KR132_HUMAN
ID KR132_HUMAN Reviewed; 175 AA.
AC Q52LG2;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Keratin-associated protein 13-2;
GN Name=KRTAP13-2; Synonyms=KAP13.2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hair root;
RA Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT "Identification of complete keratin-associated protein (KAP) gene cluster
RT spanning 800 kb region on human chromosome 21q22.11.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- INTERACTION:
CC Q52LG2; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-11953846, EBI-12224467;
CC Q52LG2; P50995: ANXA11; NbExp=3; IntAct=EBI-11953846, EBI-715243;
CC Q52LG2; P41182: BCL6; NbExp=3; IntAct=EBI-11953846, EBI-765407;
CC Q52LG2; Q9H5F2: C11orf1; NbExp=3; IntAct=EBI-11953846, EBI-718615;
CC Q52LG2; Q6P5X5: C22orf39; NbExp=3; IntAct=EBI-11953846, EBI-7317823;
CC Q52LG2; O43439-4: CBFA2T2; NbExp=3; IntAct=EBI-11953846, EBI-11954144;
CC Q52LG2; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-11953846, EBI-11977221;
CC Q52LG2; Q8N4L8: CCDC24; NbExp=3; IntAct=EBI-11953846, EBI-1104933;
CC Q52LG2; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-11953846, EBI-10961624;
CC Q52LG2; O75909-2: CCNK; NbExp=3; IntAct=EBI-11953846, EBI-12010594;
CC Q52LG2; P05813: CRYBA1; NbExp=3; IntAct=EBI-11953846, EBI-7043337;
CC Q52LG2; A8MUP2: CSKMT; NbExp=3; IntAct=EBI-11953846, EBI-12842046;
CC Q52LG2; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11953846, EBI-3867333;
CC Q52LG2; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-11953846, EBI-744099;
CC Q52LG2; Q9UM22: EPDR1; NbExp=3; IntAct=EBI-11953846, EBI-946972;
CC Q52LG2; Q16134: ETFDH; NbExp=3; IntAct=EBI-11953846, EBI-2870454;
CC Q52LG2; Q9NW38: FANCL; NbExp=3; IntAct=EBI-11953846, EBI-2339898;
CC Q52LG2; Q96EF6: FBXO17; NbExp=3; IntAct=EBI-11953846, EBI-2510157;
CC Q52LG2; A0A0C3SFZ9: FCHO1; NbExp=3; IntAct=EBI-11953846, EBI-11977403;
CC Q52LG2; P23771-2: GATA3; NbExp=3; IntAct=EBI-11953846, EBI-6672518;
CC Q52LG2; P57678: GEMIN4; NbExp=3; IntAct=EBI-11953846, EBI-356700;
CC Q52LG2; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-11953846, EBI-11975289;
CC Q52LG2; Q13227: GPS2; NbExp=3; IntAct=EBI-11953846, EBI-713355;
CC Q52LG2; P28799: GRN; NbExp=3; IntAct=EBI-11953846, EBI-747754;
CC Q52LG2; P31943: HNRNPH1; NbExp=3; IntAct=EBI-11953846, EBI-351590;
CC Q52LG2; P49639: HOXA1; NbExp=5; IntAct=EBI-11953846, EBI-740785;
CC Q52LG2; O43593: HR; NbExp=3; IntAct=EBI-11953846, EBI-2880706;
CC Q52LG2; Q7L273: KCTD9; NbExp=3; IntAct=EBI-11953846, EBI-4397613;
CC Q52LG2; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-11953846, EBI-6426443;
CC Q52LG2; Q5T749: KPRP; NbExp=3; IntAct=EBI-11953846, EBI-10981970;
CC Q52LG2; P12035: KRT3; NbExp=3; IntAct=EBI-11953846, EBI-2430095;
CC Q52LG2; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11953846, EBI-11959885;
CC Q52LG2; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-11953846, EBI-10172150;
CC Q52LG2; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-11953846, EBI-1052037;
CC Q52LG2; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-11953846, EBI-10176379;
