KR133_HUMAN
ID KR133_HUMAN Reviewed; 172 AA.
AC Q3SY46; Q3LI78;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Keratin-associated protein 13-3;
GN Name=KRTAP13-3; Synonyms=KAP13.3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Small intestine;
RA Obayashi I., Shibuya K., Kudoh J., Shimizu N.;
RT "Identification of eight novel genes from keratin associated protein gene
RT cluster on human chromosome 21q22.11.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- INTERACTION:
CC Q3SY46; Q7Z3C6-3: ATG9A; NbExp=5; IntAct=EBI-10241252, EBI-12006308;
CC Q3SY46; P54253: ATXN1; NbExp=3; IntAct=EBI-10241252, EBI-930964;
CC Q3SY46; Q9NWQ9: C14orf119; NbExp=3; IntAct=EBI-10241252, EBI-725606;
CC Q3SY46; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-10241252, EBI-8643161;
CC Q3SY46; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-10241252, EBI-10171570;
CC Q3SY46; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-10241252, EBI-744556;
CC Q3SY46; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-10241252, EBI-10961624;
CC Q3SY46; O95833: CLIC3; NbExp=5; IntAct=EBI-10241252, EBI-10192241;
CC Q3SY46; P27658: COL8A1; NbExp=3; IntAct=EBI-10241252, EBI-747133;
CC Q3SY46; P05813: CRYBA1; NbExp=3; IntAct=EBI-10241252, EBI-7043337;
CC Q3SY46; P53672: CRYBA2; NbExp=3; IntAct=EBI-10241252, EBI-750444;
CC Q3SY46; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10241252, EBI-3867333;
CC Q3SY46; P50570-2: DNM2; NbExp=3; IntAct=EBI-10241252, EBI-10968534;
CC Q3SY46; Q86UW9: DTX2; NbExp=3; IntAct=EBI-10241252, EBI-740376;
CC Q3SY46; O95967: EFEMP2; NbExp=5; IntAct=EBI-10241252, EBI-743414;
CC Q3SY46; P16930: FAH; NbExp=3; IntAct=EBI-10241252, EBI-4397076;
CC Q3SY46; O75593: FOXH1; NbExp=3; IntAct=EBI-10241252, EBI-1759806;
CC Q3SY46; P23769: GATA2; NbExp=3; IntAct=EBI-10241252, EBI-2806671;
CC Q3SY46; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-10241252, EBI-11975289;
CC Q3SY46; O95872: GPANK1; NbExp=3; IntAct=EBI-10241252, EBI-751540;
CC Q3SY46; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-10241252, EBI-347538;
CC Q3SY46; P28799: GRN; NbExp=3; IntAct=EBI-10241252, EBI-747754;
CC Q3SY46; Q96NT3-2: GUCD1; NbExp=5; IntAct=EBI-10241252, EBI-11978177;
CC Q3SY46; Q96MH2: HEXIM2; NbExp=3; IntAct=EBI-10241252, EBI-5460660;
CC Q3SY46; P49639: HOXA1; NbExp=3; IntAct=EBI-10241252, EBI-740785;
CC Q3SY46; P31273: HOXC8; NbExp=3; IntAct=EBI-10241252, EBI-1752118;
CC Q3SY46; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-10241252, EBI-3918847;
CC Q3SY46; P04792: HSPB1; NbExp=3; IntAct=EBI-10241252, EBI-352682;
CC Q3SY46; Q96MP8-2: KCTD7; NbExp=3; IntAct=EBI-10241252, EBI-11954971;
CC Q3SY46; Q7L273: KCTD9; NbExp=3; IntAct=EBI-10241252, EBI-4397613;
CC Q3SY46; O60333-2: KIF1B; NbExp=3; IntAct=EBI-10241252, EBI-10975473;
CC Q3SY46; Q5T749: KPRP; NbExp=3; IntAct=EBI-10241252, EBI-10981970;
CC Q3SY46; P78385: KRT83; NbExp=3; IntAct=EBI-10241252, EBI-10221390;
CC Q3SY46; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-10241252, EBI-10217483;
CC Q3SY46; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10241252, EBI-11953334;
