KR111_HUMAN
ID KR111_HUMAN Reviewed; 163 AA.
AC Q8IUC1; A1L4I8;
DT 27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Keratin-associated protein 11-1;
DE AltName: Full=High sulfur keratin-associated protein 11.1;
GN Name=KRTAP11-1; Synonyms=KAP11.1, KRTAP11.1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Scalp;
RX PubMed=12359730; DOI=10.1074/jbc.m206422200;
RA Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Schweizer J.;
RT "Characterization of a first domain of human high glycine-tyrosine and high
RT sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1.";
RL J. Biol. Chem. 277:48993-49002(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- INTERACTION:
CC Q8IUC1; Q8TD06: AGR3; NbExp=3; IntAct=EBI-1052037, EBI-3925742;
CC Q8IUC1; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-1052037, EBI-12224467;
CC Q8IUC1; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-1052037, EBI-11954519;
CC Q8IUC1; Q8WXK3-2: ASB13; NbExp=3; IntAct=EBI-1052037, EBI-12015080;
CC Q8IUC1; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-1052037, EBI-12006308;
CC Q8IUC1; P0C7T5: ATXN1L; NbExp=3; IntAct=EBI-1052037, EBI-8624731;
CC Q8IUC1; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-1052037, EBI-745073;
CC Q8IUC1; Q8TCT0: CERK; NbExp=3; IntAct=EBI-1052037, EBI-10274247;
CC Q8IUC1; P27918: CFP; NbExp=3; IntAct=EBI-1052037, EBI-9038570;
CC Q8IUC1; Q8IWX8: CHERP; NbExp=3; IntAct=EBI-1052037, EBI-2555370;
CC Q8IUC1; P05813: CRYBA1; NbExp=3; IntAct=EBI-1052037, EBI-7043337;
CC Q8IUC1; P53672: CRYBA2; NbExp=3; IntAct=EBI-1052037, EBI-750444;
CC Q8IUC1; A8MUP2: CSKMT; NbExp=3; IntAct=EBI-1052037, EBI-12842046;
CC Q8IUC1; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-1052037, EBI-3867333;
CC Q8IUC1; Q96LJ7: DHRS1; NbExp=3; IntAct=EBI-1052037, EBI-746300;
CC Q8IUC1; Q86UW9: DTX2; NbExp=3; IntAct=EBI-1052037, EBI-740376;
CC Q8IUC1; Q9H596: DUSP21; NbExp=3; IntAct=EBI-1052037, EBI-7357329;
CC Q8IUC1; O95967: EFEMP2; NbExp=3; IntAct=EBI-1052037, EBI-743414;
CC Q8IUC1; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-1052037, EBI-744099;
CC Q8IUC1; Q16134: ETFDH; NbExp=3; IntAct=EBI-1052037, EBI-2870454;
CC Q8IUC1; Q8WU58: FAM222B; NbExp=3; IntAct=EBI-1052037, EBI-2807642;
CC Q8IUC1; Q9NW38: FANCL; NbExp=3; IntAct=EBI-1052037, EBI-2339898;
CC Q8IUC1; P48023: FASLG; NbExp=3; IntAct=EBI-1052037, EBI-495538;
CC Q8IUC1; P23142-4: FBLN1; NbExp=3; IntAct=EBI-1052037, EBI-11956479;
CC Q8IUC1; Q53EP0-3: FNDC3B; NbExp=3; IntAct=EBI-1052037, EBI-10242151;
CC Q8IUC1; O75593: FOXH1; NbExp=3; IntAct=EBI-1052037, EBI-1759806;
CC Q8IUC1; O43559: FRS3; NbExp=3; IntAct=EBI-1052037, EBI-725515;
CC Q8IUC1; P23769: GATA2; NbExp=3; IntAct=EBI-1052037, EBI-2806671;
CC Q8IUC1; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-1052037, EBI-11975289;
CC Q8IUC1; Q13227: GPS2; NbExp=3; IntAct=EBI-1052037, EBI-713355;
CC Q8IUC1; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-1052037, EBI-347538;
CC Q8IUC1; P28799: GRN; NbExp=3; IntAct=EBI-1052037, EBI-747754;
CC Q8IUC1; Q9UBP5: HEY2; NbExp=3; IntAct=EBI-1052037, EBI-750630;
CC Q8IUC1; P49639: HOXA1; NbExp=5; IntAct=EBI-1052037, EBI-740785;
CC Q8IUC1; P31273: HOXC8; NbExp=3; IntAct=EBI-1052037, EBI-1752118;
CC Q8IUC1; O43593: HR; NbExp=3; IntAct=EBI-1052037, EBI-2880706;
CC Q8IUC1; P42858: HTT; NbExp=3; IntAct=EBI-1052037, EBI-466029;
CC Q8IUC1; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-1052037, EBI-6426443;
CC Q8IUC1; P78385: KRT83; NbExp=3; IntAct=EBI-1052037, EBI-10221390;
CC Q8IUC1; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-1052037, EBI-10172150;
CC Q8IUC1; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-1052037, EBI-10171774;
CC Q8IUC1; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-1052037, EBI-10210845;
CC Q8IUC1; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-1052037, EBI-11953334;
CC Q8IUC1; P60329: KRTAP12-4; NbExp=4; IntAct=EBI-1052037, EBI-10176396;
CC Q8IUC1; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-1052037, EBI-11953846;
CC Q8IUC1; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-1052037, EBI-11992140;
CC Q8IUC1; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-1052037, EBI-3957672;
