KR109_HUMAN
ID KR109_HUMAN Reviewed; 292 AA.
AC P60411; A2RRG1; A6NIR9; Q70LJ1;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Keratin-associated protein 10-9;
DE AltName: Full=High sulfur keratin-associated protein 10.9;
DE AltName: Full=Keratin-associated protein 10.9;
DE AltName: Full=Keratin-associated protein 18-9;
DE AltName: Full=Keratin-associated protein 18.9;
GN Name=KRTAP10-9; Synonyms=KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Hair root;
RX PubMed=15028290; DOI=10.1016/j.ygeno.2003.09.024;
RA Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.;
RT "A cluster of 21 keratin-associated protein genes within introns of another
RT gene on human chromosome 21q22.3.";
RL Genomics 83:679-693(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS CYS-182 AND CYS-257.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 244-292, TISSUE SPECIFICITY, AND VARIANT
RP CYS-257.
RC TISSUE=Scalp;
RX PubMed=14962103; DOI=10.1046/j.0022-202x.2003.22128.x;
RA Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S.,
RA Schweizer J.;
RT "Hair keratin associated proteins: characterization of a second high sulfur
RT KAP gene domain on human chromosome 21.";
RL J. Invest. Dermatol. 122:147-158(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC P60411; Q6UY14-3: ADAMTSL4; NbExp=8; IntAct=EBI-10172052, EBI-10173507;
CC P60411; P43353: ALDH3B1; NbExp=3; IntAct=EBI-10172052, EBI-2558314;
CC P60411; P09923: ALPI; NbExp=3; IntAct=EBI-10172052, EBI-1052631;
CC P60411; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-10172052, EBI-11954519;
CC P60411; Q8N6T3: ARFGAP1; NbExp=3; IntAct=EBI-10172052, EBI-716933;
CC P60411; Q9ULK2: ATXN7L1; NbExp=3; IntAct=EBI-10172052, EBI-310660;
CC P60411; Q5T686: AVPI1; NbExp=3; IntAct=EBI-10172052, EBI-8640233;
CC P60411; A8KA13: BCL6B; NbExp=3; IntAct=EBI-10172052, EBI-10174813;
CC P60411; P18075: BMP7; NbExp=3; IntAct=EBI-10172052, EBI-1035195;
CC P60411; Q0VDD7: BRME1; NbExp=4; IntAct=EBI-10172052, EBI-741210;
CC P60411; Q5T681: C10orf62; NbExp=3; IntAct=EBI-10172052, EBI-744052;
CC P60411; Q6NUJ2: C11orf87; NbExp=3; IntAct=EBI-10172052, EBI-6660291;
CC P60411; Q6P5X5: C22orf39; NbExp=3; IntAct=EBI-10172052, EBI-7317823;
CC P60411; A6NFR6-4: C5orf60; NbExp=3; IntAct=EBI-10172052, EBI-10173955;
CC P60411; Q7Z7H3: CATIP; NbExp=3; IntAct=EBI-10172052, EBI-10258233;
CC P60411; Q8NEC5: CATSPER1; NbExp=11; IntAct=EBI-10172052, EBI-744545;
CC P60411; Q14781: CBX2; NbExp=3; IntAct=EBI-10172052, EBI-745934;
CC P60411; Q8TAB7: CCDC26; NbExp=3; IntAct=EBI-10172052, EBI-10271580;
CC P60411; Q6UXG3: CD300LG; NbExp=3; IntAct=EBI-10172052, EBI-10254587;
CC P60411; Q8IVW4: CDKL3; NbExp=3; IntAct=EBI-10172052, EBI-3919850;
CC P60411; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-10172052, EBI-741528;
