KR161_HUMAN
ID KR161_HUMAN Reviewed; 517 AA.
AC A8MUX0;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Keratin-associated protein 16-1;
GN Name=KRTAP16-1; Synonyms=KAP16.1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the KRTAP type 16 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC003958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471152; EAW60725.1; -; Genomic_DNA.
DR CCDS; CCDS56032.1; -.
DR RefSeq; NP_001139654.1; NM_001146182.1.
DR AlphaFoldDB; A8MUX0; -.
DR BioGRID; 394227; 1.
DR STRING; 9606.ENSP00000375147; -.
DR PhosphoSitePlus; A8MUX0; -.
DR BioMuta; KRTAP16-1; -.
DR MassIVE; A8MUX0; -.
DR PaxDb; A8MUX0; -.
DR PeptideAtlas; A8MUX0; -.
DR PRIDE; A8MUX0; -.
DR Antibodypedia; 77982; 4 antibodies from 4 providers.
DR DNASU; 100505753; -.
DR Ensembl; ENST00000391352.2; ENSP00000375147.1; ENSG00000212657.2.
DR Ensembl; ENST00000572734.1; ENSP00000460805.1; ENSG00000263186.1.
DR GeneID; 100505753; -.
DR KEGG; hsa:100505753; -.
DR MANE-Select; ENST00000391352.2; ENSP00000375147.1; NM_001146182.2; NP_001139654.1.
DR UCSC; uc021txi.1; human.
DR CTD; 100505753; -.
DR GeneCards; KRTAP16-1; -.
DR HGNC; HGNC:18916; KRTAP16-1.
DR HPA; ENSG00000212657; Tissue enriched (skin).
DR neXtProt; NX_A8MUX0; -.
DR PharmGKB; PA134895884; -.
DR VEuPathDB; HostDB:ENSG00000212657; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000163658; -.
DR HOGENOM; CLU_573136_0_0_1; -.
DR InParanoid; A8MUX0; -.
DR OMA; TCEDSCG; -.
DR OrthoDB; 1286075at2759; -.
DR PhylomeDB; A8MUX0; -.
DR PathwayCommons; A8MUX0; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; A8MUX0; -.
DR BioGRID-ORCS; 100505753; 6 hits in 1057 CRISPR screens.
DR Pharos; A8MUX0; Tdark.
DR PRO; PR:A8MUX0; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; A8MUX0; protein.
DR Bgee; ENSG00000212657; Expressed in granulocyte and 15 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 3.
DR Pfam; PF13885; Keratin_B2_2; 5.
PE 3: Inferred from homology;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..517
FT /note="Keratin-associated protein 16-1"
FT /id="PRO_0000348959"
FT REPEAT 73..77
FT /note="1"
FT REPEAT 93..97
FT /note="2"
FT REPEAT 128..132
FT /note="3"
FT REPEAT 153..157
FT /note="4"
FT REPEAT 168..172
FT /note="5"
FT REPEAT 198..202
FT /note="6"
FT REPEAT 208..212
FT /note="7"
FT REPEAT 228..232
FT /note="8"
FT REPEAT 248..252
FT /note="9"
FT REPEAT 283..287
FT /note="10"
FT REPEAT 303..307
FT /note="11"
FT REGION 73..307
FT /note="11 X 5 AA repeats of C-C-X(3)"
FT REGION 483..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 53912 MW; 07C37A6458478222 CRC64;
MSGSCSSRKC FSVPATSLCS TEVSCGGPIC LPSSCQSQTW QLVTCQDSCG SSSCGPQCRQ
PSCPVSSCAQ PLCCDPVICE PSCSVSSGCQ PVCCEATTCE PSCSVSNCYQ PVCFEATICE
PSCSVSNCCQ PVCFEATVCE PSCSVSSCAQ PVCCEPAICE PSCSVSSCCQ PVGSEATSCQ
PVLCVPTSCQ PVLCKSSCCQ PVVCEPSCCS AVCTLPSSCQ PVVCEPSCCQ PVCPTPTCSV
TSSCQAVCCD PSPCEPSCSE SSICQPATCV ALVCEPVCLR PVCCVQSSCE PPSVPSTCQE
PSCCVSSICQ PICSEPSPCS PAVCVSSPCQ PTCYVVKRCP SVCPEPVSCP STSCRPLSCS
PGSSASAICR PTCPRTFYIP SSSKRPCSAT ISYRPVSRPI CRPICSGLLT YRQPYMTSIS
YRPACYRPCY SILRRPACVT SYSCRPVYFR PSCTESDSCK RDCKKSTSSQ LDCVDTTPCK
VDVSEEAPCQ PTEAKPISPT TREAAAAQPA ASKPANC