CC Q8IUC1; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-1052037, EBI-10302392;
CC Q8IUC1; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-1052037, EBI-10172511;
CC Q8IUC1; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-1052037, EBI-11993296;
CC Q8IUC1; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-1052037, EBI-11974251;
CC Q8IUC1; Q6L8H1: KRTAP5-4; NbExp=3; IntAct=EBI-1052037, EBI-11963072;
CC Q8IUC1; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-1052037, EBI-10250562;
CC Q8IUC1; P26371: KRTAP5-9; NbExp=4; IntAct=EBI-1052037, EBI-3958099;
CC Q8IUC1; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-1052037, EBI-12111050;
CC Q8IUC1; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-1052037, EBI-11962084;
CC Q8IUC1; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-1052037, EBI-1044640;
CC Q8IUC1; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-1052037, EBI-1043191;
CC Q8IUC1; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-1052037, EBI-11958364;
CC Q8IUC1; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-1052037, EBI-11962058;
CC Q8IUC1; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-1052037, EBI-10245913;
CC Q8IUC1; Q5T754: LCE1F; NbExp=3; IntAct=EBI-1052037, EBI-11958008;
CC Q8IUC1; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-1052037, EBI-10246607;
CC Q8IUC1; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-1052037, EBI-9394625;
CC Q8IUC1; Q5T5A8: LCE3C; NbExp=3; IntAct=EBI-1052037, EBI-10245291;
CC Q8IUC1; P56470: LGALS4; NbExp=3; IntAct=EBI-1052037, EBI-720805;
CC Q8IUC1; P0CW20: LIMS4; NbExp=3; IntAct=EBI-1052037, EBI-10196832;
CC Q8IUC1; P61968: LMO4; NbExp=3; IntAct=EBI-1052037, EBI-2798728;
CC Q8IUC1; O14770-4: MEIS2; NbExp=3; IntAct=EBI-1052037, EBI-8025850;
CC Q8IUC1; P41271-2: NBL1; NbExp=3; IntAct=EBI-1052037, EBI-12135485;
CC Q8IUC1; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-1052037, EBI-1210753;
CC Q8IUC1; Q8WWZ8: OIT3; NbExp=3; IntAct=EBI-1052037, EBI-10277776;
CC Q8IUC1; Q7RTU3: OLIG3; NbExp=3; IntAct=EBI-1052037, EBI-10225049;
CC Q8IUC1; O14581: OR7A17; NbExp=3; IntAct=EBI-1052037, EBI-13329281;
CC Q8IUC1; P32242: OTX1; NbExp=5; IntAct=EBI-1052037, EBI-740446;
CC Q8IUC1; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-1052037, EBI-11956269;
CC Q8IUC1; O15496: PLA2G10; NbExp=3; IntAct=EBI-1052037, EBI-726466;
CC Q8IUC1; Q9NRY6: PLSCR3; NbExp=3; IntAct=EBI-1052037, EBI-750734;
CC Q8IUC1; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-1052037, EBI-740343;
CC Q8IUC1; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-1052037, EBI-11987469;
CC Q8IUC1; Q9H0F5: RNF38; NbExp=3; IntAct=EBI-1052037, EBI-2341200;
CC Q8IUC1; Q86YT5: SLC13A5; NbExp=3; IntAct=EBI-1052037, EBI-12002412;
CC Q8IUC1; P09234: SNRPC; NbExp=3; IntAct=EBI-1052037, EBI-766589;
CC Q8IUC1; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-1052037, EBI-11959123;
CC Q8IUC1; O43609: SPRY1; NbExp=3; IntAct=EBI-1052037, EBI-3866665;
CC Q8IUC1; O75716: STK16; NbExp=3; IntAct=EBI-1052037, EBI-749295;
CC Q8IUC1; O95947: TBX6; NbExp=3; IntAct=EBI-1052037, EBI-2824328;
CC Q8IUC1; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-1052037, EBI-750487;
CC Q8IUC1; Q8NEK8: TENT5D; NbExp=3; IntAct=EBI-1052037, EBI-744726;
CC Q8IUC1; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-1052037, EBI-11952651;
CC Q8IUC1; Q08117-2: TLE5; NbExp=3; IntAct=EBI-1052037, EBI-11741437;
CC Q8IUC1; O43711: TLX3; NbExp=3; IntAct=EBI-1052037, EBI-3939165;
CC Q8IUC1; Q63HR2: TNS2; NbExp=5; IntAct=EBI-1052037, EBI-949753;
CC Q8IUC1; Q6EMK4: VASN; NbExp=3; IntAct=EBI-1052037, EBI-10249550;
CC Q8IUC1; O95231: VENTX; NbExp=3; IntAct=EBI-1052037, EBI-10191303;
CC Q8IUC1; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-1052037, EBI-11957216;
CC Q8IUC1; B2RUY7: VWC2L; NbExp=3; IntAct=EBI-1052037, EBI-11747707;
CC Q8IUC1; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-1052037, EBI-12040603;
CC Q8IUC1; Q9GZM5: YIPF3; NbExp=3; IntAct=EBI-1052037, EBI-743787;
CC Q8IUC1; Q15915: ZIC1; NbExp=3; IntAct=EBI-1052037, EBI-11963196;
CC -!- TISSUE SPECIFICITY: Expressed in the upper matrix and in the entire
CC hair cortex.