CC P60411; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-10172052, EBI-947551;
CC P60411; P07510: CHRNG; NbExp=4; IntAct=EBI-10172052, EBI-9008836;
CC P60411; P07510-2: CHRNG; NbExp=6; IntAct=EBI-10172052, EBI-11979451;
CC P60411; P61024: CKS1B; NbExp=3; IntAct=EBI-10172052, EBI-456371;
CC P60411; Q9HAZ1: CLK4; NbExp=3; IntAct=EBI-10172052, EBI-633400;
CC P60411; Q8NE01: CNNM3; NbExp=6; IntAct=EBI-10172052, EBI-741032;
CC P60411; Q8NE01-3: CNNM3; NbExp=3; IntAct=EBI-10172052, EBI-10269984;
CC P60411; Q9UGL9: CRCT1; NbExp=8; IntAct=EBI-10172052, EBI-713677;
CC P60411; Q02930-3: CREB5; NbExp=8; IntAct=EBI-10172052, EBI-10192698;
CC P60411; Q9H4G1: CST9L; NbExp=3; IntAct=EBI-10172052, EBI-3923092;
CC P60411; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10172052, EBI-3867333;
CC P60411; Q96LJ7: DHRS1; NbExp=3; IntAct=EBI-10172052, EBI-746300;
CC P60411; Q6P158: DHX57; NbExp=6; IntAct=EBI-10172052, EBI-1051531;
CC P60411; Q9NQL9: DMRT3; NbExp=6; IntAct=EBI-10172052, EBI-9679045;
CC P60411; Q92608: DOCK2; NbExp=3; IntAct=EBI-10172052, EBI-448771;
CC P60411; O60573: EIF4E2; NbExp=3; IntAct=EBI-10172052, EBI-398610;
CC P60411; Q15910-2: EZH2; NbExp=3; IntAct=EBI-10172052, EBI-10699473;
CC P60411; Q9H5Z6: FAM124B; NbExp=3; IntAct=EBI-10172052, EBI-741626;
CC P60411; Q3B820: FAM161A; NbExp=3; IntAct=EBI-10172052, EBI-719941;
CC P60411; Q5TZK3: FAM74A6; NbExp=3; IntAct=EBI-10172052, EBI-10247271;
CC P60411; Q5HYJ3: FAM76B; NbExp=3; IntAct=EBI-10172052, EBI-751192;
CC P60411; Q5HYJ3-3: FAM76B; NbExp=3; IntAct=EBI-10172052, EBI-11956087;
CC P60411; O95363: FARS2; NbExp=6; IntAct=EBI-10172052, EBI-2513774;
CC P60411; Q969U6: FBXW5; NbExp=3; IntAct=EBI-10172052, EBI-741068;
CC P60411; Q9H0R8: GABARAPL1; NbExp=3; IntAct=EBI-10172052, EBI-746969;
CC P60411; P60520: GABARAPL2; NbExp=3; IntAct=EBI-10172052, EBI-720116;
CC P60411; P23769: GATA2; NbExp=3; IntAct=EBI-10172052, EBI-2806671;
CC P60411; P43220: GLP1R; NbExp=3; IntAct=EBI-10172052, EBI-7466542;
CC P60411; O76003: GLRX3; NbExp=8; IntAct=EBI-10172052, EBI-374781;
CC P60411; Q9Y223: GNE; NbExp=3; IntAct=EBI-10172052, EBI-4291090;
CC P60411; Q9NWQ4: GPATCH2L; NbExp=3; IntAct=EBI-10172052, EBI-5666657;
CC P60411; P09211: GSTP1; NbExp=3; IntAct=EBI-10172052, EBI-353467;
CC P60411; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-10172052, EBI-11978177;
CC P60411; D9YZU9: HBG2; NbExp=3; IntAct=EBI-10172052, EBI-10176884;
CC P60411; P02008: HBZ; NbExp=3; IntAct=EBI-10172052, EBI-719843;
CC P60411; P08631: HCK; NbExp=3; IntAct=EBI-10172052, EBI-346340;
CC P60411; P08631-2: HCK; NbExp=3; IntAct=EBI-10172052, EBI-9834454;
CC P60411; Q96HZ4: HES6; NbExp=3; IntAct=EBI-10172052, EBI-7469266;
CC P60411; P49639: HOXA1; NbExp=8; IntAct=EBI-10172052, EBI-740785;