CC Q52LG2; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-11953846, EBI-11953334;
CC Q52LG2; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-11953846, EBI-11992140;
CC Q52LG2; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-11953846, EBI-3957672;
CC Q52LG2; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-11953846, EBI-9996449;
CC Q52LG2; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-11953846, EBI-3957694;
CC Q52LG2; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-11953846, EBI-11958132;
CC Q52LG2; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-11953846, EBI-11993254;
CC Q52LG2; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11953846, EBI-1044640;
CC Q52LG2; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-11953846, EBI-746778;
CC Q52LG2; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-11953846, EBI-16439278;
CC Q52LG2; Q86SG6: NEK8; NbExp=3; IntAct=EBI-11953846, EBI-1752987;
CC Q52LG2; P0CG21: NHLRC4; NbExp=3; IntAct=EBI-11953846, EBI-12868744;
CC Q52LG2; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11953846, EBI-22310682;
CC Q52LG2; O43482: OIP5; NbExp=3; IntAct=EBI-11953846, EBI-536879;
CC Q52LG2; P32242: OTX1; NbExp=3; IntAct=EBI-11953846, EBI-740446;
CC Q52LG2; P07237: P4HB; NbExp=3; IntAct=EBI-11953846, EBI-395883;
CC Q52LG2; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-11953846, EBI-11022007;
CC Q52LG2; Q8N4B1-4: PHETA1; NbExp=3; IntAct=EBI-11953846, EBI-14131832;
CC Q52LG2; P78337: PITX1; NbExp=3; IntAct=EBI-11953846, EBI-748265;
CC Q52LG2; Q16633: POU2AF1; NbExp=3; IntAct=EBI-11953846, EBI-943588;
CC Q52LG2; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-11953846, EBI-12000762;
CC Q52LG2; Q6P9E2: RECK; NbExp=3; IntAct=EBI-11953846, EBI-10253121;
CC Q52LG2; Q9BQY4: RHOXF2; NbExp=3; IntAct=EBI-11953846, EBI-372094;
CC Q52LG2; Q9H1K4: SLC25A18; NbExp=3; IntAct=EBI-11953846, EBI-6269587;
CC Q52LG2; O75093: SLIT1; NbExp=3; IntAct=EBI-11953846, EBI-947791;
CC Q52LG2; Q53HV7-2: SMUG1; NbExp=3; IntAct=EBI-11953846, EBI-12275818;
CC Q52LG2; P09234: SNRPC; NbExp=3; IntAct=EBI-11953846, EBI-766589;
CC Q52LG2; Q9Y4P9-2: SPEF1; NbExp=3; IntAct=EBI-11953846, EBI-12303571;
CC Q52LG2; O75716: STK16; NbExp=3; IntAct=EBI-11953846, EBI-749295;
CC Q52LG2; Q9Y4C2-2: TCAF1; NbExp=3; IntAct=EBI-11953846, EBI-11974855;
CC Q52LG2; Q96LM6: TEX37; NbExp=3; IntAct=EBI-11953846, EBI-743976;
CC Q52LG2; Q08117-2: TLE5; NbExp=3; IntAct=EBI-11953846, EBI-11741437;
CC Q52LG2; Q63HR2: TNS2; NbExp=3; IntAct=EBI-11953846, EBI-949753;
CC Q52LG2; O75865-2: TRAPPC6A; NbExp=3; IntAct=EBI-11953846, EBI-8451480;
CC Q52LG2; Q6AZZ1: TRIM68; NbExp=3; IntAct=EBI-11953846, EBI-2130449;
CC Q52LG2; Q8N831: TSPYL6; NbExp=3; IntAct=EBI-11953846, EBI-12023322;
CC Q52LG2; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-11953846, EBI-3918381;
CC Q52LG2; Q8IV45: UNC5CL; NbExp=3; IntAct=EBI-11953846, EBI-12238241;
CC Q52LG2; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-11953846, EBI-11957216;
CC Q52LG2; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-11953846, EBI-11957238;
CC Q52LG2; Q15915: ZIC1; NbExp=3; IntAct=EBI-11953846, EBI-11963196;
CC -!- SIMILARITY: Belongs to the PMG family. {ECO:0000305}.
