ID   KR122_BOVIN             Reviewed;         124 AA.
AC   Q05B44;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Keratin-associated protein 12-2 {ECO:0000250|UniProtKB:P59991, ECO:0000312|EMBL:AAI22854.1};
GN   Name=KRTAP12-2 {ECO:0000312|EMBL:AAI22854.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAI22854.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI22854.1};
RC   TISSUE=Fetal skin {ECO:0000312|EMBL:AAI22854.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins (By similarity). {ECO:0000250|UniProtKB:P59991}.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250|UniProtKB:P59991}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 12 family. {ECO:0000255}.
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DR   EMBL; BC122853; AAI22854.1; -; mRNA.
DR   RefSeq; NP_001073820.1; NM_001080351.1.
DR   AlphaFoldDB; Q05B44; -.
DR   STRING; 9913.ENSBTAP00000024766; -.
DR   PaxDb; Q05B44; -.
DR   Ensembl; ENSBTAT00000024766; ENSBTAP00000024766; ENSBTAG00000018610.
DR   GeneID; 783717; -.
DR   KEGG; bta:783717; -.
DR   CTD; 353323; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018610; -.
DR   eggNOG; KOG4726; Eukaryota.
DR   GeneTree; ENSGT00940000161526; -.
DR   HOGENOM; CLU_138013_0_0_1; -.
DR   InParanoid; Q05B44; -.
DR   OMA; NSCRCIY; -.
DR   OrthoDB; 1616617at2759; -.
DR   TreeFam; TF339135; -.
DR   Reactome; R-BTA-6805567; Keratinization.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000018610; Expressed in zone of skin and 11 other tissues.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   InterPro; IPR002494; KAP.
DR   PANTHER; PTHR23262; PTHR23262; 1.
DR   Pfam; PF13885; Keratin_B2_2; 1.
PE   2: Evidence at transcript level;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..124
FT                   /note="Keratin-associated protein 12-2"
FT                   /id="PRO_0000355592"
FT   REPEAT          10..13
FT                   /note="1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          14..18
FT                   /note="2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          19..23
FT                   /note="3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          24..28
FT                   /note="4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          33..38
FT                   /note="5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          39..43
FT                   /note="6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          44..48
FT                   /note="7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          49..52
FT                   /note="8"
FT                   /evidence="ECO:0000255"
FT   REPEAT          53..57
FT                   /note="9"
FT                   /evidence="ECO:0000255"
FT   REPEAT          58..62
FT                   /note="10"
FT                   /evidence="ECO:0000255"
FT   REPEAT          63..67
FT                   /note="11"
FT                   /evidence="ECO:0000255"
FT   REPEAT          68..72
FT                   /note="12"
FT                   /evidence="ECO:0000255"
FT   REPEAT          73..77
FT                   /note="13"
FT                   /evidence="ECO:0000255"
FT   REPEAT          78..82
FT                   /note="14"
FT                   /evidence="ECO:0000255"
FT   REPEAT          83..87
FT                   /note="15"
FT                   /evidence="ECO:0000255"
FT   REPEAT          88..92
FT                   /note="16"
FT                   /evidence="ECO:0000255"
FT   REPEAT          98..102
FT                   /note="17"
FT                   /evidence="ECO:0000255"
FT   REPEAT          103..107
FT                   /note="18"
FT                   /evidence="ECO:0000255"
FT   REPEAT          108..112
FT                   /note="19"
FT                   /evidence="ECO:0000255"
FT   REPEAT          113..117
FT                   /note="20"
FT                   /evidence="ECO:0000255"
FT   REGION          10..117
FT                   /note="20 X 5 AA approximate repeats"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   124 AA;  12920 MW;  CABE73D722D74876 CRC64;
     MCHTSCSSGC QAACVPSSCQ PSCSTSSPCH TSCFTSSLCQ PTCSTSSTCQ ATCVPVSYRP
     AVCLPVTYKP TLCVTPSCQS SVFLPVSYRP AVYVAPSCQS SGCYQPSCPT LVYRPISCST
     SSCF