KR108_HUMAN
ID KR108_HUMAN Reviewed; 259 AA.
AC P60410; A0JNW4;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Keratin-associated protein 10-8;
DE AltName: Full=High sulfur keratin-associated protein 10.8;
DE AltName: Full=Keratin-associated protein 10.8;
DE AltName: Full=Keratin-associated protein 18-8;
DE AltName: Full=Keratin-associated protein 18.8;
GN Name=KRTAP10-8; Synonyms=KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT ARG-26.
RC TISSUE=Hair root;
RX PubMed=15028290; DOI=10.1016/j.ygeno.2003.09.024;
RA Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.;
RT "A cluster of 21 keratin-associated protein genes within introns of another
RT gene on human chromosome 21q22.3.";
RL Genomics 83:679-693(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-26.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=14962103; DOI=10.1046/j.0022-202x.2003.22128.x;
RA Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S.,
RA Schweizer J.;
RT "Hair keratin associated proteins: characterization of a second high sulfur
RT KAP gene domain on human chromosome 21.";
RL J. Invest. Dermatol. 122:147-158(2004).
RN [5]
RP VARIANTS [LARGE SCALE ANALYSIS] ASN-64 AND PHE-159.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC P60410; Q96HD9: ACY3; NbExp=3; IntAct=EBI-10171774, EBI-3916242;
CC P60410; O43184-4: ADAM12; NbExp=5; IntAct=EBI-10171774, EBI-12006944;
CC P60410; Q9UHI8: ADAMTS1; NbExp=3; IntAct=EBI-10171774, EBI-2511802;
CC P60410; P82987: ADAMTSL3; NbExp=6; IntAct=EBI-10171774, EBI-10221726;
CC P60410; Q6UY14-3: ADAMTSL4; NbExp=6; IntAct=EBI-10171774, EBI-10173507;
CC P60410; Q6ZN18-2: AEBP2; NbExp=3; IntAct=EBI-10171774, EBI-10255023;
CC P60410; Q8WTP8: AEN; NbExp=3; IntAct=EBI-10171774, EBI-8637627;
CC P60410; Q9UIJ7: AK3; NbExp=3; IntAct=EBI-10171774, EBI-3916527;
CC P60410; P43353: ALDH3B1; NbExp=6; IntAct=EBI-10171774, EBI-2558314;
CC P60410; P09923: ALPI; NbExp=3; IntAct=EBI-10171774, EBI-1052631;
CC P60410; P05187: ALPP; NbExp=3; IntAct=EBI-10171774, EBI-1211484;
CC P60410; Q9Y4X0: AMMECR1; NbExp=3; IntAct=EBI-10171774, EBI-8583355;
CC P60410; Q9Y4X0-3: AMMECR1; NbExp=3; IntAct=EBI-10171774, EBI-12823597;
CC P60410; Q49AR9: ANKS1A; NbExp=5; IntAct=EBI-10171774, EBI-11954519;
CC P60410; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-10171774, EBI-541426;
CC P60410; B3KTP4: ApoL6; NbExp=3; IntAct=EBI-10171774, EBI-10175904;
CC P60410; Q9BWW8: APOL6; NbExp=3; IntAct=EBI-10171774, EBI-11574440;
CC P60410; P29972: AQP1; NbExp=3; IntAct=EBI-10171774, EBI-745213;
CC P60410; P15514: AREG; NbExp=3; IntAct=EBI-10171774, EBI-953674;
CC P60410; Q03989: ARID5A; NbExp=3; IntAct=EBI-10171774, EBI-948603;
CC P60410; Q9BZE9: ASPSCR1; NbExp=3; IntAct=EBI-10171774, EBI-1993677;
CC P60410; Q7Z3C6: ATG9A; NbExp=3; IntAct=EBI-10171774, EBI-727146;
CC P60410; Q7Z3C6-3: ATG9A; NbExp=5; IntAct=EBI-10171774, EBI-12006308;
CC P60410; P30049: ATP5F1D; NbExp=3; IntAct=EBI-10171774, EBI-1049505;
CC P60410; Q5T686: AVPI1; NbExp=3; IntAct=EBI-10171774, EBI-8640233;
CC P60410; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-10171774, EBI-4400025;
CC P60410; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-10171774, EBI-742750;
CC P60410; A8KA13: BCL6B; NbExp=3; IntAct=EBI-10171774, EBI-10174813;
CC P60410; Q9BXY8: BEX2; NbExp=6; IntAct=EBI-10171774, EBI-745073;
CC P60410; A8K571: BMP7; NbExp=3; IntAct=EBI-10171774, EBI-10174327;
CC P60410; P18075: BMP7; NbExp=3; IntAct=EBI-10171774, EBI-1035195;
CC P60410; Q0VDD7-2: BRME1; NbExp=3; IntAct=EBI-10171774, EBI-12040255;
CC P60410; Q5T681: C10orf62; NbExp=3; IntAct=EBI-10171774, EBI-744052;
CC P60410; Q6NUJ2: C11orf87; NbExp=6; IntAct=EBI-10171774, EBI-6660291;
CC P60410; Q8WW18: C17orf50; NbExp=3; IntAct=EBI-10171774, EBI-12877892;
CC P60410; Q9UFG5: C19orf25; NbExp=3; IntAct=EBI-10171774, EBI-741214;
CC P60410; Q6P5X5: C22orf39; NbExp=5; IntAct=EBI-10171774, EBI-7317823;
CC P60410; Q2NKX9: C2orf68; NbExp=3; IntAct=EBI-10171774, EBI-11603468;
CC P60410; P01024: C3; NbExp=3; IntAct=EBI-10171774, EBI-905851;
CC P60410; Q96NX5: CAMK1G; NbExp=3; IntAct=EBI-10171774, EBI-3920838;
CC P60410; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-10171774, EBI-3866279;
CC P60410; Q9Y2V2: CARHSP1; NbExp=6; IntAct=EBI-10171774, EBI-718719;
CC P60410; Q8NEC5: CATSPER1; NbExp=8; IntAct=EBI-10171774, EBI-744545;
CC P60410; Q8TAB7: CCDC26; NbExp=3; IntAct=EBI-10171774, EBI-10271580;
