KR123_HUMAN
ID KR123_HUMAN Reviewed; 96 AA.
AC P60328;
DT 02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Keratin-associated protein 12-3;
DE AltName: Full=High sulfur keratin-associated protein 12.3;
DE AltName: Full=Keratin-associated protein 12.3;
GN Name=KRTAP12-3; Synonyms=KAP12.3, KRTAP12.3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT ARG-17.
RC TISSUE=Hair root;
RX PubMed=15028290; DOI=10.1016/j.ygeno.2003.09.024;
RA Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.;
RT "A cluster of 21 keratin-associated protein genes within introns of another
RT gene on human chromosome 21q22.3.";
RL Genomics 83:679-693(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=14962103; DOI=10.1046/j.0022-202x.2003.22128.x;
RA Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S.,
RA Schweizer J.;
RT "Hair keratin associated proteins: characterization of a second high sulfur
RT KAP gene domain on human chromosome 21.";
RL J. Invest. Dermatol. 122:147-158(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC P60328; P82987: ADAMTSL3; NbExp=3; IntAct=EBI-11953334, EBI-10221726;
CC P60328; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-11953334, EBI-10173507;
CC P60328; P21549: AGXT; NbExp=3; IntAct=EBI-11953334, EBI-727098;
CC P60328; P43353: ALDH3B1; NbExp=3; IntAct=EBI-11953334, EBI-2558314;
CC P60328; A8KA13: BCL6B; NbExp=3; IntAct=EBI-11953334, EBI-10174813;
CC P60328; P18075: BMP7; NbExp=3; IntAct=EBI-11953334, EBI-1035195;
CC P60328; Q6NUJ2: C11orf87; NbExp=3; IntAct=EBI-11953334, EBI-6660291;
CC P60328; Q6P5X5: C22orf39; NbExp=3; IntAct=EBI-11953334, EBI-7317823;
CC P60328; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-11953334, EBI-3866279;
CC P60328; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-11953334, EBI-744545;
CC P60328; Q14781-2: CBX2; NbExp=3; IntAct=EBI-11953334, EBI-11974585;
CC P60328; Q8N6W0: CELF5; NbExp=3; IntAct=EBI-11953334, EBI-12139335;
CC P60328; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-11953334, EBI-741528;
CC P60328; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-11953334, EBI-947551;
CC P60328; P07510-2: CHRNG; NbExp=3; IntAct=EBI-11953334, EBI-11979451;
CC P60328; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-11953334, EBI-741032;
CC P60328; P27658: COL8A1; NbExp=3; IntAct=EBI-11953334, EBI-747133;
CC P60328; Q9UGL9: CRCT1; NbExp=3; IntAct=EBI-11953334, EBI-713677;
CC P60328; Q02930-3: CREB5; NbExp=3; IntAct=EBI-11953334, EBI-10192698;
CC P60328; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11953334, EBI-3867333;
CC P60328; Q5D0E6-2: DALRD3; NbExp=3; IntAct=EBI-11953334, EBI-9090939;
CC P60328; Q96LJ7: DHRS1; NbExp=3; IntAct=EBI-11953334, EBI-746300;
CC P60328; Q6P158: DHX57; NbExp=3; IntAct=EBI-11953334, EBI-1051531;
CC P60328; O96015: DNAL4; NbExp=3; IntAct=EBI-11953334, EBI-742362;
CC P60328; Q92608: DOCK2; NbExp=3; IntAct=EBI-11953334, EBI-448771;
CC P60328; P48023: FASLG; NbExp=3; IntAct=EBI-11953334, EBI-495538;
CC P60328; Q969U6: FBXW5; NbExp=3; IntAct=EBI-11953334, EBI-741068;
CC P60328; O76003: GLRX3; NbExp=3; IntAct=EBI-11953334, EBI-374781;
CC P60328; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-11953334, EBI-11975289;
CC P60328; Q9Y5Q8: GTF3C5; NbExp=3; IntAct=EBI-11953334, EBI-1045409;
CC P60328; P49639: HOXA1; NbExp=6; IntAct=EBI-11953334, EBI-740785;
CC P60328; P16144-2: ITGB4; NbExp=3; IntAct=EBI-11953334, EBI-11051601;
CC P60328; Q15040: JOSD1; NbExp=3; IntAct=EBI-11953334, EBI-2510602;
CC P60328; Q5T749: KPRP; NbExp=6; IntAct=EBI-11953334, EBI-10981970;
CC P60328; P35900: KRT20; NbExp=3; IntAct=EBI-11953334, EBI-742094;
CC P60328; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11953334, EBI-11959885;
CC P60328; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-11953334, EBI-10172290;
CC P60328; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11953334, EBI-10171774;
CC P60328; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-11953334, EBI-10172052;
