KR151_HUMAN
ID KR151_HUMAN Reviewed; 137 AA.
AC Q3LI76; Q2M3F4;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Keratin-associated protein 15-1;
GN Name=KRTAP15-1; Synonyms=KAP15.1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT MET-43.
RC TISSUE=Hair root;
RA Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT "Identification of complete keratin-associated protein (KAP) gene cluster
RT spanning 800 kb region on human chromosome 21q22.11.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-43.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- INTERACTION:
CC Q3LI76; Q96HD9: ACY3; NbExp=3; IntAct=EBI-11992140, EBI-3916242;
CC Q3LI76; Q8IWG5: ANKHD1; NbExp=3; IntAct=EBI-11992140, EBI-355540;
CC Q3LI76; Q03989: ARID5A; NbExp=3; IntAct=EBI-11992140, EBI-948603;
CC Q3LI76; Q8WXK3-2: ASB13; NbExp=3; IntAct=EBI-11992140, EBI-12015080;
CC Q3LI76; Q86V38: ATN1; NbExp=3; IntAct=EBI-11992140, EBI-11954292;
CC Q3LI76; Q5SWW7: C10orf55; NbExp=3; IntAct=EBI-11992140, EBI-12809220;
CC Q3LI76; Q9UQM7: CAMK2A; NbExp=3; IntAct=EBI-11992140, EBI-1383687;
CC Q3LI76; Q8N4L8: CCDC24; NbExp=3; IntAct=EBI-11992140, EBI-1104933;
CC Q3LI76; Q5T4B2: CERCAM; NbExp=3; IntAct=EBI-11992140, EBI-12261896;
CC Q3LI76; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11992140, EBI-3867333;
CC Q3LI76; Q15038: DAZAP2; NbExp=5; IntAct=EBI-11992140, EBI-724310;
CC Q3LI76; Q86UW9: DTX2; NbExp=3; IntAct=EBI-11992140, EBI-740376;
CC Q3LI76; A0A0C3SFZ9: FCHO1; NbExp=3; IntAct=EBI-11992140, EBI-11977403;
CC Q3LI76; O60548: FOXD2; NbExp=3; IntAct=EBI-11992140, EBI-17282008;
CC Q3LI76; P57678: GEMIN4; NbExp=3; IntAct=EBI-11992140, EBI-356700;
CC Q3LI76; P28799: GRN; NbExp=3; IntAct=EBI-11992140, EBI-747754;
CC Q3LI76; P49639: HOXA1; NbExp=7; IntAct=EBI-11992140, EBI-740785;
CC Q3LI76; O43593: HR; NbExp=3; IntAct=EBI-11992140, EBI-2880706;
CC Q3LI76; Q0VD86: INCA1; NbExp=3; IntAct=EBI-11992140, EBI-6509505;
CC Q3LI76; Q5TA45: INTS11; NbExp=3; IntAct=EBI-11992140, EBI-748258;
CC Q3LI76; P16144-2: ITGB4; NbExp=3; IntAct=EBI-11992140, EBI-11051601;
CC Q3LI76; Q5T749: KPRP; NbExp=3; IntAct=EBI-11992140, EBI-10981970;
CC Q3LI76; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11992140, EBI-10171774;
CC Q3LI76; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-11992140, EBI-1052037;
CC Q3LI76; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-11992140, EBI-10210845;
CC Q3LI76; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-11992140, EBI-10176379;
CC Q3LI76; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-11992140, EBI-11953846;
CC Q3LI76; Q8IUB9: KRTAP19-1; NbExp=3; IntAct=EBI-11992140, EBI-12811111;
CC Q3LI76; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-11992140, EBI-1048945;
CC Q3LI76; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-11992140, EBI-9996449;
CC Q3LI76; Q9BYR7: KRTAP3-2; NbExp=5; IntAct=EBI-11992140, EBI-751260;
CC Q3LI76; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-11992140, EBI-3957694;