CC P60410; F6RF56: CCNJL; NbExp=3; IntAct=EBI-10171774, EBI-10177725;
CC P60410; Q9UKJ5: CHIC2; NbExp=6; IntAct=EBI-10171774, EBI-741528;
CC P60410; Q9H2X0: CHRD; NbExp=6; IntAct=EBI-10171774, EBI-947551;
CC P60410; P07510: CHRNG; NbExp=4; IntAct=EBI-10171774, EBI-9008836;
CC P60410; P07510-2: CHRNG; NbExp=6; IntAct=EBI-10171774, EBI-11979451;
CC P60410; Q9HAZ1: CLK4; NbExp=3; IntAct=EBI-10171774, EBI-633400;
CC P60410; Q8NE01: CNNM3; NbExp=6; IntAct=EBI-10171774, EBI-741032;
CC P60410; P27658: COL8A1; NbExp=8; IntAct=EBI-10171774, EBI-747133;
CC P60410; Q14061: COX17; NbExp=3; IntAct=EBI-10171774, EBI-711311;
CC P60410; Q9UGL9: CRCT1; NbExp=6; IntAct=EBI-10171774, EBI-713677;
CC P60410; Q02930-3: CREB5; NbExp=10; IntAct=EBI-10171774, EBI-10192698;
CC P60410; P06850: CRH; NbExp=3; IntAct=EBI-10171774, EBI-3870390;
CC P60410; Q49AN0: CRY2; NbExp=3; IntAct=EBI-10171774, EBI-2212355;
CC P60410; P09603: CSF1; NbExp=3; IntAct=EBI-10171774, EBI-2872294;
CC P60410; Q99895: CTRC; NbExp=3; IntAct=EBI-10171774, EBI-10295404;
CC P60410; Q96SQ9: CYP2S1; NbExp=3; IntAct=EBI-10171774, EBI-8633740;
CC P60410; A8MQ03: CYSRT1; NbExp=6; IntAct=EBI-10171774, EBI-3867333;
CC P60410; O43602: DCX; NbExp=3; IntAct=EBI-10171774, EBI-8646694;
CC P60410; Q9NXZ2: DDX43; NbExp=3; IntAct=EBI-10171774, EBI-10316543;
CC P60410; Q8NHQ9: DDX55; NbExp=3; IntAct=EBI-10171774, EBI-5459844;
CC P60410; P26196: DDX6; NbExp=6; IntAct=EBI-10171774, EBI-351257;
CC P60410; Q9GZP9: DERL2; NbExp=3; IntAct=EBI-10171774, EBI-7962814;
CC P60410; Q96LJ7: DHRS1; NbExp=8; IntAct=EBI-10171774, EBI-746300;
CC P60410; Q6P158: DHX57; NbExp=6; IntAct=EBI-10171774, EBI-1051531;
CC P60410; Q9NQL9: DMRT3; NbExp=6; IntAct=EBI-10171774, EBI-9679045;
CC P60410; Q92608: DOCK2; NbExp=6; IntAct=EBI-10171774, EBI-448771;
CC P60410; P42892: ECE1; NbExp=3; IntAct=EBI-10171774, EBI-2859983;
CC P60410; O95967: EFEMP2; NbExp=3; IntAct=EBI-10171774, EBI-743414;
CC P60410; O60573: EIF4E2; NbExp=3; IntAct=EBI-10171774, EBI-398610;
CC P60410; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-10171774, EBI-744099;
CC P60410; Q9UM22: EPDR1; NbExp=3; IntAct=EBI-10171774, EBI-946972;
CC P60410; Q8N9I5: FADS6; NbExp=3; IntAct=EBI-10171774, EBI-3943864;
CC P60410; P16930: FAH; NbExp=3; IntAct=EBI-10171774, EBI-4397076;
CC P60410; Q9BQ89: FAM110A; NbExp=3; IntAct=EBI-10171774, EBI-1752811;
CC P60410; Q3B820: FAM161A; NbExp=3; IntAct=EBI-10171774, EBI-719941;
CC P60410; A6H8Z2: FAM221B; NbExp=3; IntAct=EBI-10171774, EBI-12006844;
CC P60410; Q08E93: FAM27E3; NbExp=3; IntAct=EBI-10171774, EBI-2602739;
CC P60410; Q8NEG0: FAM71C; NbExp=3; IntAct=EBI-10171774, EBI-752049;
CC P60410; Q5TZK3: FAM74A6; NbExp=3; IntAct=EBI-10171774, EBI-10247271;
CC P60410; Q5HYJ3: FAM76B; NbExp=3; IntAct=EBI-10171774, EBI-751192;
CC P60410; Q5HYJ3-3: FAM76B; NbExp=3; IntAct=EBI-10171774, EBI-11956087;
CC P60410; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-10171774, EBI-6658203;
CC P60410; O95363: FARS2; NbExp=3; IntAct=EBI-10171774, EBI-2513774;
CC P60410; Q9NWN3: FBXO34; NbExp=3; IntAct=EBI-10171774, EBI-719816;
CC P60410; Q969U6: FBXW5; NbExp=6; IntAct=EBI-10171774, EBI-741068;
CC P60410; A0PJY2: FEZF1; NbExp=3; IntAct=EBI-10171774, EBI-11988727;
CC P60410; Q99853: FOXB1; NbExp=3; IntAct=EBI-10171774, EBI-3916225;
CC P60410; O43559: FRS3; NbExp=3; IntAct=EBI-10171774, EBI-725515;
CC P60410; Q9BXU8: FTHL17; NbExp=3; IntAct=EBI-10171774, EBI-12156897;
CC P60410; Q9ULW2: FZD10; NbExp=3; IntAct=EBI-10171774, EBI-8803802;
CC P60410; P55040: GEM; NbExp=3; IntAct=EBI-10171774, EBI-744104;
CC P60410; Q9NXC2: GFOD1; NbExp=3; IntAct=EBI-10171774, EBI-8799578;
CC P60410; P43220: GLP1R; NbExp=3; IntAct=EBI-10171774, EBI-7466542;
CC P60410; O76003: GLRX3; NbExp=8; IntAct=EBI-10171774, EBI-374781;
CC P60410; Q6IB77: GLYAT; NbExp=3; IntAct=EBI-10171774, EBI-715463;
CC P60410; P04899: GNAI2; NbExp=3; IntAct=EBI-10171774, EBI-353997;
CC P60410; Q9Y223: GNE; NbExp=3; IntAct=EBI-10171774, EBI-4291090;
CC P60410; Q9Y223-2: GNE; NbExp=5; IntAct=EBI-10171774, EBI-11975289;
CC P60410; Q0D2H9: GOLGA8DP; NbExp=3; IntAct=EBI-10171774, EBI-10181276;
CC P60410; O95872: GPANK1; NbExp=3; IntAct=EBI-10171774, EBI-751540;
CC P60410; Q86YW7: GPHB5; NbExp=3; IntAct=EBI-10171774, EBI-11659720;
CC P60410; P28799: GRN; NbExp=3; IntAct=EBI-10171774, EBI-747754;
