3; IntAct=EBI-10172290, EBI-8481036;
CC P60409; Q6UXX9-2: RSPO2; NbExp=3; IntAct=EBI-10172290, EBI-12009390;
CC P60409; Q86UN2: RTN4RL1; NbExp=3; IntAct=EBI-10172290, EBI-10258951;
CC P60409; P57060: RWDD2B; NbExp=3; IntAct=EBI-10172290, EBI-724442;
CC P60409; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-10172290, EBI-748391;
CC P60409; O00560: SDCBP; NbExp=3; IntAct=EBI-10172290, EBI-727004;
CC P60409; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-10172290, EBI-10313866;
CC P60409; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-10172290, EBI-11955083;
CC P60409; Q9UHI7: SLC23A1; NbExp=3; IntAct=EBI-10172290, EBI-1759386;
CC P60409; Q6ZT89: SLC25A48; NbExp=3; IntAct=EBI-10172290, EBI-10255185;
CC P60409; Q9NP91: SLC6A20; NbExp=3; IntAct=EBI-10172290, EBI-10311198;
CC P60409; Q9NRQ5: SMCO4; NbExp=3; IntAct=EBI-10172290, EBI-8640191;
CC P60409; P49901: SMCP; NbExp=6; IntAct=EBI-10172290, EBI-750494;
CC P60409; Q96E40: SPACA9; NbExp=3; IntAct=EBI-10172290, EBI-722584;
CC P60409; Q86W54-2: SPATA24; NbExp=3; IntAct=EBI-10172290, EBI-12041693;
CC P60409; Q6RVD6: SPATA8; NbExp=3; IntAct=EBI-10172290, EBI-8635958;
CC P60409; Q9UQ90: SPG7; NbExp=3; IntAct=EBI-10172290, EBI-717201;
CC P60409; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-10172290, EBI-5235340;
CC P60409; O43609: SPRY1; NbExp=6; IntAct=EBI-10172290, EBI-3866665;
CC P60409; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-10172290, EBI-2212028;
CC P60409; O75716: STK16; NbExp=3; IntAct=EBI-10172290, EBI-749295;
CC P60409; O43463: SUV39H1; NbExp=6; IntAct=EBI-10172290, EBI-349968;
CC P60409; Q15560: TCEA2; NbExp=3; IntAct=EBI-10172290, EBI-710310;
CC P60409; Q8N8B7: TCEANC; NbExp=3; IntAct=EBI-10172290, EBI-954696;
CC P60409; Q7L2K0: TEDC2; NbExp=3; IntAct=EBI-10172290, EBI-8465456;
CC P60409; Q7Z6R9: TFAP2D; NbExp=5; IntAct=EBI-10172290, EBI-11952651;
CC P60409; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-10172290, EBI-741515;
CC P60409; Q8TBB0: THAP6; NbExp=3; IntAct=EBI-10172290, EBI-3925505;
CC P60409; Q08117: TLE5; NbExp=3; IntAct=EBI-10172290, EBI-717810;
CC P60409; Q08117-2: TLE5; NbExp=3; IntAct=EBI-10172290, EBI-11741437;
CC P60409; Q96EY4: TMA16; NbExp=3; IntAct=EBI-10172290, EBI-1045338;
CC P60409; Q4VB56: TNP2; NbExp=3; IntAct=EBI-10172290, EBI-10241829;
CC P60409; Q63HR2: TNS2; NbExp=3; IntAct=EBI-10172290, EBI-949753;
CC P60409; O14656: TOR1A; NbExp=6; IntAct=EBI-10172290, EBI-524257;
CC P60409; Q9NSU2-1: TREX1; NbExp=6; IntAct=EBI-10172290, EBI-16746122;
CC P60409; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-10172290, EBI-5235829;
