KR10B_HUMAN
ID KR10B_HUMAN Reviewed; 298 AA.
AC P60412; A2RRF9;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Keratin-associated protein 10-11;
DE AltName: Full=High sulfur keratin-associated protein 10.11;
DE AltName: Full=Keratin-associated protein 10.11;
DE AltName: Full=Keratin-associated protein 18-11;
DE AltName: Full=Keratin-associated protein 18.11;
GN Name=KRTAP10-11;
GN Synonyms=KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Hair root;
RX PubMed=15028290; DOI=10.1016/j.ygeno.2003.09.024;
RA Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.;
RT "A cluster of 21 keratin-associated protein genes within introns of another
RT gene on human chromosome 21q22.3.";
RL Genomics 83:679-693(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=14962103; DOI=10.1046/j.0022-202x.2003.22128.x;
RA Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S.,
RA Schweizer J.;
RT "Hair keratin associated proteins: characterization of a second high sulfur
RT KAP gene domain on human chromosome 21.";
RL J. Invest. Dermatol. 122:147-158(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC P60412; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-10217483, EBI-10173507;
CC P60412; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-10217483, EBI-11954519;
CC P60412; Q6P5X5: C22orf39; NbExp=3; IntAct=EBI-10217483, EBI-7317823;
CC P60412; Q13554: CAMK2B; NbExp=3; IntAct=EBI-10217483, EBI-1058722;
CC P60412; Q8NEC5: CATSPER1; NbExp=6; IntAct=EBI-10217483, EBI-744545;
CC P60412; Q02930-3: CREB5; NbExp=6; IntAct=EBI-10217483, EBI-10192698;
CC P60412; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10217483, EBI-3867333;
CC P60412; Q5HYJ3: FAM76B; NbExp=3; IntAct=EBI-10217483, EBI-751192;
CC P60412; Q5HYJ3-3: FAM76B; NbExp=3; IntAct=EBI-10217483, EBI-11956087;
CC P60412; Q9NWN3: FBXO34; NbExp=3; IntAct=EBI-10217483, EBI-719816;
CC P60412; O76003: GLRX3; NbExp=4; IntAct=EBI-10217483, EBI-374781;
CC P60412; P49639: HOXA1; NbExp=9; IntAct=EBI-10217483, EBI-740785;
CC P60412; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-10217483, EBI-11959885;
CC P60412; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10217483, EBI-11749135;
CC P60412; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10217483, EBI-10171774;
CC P60412; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-10217483, EBI-10241252;
CC P60412; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-10217483, EBI-10172511;
CC P60412; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-10217483, EBI-3958099;
CC P60412; Q9BYQ4: KRTAP9-2; NbExp=6; IntAct=EBI-10217483, EBI-1044640;
CC P60412; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-10217483, EBI-1043191;
CC P60412; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-10217483, EBI-10245913;
CC P60412; Q5T752: LCE1D; NbExp=3; IntAct=EBI-10217483, EBI-11741311;
CC P60412; Q5T753: LCE1E; NbExp=3; IntAct=EBI-10217483, EBI-11955335;
CC P60412; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-10217483, EBI-11974495;
CC P60412; Q5T5A8: LCE3C; NbExp=3; IntAct=EBI-10217483, EBI-10245291;
CC P60412; P50222: MEOX2; NbExp=3; IntAct=EBI-10217483, EBI-748397;
CC P60412; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-10217483, EBI-16439278;
CC P60412; Q13875-3: MOBP; NbExp=3; IntAct=EBI-10217483, EBI-12013470;
CC P60412; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10217483, EBI-945833;
CC P60412; P32242: OTX1; NbExp=6; IntAct=EBI-10217483, EBI-740446;
CC P60412; O15162: PLSCR1; NbExp=3; IntAct=EBI-10217483, EBI-740019;
CC P60412; Q12837: POU4F2; NbExp=3; IntAct=EBI-10217483, EBI-17236143;
CC P60412; O43741: PRKAB2; NbExp=3; IntAct=EBI-10217483, EBI-1053424;
CC P60412; P54619: PRKAG1; NbExp=5; IntAct=EBI-10217483, EBI-1181439;
CC P60412; P49901: SMCP; NbExp=3; IntAct=EBI-10217483, EBI-750494;
CC P60412; A0A024R4B0: SPATA3; NbExp=3; IntAct=EBI-10217483, EBI-14123856;
CC P60412; O43609: SPRY1; NbExp=3; IntAct=EBI-10217483, EBI-3866665;
CC P60412; O43597: SPRY2; NbExp=3; IntAct=EBI-10217483, EBI-742487;
CC P60412; Q08117-2: TLE5; NbExp=3; IntAct=EBI-10217483, EBI-11741437;
CC P60412; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-10217483, EBI-6427977;
CC -!- TISSUE SPECIFICITY: Restricted to a narrow region of the hair fiber
CC cuticle, lying approximately 20 cell layers above the apex of the
CC dermal papilla of the hair root; not detected in any other tissues.
