KR121_MOUSE
ID KR121_MOUSE Reviewed; 130 AA.
AC Q9Z287;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Keratin-associated protein 12-1 {ECO:0000250|UniProtKB:P59990, ECO:0000312|EMBL:AAD11776.1};
GN Name=Krtap12-1 {ECO:0000312|MGI:MGI:1328315};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAD11776.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=9878246; DOI=10.1006/geno.1998.5590;
RA Cole S.E., Reeves R.H.;
RT "A cluster of keratin-associated proteins on mouse chromosome 10 in the
RT region of conserved linkage with human chromosome 21.";
RL Genomics 54:437-442(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|EMBL:AAI07320.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins (By similarity). {ECO:0000250|UniProtKB:P59990}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250|UniProtKB:P59990}.
CC -!- TISSUE SPECIFICITY: Expressed only in the head and back skin of a 3 day
CC old mouse. Not expressed in adult skin. {ECO:0000269|PubMed:9878246}.
CC -!- SIMILARITY: Belongs to the KRTAP type 12 family. {ECO:0000255}.
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DR EMBL; AF081797; AAD11776.1; -; Genomic_DNA.
DR EMBL; CH466553; EDL31791.1; -; Genomic_DNA.
DR EMBL; BC107319; AAI07320.1; -; mRNA.
DR EMBL; BC107320; AAI07321.1; -; mRNA.
DR CCDS; CCDS23959.1; -.
DR RefSeq; NP_034800.1; NM_010670.1.
DR AlphaFoldDB; Q9Z287; -.
DR STRING; 10090.ENSMUSP00000074876; -.
DR PaxDb; Q9Z287; -.
DR PRIDE; Q9Z287; -.
DR ProteomicsDB; 264796; -.
DR DNASU; 16694; -.
DR Ensembl; ENSMUST00000092370; ENSMUSP00000090024; ENSMUSG00000069583.
DR GeneID; 16694; -.
DR KEGG; mmu:16694; -.
DR UCSC; uc007fwc.1; mouse.
DR CTD; 353332; -.
DR MGI; MGI:1328315; Krtap12-1.
DR VEuPathDB; HostDB:ENSMUSG00000069583; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000161526; -.
DR HOGENOM; CLU_138013_0_0_1; -.
DR InParanoid; Q9Z287; -.
DR OMA; CKPITCS; -.
DR PhylomeDB; Q9Z287; -.
DR TreeFam; TF339135; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR BioGRID-ORCS; 16694; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q9Z287; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9Z287; protein.
DR Bgee; ENSMUSG00000069583; Expressed in lip and 25 other tissues.
DR Genevisible; Q9Z287; MM.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 2.
DR Pfam; PF13885; Keratin_B2_2; 2.
PE 2: Evidence at transcript level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..130
FT /note="Keratin-associated protein 12-1"
FT /id="PRO_0000355591"
FT REPEAT 10..14
FT /note="1"
FT /evidence="ECO:0000255"
FT REPEAT 15..29
FT /note="2"
FT /evidence="ECO:0000255"
FT REPEAT 34..38
FT /note="3"
FT /evidence="ECO:0000255"
FT REPEAT 40..44
FT /note="4"
FT /evidence="ECO:0000255"
FT REPEAT 45..49
FT /note="5"
FT /evidence="ECO:0000255"
FT REPEAT 60..64
FT /note="6"
FT /evidence="ECO:0000255"
FT REPEAT 85..89
FT /note="7"
FT /evidence="ECO:0000255"
FT REPEAT 90..94
FT /note="8"
FT /evidence="ECO:0000255"
FT REPEAT 95..99
FT /note="9"
FT /evidence="ECO:0000255"
FT REPEAT 104..108
FT /note="10"
FT /evidence="ECO:0000255"
FT REPEAT 109..113
FT /note="11"
FT /evidence="ECO:0000255"
FT REPEAT 114..118
FT /note="12"
FT /evidence="ECO:0000255"
FT REPEAT 119..123
FT /note="13"
FT /evidence="ECO:0000255"
FT REPEAT 124..128
FT /note="14"
FT /evidence="ECO:0000255"
FT REGION 10..128
FT /note="14 X 5 AA approximate repeats"
FT /evidence="ECO:0000255"
SQ SEQUENCE 130 AA; 13119 MW; 91FC4AA2C2154B1D CRC64;
MCHTSCSSGC QPSCCVSSSC QPSCCVSSPC QASCFVSSPC QPSCCVSSSC QSACCRPAIC
IPVRYQVACC VPVSCGPTVC MAPSCQSSVC VPVSCRPVCV TSSCQSSGCC QPSCPTLVCK
PVTCSNPSCC