CC -!- SIMILARITY: Belongs to the PMG family. {ECO:0000305}.
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DR EMBL; AJ457065; CAD29721.1; -; mRNA.
DR EMBL; AP000244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC130555; AAI30556.1; -; mRNA.
DR EMBL; BC130557; AAI30558.1; -; mRNA.
DR CCDS; CCDS13608.1; -.
DR RefSeq; NP_787054.1; NM_175858.2.
DR AlphaFoldDB; Q8IUC1; -.
DR BioGRID; 130626; 106.
DR IntAct; Q8IUC1; 103.
DR STRING; 9606.ENSP00000330720; -.
DR BioMuta; KRTAP11-1; -.
DR DMDM; 32363182; -.
DR MassIVE; Q8IUC1; -.
DR PaxDb; Q8IUC1; -.
DR PeptideAtlas; Q8IUC1; -.
DR PRIDE; Q8IUC1; -.
DR ProteomicsDB; 70540; -.
DR Antibodypedia; 22495; 75 antibodies from 20 providers.
DR DNASU; 337880; -.
DR Ensembl; ENST00000332378.6; ENSP00000330720.4; ENSG00000182591.6.
DR GeneID; 337880; -.
DR KEGG; hsa:337880; -.
DR MANE-Select; ENST00000332378.6; ENSP00000330720.4; NM_175858.3; NP_787054.1.
DR UCSC; uc002yov.4; human.
DR CTD; 337880; -.
DR GeneCards; KRTAP11-1; -.
DR HGNC; HGNC:18922; KRTAP11-1.
DR HPA; ENSG00000182591; Tissue enriched (skin).
DR MIM; 600064; gene.
DR neXtProt; NX_Q8IUC1; -.
DR OpenTargets; ENSG00000182591; -.
DR PharmGKB; PA134907329; -.
DR VEuPathDB; HostDB:ENSG00000182591; -.
DR eggNOG; ENOG502SSBU; Eukaryota.
DR GeneTree; ENSGT00730000111463; -.
DR HOGENOM; CLU_1906002_0_0_1; -.
DR InParanoid; Q8IUC1; -.
DR OMA; CQPVGGI; -.
DR OrthoDB; 1477787at2759; -.
DR PhylomeDB; Q8IUC1; -.
DR TreeFam; TF337331; -.
DR PathwayCommons; Q8IUC1; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q8IUC1; -.
DR BioGRID-ORCS; 337880; 7 hits in 1059 CRISPR screens.
DR GenomeRNAi; 337880; -.
DR Pharos; Q8IUC1; Tbio.
DR PRO; PR:Q8IUC1; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q8IUC1; protein.
DR Bgee; ENSG00000182591; Expressed in zone of skin and 82 other tissues.
DR Genevisible; Q8IUC1; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR007951; KRTAP_PMG.
DR PANTHER; PTHR19051; PTHR19051; 1.
DR Pfam; PF05287; PMG; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..163
FT /note="Keratin-associated protein 11-1"
FT /id="PRO_0000185194"
FT REPEAT 111..120
FT /note="1"
FT REPEAT 121..130
FT /note="2"
FT REPEAT 131..140
FT /note="3"
FT REPEAT 141..150
FT /note="4"
FT REGION 111..150
FT /note="4 X 10 AA approximate repeats"
FT VARIANT 111
FT /note="C -> S (in dbSNP:rs9636845)"
FT /id="VAR_053467"
SQ SEQUENCE 163 AA; 17085 MW; F485585FF46AD7BA CRC64;
MSFNCSTRNC SSRPIGGRCI VPVAQVTTTS TTDADCLGGI CLPSSFQTGS WLLDHCQETC
CEPTACQPTC YRRTSCVSNP CQVTCSRQTT CISNPCSTTY SRPLTFVSSG CQPLGGISSV
CQPVGGISTV CQPVGGVSTV CQPACGVSRT YQQSCVSSCR RTC