CC P60411; P17482: HOXB9; NbExp=3; IntAct=EBI-10172052, EBI-745290;
CC P60411; P31273: HOXC8; NbExp=3; IntAct=EBI-10172052, EBI-1752118;
CC P60411; P37235: HPCAL1; NbExp=6; IntAct=EBI-10172052, EBI-749311;
CC P60411; O75506: HSBP1; NbExp=3; IntAct=EBI-10172052, EBI-748664;
CC P60411; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-10172052, EBI-3918847;
CC P60411; Q969P0: IGSF8; NbExp=3; IntAct=EBI-10172052, EBI-8293590;
CC P60411; Q92835: INPP5D; NbExp=3; IntAct=EBI-10172052, EBI-1380477;
CC P60411; Q8NA54: IQUB; NbExp=3; IntAct=EBI-10172052, EBI-10220600;
CC P60411; P16144-2: ITGB4; NbExp=5; IntAct=EBI-10172052, EBI-11051601;
CC P60411; L7RT22: ITGB5; NbExp=3; IntAct=EBI-10172052, EBI-10178729;
CC P60411; P18084: ITGB5; NbExp=3; IntAct=EBI-10172052, EBI-1223434;
CC P60411; Q92993: KAT5; NbExp=3; IntAct=EBI-10172052, EBI-399080;
CC P60411; A0A384DVV8: KIAA0040; NbExp=3; IntAct=EBI-10172052, EBI-20764875;
CC P60411; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-10172052, EBI-6426443;
CC P60411; P35900: KRT20; NbExp=3; IntAct=EBI-10172052, EBI-742094;
CC P60411; P78385: KRT83; NbExp=3; IntAct=EBI-10172052, EBI-10221390;
CC P60411; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-10172052, EBI-11959885;
CC P60411; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10172052, EBI-11749135;
CC P60411; P60409: KRTAP10-7; NbExp=6; IntAct=EBI-10172052, EBI-10172290;
CC P60411; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-10172052, EBI-10171774;
CC P60411; P59990: KRTAP12-1; NbExp=6; IntAct=EBI-10172052, EBI-10210845;
CC P60411; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10172052, EBI-11953334;
CC P60411; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-10172052, EBI-3957672;
CC P60411; Q9BYQ6: KRTAP4-11; NbExp=6; IntAct=EBI-10172052, EBI-10302392;
CC P60411; Q9BQ66: KRTAP4-12; NbExp=6; IntAct=EBI-10172052, EBI-739863;
CC P60411; Q9BYR5: KRTAP4-2; NbExp=5; IntAct=EBI-10172052, EBI-10172511;
CC P60411; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-10172052, EBI-11993296;
CC P60411; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-10172052, EBI-10250562;
CC P60411; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-10172052, EBI-3958099;
CC P60411; Q9BYQ4: KRTAP9-2; NbExp=9; IntAct=EBI-10172052, EBI-1044640;
CC P60411; Q9BYQ3: KRTAP9-3; NbExp=6; IntAct=EBI-10172052, EBI-1043191;
CC P60411; Q9BYQ2: KRTAP9-4; NbExp=3; IntAct=EBI-10172052, EBI-10185730;
CC P60411; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-10172052, EBI-11962058;
CC P60411; Q5T7P3: LCE1B; NbExp=12; IntAct=EBI-10172052, EBI-10245913;
CC P60411; Q5T752: LCE1D; NbExp=5; IntAct=EBI-10172052, EBI-11741311;
CC P60411; Q5T753: LCE1E; NbExp=3; IntAct=EBI-10172052, EBI-11955335;
