ID   ARC1A_BOVIN             Reviewed;         370 AA.
AC   Q1JP79; A6QLF5;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Actin-related protein 2/3 complex subunit 1A;
GN   Name=ARPC1A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably functions as component of the Arp2/3 complex which
CC       is involved in regulation of actin polymerization and together with an
CC       activating nucleation-promoting factor (NPF) mediates the formation of
CC       branched actin networks (By similarity). In addition to its role in the
CC       cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin
CC       polymerization in the nucleus, thereby regulating gene transcription
CC       and repair of damaged DNA (By similarity).
CC       {ECO:0000250|UniProtKB:Q8AVT9, ECO:0000250|UniProtKB:Q92747}.
CC   -!- SUBUNIT: Probable component of the Arp2/3 complex in which it may
CC       replace ARPC1B. {ECO:0000250|UniProtKB:Q92747}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q92747}. Nucleus {ECO:0000250|UniProtKB:Q8AVT9}.
CC   -!- SIMILARITY: Belongs to the WD repeat ARPC1 family. {ECO:0000305}.
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DR   EMBL; BT025475; ABF57431.1; -; mRNA.
DR   EMBL; BC147946; AAI47947.1; -; mRNA.
DR   RefSeq; NP_001068827.1; NM_001075359.1.
DR   RefSeq; XP_005225118.1; XM_005225061.3.
DR   AlphaFoldDB; Q1JP79; -.
DR   SMR; Q1JP79; -.
DR   STRING; 9913.ENSBTAP00000005555; -.
DR   PaxDb; Q1JP79; -.
DR   PRIDE; Q1JP79; -.
DR   Ensembl; ENSBTAT00000005555; ENSBTAP00000005555; ENSBTAG00000004242.
DR   GeneID; 508402; -.
DR   KEGG; bta:508402; -.
DR   CTD; 10552; -.
DR   VEuPathDB; HostDB:ENSBTAG00000004242; -.
DR   VGNC; VGNC:50215; ARPC1A.
DR   eggNOG; KOG1523; Eukaryota.
DR   GeneTree; ENSGT00950000183183; -.
DR   HOGENOM; CLU_034396_1_0_1; -.
DR   InParanoid; Q1JP79; -.
DR   OMA; YVWEPSP; -.
DR   OrthoDB; 848569at2759; -.
DR   TreeFam; TF315041; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000004242; Expressed in surface of tongue and 105 other tissues.
DR   ExpressionAtlas; Q1JP79; baseline and differential.
DR   GO; GO:0005885; C:Arp2/3 protein complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0035861; C:site of double-strand break; ISS:UniProtKB.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IBA:GO_Central.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR030140; ARC1A.
DR   InterPro; IPR017383; ARPC1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10709; PTHR10709; 1.
DR   PANTHER; PTHR10709:SF11; PTHR10709:SF11; 1.
DR   Pfam; PF00400; WD40; 2.
DR   PIRSF; PIRSF038093; ARP2/3_su1; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..370
FT                   /note="Actin-related protein 2/3 complex subunit 1A"
FT                   /id="PRO_0000254024"
FT   REPEAT          6..45
FT                   /note="WD 1"
FT   REPEAT          50..89
FT                   /note="WD 2"
FT   REPEAT          140..179
FT                   /note="WD 3"
FT   REPEAT          202..241
FT                   /note="WD 4"
FT   REPEAT          244..284
FT                   /note="WD 5"
FT   REPEAT          322..365
FT                   /note="WD 6"
SQ   SEQUENCE   370 AA;  41539 MW;  59A1CAC85CC769AA CRC64;
     MSLHQFLLEP ITCHAWNRDR TQIALSPNNH EVHIYKKNGG QWVKAHELKE HNGHITGIDW
     APKSDRIVTC GADRNAYVWS QKDGVWKPTL VILRINRAAT FVKWSPLENK FAVGSGARLI
     SVCYFESEND WWVSKHIKKP IRSTVLSLDW HPNNVLLAAG SCDFKCRVFS AYIKEVDEKP
     ASTPWGSKMP FGQLMSEFGG SGTGGWVHGV SFSASGSRLA WVSHDSTVSV ADASKSVQVS
     TLKTEFLPLL SVSFVSENSV VAAGHDCCPM LFNYDDRGCL TFVSKLDIPK QSIQRNMSAM
     ERFRNMDKRA TTEDRNTALE TLHQNSITQV SIYEVDKQDC RKFCTTGIDG AMTIWDFKTL
     ESSIQGLRIM