ARC1A_ARATH
ID ARC1A_ARATH Reviewed; 378 AA.
AC O80856;
DT 29-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 150.
DE RecName: Full=Actin-related protein 2/3 complex subunit 1A;
DE AltName: Full=Actin-related protein C1;
DE AltName: Full=Actin-related protein C1A;
DE AltName: Full=Arp2/3 complex 41 kDa subunit;
DE AltName: Full=p41-ARC;
GN Name=ARPC1A; OrderedLocusNames=At2g30910; ORFNames=F7F1.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP TISSUE SPECIFICITY, AND IDENTIFICATION OF THE ARP2/3 COMPLEX.
RX PubMed=12913159; DOI=10.1104/pp.103.028563;
RA Li S., Blanchoin L., Yang Z., Lord E.M.;
RT "The putative Arabidopsis arp2/3 complex controls leaf cell
RT morphogenesis.";
RL Plant Physiol. 132:2034-2044(2003).
RN [6]
RP REVIEW.
RX PubMed=15653407; DOI=10.1016/j.pbi.2004.11.004;
RA Szymanski D.B.;
RT "Breaking the WAVE complex: the point of Arabidopsis trichomes.";
RL Curr. Opin. Plant Biol. 8:103-112(2005).
CC -!- FUNCTION: Functions as component of the Arp2/3 complex which is
CC involved in regulation of actin polymerization and together with an
CC activating nucleation-promoting factor (NPF) mediates the formation of
CC branched actin networks. Arp2/3 complex plays a critical role in the
CC control of cell morphogenesis via the modulation of cell polarity
CC development. {ECO:0000250}.
CC -!- SUBUNIT: Component of the Arp2/3 complex composed of ARP2, ARP3,
CC ARPC1/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and
CC ARPC5/p16-ARC.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=O80856-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed at low levels in all tissues with a
CC relatively highest expression in inflorescences.
CC {ECO:0000269|PubMed:12913159}.
CC -!- SIMILARITY: Belongs to the WD repeat ARPC1 family. {ECO:0000305}.
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DR EMBL; AC004669; AAC20725.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08455.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08457.1; -; Genomic_DNA.
DR EMBL; BT004616; AAO42862.1; -; mRNA.
DR EMBL; AK227543; BAE99541.1; -; mRNA.
DR PIR; B84714; B84714.
DR RefSeq; NP_001189645.1; NM_001202716.1. [O80856-1]
DR RefSeq; NP_180648.1; NM_128643.4. [O80856-1]
DR AlphaFoldDB; O80856; -.
DR SMR; O80856; -.
DR BioGRID; 2990; 1.
DR STRING; 3702.AT2G30910.3; -.
DR iPTMnet; O80856; -.
DR PaxDb; O80856; -.
DR ProteomicsDB; 245182; -. [O80856-1]
DR EnsemblPlants; AT2G30910.1; AT2G30910.1; AT2G30910. [O80856-1]
DR EnsemblPlants; AT2G30910.3; AT2G30910.3; AT2G30910. [O80856-1]
DR GeneID; 817641; -.
DR Gramene; AT2G30910.1; AT2G30910.1; AT2G30910. [O80856-1]
DR Gramene; AT2G30910.3; AT2G30910.3; AT2G30910. [O80856-1]
DR KEGG; ath:AT2G30910; -.
DR Araport; AT2G30910; -.
DR TAIR; locus:2052871; AT2G30910.
DR eggNOG; KOG1523; Eukaryota.
DR HOGENOM; CLU_034396_0_0_1; -.
DR InParanoid; O80856; -.
DR OMA; YVWEPSP; -.
DR PhylomeDB; O80856; -.
DR PRO; PR:O80856; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O80856; baseline and differential.
DR Genevisible; O80856; AT.
DR GO; GO:0005885; C:Arp2/3 protein complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; HDA:TAIR.
DR GO; GO:0005634; C:nucleus; HDA:TAIR.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; TAS:TAIR.
DR GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IBA:GO_Central.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR017383; ARPC1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR10709; PTHR10709; 1.
DR Pfam; PF00400; WD40; 2.
DR PIRSF; PIRSF038093; ARP2/3_su1; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; Alternative splicing; Cytoplasm; Cytoskeleton;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..378
FT /note="Actin-related protein 2/3 complex subunit 1A"
FT /id="PRO_0000422526"
FT REPEAT 8..47
FT /note="WD 1"
FT REPEAT 53..92
FT /note="WD 2"
FT REPEAT 97..138
FT /note="WD 3"
FT REPEAT 143..182
FT /note="WD 4"
FT REPEAT 203..242
FT /note="WD 5"
FT REPEAT 257..295
FT /note="WD 6"
FT REPEAT 331..375
FT /note="WD 7"
SQ SEQUENCE 378 AA; 41956 MW; C8A38111E5472188 CRC64;
MAVVDVHRFA ESITCHAWSP DLSMVALCPN NTEVHIYKSL SQDHWERLHV LQKHDQIVSG
IDWSSKSNKI VTVSHDRNSY VWSLEGAEWV PTLVILRLNR AALCVQWSPK ENKFAVGSGA
KTVCICYYEQ ENNWWVSKLI RKRHESSVTS VAWHPNNVLL ATTSTDGKCR VFSTFIKGVD
TKDSKAGSPA ETKFGEQILQ LDLSYSWAFG VKWSPSGNTL AYVGHSSMIY FVDDVGPSPL
AQSVAFRDLP LRDVLFISEK MVIGVGYDSN PMVFASDDTG IWSFIRYIGE KKAASSNSSY
SSQFSEAFGK FYGSQSKSTT ANDASESRGG VHDNCINSIV SLSKAGSPKV MRFSTSGLDG
KVAIWDLENM EQELGNQF