CC P60411; Q5T754: LCE1F; NbExp=5; IntAct=EBI-10172052, EBI-11958008;
CC P60411; Q5TA79: LCE2A; NbExp=6; IntAct=EBI-10172052, EBI-10246607;
CC P60411; O14633: LCE2B; NbExp=3; IntAct=EBI-10172052, EBI-11478468;
CC P60411; Q5TA81: LCE2C; NbExp=5; IntAct=EBI-10172052, EBI-11973993;
CC P60411; Q5TA82: LCE2D; NbExp=6; IntAct=EBI-10172052, EBI-10246750;
CC P60411; Q5TA76: LCE3A; NbExp=5; IntAct=EBI-10172052, EBI-9394625;
CC P60411; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-10172052, EBI-11974495;
CC P60411; Q5T5A8: LCE3C; NbExp=10; IntAct=EBI-10172052, EBI-10245291;
CC P60411; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-10172052, EBI-6658837;
CC P60411; Q5T5B0: LCE3E; NbExp=7; IntAct=EBI-10172052, EBI-10245456;
CC P60411; Q5TA78: LCE4A; NbExp=6; IntAct=EBI-10172052, EBI-10246358;
CC P60411; Q5TCM9: LCE5A; NbExp=4; IntAct=EBI-10172052, EBI-11955689;
CC P60411; Q9P127: LUZP4; NbExp=3; IntAct=EBI-10172052, EBI-10198848;
CC P60411; Q8N8X9: MAB21L3; NbExp=3; IntAct=EBI-10172052, EBI-10268010;
CC P60411; O60336: MAPKBP1; NbExp=3; IntAct=EBI-10172052, EBI-947402;
CC P60411; P56270-2: MAZ; NbExp=3; IntAct=EBI-10172052, EBI-12068586;
CC P60411; Q96HR3: MED30; NbExp=3; IntAct=EBI-10172052, EBI-394659;
CC P60411; P50222: MEOX2; NbExp=4; IntAct=EBI-10172052, EBI-748397;
CC P60411; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-10172052, EBI-16439278;
CC P60411; Q13875: MOBP; NbExp=6; IntAct=EBI-10172052, EBI-10230628;
CC P60411; Q13875-3: MOBP; NbExp=3; IntAct=EBI-10172052, EBI-12013470;
CC P60411; A1L3X4: MT1DP; NbExp=3; IntAct=EBI-10172052, EBI-10172129;
CC P60411; P50539-3: MXI1; NbExp=3; IntAct=EBI-10172052, EBI-10211940;
CC P60411; Q86VE0: MYPOP; NbExp=3; IntAct=EBI-10172052, EBI-2858213;
CC P60411; Q8IW45: NAXD; NbExp=3; IntAct=EBI-10172052, EBI-8650724;
CC P60411; Q9NQS3: NECTIN3; NbExp=3; IntAct=EBI-10172052, EBI-2826725;
CC P60411; Q969G9: NKD1; NbExp=3; IntAct=EBI-10172052, EBI-1538217;
CC P60411; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10172052, EBI-945833;
CC P60411; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10172052, EBI-22310682;
CC P60411; P48146: NPBWR2; NbExp=3; IntAct=EBI-10172052, EBI-10210114;
CC P60411; Q9NQX5: NPDC1; NbExp=6; IntAct=EBI-10172052, EBI-748927;
CC P60411; P16860: NPPB; NbExp=3; IntAct=EBI-10172052, EBI-747044;
CC P60411; Q6NSM0: NR1D2; NbExp=4; IntAct=EBI-10172052, EBI-10250949;
CC P60411; Q7Z417: NUFIP2; NbExp=8; IntAct=EBI-10172052, EBI-1210753;
CC P60411; P32242: OTX1; NbExp=9; IntAct=EBI-10172052, EBI-740446;
CC P60411; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-10172052, EBI-11956269;
CC P60411; O76083-2: PDE9A; NbExp=3; IntAct=EBI-10172052, EBI-11524542;
CC P60411; P09619: PDGFRB; NbExp=3; IntAct=EBI-10172052, EBI-641237;