CC Q3LI76; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-11992140, EBI-10302392;
CC Q3LI76; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-11992140, EBI-11993296;
CC Q3LI76; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-11992140, EBI-11974251;
CC Q3LI76; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-11992140, EBI-11962084;
CC Q3LI76; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11992140, EBI-1044640;
CC Q3LI76; Q8WWR8-2: NEU4; NbExp=3; IntAct=EBI-11992140, EBI-10277551;
CC Q3LI76; P0CG21: NHLRC4; NbExp=3; IntAct=EBI-11992140, EBI-12868744;
CC Q3LI76; Q86UR1-2: NOXA1; NbExp=3; IntAct=EBI-11992140, EBI-12025760;
CC Q3LI76; P32242: OTX1; NbExp=3; IntAct=EBI-11992140, EBI-740446;
CC Q3LI76; Q9HBE1-4: PATZ1; NbExp=5; IntAct=EBI-11992140, EBI-11022007;
CC Q3LI76; Q9UBV8: PEF1; NbExp=3; IntAct=EBI-11992140, EBI-724639;
CC Q3LI76; Q99697-2: PITX2; NbExp=3; IntAct=EBI-11992140, EBI-12138495;
CC Q3LI76; Q9NRY6: PLSCR3; NbExp=3; IntAct=EBI-11992140, EBI-750734;
CC Q3LI76; P28069: POU1F1; NbExp=3; IntAct=EBI-11992140, EBI-8673859;
CC Q3LI76; Q16633: POU2AF1; NbExp=3; IntAct=EBI-11992140, EBI-943588;
CC Q3LI76; Q9NZ81: PRR13; NbExp=3; IntAct=EBI-11992140, EBI-740924;
CC Q3LI76; P20618: PSMB1; NbExp=3; IntAct=EBI-11992140, EBI-372273;
CC Q3LI76; Q93062-3: RBPMS; NbExp=6; IntAct=EBI-11992140, EBI-740343;
CC Q3LI76; Q9BQY4: RHOXF2; NbExp=3; IntAct=EBI-11992140, EBI-372094;
CC Q3LI76; Q13671: RIN1; NbExp=3; IntAct=EBI-11992140, EBI-366017;
CC Q3LI76; Q9H0X6: RNF208; NbExp=3; IntAct=EBI-11992140, EBI-751555;
CC Q3LI76; Q16348: SLC15A2; NbExp=3; IntAct=EBI-11992140, EBI-12806032;
CC Q3LI76; Q53HV7-2: SMUG1; NbExp=3; IntAct=EBI-11992140, EBI-12275818;
CC Q3LI76; O95416: SOX14; NbExp=3; IntAct=EBI-11992140, EBI-9087806;
CC Q3LI76; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-11992140, EBI-11959123;
CC Q3LI76; Q9BXF9: TEKT3; NbExp=3; IntAct=EBI-11992140, EBI-8644516;
CC Q3LI76; Q96M29: TEKT5; NbExp=3; IntAct=EBI-11992140, EBI-10239812;
CC Q3LI76; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-11992140, EBI-11952651;
CC Q3LI76; Q04726-4: TLE3; NbExp=3; IntAct=EBI-11992140, EBI-12014388;
CC Q3LI76; Q9H0E2: TOLLIP; NbExp=3; IntAct=EBI-11992140, EBI-74615;
CC Q3LI76; Q5T6F2: UBAP2; NbExp=3; IntAct=EBI-11992140, EBI-2514383;
CC Q3LI76; Q6NVU6: UFSP1; NbExp=3; IntAct=EBI-11992140, EBI-12068150;
CC Q3LI76; Q08AM6: VAC14; NbExp=3; IntAct=EBI-11992140, EBI-2107455;
CC Q3LI76; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-11992140, EBI-11957216;
CC Q3LI76; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-11992140, EBI-2559305;
CC Q3LI76; Q96DN2: VWCE; NbExp=3; IntAct=EBI-11992140, EBI-2850497;
CC Q3LI76; Q64LD2-2: WDR25; NbExp=3; IntAct=EBI-11992140, EBI-12032042;
CC Q3LI76; A0A0C4DGF1: ZBTB32; NbExp=3; IntAct=EBI-11992140, EBI-10188476;
CC Q3LI76; Q15915: ZIC1; NbExp=3; IntAct=EBI-11992140, EBI-11963196;
CC -!- SIMILARITY: Belongs to the PMG family. {ECO:0000305}.