CC P60410; Q96NT3-2: GUCD1; NbExp=5; IntAct=EBI-10171774, EBI-11978177;
CC P60410; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-10171774, EBI-11956675;
CC P60410; P08631-2: HCK; NbExp=3; IntAct=EBI-10171774, EBI-9834454;
CC P60410; V9HWJ5: HEL-S-90n; NbExp=3; IntAct=EBI-10171774, EBI-10330335;
CC P60410; Q03014: HHEX; NbExp=6; IntAct=EBI-10171774, EBI-747421;
CC P60410; P49639: HOXA1; NbExp=9; IntAct=EBI-10171774, EBI-740785;
CC P60410; P09067: HOXB5; NbExp=3; IntAct=EBI-10171774, EBI-3893317;
CC P60410; P17482: HOXB9; NbExp=3; IntAct=EBI-10171774, EBI-745290;
CC P60410; P31273: HOXC8; NbExp=5; IntAct=EBI-10171774, EBI-1752118;
CC P60410; P37235: HPCAL1; NbExp=6; IntAct=EBI-10171774, EBI-749311;
CC P60410; O60243: HS6ST1; NbExp=3; IntAct=EBI-10171774, EBI-12294537;
CC P60410; Q9H2F3: HSD3B7; NbExp=8; IntAct=EBI-10171774, EBI-3918847;
CC P60410; Q96MM6: HSPA12B; NbExp=3; IntAct=EBI-10171774, EBI-10291310;
CC P60410; P10809: HSPD1; NbExp=3; IntAct=EBI-10171774, EBI-352528;
CC P60410; P05362: ICAM1; NbExp=3; IntAct=EBI-10171774, EBI-1035358;
CC P60410; P24592: IGFBP6; NbExp=3; IntAct=EBI-10171774, EBI-947015;
CC P60410; Q969P0: IGSF8; NbExp=6; IntAct=EBI-10171774, EBI-8293590;
CC P60410; P22301: IL10; NbExp=3; IntAct=EBI-10171774, EBI-1031632;
CC P60410; Q14005-2: IL16; NbExp=3; IntAct=EBI-10171774, EBI-17178971;
CC P60410; P31785: IL2RG; NbExp=3; IntAct=EBI-10171774, EBI-80475;
CC P60410; Q9C086: INO80B; NbExp=3; IntAct=EBI-10171774, EBI-715611;
CC P60410; Q6P9B9: INTS5; NbExp=3; IntAct=EBI-10171774, EBI-7600112;
CC P60410; Q96PC2: IP6K3; NbExp=3; IntAct=EBI-10171774, EBI-10990676;
CC P60410; P05107: ITGB2; NbExp=3; IntAct=EBI-10171774, EBI-300173;
CC P60410; P16144-2: ITGB4; NbExp=3; IntAct=EBI-10171774, EBI-11051601;
CC P60410; L7RT22: ITGB5; NbExp=3; IntAct=EBI-10171774, EBI-10178729;
CC P60410; P18084: ITGB5; NbExp=3; IntAct=EBI-10171774, EBI-1223434;
CC P60410; Q15040: JOSD1; NbExp=6; IntAct=EBI-10171774, EBI-2510602;
CC P60410; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-10171774, EBI-1055254;
CC P60410; Q2WGJ6: KLHL38; NbExp=6; IntAct=EBI-10171774, EBI-6426443;
CC P60410; O60259: KLK8; NbExp=3; IntAct=EBI-10171774, EBI-3915857;
CC P60410; Q5T749: KPRP; NbExp=3; IntAct=EBI-10171774, EBI-10981970;
CC P60410; P35900: KRT20; NbExp=6; IntAct=EBI-10171774, EBI-742094;
CC P60410; P78385: KRT83; NbExp=3; IntAct=EBI-10171774, EBI-10221390;
CC P60410; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-10171774, EBI-11959885;
CC P60410; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10171774, EBI-11749135;
CC P60410; P60014: KRTAP10-10; NbExp=3; IntAct=EBI-10171774, EBI-11955579;
CC P60410; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-10171774, EBI-10217483;
CC P60410; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-10171774, EBI-10172150;
CC P60410; P60409: KRTAP10-7; NbExp=6; IntAct=EBI-10171774, EBI-10172290;
CC P60410; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-10171774, EBI-10171774;
CC P60410; P60411: KRTAP10-9; NbExp=6; IntAct=EBI-10171774, EBI-10172052;
CC P60410; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-10171774, EBI-1052037;
CC P60410; P59990: KRTAP12-1; NbExp=6; IntAct=EBI-10171774, EBI-10210845;
CC P60410; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-10171774, EBI-10176379;
CC P60410; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10171774, EBI-11953334;
CC P60410; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-10171774, EBI-11992140;
CC P60410; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-10171774, EBI-11988175;
CC P60410; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-10171774, EBI-10241353;
CC P60410; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-10171774, EBI-9996449;
CC P60410; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-10171774, EBI-751260;
CC P60410; Q9BYQ6: KRTAP4-11; NbExp=9; IntAct=EBI-10171774, EBI-10302392;
CC P60410; Q9BQ66: KRTAP4-12; NbExp=6; IntAct=EBI-10171774, EBI-739863;
CC P60410; Q9BYR5: KRTAP4-2; NbExp=10; IntAct=EBI-10171774, EBI-10172511;
CC P60410; Q9BYR3: KRTAP4-4; NbExp=4; IntAct=EBI-10171774, EBI-11958132;
CC P60410; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-10171774, EBI-11993254;
CC P60410; Q9BYR0: KRTAP4-7; NbExp=3; IntAct=EBI-10171774, EBI-10302547;
CC P60410; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-10171774, EBI-11993296;
