KR15_ICHVA
ID KR15_ICHVA Reviewed; 380 AA.
AC Q00097;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Protein kinase ORF15;
DE EC=2.7.11.1;
GN Name=ORF15;
OS Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish
OS herpesvirus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Alloherpesviridae; Ictalurivirus.
OX NCBI_TaxID=766178;
OH NCBI_TaxID=7996; Ictaluridae (bullhead catfishes).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Auburn 1;
RX PubMed=1727613; DOI=10.1016/0042-6822(92)90056-u;
RA Davison A.J.;
RT "Channel catfish virus: a new type of herpesvirus.";
RL Virology 186:9-14(1992).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; M75136; AAA88118.1; -; Genomic_DNA.
DR PIR; G36787; TVBEI2.
DR RefSeq; NP_041106.1; NC_001493.2.
DR GeneID; 1488379; -.
DR KEGG; vg:1488379; -.
DR Proteomes; UP000007643; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..380
FT /note="Protein kinase ORF15"
FT /id="PRO_0000086173"
FT DOMAIN 93..371
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT ACT_SITE 217
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 118
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 380 AA; 42419 MW; E94270BF6462ABA7 CRC64;
MAAVNWLKDE PYPEKPTRRN HLSFGPARLP TGDWDWIMTY YKPEAREWLR TMNNPLWSGP
EDVLGLLPAG VPVTEKIFVK EVYPGLKGFL QMFIPVKVAG CLLFGFSPLS RTGMATLKTA
PVFRGGYAPA APGIPMQVYA WEMACKIDAA PRLFKWELIV GEYFVRLATL SECSAGGDVG
AYIRGGRPIS IEAAAVKTRE LASTLYLLAQ NNVYHGDVKI ANTVITEPHG RLGLIDFEMA
HPLDMTMSGL REGLEVPIKW DMVCTDEYRA PEGHGPFPDI LSAEAQLVWQ VGLFMLDVIG
IEIIENRNQG LWEQPDFPGL AAREVGIGRS LLACEHRAFL DYLTIARGCL RTNPRERPRL
TLLIAQLTKF IREVATQPEH