CC Q3SY46; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-10241252, EBI-9996449;
CC Q3SY46; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-10241252, EBI-751260;
CC Q3SY46; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-10241252, EBI-11993296;
CC Q3SY46; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-10241252, EBI-10250562;
CC Q3SY46; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-10241252, EBI-1044640;
CC Q3SY46; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-10241252, EBI-1043191;
CC Q3SY46; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-10241252, EBI-739832;
CC Q3SY46; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-10241252, EBI-2341787;
CC Q3SY46; Q9UH92-3: MLX; NbExp=3; IntAct=EBI-10241252, EBI-8852072;
CC Q3SY46; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-10241252, EBI-11750983;
CC Q3SY46; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10241252, EBI-945833;
CC Q3SY46; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10241252, EBI-22310682;
CC Q3SY46; P32242: OTX1; NbExp=3; IntAct=EBI-10241252, EBI-740446;
CC Q3SY46; P55771: PAX9; NbExp=3; IntAct=EBI-10241252, EBI-12111000;
CC Q3SY46; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-10241252, EBI-11956269;
CC Q3SY46; Q12837: POU4F2; NbExp=3; IntAct=EBI-10241252, EBI-17236143;
CC Q3SY46; O60260-5: PRKN; NbExp=3; IntAct=EBI-10241252, EBI-21251460;
CC Q3SY46; Q9Y2K5: R3HDM2; NbExp=3; IntAct=EBI-10241252, EBI-948428;
CC Q3SY46; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-10241252, EBI-740343;
CC Q3SY46; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-10241252, EBI-11984663;
CC Q3SY46; O75093: SLIT1; NbExp=3; IntAct=EBI-10241252, EBI-947791;
CC Q3SY46; Q92922: SMARCC1; NbExp=3; IntAct=EBI-10241252, EBI-355653;
CC Q3SY46; Q16637: SMN2; NbExp=3; IntAct=EBI-10241252, EBI-395421;
CC Q3SY46; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-10241252, EBI-11959123;
CC Q3SY46; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-10241252, EBI-5235340;
CC Q3SY46; Q8WWU5-7: TCP11; NbExp=3; IntAct=EBI-10241252, EBI-17721485;
CC Q3SY46; Q8WW24: TEKT4; NbExp=5; IntAct=EBI-10241252, EBI-750487;
CC Q3SY46; Q08117-2: TLE5; NbExp=5; IntAct=EBI-10241252, EBI-11741437;
CC Q3SY46; O43711: TLX3; NbExp=3; IntAct=EBI-10241252, EBI-3939165;
CC Q3SY46; Q9H0E2: TOLLIP; NbExp=5; IntAct=EBI-10241252, EBI-74615;
CC Q3SY46; Q8IWR1: TRIM59; NbExp=3; IntAct=EBI-10241252, EBI-10262539;
CC Q3SY46; Q6AZZ1: TRIM68; NbExp=3; IntAct=EBI-10241252, EBI-2130449;
CC Q3SY46; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-10241252, EBI-3918381;
CC Q3SY46; Q9BZL1: UBL5; NbExp=3; IntAct=EBI-10241252, EBI-607755;
CC Q3SY46; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-10241252, EBI-11957238;
CC Q3SY46; O76024: WFS1; NbExp=3; IntAct=EBI-10241252, EBI-720609;
CC Q3SY46; Q9P2F9: ZNF319; NbExp=3; IntAct=EBI-10241252, EBI-11993110;
CC Q3SY46; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-10241252, EBI-373456;
CC Q3SY46; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-10241252, EBI-744257;
CC -!- SIMILARITY: Belongs to the PMG family. {ECO:0000305}.
