ID   KR108_BOVIN             Reviewed;         218 AA.
AC   A6QP35;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Keratin-associated protein 10-8 {ECO:0000250|UniProtKB:P60410};
GN   Name=KRTAP10-8 {ECO:0000312|EMBL:AAI49134.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAI49134.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI49134.1};
RC   TISSUE=Fetal skin {ECO:0000312|EMBL:AAI49134.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins (By similarity). {ECO:0000250|UniProtKB:P60410}.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250|UniProtKB:P60410}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 10 family. {ECO:0000255}.
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DR   EMBL; BC149133; AAI49134.1; -; mRNA.
DR   RefSeq; NP_001094760.1; NM_001101290.1.
DR   AlphaFoldDB; A6QP35; -.
DR   STRING; 9913.ENSBTAP00000041209; -.
DR   PaxDb; A6QP35; -.
DR   PRIDE; A6QP35; -.
DR   Ensembl; ENSBTAT00000043652; ENSBTAP00000041209; ENSBTAG00000040291.
DR   GeneID; 783679; -.
DR   KEGG; bta:783679; -.
DR   CTD; 386681; -.
DR   VEuPathDB; HostDB:ENSBTAG00000040291; -.
DR   eggNOG; KOG4726; Eukaryota.
DR   GeneTree; ENSGT00940000163441; -.
DR   HOGENOM; CLU_062832_0_0_1; -.
DR   InParanoid; A6QP35; -.
DR   OMA; KPLCCKP; -.
DR   OrthoDB; 1614375at2759; -.
DR   TreeFam; TF351356; -.
DR   Reactome; R-BTA-6805567; Keratinization.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000040291; Expressed in zone of skin and 3 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProt.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   InterPro; IPR002494; KAP.
DR   InterPro; IPR007951; KRTAP_PMG.
DR   PANTHER; PTHR23262; PTHR23262; 1.
DR   Pfam; PF13885; Keratin_B2_2; 2.
DR   Pfam; PF05287; PMG; 1.
PE   2: Evidence at transcript level;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..218
FT                   /note="Keratin-associated protein 10-8"
FT                   /id="PRO_0000355590"
FT   REPEAT          50..54
FT                   /note="1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          55..59
FT                   /note="2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          60..64
FT                   /note="3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          86..90
FT                   /note="4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          96..100
FT                   /note="5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          101..105
FT                   /note="6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          111..115
FT                   /note="7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          121..125
FT                   /note="8"
FT                   /evidence="ECO:0000255"
FT   REPEAT          131..135
FT                   /note="9"
FT                   /evidence="ECO:0000255"
FT   REPEAT          136..140
FT                   /note="10"
FT                   /evidence="ECO:0000255"
FT   REPEAT          141..145
FT                   /note="11"
FT                   /evidence="ECO:0000255"
FT   REPEAT          151..155
FT                   /note="12"
FT                   /evidence="ECO:0000255"
FT   REPEAT          161..167
FT                   /note="13"
FT                   /evidence="ECO:0000255"
FT   REPEAT          168..172
FT                   /note="14"
FT                   /evidence="ECO:0000255"
FT   REPEAT          187..191
FT                   /note="15"
FT                   /evidence="ECO:0000255"
FT   REPEAT          198..202
FT                   /note="16"
FT                   /evidence="ECO:0000255"
FT   REGION          26..202
FT                   /note="16 X 5 AA repeats of C-C-X(3)"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   218 AA;  22549 MW;  B42573A39E6680CC CRC64;
     MADTCCSRTC VVAASTLSVC SSDLSCGNQV SSPSACIGSS WQVDDCQETC CEPTCCAPSC
     CAPAPRLTLI CAPVNCESSP CCQPACSSSS PCQQACCVPV CCRPVCCTPV CCRPVCCRPV
     CCTPVCCRPV CCRPVCCRPV CCRPVCCTPV CCRPMCCEAS PCSAPSSCCR PSSSVSLLCR
     PVCRPTCCVP TFFCQPSCCH PASSVSLLCQ PSCSSSAC