CC P60328; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-11953334, EBI-1052037;
CC P60328; P59990: KRTAP12-1; NbExp=6; IntAct=EBI-11953334, EBI-10210845;
CC P60328; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-11953334, EBI-11953334;
CC P60328; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-11953334, EBI-11953846;
CC P60328; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-11953334, EBI-10241252;
CC P60328; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-11953334, EBI-10241353;
CC P60328; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-11953334, EBI-3957694;
CC P60328; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-11953334, EBI-10172511;
CC P60328; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-11953334, EBI-11958132;
CC P60328; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-11953334, EBI-10250562;
CC P60328; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-11953334, EBI-3958099;
CC P60328; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-11953334, EBI-12111050;
CC P60328; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-11953334, EBI-11962084;
CC P60328; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11953334, EBI-1044640;
CC P60328; Q5T7P2: LCE1A; NbExp=6; IntAct=EBI-11953334, EBI-11962058;
CC P60328; Q5T7P3: LCE1B; NbExp=4; IntAct=EBI-11953334, EBI-10245913;
CC P60328; Q5T751: LCE1C; NbExp=3; IntAct=EBI-11953334, EBI-12224199;
CC P60328; Q5T753: LCE1E; NbExp=3; IntAct=EBI-11953334, EBI-11955335;
CC P60328; Q5T754: LCE1F; NbExp=7; IntAct=EBI-11953334, EBI-11958008;
CC P60328; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-11953334, EBI-10246607;
CC P60328; O14633: LCE2B; NbExp=6; IntAct=EBI-11953334, EBI-11478468;
CC P60328; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-11953334, EBI-11973993;
CC P60328; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-11953334, EBI-10246750;
CC P60328; Q5TA76: LCE3A; NbExp=6; IntAct=EBI-11953334, EBI-9394625;
CC P60328; Q5T5A8: LCE3C; NbExp=6; IntAct=EBI-11953334, EBI-10245291;
CC P60328; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-11953334, EBI-6658837;
CC P60328; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-11953334, EBI-10245456;
CC P60328; Q5TA78: LCE4A; NbExp=6; IntAct=EBI-11953334, EBI-10246358;
CC P60328; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-11953334, EBI-11955689;
CC P60328; P15018: LIF; NbExp=3; IntAct=EBI-11953334, EBI-1037189;
CC P60328; Q8IXW0: LMNTD2; NbExp=3; IntAct=EBI-11953334, EBI-12028858;
CC P60328; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-11953334, EBI-739832;
CC P60328; Q9Y5Y7: LYVE1; NbExp=3; IntAct=EBI-11953334, EBI-10329546;
CC P60328; O60336: MAPKBP1; NbExp=3; IntAct=EBI-11953334, EBI-947402;
CC P60328; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-11953334, EBI-16439278;
CC P60328; Q8IVT2: MISP; NbExp=3; IntAct=EBI-11953334, EBI-2555085;
CC P60328; Q13875-3: MOBP; NbExp=3; IntAct=EBI-11953334, EBI-12013470;
CC P60328; Q969G9: NKD1; NbExp=3; IntAct=EBI-11953334, EBI-1538217;
CC P60328; P48645: NMU; NbExp=3; IntAct=EBI-11953334, EBI-10210351;
CC P60328; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11953334, EBI-22310682;
CC P60328; Q9NQX5: NPDC1; NbExp=3; IntAct=EBI-11953334, EBI-748927;
CC P60328; Q6NSM0: NR1D2; NbExp=6; IntAct=EBI-11953334, EBI-10250949;
CC P60328; Q92570: NR4A3; NbExp=3; IntAct=EBI-11953334, EBI-13644623;
CC P60328; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-11953334, EBI-1210753;
CC P60328; P32242: OTX1; NbExp=3; IntAct=EBI-11953334, EBI-740446;
CC P60328; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-11953334, EBI-12813389;
CC P60328; Q99571: P2RX4; NbExp=3; IntAct=EBI-11953334, EBI-2828248;
CC P60328; Q15077: P2RY6; NbExp=3; IntAct=EBI-11953334, EBI-10235794;
CC P60328; Q8IVL6-2: P3H3; NbExp=3; IntAct=EBI-11953334, EBI-12149899;
CC P60328; P07237: P4HB; NbExp=3; IntAct=EBI-11953334, EBI-395883;
CC P60328; O76083-2: PDE9A; NbExp=3; IntAct=EBI-11953334, EBI-11524542;