CC P60410; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-10171774, EBI-11958178;
CC P60410; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-10171774, EBI-11974251;
CC P60410; Q6L8H1: KRTAP5-4; NbExp=3; IntAct=EBI-10171774, EBI-11963072;
CC P60410; Q6L8G9: KRTAP5-6; NbExp=8; IntAct=EBI-10171774, EBI-10250562;
CC P60410; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-10171774, EBI-3958099;
CC P60410; Q9BYQ4: KRTAP9-2; NbExp=11; IntAct=EBI-10171774, EBI-1044640;
CC P60410; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-10171774, EBI-1043191;
CC P60410; Q9BYQ2: KRTAP9-4; NbExp=3; IntAct=EBI-10171774, EBI-10185730;
CC P60410; Q9BYQ0: KRTAP9-8; NbExp=5; IntAct=EBI-10171774, EBI-11958364;
CC P60410; Q14657: LAGE3; NbExp=3; IntAct=EBI-10171774, EBI-1052105;
CC P60410; Q14847-2: LASP1; NbExp=3; IntAct=EBI-10171774, EBI-9088686;
CC P60410; Q5T7P2: LCE1A; NbExp=6; IntAct=EBI-10171774, EBI-11962058;
CC P60410; Q5T7P3: LCE1B; NbExp=10; IntAct=EBI-10171774, EBI-10245913;
CC P60410; Q5T751: LCE1C; NbExp=3; IntAct=EBI-10171774, EBI-12224199;
CC P60410; Q5T752: LCE1D; NbExp=3; IntAct=EBI-10171774, EBI-11741311;
CC P60410; Q5T753: LCE1E; NbExp=3; IntAct=EBI-10171774, EBI-11955335;
CC P60410; Q5T754: LCE1F; NbExp=6; IntAct=EBI-10171774, EBI-11958008;
CC P60410; Q5TA79: LCE2A; NbExp=8; IntAct=EBI-10171774, EBI-10246607;
CC P60410; O14633: LCE2B; NbExp=6; IntAct=EBI-10171774, EBI-11478468;
CC P60410; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-10171774, EBI-11973993;
CC P60410; Q5TA82: LCE2D; NbExp=8; IntAct=EBI-10171774, EBI-10246750;
CC P60410; Q5TA76: LCE3A; NbExp=5; IntAct=EBI-10171774, EBI-9394625;
CC P60410; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-10171774, EBI-11974495;
CC P60410; Q5T5A8: LCE3C; NbExp=6; IntAct=EBI-10171774, EBI-10245291;
CC P60410; Q9BYE3: LCE3D; NbExp=5; IntAct=EBI-10171774, EBI-6658837;
CC P60410; Q5T5B0: LCE3E; NbExp=11; IntAct=EBI-10171774, EBI-10245456;
CC P60410; Q5TA78: LCE4A; NbExp=9; IntAct=EBI-10171774, EBI-10246358;
CC P60410; Q5TCM9: LCE5A; NbExp=5; IntAct=EBI-10171774, EBI-11955689;
CC P60410; Q5T871: LELP1; NbExp=3; IntAct=EBI-10171774, EBI-18115868;
CC P60410; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-10171774, EBI-726510;
CC P60410; Q9BU23-2: LMF2; NbExp=3; IntAct=EBI-10171774, EBI-12132296;
CC P60410; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-10171774, EBI-739832;
CC P60410; Q17RD9: LOC200261; NbExp=3; IntAct=EBI-10171774, EBI-10239007;
CC P60410; O75427: LRCH4; NbExp=3; IntAct=EBI-10171774, EBI-718707;
CC P60410; Q6PJG9: LRFN4; NbExp=3; IntAct=EBI-10171774, EBI-7910762;
CC P60410; Q9P127: LUZP4; NbExp=3; IntAct=EBI-10171774, EBI-10198848;
CC P60410; Q9Y5Y7: LYVE1; NbExp=3; IntAct=EBI-10171774, EBI-10329546;
CC P60410; O75367: MACROH2A1; NbExp=3; IntAct=EBI-10171774, EBI-2868511;
CC P60410; O60336: MAPKBP1; NbExp=8; IntAct=EBI-10171774, EBI-947402;
CC P60410; O15232: MATN3; NbExp=3; IntAct=EBI-10171774, EBI-6262458;
CC P60410; O14770-4: MEIS2; NbExp=3; IntAct=EBI-10171774, EBI-8025850;
CC P60410; P08582-2: MELTF; NbExp=3; IntAct=EBI-10171774, EBI-10195914;
CC P60410; P50222: MEOX2; NbExp=3; IntAct=EBI-10171774, EBI-748397;
CC P60410; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-10171774, EBI-16439278;
CC P60410; Q6P2C6: MLLT6; NbExp=3; IntAct=EBI-10171774, EBI-5773143;
CC P60410; Q13875: MOBP; NbExp=3; IntAct=EBI-10171774, EBI-10230628;
CC P60410; Q13875-3: MOBP; NbExp=3; IntAct=EBI-10171774, EBI-12013470;
CC P60410; Q13330: MTA1; NbExp=3; IntAct=EBI-10171774, EBI-714236;
CC P60410; Q969V5: MUL1; NbExp=3; IntAct=EBI-10171774, EBI-744120;
CC P60410; P50539-3: MXI1; NbExp=6; IntAct=EBI-10171774, EBI-10211940;
CC P60410; Q86VE0: MYPOP; NbExp=3; IntAct=EBI-10171774, EBI-2858213;
CC P60410; Q15742: NAB2; NbExp=3; IntAct=EBI-10171774, EBI-8641936;
CC P60410; Q8IW45: NAXD; NbExp=6; IntAct=EBI-10171774, EBI-8650724;
CC P60410; Q92692-2: NECTIN2; NbExp=3; IntAct=EBI-10171774, EBI-6979889;
CC P60410; Q9NQS3: NECTIN3; NbExp=3; IntAct=EBI-10171774, EBI-2826725;
CC P60410; Q9NQS3-2: NECTIN3; NbExp=3; IntAct=EBI-10171774, EBI-12106440;
CC P60410; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-10171774, EBI-11750983;
CC P60410; Q969G9: NKD1; NbExp=3; IntAct=EBI-10171774, EBI-1538217;
CC P60410; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10171774, EBI-945833;