CC P60411; Q9UHJ9: PGAP2; NbExp=3; IntAct=EBI-10172052, EBI-10321427;
CC P60411; Q96S52: PIGS; NbExp=3; IntAct=EBI-10172052, EBI-2908273;
CC P60411; Q13526: PIN1; NbExp=3; IntAct=EBI-10172052, EBI-714158;
CC P60411; O15162: PLSCR1; NbExp=3; IntAct=EBI-10172052, EBI-740019;
CC P60411; Q12837: POU4F2; NbExp=6; IntAct=EBI-10172052, EBI-17236143;
CC P60411; P54646: PRKAA2; NbExp=3; IntAct=EBI-10172052, EBI-1383852;
CC P60411; O43741: PRKAB2; NbExp=6; IntAct=EBI-10172052, EBI-1053424;
CC P60411; Q8WWY3: PRPF31; NbExp=6; IntAct=EBI-10172052, EBI-1567797;
CC P60411; P43115-12: PTGER3; NbExp=3; IntAct=EBI-10172052, EBI-10234038;
CC P60411; Q8WUK0: PTPMT1; NbExp=3; IntAct=EBI-10172052, EBI-7199479;
CC P60411; P15151: PVR; NbExp=3; IntAct=EBI-10172052, EBI-3919694;
CC P60411; Q9Y272: RASD1; NbExp=3; IntAct=EBI-10172052, EBI-740818;
CC P60411; Q9BSD3: RHNO1; NbExp=3; IntAct=EBI-10172052, EBI-9658624;
CC P60411; Q6UXX9: RSPO2; NbExp=3; IntAct=EBI-10172052, EBI-8481036;
CC P60411; Q8WTV0: SCARB1; NbExp=3; IntAct=EBI-10172052, EBI-78657;
CC P60411; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-10172052, EBI-748391;
CC P60411; Q13214-2: SEMA3B; NbExp=3; IntAct=EBI-10172052, EBI-11017428;
CC P60411; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-10172052, EBI-10313866;
CC P60411; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-10172052, EBI-11955083;
CC P60411; Q9UHI7: SLC23A1; NbExp=3; IntAct=EBI-10172052, EBI-1759386;
CC P60411; Q9NP91: SLC6A20; NbExp=3; IntAct=EBI-10172052, EBI-10311198;
CC P60411; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-10172052, EBI-455078;
CC P60411; P49901: SMCP; NbExp=8; IntAct=EBI-10172052, EBI-750494;
CC P60411; Q96E40: SPACA9; NbExp=3; IntAct=EBI-10172052, EBI-722584;
CC P60411; Q6RVD6: SPATA8; NbExp=3; IntAct=EBI-10172052, EBI-8635958;
CC P60411; Q9UQ90: SPG7; NbExp=3; IntAct=EBI-10172052, EBI-717201;
CC P60411; O43609: SPRY1; NbExp=6; IntAct=EBI-10172052, EBI-3866665;
CC P60411; O43597: SPRY2; NbExp=3; IntAct=EBI-10172052, EBI-742487;
CC P60411; O75716: STK16; NbExp=3; IntAct=EBI-10172052, EBI-749295;
CC P60411; Q9NUY8: TBC1D23; NbExp=3; IntAct=EBI-10172052, EBI-2853126;
CC P60411; Q9NUY8-2: TBC1D23; NbExp=3; IntAct=EBI-10172052, EBI-10314276;
CC P60411; Q7L2K0: TEDC2; NbExp=3; IntAct=EBI-10172052, EBI-8465456;
CC P60411; O43493: TGOLN2; NbExp=3; IntAct=EBI-10172052, EBI-1752146;
CC P60411; Q9P2Z0: THAP10; NbExp=3; IntAct=EBI-10172052, EBI-745404;
CC P60411; Q08117: TLE5; NbExp=3; IntAct=EBI-10172052, EBI-717810;
CC P60411; O95407: TNFRSF6B; NbExp=3; IntAct=EBI-10172052, EBI-524171;
CC P60411; Q05952: TNP2; NbExp=3; IntAct=EBI-10172052, EBI-12039775;
CC P60411; Q4VB56: TNP2; NbExp=3; IntAct=EBI-10172052, EBI-10241829;
CC P60411; Q8WV44: TRIM41; NbExp=5; IntAct=EBI-10172052, EBI-725997;