CC P60409; P49638: TTPA; NbExp=3; IntAct=EBI-10172290, EBI-10210710;
CC P60409; O75386: TULP3; NbExp=3; IntAct=EBI-10172290, EBI-5357290;
CC P60409; Q86UY0: TXNDC5; NbExp=3; IntAct=EBI-10172290, EBI-2825190;
CC P60409; Q06418: TYRO3; NbExp=3; IntAct=EBI-10172290, EBI-3951628;
CC P60409; P55851: UCP2; NbExp=3; IntAct=EBI-10172290, EBI-2842077;
CC P60409; Q9UBK9: UXT; NbExp=3; IntAct=EBI-10172290, EBI-357355;
CC P60409; Q6EMK4: VASN; NbExp=3; IntAct=EBI-10172290, EBI-10249550;
CC P60409; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-10172290, EBI-11957216;
CC P60409; Q9UEU0: VTI1B; NbExp=3; IntAct=EBI-10172290, EBI-723716;
CC P60409; O96014: WNT11; NbExp=3; IntAct=EBI-10172290, EBI-8058160;
CC P60409; P19544-6: WT1; NbExp=3; IntAct=EBI-10172290, EBI-11745701;
CC P60409; O43167: ZBTB24; NbExp=3; IntAct=EBI-10172290, EBI-744471;
CC P60409; P10074: ZBTB48; NbExp=3; IntAct=EBI-10172290, EBI-744864;
CC P60409; Q96C00: ZBTB9; NbExp=7; IntAct=EBI-10172290, EBI-395708;
CC P60409; Q8N8Y5: ZFP41; NbExp=3; IntAct=EBI-10172290, EBI-12224489;
CC P60409; Q68DK2-5: ZFYVE26; NbExp=6; IntAct=EBI-10172290, EBI-8656416;
CC P60409; Q9NZV7: ZIM2; NbExp=3; IntAct=EBI-10172290, EBI-11962760;
CC P60409; Q8IZC7: ZNF101; NbExp=6; IntAct=EBI-10172290, EBI-5278328;
CC P60409; Q15973: ZNF124; NbExp=3; IntAct=EBI-10172290, EBI-2555767;
CC P60409; P52736: ZNF133; NbExp=3; IntAct=EBI-10172290, EBI-2687350;
CC P60409; P52744: ZNF138; NbExp=3; IntAct=EBI-10172290, EBI-10746567;
CC P60409; Q12901-2: ZNF155; NbExp=3; IntAct=EBI-10172290, EBI-10227379;
CC P60409; Q53Z40: ZNF165; NbExp=3; IntAct=EBI-10172290, EBI-10186058;
CC P60409; Q14929: ZNF169; NbExp=3; IntAct=EBI-10172290, EBI-10234472;
CC P60409; Q9Y473: ZNF175; NbExp=3; IntAct=EBI-10172290, EBI-3438881;
CC P60409; Q9UJW8: ZNF180; NbExp=3; IntAct=EBI-10172290, EBI-10322527;
CC P60409; Q9BSG1-2: ZNF2; NbExp=3; IntAct=EBI-10172290, EBI-10297542;
CC P60409; P17024: ZNF20; NbExp=3; IntAct=EBI-10172290, EBI-717634;
CC P60409; Q9UK11: ZNF223; NbExp=4; IntAct=EBI-10172290, EBI-10322867;
CC P60409; P15622-3: ZNF250; NbExp=3; IntAct=EBI-10172290, EBI-10177272;
CC P60409; Q9Y2P7: ZNF256; NbExp=3; IntAct=EBI-10172290, EBI-12223065;
CC P60409; P17031: ZNF26; NbExp=3; IntAct=EBI-10172290, EBI-2841331;
CC P60409; Q3ZCT1: ZNF260; NbExp=3; IntAct=EBI-10172290, EBI-10241410;
CC P60409; O43296: ZNF264; NbExp=3; IntAct=EBI-10172290, EBI-4395808;
CC P60409; Q14584: ZNF266; NbExp=5; IntAct=EBI-10172290, EBI-7115319;
CC P60409; P17041: ZNF32; NbExp=3; IntAct=EBI-10172290, EBI-1965483;
CC P60409; A2RRD8: ZNF320; NbExp=3; IntAct=EBI-10172290, EBI-10173019;
