KR151_MOUSE
ID KR151_MOUSE Reviewed; 150 AA.
AC Q9QZU5;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Keratin-associated protein 15-1;
DE AltName: Full=Keratin-associated protein 15;
DE AltName: Full=Pubertal mammary gland-specific protein 2;
GN Name=Krtap15-1 {ECO:0000250|UniProtKB:Q3LI76};
GN Synonyms=Krtap15 {ECO:0000312|MGI:MGI:1347350},
GN Pmg2 {ECO:0000312|EMBL:AAD47277.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAD47277.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=10446281; DOI=10.1016/s0925-4773(99)00115-x;
RA Kuhn F., Lassing C., Range A., Mueller M., Hunziker T., Ziemiecki A.,
RA Andres A.-C.;
RT "Pmg-1 and pmg-2 constitute a novel family of KAP genes differentially
RT expressed during skin and mammary gland development.";
RL Mech. Dev. 86:193-196(1999).
RN [2] {ECO:0000312|EMBL:BAE21225.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE21225.1};
RC TISSUE=Skin {ECO:0000312|EMBL:BAE21225.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3] {ECO:0000312|EMBL:AAI16220.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins. {ECO:0000305}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed at high levels in skin and at lower
CC levels in the developing mammary gland. {ECO:0000269|PubMed:10446281}.
CC -!- DEVELOPMENTAL STAGE: In skin, expression starts shortly after birth and
CC reaches a first maximum at 9 days. A second peak of expression is
CC observed at 3.5 weeks, then levels decline and remain low in the adult.
CC In the developing mammary gland, expression is detected exclusively at
CC the onset of puberty. {ECO:0000269|PubMed:10446281}.
CC -!- SIMILARITY: Belongs to the PMG family. {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF162800; AAD47277.1; -; Genomic_DNA.
DR EMBL; AK132534; BAE21225.1; -; mRNA.
DR EMBL; BC116219; AAI16220.1; -; mRNA.
DR CCDS; CCDS79477.1; -.
DR RefSeq; NP_038741.1; NM_013713.1.
DR AlphaFoldDB; Q9QZU5; -.
DR STRING; 10090.ENSMUSP00000140888; -.
DR iPTMnet; Q9QZU5; -.
DR PhosphoSitePlus; Q9QZU5; -.
DR PRIDE; Q9QZU5; -.
DR ProteomicsDB; 263563; -.
DR Antibodypedia; 6633; 7 antibodies from 3 providers.
DR DNASU; 26560; -.
DR Ensembl; ENSMUST00000187823; ENSMUSP00000140888; ENSMUSG00000022931.
DR GeneID; 26560; -.
DR KEGG; mmu:26560; -.
DR UCSC; uc007zvg.1; mouse.
DR CTD; 26560; -.
DR MGI; MGI:1347350; Krtap15.
DR VEuPathDB; HostDB:ENSMUSG00000022931; -.
DR eggNOG; ENOG502TD2Y; Eukaryota.
DR GeneTree; ENSGT00940000162109; -.
DR HOGENOM; CLU_111618_0_0_1; -.
DR InParanoid; Q9QZU5; -.
DR OMA; TCDSFYP; -.
DR OrthoDB; 1292816at2759; -.
DR PhylomeDB; Q9QZU5; -.
DR BioGRID-ORCS; 26560; 1 hit in 63 CRISPR screens.
DR PRO; PR:Q9QZU5; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9QZU5; protein.
DR Bgee; ENSMUSG00000022931; Expressed in lip and 6 other tissues.
DR ExpressionAtlas; Q9QZU5; baseline and differential.
DR Genevisible; Q9QZU5; MM.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR007951; KRTAP_PMG.
DR PANTHER; PTHR19051; PTHR19051; 1.
DR Pfam; PF05287; PMG; 1.
PE 2: Evidence at transcript level;
KW Keratin; Reference proteome.
FT CHAIN 1..150
FT /note="Keratin-associated protein 15-1"
FT /id="PRO_0000271177"
SQ SEQUENCE 150 AA; 16242 MW; 60A1E3A5F6F04BDA CRC64;
MSYTCNSGNY SSQSFGGFLR QPVSTYNSFY PTSNVVYSPK NFQLGSSFYN GQQETFSEPL
EGHLPCVGSA SFHTSCFRPK QYFSSPCQGG FTGSFGYGNT GFGAFGFGSS GIRSQGCGSN
FYRPGYFSSK SIQSSYYQPG YSSGFCGSNF