CC P60411; Q8IWZ5: TRIM42; NbExp=6; IntAct=EBI-10172052, EBI-5235829;
CC P60411; Q86UY0: TXNDC5; NbExp=3; IntAct=EBI-10172052, EBI-2825190;
CC P60411; Q8TAI1: TYMSOS; NbExp=3; IntAct=EBI-10172052, EBI-742060;
CC P60411; Q06418: TYRO3; NbExp=3; IntAct=EBI-10172052, EBI-3951628;
CC P60411; Q9BRU9: UTP23; NbExp=3; IntAct=EBI-10172052, EBI-5457544;
CC P60411; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-10172052, EBI-11957216;
CC P60411; O96014: WNT11; NbExp=3; IntAct=EBI-10172052, EBI-8058160;
CC P60411; Q06250: WT1-AS; NbExp=3; IntAct=EBI-10172052, EBI-10223946;
CC P60411; Q9UBD3: XCL2; NbExp=3; IntAct=EBI-10172052, EBI-10319095;
CC P60411; Q9GZM5: YIPF3; NbExp=3; IntAct=EBI-10172052, EBI-743787;
CC P60411; P25490: YY1; NbExp=3; IntAct=EBI-10172052, EBI-765538;
CC P60411; O43167: ZBTB24; NbExp=3; IntAct=EBI-10172052, EBI-744471;
CC P60411; Q96C00: ZBTB9; NbExp=6; IntAct=EBI-10172052, EBI-395708;
CC P60411; Q68DK2-5: ZFYVE26; NbExp=3; IntAct=EBI-10172052, EBI-8656416;
CC P60411; Q15973: ZNF124; NbExp=6; IntAct=EBI-10172052, EBI-2555767;
CC P60411; Q12901-2: ZNF155; NbExp=3; IntAct=EBI-10172052, EBI-10227379;
CC P60411; P49910: ZNF165; NbExp=3; IntAct=EBI-10172052, EBI-741694;
CC P60411; P17024: ZNF20; NbExp=3; IntAct=EBI-10172052, EBI-717634;
CC P60411; Q9BRH9: ZNF251; NbExp=3; IntAct=EBI-10172052, EBI-7254491;
CC P60411; Q14C61: ZNF264; NbExp=3; IntAct=EBI-10172052, EBI-2826570;
CC P60411; Q9NSD4: ZNF275; NbExp=3; IntAct=EBI-10172052, EBI-17263125;
CC P60411; Q9HBT8: ZNF286A; NbExp=3; IntAct=EBI-10172052, EBI-10754950;
CC P60411; Q96PQ6-4: ZNF317; NbExp=3; IntAct=EBI-10172052, EBI-10292528;
CC P60411; Q9P2F9: ZNF319; NbExp=3; IntAct=EBI-10172052, EBI-11993110;
CC P60411; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-10172052, EBI-740727;
CC P60411; Q8N7K0: ZNF433; NbExp=3; IntAct=EBI-10172052, EBI-10267553;
CC P60411; Q8NDP4: ZNF439; NbExp=3; IntAct=EBI-10172052, EBI-747580;
CC P60411; Q8IYI8: ZNF440; NbExp=6; IntAct=EBI-10172052, EBI-726439;
CC P60411; Q8WTR7: ZNF473; NbExp=3; IntAct=EBI-10172052, EBI-751409;
CC P60411; Q6ZNH5: ZNF497; NbExp=3; IntAct=EBI-10172052, EBI-10486136;
CC P60411; Q96C55: ZNF524; NbExp=3; IntAct=EBI-10172052, EBI-10283126;
CC P60411; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-10172052, EBI-10273713;
CC P60411; Q7Z3I7: ZNF572; NbExp=6; IntAct=EBI-10172052, EBI-10172590;
CC P60411; Q3MI94: ZNF578; NbExp=3; IntAct=EBI-10172052, EBI-10241108;
CC P60411; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-10172052, EBI-745520;
CC P60411; Q96SQ5: ZNF587; NbExp=6; IntAct=EBI-10172052, EBI-6427977;
CC P60411; Q96NL3: ZNF599; NbExp=3; IntAct=EBI-10172052, EBI-8653994;
CC P60411; Q96I27: ZNF625; NbExp=3; IntAct=EBI-10172052, EBI-4395587;