CC P60410; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10171774, EBI-22310682;
CC P60410; Q9NQX5: NPDC1; NbExp=3; IntAct=EBI-10171774, EBI-748927;
CC P60410; Q6NSM0: NR1D2; NbExp=8; IntAct=EBI-10171774, EBI-10250949;
CC P60410; Q92570: NR4A3; NbExp=3; IntAct=EBI-10171774, EBI-13644623;
CC P60410; Q9HB63: NTN4; NbExp=3; IntAct=EBI-10171774, EBI-743459;
CC P60410; Q7Z417: NUFIP2; NbExp=6; IntAct=EBI-10171774, EBI-1210753;
CC P60410; Q7RTU3: OLIG3; NbExp=5; IntAct=EBI-10171774, EBI-10225049;
CC P60410; Q14982: OPCML; NbExp=3; IntAct=EBI-10171774, EBI-6447201;
CC P60410; P32242: OTX1; NbExp=8; IntAct=EBI-10171774, EBI-740446;
CC P60410; Q99572: P2RX7; NbExp=3; IntAct=EBI-10171774, EBI-1753251;
CC P60410; Q15077: P2RY6; NbExp=3; IntAct=EBI-10171774, EBI-10235794;
CC P60410; Q02548: PAX5; NbExp=3; IntAct=EBI-10171774, EBI-296331;
CC P60410; Q9H1Q7: PCED1A; NbExp=3; IntAct=EBI-10171774, EBI-748452;
CC P60410; Q92824: PCSK5; NbExp=3; IntAct=EBI-10171774, EBI-751290;
CC P60410; Q92824-2: PCSK5; NbExp=6; IntAct=EBI-10171774, EBI-11956269;
CC P60410; O76083: PDE9A; NbExp=3; IntAct=EBI-10171774, EBI-742764;
CC P60410; O76083-2: PDE9A; NbExp=3; IntAct=EBI-10171774, EBI-11524542;
CC P60410; P13667: PDIA4; NbExp=3; IntAct=EBI-10171774, EBI-1054653;
CC P60410; Q9HCN3: PGAP6; NbExp=3; IntAct=EBI-10171774, EBI-10310808;
CC P60410; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-10171774, EBI-14084211;
CC P60410; Q96S52: PIGS; NbExp=3; IntAct=EBI-10171774, EBI-2908273;
CC P60410; Q13526: PIN1; NbExp=3; IntAct=EBI-10171774, EBI-714158;
CC P60410; Q13563: PKD2; NbExp=3; IntAct=EBI-10171774, EBI-7813714;
CC P60410; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-10171774, EBI-769257;
CC P60410; P28069: POU1F1; NbExp=3; IntAct=EBI-10171774, EBI-8673859;
CC P60410; Q12837: POU4F2; NbExp=3; IntAct=EBI-10171774, EBI-17236143;
CC P60410; O43741: PRKAB2; NbExp=6; IntAct=EBI-10171774, EBI-1053424;
CC P60410; Q8WWY3: PRPF31; NbExp=9; IntAct=EBI-10171774, EBI-1567797;
CC P60410; Q9NZ81: PRR13; NbExp=6; IntAct=EBI-10171774, EBI-740924;
CC P60410; A6NJB7-2: PRR19; NbExp=3; IntAct=EBI-10171774, EBI-11998870;
CC P60410; P43115-12: PTGER3; NbExp=3; IntAct=EBI-10171774, EBI-10234038;
CC P60410; Q13308: PTK7; NbExp=3; IntAct=EBI-10171774, EBI-2803245;
CC P60410; Q8WUK0: PTPMT1; NbExp=6; IntAct=EBI-10171774, EBI-7199479;
CC P60410; Q9HD43: PTPRH; NbExp=3; IntAct=EBI-10171774, EBI-1267176;
CC P60410; P15151: PVR; NbExp=6; IntAct=EBI-10171774, EBI-3919694;
CC P60410; Q15274: QPRT; NbExp=3; IntAct=EBI-10171774, EBI-739851;
CC P60410; Q9Y2K5: R3HDM2; NbExp=5; IntAct=EBI-10171774, EBI-948428;
CC P60410; Q9Y2K5-2: R3HDM2; NbExp=3; IntAct=EBI-10171774, EBI-10326419;
CC P60410; A4D1S5: RAB19; NbExp=3; IntAct=EBI-10171774, EBI-4401710;
CC P60410; P20336: RAB3A; NbExp=3; IntAct=EBI-10171774, EBI-1045943;
CC P60410; Q12967-6: RALGDS; NbExp=3; IntAct=EBI-10171774, EBI-12005546;
CC P60410; Q9Y272: RASD1; NbExp=3; IntAct=EBI-10171774, EBI-740818;
CC P60410; Q6P9E2: RECK; NbExp=3; IntAct=EBI-10171774, EBI-10253121;
CC P60410; O15211: RGL2; NbExp=3; IntAct=EBI-10171774, EBI-712355;
CC P60410; O75783: RHBDL1; NbExp=3; IntAct=EBI-10171774, EBI-12104986;
CC P60410; Q9BSD3: RHNO1; NbExp=3; IntAct=EBI-10171774, EBI-9658624;
CC P60410; Q9H0F5: RNF38; NbExp=3; IntAct=EBI-10171774, EBI-2341200;
CC P60410; O76064: RNF8; NbExp=3; IntAct=EBI-10171774, EBI-373337;
CC P60410; Q86WX3: RPS19BP1; NbExp=3; IntAct=EBI-10171774, EBI-4479407;
CC P60410; P62857: RPS28; NbExp=3; IntAct=EBI-10171774, EBI-353027;
CC P60410; Q86UN2: RTN4RL1; NbExp=3; IntAct=EBI-10171774, EBI-10258951;
CC P60410; Q14162: SCARF1; NbExp=3; IntAct=EBI-10171774, EBI-12056025;
CC P60410; Q9BWG6: SCNM1; NbExp=6; IntAct=EBI-10171774, EBI-748391;
CC P60410; Q13214-2: SEMA3B; NbExp=3; IntAct=EBI-10171774, EBI-11017428;
CC P60410; Q9NR46: SH3GLB2; NbExp=3; IntAct=EBI-10171774, EBI-749607;
CC P60410; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-10171774, EBI-10313866;
CC P60410; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-10171774, EBI-11955083;
CC P60410; Q86YT5: SLC13A5; NbExp=3; IntAct=EBI-10171774, EBI-12002412;
CC P60410; A1A5C7: SLC22A23; NbExp=3; IntAct=EBI-10171774, EBI-10171756;
CC P60410; Q9UHI7: SLC23A1; NbExp=4; IntAct=EBI-10171774, EBI-1759386;
CC P60410; Q9UHI7-3: SLC23A1; NbExp=3; IntAct=EBI-10171774, EBI-11998660;
CC P60410; Q9UBX3: SLC25A10; NbExp=3; IntAct=EBI-10171774, EBI-750394;
