ID   KR134_HUMAN             Reviewed;         160 AA.
AC   Q3LI77; A2RRL3;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Keratin-associated protein 13-4;
GN   Name=KRTAP13-4; Synonyms=KAP13.4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hair root;
RA   Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT   "Identification of complete keratin-associated protein (KAP) gene cluster
RT   spanning 800 kb region on human chromosome 21q22.11.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-59.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins.
CC   -!- SUBUNIT: Interacts with hair keratins.
CC   -!- INTERACTION:
CC       Q3LI77; O95429: BAG4; NbExp=3; IntAct=EBI-11953996, EBI-2949658;
CC       Q3LI77; Q86X02: CDR2L; NbExp=3; IntAct=EBI-11953996, EBI-11063830;
CC       Q3LI77; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11953996, EBI-3867333;
CC       Q3LI77; A0A0C3SFZ9: FCHO1; NbExp=3; IntAct=EBI-11953996, EBI-11977403;
CC       Q3LI77; P57678: GEMIN4; NbExp=3; IntAct=EBI-11953996, EBI-356700;
CC       Q3LI77; P49639: HOXA1; NbExp=3; IntAct=EBI-11953996, EBI-740785;
CC       Q3LI77; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11953996, EBI-22310682;
CC       Q3LI77; Q9BQY4: RHOXF2; NbExp=3; IntAct=EBI-11953996, EBI-372094;
CC   -!- SIMILARITY: Belongs to the PMG family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB096941; BAE46356.1; -; mRNA.
DR   EMBL; BC131691; AAI31692.1; -; mRNA.
DR   CCDS; CCDS13592.1; -.
DR   RefSeq; NP_853631.1; NM_181600.1.
DR   AlphaFoldDB; Q3LI77; -.
DR   BioGRID; 129962; 9.
DR   IntAct; Q3LI77; 8.
DR   STRING; 9606.ENSP00000334834; -.
DR   iPTMnet; Q3LI77; -.
DR   PhosphoSitePlus; Q3LI77; -.
DR   BioMuta; KRTAP13-4; -.
DR   DMDM; 82592930; -.
DR   MassIVE; Q3LI77; -.
DR   PaxDb; Q3LI77; -.
DR   PeptideAtlas; Q3LI77; -.
DR   PRIDE; Q3LI77; -.
DR   ProteomicsDB; 61773; -.
DR   Antibodypedia; 76517; 28 antibodies from 5 providers.
DR   DNASU; 284827; -.
DR   Ensembl; ENST00000334068.3; ENSP00000334834.2; ENSG00000186971.3.
DR   GeneID; 284827; -.
DR   KEGG; hsa:284827; -.
DR   MANE-Select; ENST00000334068.4; ENSP00000334834.2; NM_181600.3; NP_853631.1.
DR   UCSC; uc011acw.3; human.
DR   CTD; 284827; -.
DR   GeneCards; KRTAP13-4; -.
DR   HGNC; HGNC:18926; KRTAP13-4.
DR   HPA; ENSG00000186971; Not detected.
DR   neXtProt; NX_Q3LI77; -.
DR   PharmGKB; PA134861175; -.
DR   VEuPathDB; HostDB:ENSG00000186971; -.
DR   eggNOG; ENOG502STG2; Eukaryota.
DR   GeneTree; ENSGT00940000162756; -.
DR   HOGENOM; CLU_111618_0_0_1; -.
DR   InParanoid; Q3LI77; -.
DR   OMA; QKTCWEP; -.
DR   OrthoDB; 1292816at2759; -.
DR   PhylomeDB; Q3LI77; -.
DR   TreeFam; TF337331; -.
DR   PathwayCommons; Q3LI77; -.
DR   Reactome; R-HSA-6805567; Keratinization.
DR   SignaLink; Q3LI77; -.
DR   BioGRID-ORCS; 284827; 12 hits in 1055 CRISPR screens.
DR   GenomeRNAi; 284827; -.
DR   Pharos; Q3LI77; Tdark.
DR   PRO; PR:Q3LI77; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; Q3LI77; protein.
DR   Bgee; ENSG00000186971; Expressed in subcutaneous adipose tissue and 12 other tissues.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   InterPro; IPR007951; KRTAP_PMG.
DR   PANTHER; PTHR19051; PTHR19051; 1.
DR   Pfam; PF05287; PMG; 1.
PE   1: Evidence at protein level;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..160
FT                   /note="Keratin-associated protein 13-4"
FT                   /id="PRO_0000185204"
FT   REPEAT          41..50
FT                   /note="1"
FT   REPEAT          51..60
FT                   /note="2"
FT   REPEAT          61..70
FT                   /note="3"
FT   REPEAT          77..86
FT                   /note="4"
FT   REGION          41..86
FT                   /note="4 X 10 AA approximate repeats"
FT   VARIANT         59
FT                   /note="A -> T (in dbSNP:rs2226548)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_047849"
FT   VARIANT         154
FT                   /note="R -> H (in dbSNP:rs999597)"
FT                   /id="VAR_053472"
SQ   SEQUENCE   160 AA;  17755 MW;  47BD7F4FAE141CD8 CRC64;
     MSYNCCSRNF SSRSFGGYLY YPGSYPSSLV YSTALCSPST CQLRSSLYRD CQKTCWEPAS
     CQKSCYRPRT SILCCPCQTT CSGSLGFRSS SCRSQGYGSR CCYSLGNGSS GFRFLKYGGC
     GFPSLSYGSR FCYPNYLASG AWQSSCYRPI CGSRFYQFTC