CC P60328; P09619: PDGFRB; NbExp=3; IntAct=EBI-11953334, EBI-641237;
CC P60328; Q9HCN3: PGAP6; NbExp=3; IntAct=EBI-11953334, EBI-10310808;
CC P60328; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-11953334, EBI-14084211;
CC P60328; Q12837: POU4F2; NbExp=3; IntAct=EBI-11953334, EBI-17236143;
CC P60328; P41222: PTGDS; NbExp=3; IntAct=EBI-11953334, EBI-948821;
CC P60328; Q8WUK0: PTPMT1; NbExp=3; IntAct=EBI-11953334, EBI-7199479;
CC P60328; Q9Y2K5: R3HDM2; NbExp=3; IntAct=EBI-11953334, EBI-948428;
CC P60328; Q6UXX9-2: RSPO2; NbExp=3; IntAct=EBI-11953334, EBI-12009390;
CC P60328; Q8WWX9: SELENOM; NbExp=3; IntAct=EBI-11953334, EBI-10277687;
CC P60328; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-11953334, EBI-11955083;
CC P60328; Q86YT5: SLC13A5; NbExp=3; IntAct=EBI-11953334, EBI-12002412;
CC P60328; Q16348: SLC15A2; NbExp=3; IntAct=EBI-11953334, EBI-12806032;
CC P60328; Q9UHI7-3: SLC23A1; NbExp=3; IntAct=EBI-11953334, EBI-11998660;
CC P60328; A0A024R4B0: SPATA3; NbExp=3; IntAct=EBI-11953334, EBI-14123856;
CC P60328; O43609: SPRY1; NbExp=3; IntAct=EBI-11953334, EBI-3866665;
CC P60328; Q15560: TCEA2; NbExp=3; IntAct=EBI-11953334, EBI-710310;
CC P60328; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-11953334, EBI-11955057;
CC P60328; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-11953334, EBI-11952651;
CC P60328; Q05952: TNP2; NbExp=3; IntAct=EBI-11953334, EBI-12039775;
CC P60328; Q63HR2: TNS2; NbExp=3; IntAct=EBI-11953334, EBI-949753;
CC P60328; P49638: TTPA; NbExp=3; IntAct=EBI-11953334, EBI-10210710;
CC P60328; Q9BRU9: UTP23; NbExp=3; IntAct=EBI-11953334, EBI-5457544;
CC P60328; Q9UBK9: UXT; NbExp=4; IntAct=EBI-11953334, EBI-357355;
CC P60328; Q6EMK4: VASN; NbExp=6; IntAct=EBI-11953334, EBI-10249550;
CC P60328; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-11953334, EBI-11957216;
CC P60328; Q8IW00: VSTM4; NbExp=3; IntAct=EBI-11953334, EBI-4311759;
CC P60328; Q64LD2-2: WDR25; NbExp=3; IntAct=EBI-11953334, EBI-12032042;
CC P60328; O96014: WNT11; NbExp=3; IntAct=EBI-11953334, EBI-8058160;
CC P60328; P25490: YY1; NbExp=3; IntAct=EBI-11953334, EBI-765538;
CC P60328; Q8WTX9: ZDHHC1; NbExp=3; IntAct=EBI-11953334, EBI-2818796;
CC P60328; Q8IZC7: ZNF101; NbExp=3; IntAct=EBI-11953334, EBI-5278328;
CC P60328; Q15973: ZNF124; NbExp=3; IntAct=EBI-11953334, EBI-2555767;
CC P60328; P52744: ZNF138; NbExp=3; IntAct=EBI-11953334, EBI-10746567;
CC P60328; P17024: ZNF20; NbExp=3; IntAct=EBI-11953334, EBI-717634;
CC P60328; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-11953334, EBI-347633;
CC P60328; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-11953334, EBI-740727;
CC P60328; Q8NDP4: ZNF439; NbExp=3; IntAct=EBI-11953334, EBI-747580;
CC P60328; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-11953334, EBI-726439;
CC P60328; Q7Z7K2: ZNF467; NbExp=3; IntAct=EBI-11953334, EBI-11986485;
CC P60328; Q9ULM2: ZNF490; NbExp=3; IntAct=EBI-11953334, EBI-1105370;
CC P60328; Q8N8L2: ZNF491; NbExp=3; IntAct=EBI-11953334, EBI-12019860;
CC P60328; Q6ZNH5: ZNF497; NbExp=3; IntAct=EBI-11953334, EBI-10486136;
CC P60328; Q96N58: ZNF578; NbExp=3; IntAct=EBI-11953334, EBI-11955189;
CC P60328; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-11953334, EBI-6427977;
CC P60328; Q5T619: ZNF648; NbExp=3; IntAct=EBI-11953334, EBI-11985915;
CC P60328; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-11953334, EBI-11090299;
CC P60328; P51504: ZNF80; NbExp=3; IntAct=EBI-11953334, EBI-12013828;
CC P60328; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-11953334, EBI-5667516;
CC P60328; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-11953334, EBI-11962574;
CC P60328; Q9Y5A6: ZSCAN21; NbExp=3; IntAct=EBI-11953334, EBI-10281938;
CC -!- TISSUE SPECIFICITY: Restricted to a narrow region of the hair fiber
CC cuticle, lying approximately 20 cell layers above the apex of the
CC dermal papilla of the hair root; not detected in any other tissues.