CC P60410; Q9H0C2: SLC25A31; NbExp=3; IntAct=EBI-10171774, EBI-6149672;
CC P60410; Q86VD7: SLC25A42; NbExp=3; IntAct=EBI-10171774, EBI-6598313;
CC P60410; Q9NP91: SLC6A20; NbExp=6; IntAct=EBI-10171774, EBI-10311198;
CC P60410; O75093: SLIT1; NbExp=3; IntAct=EBI-10171774, EBI-947791;
CC P60410; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-10171774, EBI-455078;
CC P60410; P49901: SMCP; NbExp=9; IntAct=EBI-10171774, EBI-750494;
CC P60410; Q9H0W8: SMG9; NbExp=3; IntAct=EBI-10171774, EBI-2872322;
CC P60410; Q9H4F8: SMOC1; NbExp=3; IntAct=EBI-10171774, EBI-2801103;
CC P60410; Q96E40: SPACA9; NbExp=3; IntAct=EBI-10171774, EBI-722584;
CC P60410; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-10171774, EBI-11959123;
CC P60410; Q86W54-2: SPATA24; NbExp=3; IntAct=EBI-10171774, EBI-12041693;
CC P60410; A0A024R4B0: SPATA3; NbExp=3; IntAct=EBI-10171774, EBI-14123856;
CC P60410; O43609: SPRY1; NbExp=6; IntAct=EBI-10171774, EBI-3866665;
CC P60410; O43597: SPRY2; NbExp=3; IntAct=EBI-10171774, EBI-742487;
CC P60410; O75716: STK16; NbExp=6; IntAct=EBI-10171774, EBI-749295;
CC P60410; Q9UGT4: SUSD2; NbExp=3; IntAct=EBI-10171774, EBI-1054721;
CC P60410; Q92537: SUSD6; NbExp=6; IntAct=EBI-10171774, EBI-2866213;
CC P60410; O43463: SUV39H1; NbExp=3; IntAct=EBI-10171774, EBI-349968;
CC P60410; P09758: TACSTD2; NbExp=3; IntAct=EBI-10171774, EBI-4324738;
CC P60410; Q9BX59: TAPBPL; NbExp=3; IntAct=EBI-10171774, EBI-12017416;
CC P60410; Q9NUY8: TBC1D23; NbExp=3; IntAct=EBI-10171774, EBI-2853126;
CC P60410; Q9Y4C2-2: TCAF1; NbExp=3; IntAct=EBI-10171774, EBI-11974855;
CC P60410; Q15560: TCEA2; NbExp=3; IntAct=EBI-10171774, EBI-710310;
CC P60410; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-10171774, EBI-11955057;
CC P60410; Q7Z6R9: TFAP2D; NbExp=5; IntAct=EBI-10171774, EBI-11952651;
CC P60410; P01137: TGFB1; NbExp=3; IntAct=EBI-10171774, EBI-779636;
CC P60410; Q9P2Z0: THAP10; NbExp=3; IntAct=EBI-10171774, EBI-745404;
CC P60410; Q9BT49: THAP7; NbExp=6; IntAct=EBI-10171774, EBI-741350;
CC P60410; P35590: TIE1; NbExp=3; IntAct=EBI-10171774, EBI-2256865;
CC P60410; Q08117: TLE5; NbExp=3; IntAct=EBI-10171774, EBI-717810;
CC P60410; Q08117-2: TLE5; NbExp=3; IntAct=EBI-10171774, EBI-11741437;
CC P60410; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-10171774, EBI-2844246;
CC P60410; Q86TG1: TMEM150A; NbExp=3; IntAct=EBI-10171774, EBI-2799342;
CC P60410; Q96KP6: TNIP3; NbExp=3; IntAct=EBI-10171774, EBI-2509913;
CC P60410; Q05952: TNP2; NbExp=3; IntAct=EBI-10171774, EBI-12039775;
CC P60410; Q4VB56: TNP2; NbExp=3; IntAct=EBI-10171774, EBI-10241829;
CC P60410; Q9Y5L0: TNPO3; NbExp=3; IntAct=EBI-10171774, EBI-1042571;
CC P60410; Q63HR2: TNS2; NbExp=3; IntAct=EBI-10171774, EBI-949753;
CC P60410; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-10171774, EBI-725997;
CC P60410; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-10171774, EBI-5235829;
CC P60410; Q9Y260: TRPV6; NbExp=3; IntAct=EBI-10171774, EBI-750052;
CC P60410; O14817: TSPAN4; NbExp=3; IntAct=EBI-10171774, EBI-8652667;
CC P60410; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-10171774, EBI-9090990;
CC P60410; Q86UY0: TXNDC5; NbExp=3; IntAct=EBI-10171774, EBI-2825190;
CC P60410; Q8TAI1: TYMSOS; NbExp=3; IntAct=EBI-10171774, EBI-742060;
CC P60410; Q06418: TYRO3; NbExp=3; IntAct=EBI-10171774, EBI-3951628;
CC P60410; Q9BZL1: UBL5; NbExp=3; IntAct=EBI-10171774, EBI-607755;
CC P60410; Q9BRU9: UTP23; NbExp=6; IntAct=EBI-10171774, EBI-5457544;
CC P60410; Q9UBK9: UXT; NbExp=6; IntAct=EBI-10171774, EBI-357355;
CC P60410; Q6EMK4: VASN; NbExp=3; IntAct=EBI-10171774, EBI-10249550;
CC P60410; O95231: VENTX; NbExp=3; IntAct=EBI-10171774, EBI-10191303;
CC P60410; Q14119: VEZF1; NbExp=3; IntAct=EBI-10171774, EBI-11980193;
CC P60410; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-10171774, EBI-11957216;
CC P60410; Q9H270: VPS11; NbExp=6; IntAct=EBI-10171774, EBI-373380;
CC P60410; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-10171774, EBI-11957238;
CC P60410; B2RUY7: VWC2L; NbExp=3; IntAct=EBI-10171774, EBI-11747707;
CC P60410; Q9Y5W5: WIF1; NbExp=6; IntAct=EBI-10171774, EBI-3922719;
CC P60410; O96014: WNT11; NbExp=3; IntAct=EBI-10171774, EBI-8058160;
CC P60410; P19544: WT1; NbExp=3; IntAct=EBI-10171774, EBI-2320534;
CC P60410; Q06250: WT1-AS; NbExp=3; IntAct=EBI-10171774, EBI-10223946;