CC P60409; Q86UD4: ZNF329; NbExp=3; IntAct=EBI-10172290, EBI-7233259;
CC P60409; Q9Y3M9: ZNF337; NbExp=3; IntAct=EBI-10172290, EBI-714987;
CC P60409; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-10172290, EBI-347633;
CC P60409; P51814: ZNF41; NbExp=3; IntAct=EBI-10172290, EBI-2681830;
CC P60409; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-10172290, EBI-744257;
CC P60409; Q8TAU3: ZNF417; NbExp=6; IntAct=EBI-10172290, EBI-740727;
CC P60409; Q8TF45: ZNF418; NbExp=3; IntAct=EBI-10172290, EBI-3446851;
CC P60409; Q96HQ0: ZNF419; NbExp=3; IntAct=EBI-10172290, EBI-10288482;
CC P60409; Q8TAQ5: ZNF420; NbExp=3; IntAct=EBI-10172290, EBI-3923307;
CC P60409; Q6IV72: ZNF425; NbExp=3; IntAct=EBI-10172290, EBI-10250516;
CC P60409; Q8N7K0: ZNF433; NbExp=3; IntAct=EBI-10172290, EBI-10267553;
CC P60409; Q8NDP4: ZNF439; NbExp=3; IntAct=EBI-10172290, EBI-747580;
CC P60409; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-10172290, EBI-726439;
CC P60409; Q8N0Y2-2: ZNF444; NbExp=3; IntAct=EBI-10172290, EBI-12010736;
CC P60409; Q9ULM2: ZNF490; NbExp=6; IntAct=EBI-10172290, EBI-1105370;
CC P60409; Q8N8L2: ZNF491; NbExp=5; IntAct=EBI-10172290, EBI-12019860;
CC P60409; Q96C55: ZNF524; NbExp=3; IntAct=EBI-10172290, EBI-10283126;
CC P60409; Q08ER8: ZNF543; NbExp=3; IntAct=EBI-10172290, EBI-10226133;
CC P60409; Q8NEP9: ZNF555; NbExp=3; IntAct=EBI-10172290, EBI-10270752;
CC P60409; Q8TBZ8: ZNF564; NbExp=6; IntAct=EBI-10172290, EBI-10273713;
CC P60409; Q7Z3I7: ZNF572; NbExp=3; IntAct=EBI-10172290, EBI-10172590;
CC P60409; Q86XF7: ZNF575; NbExp=3; IntAct=EBI-10172290, EBI-14069183;
CC P60409; Q3MI94: ZNF578; NbExp=3; IntAct=EBI-10172290, EBI-10241108;
CC P60409; Q96N58: ZNF578; NbExp=3; IntAct=EBI-10172290, EBI-11955189;
CC P60409; Q9UK33: ZNF580; NbExp=3; IntAct=EBI-10172290, EBI-746277;
CC P60409; Q9P0T4: ZNF581; NbExp=6; IntAct=EBI-10172290, EBI-745520;
CC P60409; Q96SQ5: ZNF587; NbExp=6; IntAct=EBI-10172290, EBI-6427977;
CC P60409; Q96I27: ZNF625; NbExp=3; IntAct=EBI-10172290, EBI-4395587;
CC P60409; Q5HYK9: ZNF667; NbExp=3; IntAct=EBI-10172290, EBI-7115499;
CC P60409; Q9BS34: ZNF670; NbExp=3; IntAct=EBI-10172290, EBI-745276;
CC P60409; Q9H7X3: ZNF696; NbExp=5; IntAct=EBI-10172290, EBI-11090299;
CC P60409; Q8N508: ZNF697; NbExp=3; IntAct=EBI-10172290, EBI-10265733;
CC P60409; Q96C28: ZNF707; NbExp=3; IntAct=EBI-10172290, EBI-748111;
CC P60409; Q96H86: ZNF764; NbExp=3; IntAct=EBI-10172290, EBI-745775;
CC P60409; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-10172290, EBI-10251462;
CC P60409; Q96MU6: ZNF778; NbExp=3; IntAct=EBI-10172290, EBI-10291463;