CC P60411; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-10172052, EBI-16429014;
CC P60411; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-10172052, EBI-11090299;
CC P60411; Q8N508: ZNF697; NbExp=3; IntAct=EBI-10172052, EBI-10265733;
CC P60411; Q32M78: ZNF699; NbExp=3; IntAct=EBI-10172052, EBI-10217363;
CC P60411; Q96H86: ZNF764; NbExp=3; IntAct=EBI-10172052, EBI-745775;
CC P60411; Q6NX45: ZNF774; NbExp=6; IntAct=EBI-10172052, EBI-10251462;
CC P60411; Q9ULD5: ZNF777; NbExp=3; IntAct=EBI-10172052, EBI-11975599;
CC P60411; Q3KQV3: ZNF792; NbExp=6; IntAct=EBI-10172052, EBI-10240849;
CC P60411; P51504: ZNF80; NbExp=3; IntAct=EBI-10172052, EBI-12013828;
CC P60411; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-10172052, EBI-11962574;
CC P60411; Q08AG5: ZNF844; NbExp=3; IntAct=EBI-10172052, EBI-10225757;
CC P60411; A6NHJ4: ZNF860; NbExp=3; IntAct=EBI-10172052, EBI-17263060;
CC P60411; Q9Y5A6: ZSCAN21; NbExp=3; IntAct=EBI-10172052, EBI-10281938;
CC P60411; Q16670: ZSCAN26; NbExp=3; IntAct=EBI-10172052, EBI-3920053;
CC P60411; A8K932; NbExp=3; IntAct=EBI-10172052, EBI-10174671;
CC P60411; Q5XG85; NbExp=3; IntAct=EBI-10172052, EBI-10248413;
CC P60411; Q9H6F0; NbExp=3; IntAct=EBI-10172052, EBI-10307481;
CC P60411; Q9NWL9; NbExp=3; IntAct=EBI-10172052, EBI-10315054;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced.;
CC Name=1;
CC IsoId=P60411-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Restricted to a narrow region of the hair fiber
CC cuticle, lying approximately 20 cell layers above the apex of the
CC dermal papilla of the hair root; not detected in any other tissues.
CC {ECO:0000269|PubMed:14962103, ECO:0000269|PubMed:15028290}.
CC -!- SIMILARITY: Belongs to the KRTAP type 10 family. {ECO:0000305}.
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DR EMBL; AB076356; BAD01543.1; -; mRNA.
DR EMBL; AL773602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471079; EAX09409.1; -; Genomic_DNA.
DR EMBL; CH471079; EAX09411.1; -; Genomic_DNA.
DR EMBL; BC131613; AAI31614.1; -; mRNA.
DR EMBL; AJ566386; CAD97466.1; -; mRNA.
DR CCDS; CCDS42961.1; -. [P60411-1]
DR RefSeq; NP_941963.2; NM_198690.2. [P60411-1]
DR RefSeq; NP_941965.2; NM_198692.2.
DR AlphaFoldDB; P60411; -.
DR BioGRID; 132127; 228.
DR BioGRID; 132129; 38.
DR IntAct; P60411; 223.
DR STRING; 9606.ENSP00000381009; -.
DR MoonDB; P60411; Predicted.
DR iPTMnet; P60411; -.
DR PhosphoSitePlus; P60411; -.
DR BioMuta; KRTAP10-9; -.
DR DMDM; 294862449; -.
DR MassIVE; P60411; -.
DR PaxDb; P60411; -.
DR PeptideAtlas; P60411; -.
DR PRIDE; P60411; -.
DR DNASU; 386676; -.
DR Ensembl; ENST00000397911.5; ENSP00000381009.3; ENSG00000221837.7. [P60411-1]
DR GeneID; 386676; -.
DR GeneID; 386678; -.
DR KEGG; hsa:386676; -.
DR KEGG; hsa:386678; -.