CC P60410; Q9GZM5: YIPF3; NbExp=3; IntAct=EBI-10171774, EBI-743787;
CC P60410; P25490: YY1; NbExp=3; IntAct=EBI-10171774, EBI-765538;
CC P60410; O43167: ZBTB24; NbExp=6; IntAct=EBI-10171774, EBI-744471;
CC P60410; P24278: ZBTB25; NbExp=3; IntAct=EBI-10171774, EBI-739899;
CC P60410; Q8WTX9: ZDHHC1; NbExp=3; IntAct=EBI-10171774, EBI-2818796;
CC P60410; Q9BQ24: ZFYVE21; NbExp=3; IntAct=EBI-10171774, EBI-2849569;
CC P60410; Q15915: ZIC1; NbExp=3; IntAct=EBI-10171774, EBI-11963196;
CC P60410; Q8IZC7: ZNF101; NbExp=3; IntAct=EBI-10171774, EBI-5278328;
CC P60410; Q9UII5: ZNF107; NbExp=3; IntAct=EBI-10171774, EBI-7234993;
CC P60410; P58317: ZNF121; NbExp=3; IntAct=EBI-10171774, EBI-1228269;
CC P60410; Q15973: ZNF124; NbExp=6; IntAct=EBI-10171774, EBI-2555767;
CC P60410; P52744: ZNF138; NbExp=3; IntAct=EBI-10171774, EBI-10746567;
CC P60410; P52744-2: ZNF138; NbExp=3; IntAct=EBI-10171774, EBI-10213071;
CC P60410; P49910: ZNF165; NbExp=3; IntAct=EBI-10171774, EBI-741694;
CC P60410; P17024: ZNF20; NbExp=6; IntAct=EBI-10171774, EBI-717634;
CC P60410; P17027: ZNF23; NbExp=3; IntAct=EBI-10171774, EBI-5657766;
CC P60410; P15622-3: ZNF250; NbExp=3; IntAct=EBI-10171774, EBI-10177272;
CC P60410; O43296: ZNF264; NbExp=3; IntAct=EBI-10171774, EBI-4395808;
CC P60410; Q14584: ZNF266; NbExp=3; IntAct=EBI-10171774, EBI-7115319;
CC P60410; Q9P2F9: ZNF319; NbExp=3; IntAct=EBI-10171774, EBI-11993110;
CC P60410; P17041: ZNF32; NbExp=3; IntAct=EBI-10171774, EBI-1965483;
CC P60410; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-10171774, EBI-373456;
CC P60410; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-10171774, EBI-347633;
CC P60410; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-10171774, EBI-744257;
CC P60410; Q8TAU3: ZNF417; NbExp=6; IntAct=EBI-10171774, EBI-740727;
CC P60410; Q8NDP4: ZNF439; NbExp=6; IntAct=EBI-10171774, EBI-747580;
CC P60410; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-10171774, EBI-726439;
CC P60410; Q8N0Y2-2: ZNF444; NbExp=3; IntAct=EBI-10171774, EBI-12010736;
CC P60410; Q8WTR7: ZNF473; NbExp=6; IntAct=EBI-10171774, EBI-751409;
CC P60410; Q9ULM2: ZNF490; NbExp=3; IntAct=EBI-10171774, EBI-1105370;
CC P60410; Q8N8L2: ZNF491; NbExp=3; IntAct=EBI-10171774, EBI-12019860;
CC P60410; Q6ZNH5: ZNF497; NbExp=3; IntAct=EBI-10171774, EBI-10486136;
CC P60410; Q96C55: ZNF524; NbExp=3; IntAct=EBI-10171774, EBI-10283126;
CC P60410; Q9BR84: ZNF559; NbExp=3; IntAct=EBI-10171774, EBI-746605;
CC P60410; Q7Z3I7: ZNF572; NbExp=9; IntAct=EBI-10171774, EBI-10172590;
CC P60410; Q86XF7: ZNF575; NbExp=3; IntAct=EBI-10171774, EBI-14069183;
CC P60410; Q3MI94: ZNF578; NbExp=3; IntAct=EBI-10171774, EBI-10241108;
CC P60410; Q96N58: ZNF578; NbExp=3; IntAct=EBI-10171774, EBI-11955189;
CC P60410; Q9UK33: ZNF580; NbExp=3; IntAct=EBI-10171774, EBI-746277;
CC P60410; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-10171774, EBI-745520;
CC P60410; Q96SQ5: ZNF587; NbExp=6; IntAct=EBI-10171774, EBI-6427977;
CC P60410; Q96I27-2: ZNF625; NbExp=3; IntAct=EBI-10171774, EBI-12038525;
CC P60410; Q5T619: ZNF648; NbExp=3; IntAct=EBI-10171774, EBI-11985915;
CC P60410; Q96BR6: ZNF669; NbExp=3; IntAct=EBI-10171774, EBI-12006574;
CC P60410; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-10171774, EBI-11090299;
CC P60410; Q8N508: ZNF697; NbExp=3; IntAct=EBI-10171774, EBI-10265733;
CC P60410; Q96BV0: ZNF775; NbExp=3; IntAct=EBI-10171774, EBI-7149881;
CC P60410; Q8N393: ZNF786; NbExp=3; IntAct=EBI-10171774, EBI-10265203;
CC P60410; Q15937: ZNF79; NbExp=3; IntAct=EBI-10171774, EBI-10237274;
CC P60410; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-10171774, EBI-10240849;
CC P60410; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-10171774, EBI-11962574;
CC P60410; O43309: ZSCAN12; NbExp=3; IntAct=EBI-10171774, EBI-1210440;
CC P60410; Q9Y5A6: ZSCAN21; NbExp=6; IntAct=EBI-10171774, EBI-10281938;
CC P60410; A0A384ME25; NbExp=6; IntAct=EBI-10171774, EBI-10211777;
CC P60410; Q5BKY6; NbExp=3; IntAct=EBI-10171774, EBI-10243533;
CC P60410; Q5XG85; NbExp=3; IntAct=EBI-10171774, EBI-10248413;
CC P60410; Q6ZVW3; NbExp=3; IntAct=EBI-10171774, EBI-10255586;
CC P60410; Q9NWL9; NbExp=3; IntAct=EBI-10171774, EBI-10315054;
CC -!- TISSUE SPECIFICITY: Restricted to a narrow region of the hair fiber
CC cuticle, lying approximately 20 cell layers above the apex of the
CC dermal papilla of the hair root; not detected in any other tissues.