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DR EMBL; AB096940; BAE46355.1; -; mRNA.
DR EMBL; BC103965; AAI03966.1; -; mRNA.
DR CCDS; CCDS13591.1; -.
DR RefSeq; NP_853653.1; NM_181622.1.
DR AlphaFoldDB; Q3SY46; -.
DR BioGRID; 130645; 90.
DR IntAct; Q3SY46; 74.
DR STRING; 9606.ENSP00000375109; -.
DR iPTMnet; Q3SY46; -.
DR PhosphoSitePlus; Q3SY46; -.
DR BioMuta; KRTAP13-3; -.
DR DMDM; 82592929; -.
DR MassIVE; Q3SY46; -.
DR PaxDb; Q3SY46; -.
DR PeptideAtlas; Q3SY46; -.
DR PRIDE; Q3SY46; -.
DR Antibodypedia; 64674; 84 antibodies from 16 providers.
DR DNASU; 337960; -.
DR Ensembl; ENST00000390690.2; ENSP00000375109.2; ENSG00000240432.3.
DR GeneID; 337960; -.
DR KEGG; hsa:337960; -.
DR MANE-Select; ENST00000390690.3; ENSP00000375109.2; NM_181622.2; NP_853653.1.
DR UCSC; uc002yob.2; human.
DR CTD; 337960; -.
DR GeneCards; KRTAP13-3; -.
DR HGNC; HGNC:18925; KRTAP13-3.
DR HPA; ENSG00000240432; Not detected.
DR neXtProt; NX_Q3SY46; -.
DR PharmGKB; PA134901486; -.
DR VEuPathDB; HostDB:ENSG00000240432; -.
DR eggNOG; ENOG502STG2; Eukaryota.
DR GeneTree; ENSGT00940000161951; -.
DR HOGENOM; CLU_111618_0_0_1; -.
DR InParanoid; Q3SY46; -.
DR OMA; FRYLNYR; -.
DR OrthoDB; 1292816at2759; -.
DR PhylomeDB; Q3SY46; -.
DR TreeFam; TF337331; -.
DR PathwayCommons; Q3SY46; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q3SY46; -.
DR BioGRID-ORCS; 337960; 7 hits in 1055 CRISPR screens.
DR GenomeRNAi; 337960; -.
DR Pharos; Q3SY46; Tdark.
DR PRO; PR:Q3SY46; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q3SY46; protein.
DR Bgee; ENSG00000240432; Expressed in olfactory segment of nasal mucosa and 1 other tissue.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR007951; KRTAP_PMG.
DR PANTHER; PTHR19051; PTHR19051; 1.
DR Pfam; PF05287; PMG; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..172
FT /note="Keratin-associated protein 13-3"
FT /id="PRO_0000185202"
FT REPEAT 46..55
FT /note="1"
FT REPEAT 56..65
FT /note="2"
FT REPEAT 66..75
FT /note="3"
FT REPEAT 76..85
FT /note="4"
FT REPEAT 92..101
FT /note="5"
FT REGION 46..101
FT /note="5 X 10 AA approximate repeats"
FT CONFLICT 13
FT /note="C -> R (in Ref. 1; BAE46355)"
FT /evidence="ECO:0000305"
FT CONFLICT 18
FT /note="Y -> H (in Ref. 1; BAE46355)"
FT /evidence="ECO:0000305"
FT CONFLICT 108
FT /note="C -> R (in Ref. 1; BAE46355)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 172 AA; 19236 MW; 230EA3775278CBF3 CRC64;
MSYNCCSRNF SSCSHGGYLH YPGSSCGSSY PSNLVYSTDL CSPSTCQLGS SLYRGCQETC
WRPNSCQTLC VESSPCHTSC YYPRTHMLCN SCLTMHVGSR GFGSNSCCSL SCGSRSCSSL
GCGSNGFRYL NYRIHTSPSQ SYRSRFCHPI YFPPRRWFHS SCYQPFCRSG FY