CC {ECO:0000269|PubMed:14962103, ECO:0000269|PubMed:15028290}.
CC -!- SIMILARITY: Belongs to the KRTAP type 12 family. {ECO:0000305}.
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DR EMBL; AB076361; BAD01548.1; -; mRNA.
DR EMBL; AL773602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS42964.1; -.
DR RefSeq; NP_941970.2; NM_198697.2.
DR AlphaFoldDB; P60328; -.
DR BioGRID; 132134; 143.
DR IntAct; P60328; 139.
DR STRING; 9606.ENSP00000381005; -.
DR BioMuta; KRTAP12-3; -.
DR DMDM; 296434553; -.
DR MassIVE; P60328; -.
DR PaxDb; P60328; -.
DR PeptideAtlas; P60328; -.
DR PRIDE; P60328; -.
DR DNASU; 386683; -.
DR Ensembl; ENST00000397907.1; ENSP00000381005.1; ENSG00000205439.10.
DR GeneID; 386683; -.
DR KEGG; hsa:386683; -.
DR MANE-Select; ENST00000397907.1; ENSP00000381005.1; NM_198697.2; NP_941970.2.
DR UCSC; uc002zft.3; human.
DR CTD; 386683; -.
DR GeneCards; KRTAP12-3; -.
DR HGNC; HGNC:20531; KRTAP12-3.
DR HPA; ENSG00000205439; Tissue enriched (skin).
DR neXtProt; NX_P60328; -.
DR OpenTargets; ENSG00000205439; -.
DR PharmGKB; PA134986807; -.
DR VEuPathDB; HostDB:ENSG00000205439; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000163527; -.
DR HOGENOM; CLU_138013_1_0_1; -.
DR InParanoid; P60328; -.
DR OMA; CKPITCS; -.
DR OrthoDB; 1616617at2759; -.
DR PhylomeDB; P60328; -.
DR TreeFam; TF339135; -.
DR PathwayCommons; P60328; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; P60328; -.
DR BioGRID-ORCS; 386683; 3 hits in 994 CRISPR screens.
DR GenomeRNAi; 386683; -.
DR Pharos; P60328; Tdark.
DR PRO; PR:P60328; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; P60328; protein.
DR Bgee; ENSG00000205439; Expressed in granulocyte and 23 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 1.
DR Pfam; PF13885; Keratin_B2_2; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..96
FT /note="Keratin-associated protein 12-3"
FT /id="PRO_0000185198"
FT REPEAT 10..14
FT /note="1"
FT REPEAT 15..19
FT /note="2"
FT REPEAT 24..28
FT /note="3"
FT REPEAT 30..34
FT /note="4"
FT REPEAT 35..39
FT /note="5"
FT REPEAT 45..49
FT /note="6"
FT REPEAT 50..54
FT /note="7"
FT REPEAT 55..59
FT /note="8"
FT REPEAT 60..64
FT /note="9"
FT REPEAT 70..74
FT /note="10"
FT REPEAT 75..79
FT /note="11"
FT REPEAT 80..84
FT /note="12"
FT REPEAT 85..89
FT /note="13"
FT REPEAT 90..94
FT /note="14"
FT REGION 10..94
FT /note="14 X 5 AA approximate repeats"
FT VARIANT 17
FT /note="H -> R (in dbSNP:rs9306111)"
FT /evidence="ECO:0000269|PubMed:15028290"
FT /id="VAR_017592"
SQ SEQUENCE 96 AA; 9947 MW; 6D870B11E34F111C CRC64;
MCHTSCSPAC QPTCCIHSPC QASCYVPVSC QSSVCMPVSC TRIVCVAPSC QPSVCVPVSC
RPIIYVTPSC QSSGCCQPPC TTALCRPISC STPSCC