DR MANE-Select; ENST00000397911.5; ENSP00000381009.3; NM_198690.3; NP_941963.2.
DR UCSC; uc002zfp.5; human. [P60411-1]
DR CTD; 386676; -.
DR CTD; 386678; -.
DR GeneCards; KRTAP10-9; -.
DR HGNC; HGNC:22971; KRTAP10-9.
DR HPA; ENSG00000221837; Tissue enriched (skin).
DR neXtProt; NX_P60411; -.
DR PharmGKB; PA134873081; -.
DR VEuPathDB; HostDB:ENSG00000221837; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000164049; -.
DR InParanoid; P60411; -.
DR OMA; YQPACCA; -.
DR OrthoDB; 1622331at2759; -.
DR PhylomeDB; P60411; -.
DR TreeFam; TF351356; -.
DR PathwayCommons; P60411; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; P60411; -.
DR BioGRID-ORCS; 386676; 110 hits in 1018 CRISPR screens.
DR BioGRID-ORCS; 386678; 17 hits in 989 CRISPR screens.
DR Pharos; P60411; Tdark.
DR PRO; PR:P60411; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; P60411; protein.
DR Bgee; ENSG00000221837; Expressed in skin of abdomen and 3 other tissues.
DR ExpressionAtlas; P60411; baseline and differential.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 3.
DR Pfam; PF13885; Keratin_B2_2; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Keratin; Reference proteome; Repeat.
FT CHAIN 1..292
FT /note="Keratin-associated protein 10-9"
FT /id="PRO_0000185217"
FT REPEAT 26..30
FT /note="1"
FT REPEAT 31..35
FT /note="2"
FT REPEAT 36..40
FT /note="3"
FT REPEAT 57..61
FT /note="4"
FT REPEAT 79..83
FT /note="5"
FT REPEAT 99..103
FT /note="6"
FT REPEAT 104..108
FT /note="7"
FT REPEAT 109..113
FT /note="8"
FT REPEAT 114..118
FT /note="9"
FT REPEAT 120..124
FT /note="10"
FT REPEAT 130..134
FT /note="11"
FT REPEAT 140..144
FT /note="12"
FT REPEAT 145..149
FT /note="13"
FT REPEAT 150..154
FT /note="14"
FT REPEAT 162..166
FT /note="15"
FT REPEAT 172..176
FT /note="16"
FT REPEAT 182..186
FT /note="17"
FT REPEAT 187..191
FT /note="18"
FT REPEAT 192..196
FT /note="19"
FT REPEAT 197..201
FT /note="20"
FT REPEAT 209..213
FT /note="21"
FT REPEAT 219..223
FT /note="22"
FT REPEAT 224..228
FT /note="23"
FT REPEAT 243..247
FT /note="24"
FT REPEAT 250..254
FT /note="25"
FT REGION 26..254
FT /note="25 X 5 AA repeats of C-C-X(3)"
FT VARIANT 182
FT /note="Y -> C (in dbSNP:rs8127342)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_017739"
FT VARIANT 257
FT /note="R -> C (in dbSNP:rs9980129)"
FT /evidence="ECO:0000269|PubMed:14962103,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_060052"
FT CONFLICT 102
FT /note="P -> PVCCKT (in Ref. 3; EAX09409)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 292 AA; 30037 MW; E61D891212803B98 CRC64;
MAASTMSIRS SAYSDSWQVD DCPESCCEPP CCATSCCAPA PCLTLVCTPV SRVSSPCCQV
TCEPSPCQSG CTSSCTPSCC QQSSCQPAYC TSSPCQQACC VPVCCKPVCC VPVCCGASSC
CQQSSYQPAC CASSSCQPAC CVPVCCKPVC CAPTCSEDSY SCCQQSSCQP ACCTSSPCQQ
SYCVPVCCKP VCCKPICCVP VCSGASSLCC QQSGCQPACC TTSCCRPSSS VSLLCRPVCR
PACCVPVSSC CAPTSSRQPS YCRQASCVSL LCRPVCSRPA CYSFSSGQKS SC