CC {ECO:0000269|PubMed:14962103, ECO:0000269|PubMed:15028290}.
CC -!- SIMILARITY: Belongs to the KRTAP type 10 family. {ECO:0000305}.
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DR EMBL; AB076359; BAD01546.1; -; mRNA.
DR EMBL; AL773602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC131611; AAI31612.1; -; mRNA.
DR CCDS; CCDS42962.1; -.
DR RefSeq; NP_941965.2; NM_198692.2.
DR AlphaFoldDB; P60412; -.
DR BioGRID; 132129; 38.
DR IntAct; P60412; 39.
DR STRING; 9606.ENSP00000334197; -.
DR BioMuta; KRTAP10-11; -.
DR DMDM; 296439312; -.
DR MassIVE; P60412; -.
DR PaxDb; P60412; -.
DR PeptideAtlas; P60412; -.
DR PRIDE; P60412; -.
DR DNASU; 386678; -.
DR Ensembl; ENST00000334670.9; ENSP00000334197.8; ENSG00000243489.4.
DR GeneID; 386678; -.
DR KEGG; hsa:386678; -.
DR MANE-Select; ENST00000334670.9; ENSP00000334197.8; NM_198692.3; NP_941965.2.
DR UCSC; uc002zfr.5; human.
DR CTD; 386678; -.
DR GeneCards; KRTAP10-11; -.
DR HGNC; HGNC:20528; KRTAP10-11.
DR HPA; ENSG00000243489; Tissue enriched (skin).
DR neXtProt; NX_P60412; -.
DR OpenTargets; ENSG00000243489; -.
DR PharmGKB; PA134873081; -.
DR VEuPathDB; HostDB:ENSG00000243489; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000165026; -.
DR InParanoid; P60412; -.
DR OMA; YCKPICC; -.
DR OrthoDB; 1622331at2759; -.
DR PhylomeDB; P60412; -.
DR TreeFam; TF351356; -.
DR PathwayCommons; P60412; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; P60412; -.
DR BioGRID-ORCS; 386678; 17 hits in 989 CRISPR screens.
DR GenomeRNAi; 386678; -.
DR Pharos; P60412; Tdark.
DR PRO; PR:P60412; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; P60412; protein.
DR Bgee; ENSG00000243489; Expressed in zone of skin and 7 other tissues.
DR Genevisible; P60412; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 3.
DR Pfam; PF13885; Keratin_B2_2; 2.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..298
FT /note="Keratin-associated protein 10-11"
FT /id="PRO_0000185219"
FT REPEAT 26..30
FT /note="1"
FT REPEAT 36..40
FT /note="2"
FT REPEAT 57..61
FT /note="3"
FT REPEAT 79..83
FT /note="4"
FT REPEAT 89..93
FT /note="5"
FT REPEAT 99..103
FT /note="6"
FT REPEAT 104..108
FT /note="7"
FT REPEAT 109..113
FT /note="8"
FT REPEAT 114..118
FT /note="9"
FT REPEAT 119..123
FT /note="10"
FT REPEAT 126..130
FT /note="11"
FT REPEAT 136..140
FT /note="12"
FT REPEAT 146..150
FT /note="13"
FT REPEAT 151..155
FT /note="14"
FT REPEAT 156..160
FT /note="15"
FT REPEAT 168..172
FT /note="16"
FT REPEAT 178..182
FT /note="17"
FT REPEAT 188..192
FT /note="18"
FT REPEAT 193..197
FT /note="19"
FT REPEAT 203..207
FT /note="20"
FT REPEAT 225..229
FT /note="21"
FT REPEAT 230..234
FT /note="22"
FT REPEAT 249..253
FT /note="23"
FT REPEAT 256..260
FT /note="24"
FT REPEAT 267..271
FT /note="25"
FT REGION 26..271
FT /note="25 X 5 AA repeats of C-C-X(3)"
FT VARIANT 130
FT /note="S -> F (in dbSNP:rs4818952)"
FT /id="VAR_060056"
FT CONFLICT 213
FT /note="S -> Y (in Ref. 1; BAD01546)"
FT /evidence="ECO:0000305"
FT CONFLICT 269
FT /note="R -> C (in Ref. 1; BAD01546 and 3; AAI31612)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 298 AA; 30243 MW; 11A332F802EE9222 CRC64;
MAASTMSVCS SAYSDSWQVD DCPESCCEPP CSAPSCCAPA PSLSLVCTPV SCVSSPCCQA
ACEPSACQSG CTSSCTPSCC QQSSCQPACC TSSPCQQACC VPVCCKTVCC KPVCCVPVCC
GAASSCCRQS SCQPACCASS SCQPACCVPV CCKPVCCVST CSEDSSSCCQ QSSCQPACCT
SSSYQQACCV PVCCKTVYCK PICCVPVCSR ASSSRCQQPS CQPACCTTSC CRPSSSVSLL
CHPVCRSTCC VPVSSCCAPT SSCQSSCCRP ASCVSLLCRP ASSRLACYSL CSGKKSSC
