KR134_MACFU
ID KR134_MACFU Reviewed; 156 AA.
AC Q4W7G8;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 32.
DE RecName: Full=Keratin-associated protein 13-4;
GN Name=KRTAP13-4; Synonyms=KAP13.4;
OS Macaca fuscata fuscata (Japanese macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9543;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Kim H., Park E.;
RT "Comparative analysis of KAP13.3 and KAP13.4 genes in primates.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- SIMILARITY: Belongs to the PMG family. {ECO:0000305}.
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DR EMBL; AB195302; BAD98709.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4W7G8; -.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR007951; KRTAP_PMG.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR PANTHER; PTHR19051; PTHR19051; 1.
DR Pfam; PF05287; PMG; 1.
PE 3: Inferred from homology;
KW Keratin; Repeat.
FT CHAIN 1..156
FT /note="Keratin-associated protein 13-4"
FT /id="PRO_0000185208"
FT REPEAT 37..46
FT /note="1"
FT REPEAT 47..56
FT /note="2"
FT REPEAT 57..66
FT /note="3"
FT REPEAT 73..82
FT /note="4"
FT REGION 37..82
FT /note="4 X 10 AA approximate repeats"
SQ SEQUENCE 156 AA; 17278 MW; 4DDA0B8AD7AF9D20 CRC64;
MSYNCCSGNF SSRSFGGYLH YPGCNPYSTA LCSPSICQLG SSLYRNCQKT CWEPTSCRKS
CYRRRTSMLC SPCQTTCSRS LGFGSSSCHS QGYGSRSCYS LGSGSSGFRF LKYGGCGFPS
LSYGSRFCYP NYLASRAWQS SCYRPICGSR FYQFTC