KR10A_HUMAN
ID KR10A_HUMAN Reviewed; 251 AA.
AC P60014;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2003, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Keratin-associated protein 10-10;
DE AltName: Full=High sulfur keratin-associated protein 10.10;
DE AltName: Full=Keratin-associated protein 10.10;
DE AltName: Full=Keratin-associated protein 18-10;
DE AltName: Full=Keratin-associated protein 18.10;
GN Name=KRTAP10-10;
GN Synonyms=KAP10.10, KAP18-10, KRTAP10.10, KRTAP18-1, KRTAP18.10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT PRO-72.
RC TISSUE=Hair root;
RX PubMed=15028290; DOI=10.1016/j.ygeno.2003.09.024;
RA Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.;
RT "A cluster of 21 keratin-associated protein genes within introns of another
RT gene on human chromosome 21q22.3.";
RL Genomics 83:679-693(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Scalp;
RX PubMed=14962103; DOI=10.1046/j.0022-202x.2003.22128.x;
RA Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S.,
RA Schweizer J.;
RT "Hair keratin associated proteins: characterization of a second high sulfur
RT KAP gene domain on human chromosome 21.";
RL J. Invest. Dermatol. 122:147-158(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC P60014; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-11955579, EBI-4400025;
CC P60014; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-11955579, EBI-744545;
CC P60014; Q02930-3: CREB5; NbExp=3; IntAct=EBI-11955579, EBI-10192698;
CC P60014; Q9Y6M4-3: CSNK1G3; NbExp=3; IntAct=EBI-11955579, EBI-11045281;
CC P60014; Q9UBR2: CTSZ; NbExp=3; IntAct=EBI-11955579, EBI-8636823;
CC P60014; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11955579, EBI-3867333;
CC P60014; P49639: HOXA1; NbExp=3; IntAct=EBI-11955579, EBI-740785;
CC P60014; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11955579, EBI-10171774;
CC P60014; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-11955579, EBI-11958132;
CC P60014; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-11955579, EBI-11987425;
CC P60014; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-11955579, EBI-3958099;
CC P60014; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-11955579, EBI-1043191;
CC P60014; Q5T753: LCE1E; NbExp=3; IntAct=EBI-11955579, EBI-11955335;
CC P60014; Q5T754: LCE1F; NbExp=3; IntAct=EBI-11955579, EBI-11958008;
CC P60014; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-11955579, EBI-11973993;
CC P60014; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-11955579, EBI-11974495;
CC P60014; P17568: NDUFB7; NbExp=3; IntAct=EBI-11955579, EBI-1246238;
CC P60014; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11955579, EBI-22310682;
CC P60014; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-11955579, EBI-742388;
CC P60014; Q8WTR7: ZNF473; NbExp=3; IntAct=EBI-11955579, EBI-751409;
CC P60014; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-11955579, EBI-6427977;
CC -!- TISSUE SPECIFICITY: Restricted to a narrow region of the hair fiber
CC cuticle, lying approximately 20 cell layers above the apex of the
CC dermal papilla of the hair root; not detected in any other tissues.
CC {ECO:0000269|PubMed:14962103, ECO:0000269|PubMed:15028290}.
CC -!- SIMILARITY: Belongs to the KRTAP type 10 family. {ECO:0000305}.
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DR EMBL; AB076358; BAD01545.1; -; mRNA.
DR EMBL; AJ566387; CAD97467.1; -; mRNA.
DR EMBL; AL773602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS33585.1; -.
DR RefSeq; NP_859016.1; NM_181688.2.
DR AlphaFoldDB; P60014; -.
DR BioGRID; 131688; 22.
DR IntAct; P60014; 21.
DR STRING; 9606.ENSP00000369438; -.
DR iPTMnet; P60014; -.
DR PhosphoSitePlus; P60014; -.
DR BioMuta; KRTAP10-10; -.
DR DMDM; 38372286; -.
DR MassIVE; P60014; -.
DR PaxDb; P60014; -.
DR PeptideAtlas; P60014; -.
DR PRIDE; P60014; -.
DR DNASU; 353333; -.