CC P60409; Q8N393: ZNF786; NbExp=3; IntAct=EBI-10172290, EBI-10265203;
CC P60409; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-10172290, EBI-10240849;
CC P60409; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-10172290, EBI-11962574;
CC P60409; Q08AG5: ZNF844; NbExp=3; IntAct=EBI-10172290, EBI-10225757;
CC P60409; Q147U1: ZNF846; NbExp=3; IntAct=EBI-10172290, EBI-10234020;
CC P60409; O43257: ZNHIT1; NbExp=3; IntAct=EBI-10172290, EBI-347522;
CC P60409; Q96SZ4: ZSCAN10; NbExp=3; IntAct=EBI-10172290, EBI-14934888;
CC P60409; Q9Y5A6: ZSCAN21; NbExp=3; IntAct=EBI-10172290, EBI-10281938;
CC P60409; Q16670: ZSCAN26; NbExp=7; IntAct=EBI-10172290, EBI-3920053;
CC P60409; B0FTY2; NbExp=3; IntAct=EBI-10172290, EBI-10175366;
CC P60409; Q53FW8; NbExp=3; IntAct=EBI-10172290, EBI-10242473;
CC P60409; Q5BKY6; NbExp=3; IntAct=EBI-10172290, EBI-10243533;
CC P60409; Q5XG85; NbExp=3; IntAct=EBI-10172290, EBI-10248413;
CC P60409; Q9H6F0; NbExp=3; IntAct=EBI-10172290, EBI-10307481;
CC -!- TISSUE SPECIFICITY: Restricted to a narrow region of the hair fiber
CC cuticle, lying approximately 20 cell layers above the apex of the
CC dermal papilla of the hair root; not detected in any other tissues.
CC {ECO:0000269|PubMed:14962103, ECO:0000269|PubMed:15028290}.
CC -!- SIMILARITY: Belongs to the KRTAP type 10 family. {ECO:0000305}.
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DR EMBL; AB076354; BAD01541.1; -; mRNA.
DR EMBL; AL773602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471079; EAX09413.1; -; Genomic_DNA.
DR EMBL; BC119643; AAI19644.1; -; mRNA.
DR EMBL; AJ566385; CAD97465.1; -; mRNA.
DR CCDS; CCDS74803.1; -.
DR RefSeq; NP_941962.1; NM_198689.2.
DR AlphaFoldDB; P60409; -.
DR BioGRID; 132126; 283.
DR IntAct; P60409; 282.
DR STRING; 9606.ENSP00000476821; -.
DR iPTMnet; P60409; -.
DR PhosphoSitePlus; P60409; -.
DR BioMuta; KRTAP10-7; -.
DR DMDM; 116242611; -.
DR MassIVE; P60409; -.
DR PaxDb; P60409; -.
DR PeptideAtlas; P60409; -.
DR PRIDE; P60409; -.
DR Antibodypedia; 76638; 2 antibodies from 2 providers.
DR DNASU; 386675; -.
DR Ensembl; ENST00000609664.2; ENSP00000476821.1; ENSG00000272804.3.
DR GeneID; 386675; -.
DR KEGG; hsa:386675; -.
DR MANE-Select; ENST00000609664.2; ENSP00000476821.1; NM_198689.3; NP_941962.1.
DR UCSC; uc032qbr.1; human.
DR CTD; 386675; -.
DR GeneCards; KRTAP10-7; -.
DR HGNC; HGNC:22970; KRTAP10-7.
DR HPA; ENSG00000272804; Tissue enriched (skin).
DR neXtProt; NX_P60409; -.
DR OpenTargets; ENSG00000272804; -.
DR PharmGKB; PA134976547; -.
DR VEuPathDB; HostDB:ENSG00000272804; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000163845; -.