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DR EMBL; AB096938; BAE46353.1; -; mRNA.
DR EMBL; BC093934; AAH93934.1; -; mRNA.
DR EMBL; BC093936; AAH93936.1; -; mRNA.
DR CCDS; CCDS13589.1; -.
DR RefSeq; NP_853652.1; NM_181621.3.
DR AlphaFoldDB; Q52LG2; -.
DR BioGRID; 130644; 108.
DR IntAct; Q52LG2; 76.
DR STRING; 9606.ENSP00000382777; -.
DR iPTMnet; Q52LG2; -.
DR PhosphoSitePlus; Q52LG2; -.
DR BioMuta; KRTAP13-2; -.
DR DMDM; 74735807; -.
DR MassIVE; Q52LG2; -.
DR PaxDb; Q52LG2; -.
DR PeptideAtlas; Q52LG2; -.
DR PRIDE; Q52LG2; -.
DR ProteomicsDB; 62423; -.
DR DNASU; 337959; -.
DR Ensembl; ENST00000399889.4; ENSP00000382777.2; ENSG00000182816.9.
DR GeneID; 337959; -.
DR KEGG; hsa:337959; -.
DR MANE-Select; ENST00000399889.4; ENSP00000382777.2; NM_181621.4; NP_853652.1.
DR UCSC; uc002ynz.5; human.
DR CTD; 337959; -.
DR GeneCards; KRTAP13-2; -.
DR HGNC; HGNC:18923; KRTAP13-2.
DR HPA; ENSG00000182816; Group enriched (intestine, skin).
DR neXtProt; NX_Q52LG2; -.
DR OpenTargets; ENSG00000182816; -.
DR PharmGKB; PA134994193; -.
DR VEuPathDB; HostDB:ENSG00000182816; -.
DR eggNOG; ENOG502STG2; Eukaryota.
DR GeneTree; ENSGT00940000162756; -.
DR HOGENOM; CLU_111618_0_0_1; -.
DR InParanoid; Q52LG2; -.
DR OMA; QEICWEP; -.
DR OrthoDB; 1292816at2759; -.
DR PhylomeDB; Q52LG2; -.
DR TreeFam; TF337331; -.
DR PathwayCommons; Q52LG2; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q52LG2; -.
DR BioGRID-ORCS; 337959; 11 hits in 1055 CRISPR screens.
DR GenomeRNAi; 337959; -.
DR Pharos; Q52LG2; Tdark.
DR PRO; PR:Q52LG2; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q52LG2; protein.
DR Bgee; ENSG00000182816; Expressed in rectum and 26 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR007951; KRTAP_PMG.
DR PANTHER; PTHR19051; PTHR19051; 1.
DR Pfam; PF05287; PMG; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..175
FT /note="Keratin-associated protein 13-2"
FT /id="PRO_0000185201"
FT REPEAT 46..55
FT /note="1"
FT REPEAT 56..65
FT /note="2"
FT REPEAT 66..75
FT /note="3"
FT REPEAT 76..85
FT /note="4"
FT REPEAT 92..101
FT /note="5"
FT REGION 46..101
FT /note="5 X 10 AA approximate repeats"
FT VARIANT 26
FT /note="R -> C (in dbSNP:rs16986753)"
FT /id="VAR_053470"
FT VARIANT 74
FT /note="S -> R (in dbSNP:rs3804010)"
FT /id="VAR_053471"
SQ SEQUENCE 175 AA; 18727 MW; 3C8B3B255CF9A1CD CRC64;
MSYNCCSGNF SSRSCGDYLR YPASSRGFSY PSNLVYSTDL CSPSTCQLGS SLYRGCQEIC
WEPTSCQTSY VESSPCQTSC YRPRTSLLCS PCKTTYSGSL GFGSSSCRSL GYGSRSCYSV
GCGSSGVRSL GYGSCGFPSL GYGSGFCRPT YLASRSCQSP CYRPAYGSTF CRSTC