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DR EMBL; AB096942; BAE46357.1; -; mRNA.
DR EMBL; BC104927; AAI04928.1; -; mRNA.
DR EMBL; BC104925; AAI04926.1; -; mRNA.
DR CCDS; CCDS13593.1; -.
DR RefSeq; NP_853654.1; NM_181623.1.
DR AlphaFoldDB; Q3LI76; -.
DR BioGRID; 129062; 80.
DR IntAct; Q3LI76; 71.
DR STRING; 9606.ENSP00000334866; -.
DR PhosphoSitePlus; Q3LI76; -.
DR BioMuta; KRTAP15-1; -.
DR DMDM; 209572640; -.
DR PaxDb; Q3LI76; -.
DR PeptideAtlas; Q3LI76; -.
DR PRIDE; Q3LI76; -.
DR Antibodypedia; 6633; 7 antibodies from 3 providers.
DR DNASU; 254950; -.
DR Ensembl; ENST00000334067.5; ENSP00000334866.3; ENSG00000186970.5.
DR GeneID; 254950; -.
DR KEGG; hsa:254950; -.
DR MANE-Select; ENST00000334067.5; ENSP00000334866.3; NM_181623.3; NP_853654.1.
DR UCSC; uc002yod.4; human.
DR CTD; 254950; -.
DR GeneCards; KRTAP15-1; -.
DR HGNC; HGNC:18927; KRTAP15-1.
DR HPA; ENSG00000186970; Not detected.
DR neXtProt; NX_Q3LI76; -.
DR PharmGKB; PA134911178; -.
DR VEuPathDB; HostDB:ENSG00000186970; -.
DR eggNOG; ENOG502TD2Y; Eukaryota.
DR GeneTree; ENSGT00940000162109; -.
DR HOGENOM; CLU_111618_0_0_1; -.
DR InParanoid; Q3LI76; -.
DR OMA; TCDSFYP; -.
DR OrthoDB; 1292816at2759; -.
DR PhylomeDB; Q3LI76; -.
DR TreeFam; TF337331; -.
DR PathwayCommons; Q3LI76; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q3LI76; -.
DR BioGRID-ORCS; 254950; 19 hits in 1057 CRISPR screens.
DR GenomeRNAi; 254950; -.
DR Pharos; Q3LI76; Tdark.
DR PRO; PR:Q3LI76; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q3LI76; protein.
DR Bgee; ENSG00000186970; Expressed in olfactory segment of nasal mucosa.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR007951; KRTAP_PMG.
DR PANTHER; PTHR19051; PTHR19051; 1.
DR Pfam; PF05287; PMG; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome.
FT CHAIN 1..137
FT /note="Keratin-associated protein 15-1"
FT /id="PRO_0000223917"
FT VARIANT 43
FT /note="L -> M (in dbSNP:rs2832873)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_047019"
SQ SEQUENCE 137 AA; 14979 MW; 8C68B00CDF87837D CRC64;
MSYNCSSGNF SSCCFGSYLR YPVSTYNLFY PSNAIYSPNT CQLGSSLYNG CQETYCEPTS
CQTSCTLARS YQTSCYCPKN SIFCSPRQTN YIRSLGCGNT GLGSLGCGST GFQSLDCGSS
FYHPTTFSSR NFQATCY