CC {ECO:0000269|PubMed:14962103, ECO:0000269|PubMed:15028290}.
CC -!- SIMILARITY: Belongs to the KRTAP type 10 family. {ECO:0000305}.
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DR EMBL; AB076355; BAD01542.1; -; mRNA.
DR EMBL; AL773602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC127016; AAI27017.1; -; mRNA.
DR CCDS; CCDS13713.1; -.
DR RefSeq; NP_941968.2; NM_198695.2.
DR AlphaFoldDB; P60410; -.
DR BioGRID; 132132; 389.
DR IntAct; P60410; 390.
DR STRING; 9606.ENSP00000335565; -.
DR iPTMnet; P60410; -.
DR PhosphoSitePlus; P60410; -.
DR BioMuta; KRTAP10-8; -.
DR DMDM; 116242612; -.
DR MassIVE; P60410; -.
DR PaxDb; P60410; -.
DR PeptideAtlas; P60410; -.
DR PRIDE; P60410; -.
DR Antibodypedia; 71343; 1 antibodies from 1 providers.
DR DNASU; 386681; -.
DR Ensembl; ENST00000334662.2; ENSP00000335565.2; ENSG00000187766.1.
DR GeneID; 386681; -.
DR KEGG; hsa:386681; -.
DR MANE-Select; ENST00000334662.2; ENSP00000335565.2; NM_198695.2; NP_941968.2.
DR UCSC; uc002zfo.1; human.
DR CTD; 386681; -.
DR DisGeNET; 386681; -.
DR GeneCards; KRTAP10-8; -.
DR HGNC; HGNC:20525; KRTAP10-8.
DR HPA; ENSG00000187766; Tissue enriched (skin).
DR neXtProt; NX_P60410; -.
DR OpenTargets; ENSG00000187766; -.
DR PharmGKB; PA134968895; -.
DR VEuPathDB; HostDB:ENSG00000187766; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000163258; -.
DR HOGENOM; CLU_062832_0_0_1; -.
DR InParanoid; P60410; -.
DR OMA; CCVSMCS; -.
DR OrthoDB; 1583483at2759; -.
DR PhylomeDB; P60410; -.
DR TreeFam; TF351356; -.
DR PathwayCommons; P60410; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; P60410; -.
DR BioGRID-ORCS; 386681; 17 hits in 1045 CRISPR screens.
DR GenomeRNAi; 386681; -.
DR Pharos; P60410; Tdark.
DR PRO; PR:P60410; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; P60410; protein.
DR Bgee; ENSG00000187766; Expressed in skin of abdomen and 3 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR InterPro; IPR002494; KAP.
DR InterPro; IPR007951; KRTAP_PMG.
DR PANTHER; PTHR23262; PTHR23262; 1.
DR Pfam; PF13885; Keratin_B2_2; 2.
DR Pfam; PF05287; PMG; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..259
FT /note="Keratin-associated protein 10-8"
FT /id="PRO_0000185216"
FT REPEAT 50..54
FT /note="1"
FT REPEAT 60..64
FT /note="2"
FT REPEAT 65..69
FT /note="3"
FT REPEAT 98..102
FT /note="4"
FT REPEAT 108..112
FT /note="5"
FT REPEAT 118..122
FT /note="6"
FT REPEAT 123..127
FT /note="7"
FT REPEAT 133..137
FT /note="8"
FT REPEAT 145..149
FT /note="9"
FT REPEAT 155..159
FT /note="10"
FT REPEAT 165..169
FT /note="11"
FT REPEAT 170..174
FT /note="12"
FT REPEAT 175..179
FT /note="13"
FT REPEAT 187..191
FT /note="14"
FT REPEAT 197..201
FT /note="15"
FT REPEAT 202..206
FT /note="16"
FT REPEAT 221..225
FT /note="17"
FT REPEAT 228..232
FT /note="18"
FT REPEAT 239..243
FT /note="19"
FT REGION 26..243
FT /note="19 X 5 AA repeats of C-C-X(3)"
FT VARIANT 26
FT /note="H -> R (in dbSNP:rs411254)"
FT /evidence="ECO:0000269|PubMed:15028290,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_028234"
FT VARIANT 64
FT /note="S -> N (in a colorectal cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036560"
FT VARIANT 159
FT /note="S -> F (in a breast cancer sample; somatic mutation;
FT dbSNP:rs763238933)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036561"
SQ SEQUENCE 259 AA; 26299 MW; 180307276CAB4607 CRC64;
MADACCTRTY VIAASTMSVC SSDVGHVSRV SSPSTCTGSS WQVDNCQESC CEPRSCASSC
CTPSCCAPAP CLALVCAPVS CEPSPCQSGC TDSCTPSCCQ QSSCQPACCT SSPCQQACCV
PVCCKSNCCK PVCCVSICSG ASSPCCQQSS CQSACCTFSP CQQACCVPIC CKPICCVPVC
SGASSLCCQK SSCQPACCTT SCCRPSSSVS LLCRPVCRPA CCVPVPSCCV PASSCQPSCC
HPASCLSFLC RPACSRLAC