DR HOGENOM; CLU_062832_0_0_1; -.
DR InParanoid; P60409; -.
DR OMA; CCHYTSS; -.
DR OrthoDB; 1629708at2759; -.
DR PhylomeDB; P60409; -.
DR PathwayCommons; P60409; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; P60409; -.
DR BioGRID-ORCS; 386675; 2 hits in 244 CRISPR screens.
DR GenomeRNAi; 386675; -.
DR Pharos; P60409; Tdark.
DR PRO; PR:P60409; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; P60409; protein.
DR Bgee; ENSG00000272804; Expressed in skin of abdomen and 7 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 3.
DR Pfam; PF13885; Keratin_B2_2; 3.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..370
FT /note="Keratin-associated protein 10-7"
FT /id="PRO_0000185215"
FT REPEAT 41..45
FT /note="1"
FT REPEAT 46..50
FT /note="2"
FT REPEAT 67..71
FT /note="3"
FT REPEAT 89..93
FT /note="4"
FT REPEAT 99..103
FT /note="5"
FT REPEAT 109..113
FT /note="6"
FT REPEAT 114..118
FT /note="7"
FT REPEAT 119..123
FT /note="8"
FT REPEAT 135..139
FT /note="9"
FT REPEAT 145..149
FT /note="10"
FT REPEAT 155..159
FT /note="11"
FT REPEAT 160..164
FT /note="12"
FT REPEAT 172..176
FT /note="13"
FT REPEAT 186..190
FT /note="14"
FT REPEAT 208..212
FT /note="15"
FT REPEAT 218..222
FT /note="16"
FT REPEAT 228..232
FT /note="17"
FT REPEAT 233..237
FT /note="18"
FT REPEAT 238..242
FT /note="19"
FT REPEAT 250..254
FT /note="20"
FT REPEAT 255..259
FT /note="21"
FT REPEAT 265..269
FT /note="22"
FT REPEAT 270..274
FT /note="23"
FT REPEAT 275..279
FT /note="24"
FT REPEAT 287..291
FT /note="25"
FT REPEAT 297..301
FT /note="26"
FT REPEAT 302..306
FT /note="27"
FT REPEAT 321..325
FT /note="28"
FT REPEAT 339..343
FT /note="29"
FT REPEAT 359..363
FT /note="30"
FT REGION 36..363
FT /note="30 X 5 AA repeats of C-C-X(3)"
FT VARIANT 111
FT /note="V -> M (in dbSNP:rs944419)"
FT /id="VAR_047852"
FT VARIANT 124
FT /note="Y -> C (in dbSNP:rs233308)"
FT /id="VAR_060051"
FT VARIANT 215
FT /note="K -> Q (in dbSNP:rs363877)"
FT /id="VAR_047853"
FT VARIANT 285
FT /note="T -> S (in dbSNP:rs446817)"
FT /id="VAR_047854"
FT VARIANT 320
FT /note="A -> T (in dbSNP:rs369720)"
FT /id="VAR_047855"
SQ SEQUENCE 370 AA; 37372 MW; D7D44544DEC05BCB CRC64;
MAASTMSVCS SDLSYGSRVC LPGSCDSCSD SWQVDDCPES CCEPPCCAPA PCLSLVCTPV
SYVSSPCCRV TCEPSPCQSG CTSSCTPSCC QQSSCQLACC ASSPCQQACC VPVCCKTVCC
KPVYCVPVCS GDSSCCQQSS CQSACCTSSP CQQACCVPIC CKPVCSGISS SCCQQSSCVS
CVSSPCCQAV CEPSPCQSGC ISSCTPSCCQ QSSCKPACCT SSPCQQACCV PVCCKPVCCV
PTCSDDSGSC CQPACCTSSQ SQQGCCVPVC CKPVCCVPVC SGASTSCCQQ SSCQPACCTT
SCCRPSSSVS LLCRPVCRPA CCVPVPSCCA PTSSCQASCC RPASCVSLLC RPACSRPACC
GPTSTQKSSC