DR Ensembl; ENST00000380095.2; ENSP00000369438.1; ENSG00000221859.2.
DR GeneID; 353333; -.
DR KEGG; hsa:353333; -.
DR MANE-Select; ENST00000380095.2; ENSP00000369438.1; NM_181688.3; NP_859016.1.
DR UCSC; uc002zfq.3; human.
DR CTD; 353333; -.
DR GeneCards; KRTAP10-10; -.
DR HGNC; HGNC:22972; KRTAP10-10.
DR HPA; ENSG00000221859; Tissue enriched (skin).
DR neXtProt; NX_P60014; -.
DR OpenTargets; ENSG00000221859; -.
DR PharmGKB; PA134906562; -.
DR VEuPathDB; HostDB:ENSG00000221859; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000163845; -.
DR HOGENOM; CLU_062832_0_0_1; -.
DR InParanoid; P60014; -.
DR OMA; GCEIASC; -.
DR OrthoDB; 1622331at2759; -.
DR PhylomeDB; P60014; -.
DR TreeFam; TF351356; -.
DR PathwayCommons; P60014; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; P60014; -.
DR BioGRID-ORCS; 353333; 12 hits in 1059 CRISPR screens.
DR GenomeRNAi; 353333; -.
DR Pharos; P60014; Tdark.
DR PRO; PR:P60014; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; P60014; protein.
DR Bgee; ENSG00000221859; Expressed in skin of abdomen and 14 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 1.
DR Pfam; PF13885; Keratin_B2_2; 2.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..251
FT /note="Keratin-associated protein 10-10"
FT /id="PRO_0000185218"
FT REPEAT 26..30
FT /note="1"
FT REPEAT 31..35
FT /note="2"
FT REPEAT 52..56
FT /note="3"
FT REPEAT 84..88
FT /note="4"
FT REPEAT 94..98
FT /note="5"
FT REPEAT 99..103
FT /note="6"
FT REPEAT 104..109
FT /note="7"
FT REPEAT 126..130
FT /note="8"
FT REPEAT 136..140
FT /note="9"
FT REPEAT 146..150
FT /note="10"
FT REPEAT 168..172
FT /note="11"
FT REPEAT 178..182
FT /note="12"
FT REPEAT 183..187
FT /note="13"
FT REPEAT 202..206
FT /note="14"
FT REPEAT 220..224
FT /note="15"
FT REGION 26..224
FT /note="15 X 5 AA repeats of C-C-X(3)"
FT VARIANT 20
FT /note="V -> D (in dbSNP:rs2838602)"
FT /id="VAR_053463"
FT VARIANT 72
FT /note="T -> P (in dbSNP:rs4818947)"
FT /evidence="ECO:0000269|PubMed:15028290"
FT /id="VAR_017755"
FT VARIANT 86
FT /note="T -> S (in dbSNP:rs9306109)"
FT /id="VAR_060053"
FT VARIANT 116
FT /note="V -> M (in dbSNP:rs60500206)"
FT /id="VAR_062114"
FT VARIANT 126
FT /note="C -> S (in dbSNP:rs4818948)"
FT /id="VAR_060054"
FT VARIANT 129
FT /note="Q -> P (in dbSNP:rs4818949)"
FT /id="VAR_060055"
FT VARIANT 158
FT /note="V -> M (in dbSNP:rs4818950)"
FT /id="VAR_053464"
SQ SEQUENCE 251 AA; 25571 MW; A128CDBB45B74962 CRC64;
MAASTMSICS SACTDSWRVV DCPESCCEPC CCAPAPSLTL VCTPVSCVSS PCCQTACEPS
ACQSGYTSSC TTPCYQQSSC QPDCCTSSPC QQACCVPVCC VPVCCVPVCN KPVCFVPTCS
ESSPSCCQQS SCQPTCCTSS PCQQACCVPV CSKSVCYVPV CSGASTSCCQ QSSCQPACCT
ASCCRPSSSV SLLCHPVCKS TCCVPVPSCG ASASSCQPSC CRTASCVSLL CRPVCSRPAC
YSLCSGQKSS C
