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KR161_MOUSE
ID   KR161_MOUSE             Reviewed;         502 AA.
AC   A2A5X5;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Keratin-associated protein 16-1;
GN   Name=Krtap16-1; Synonyms=Gm11570;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 16 family. {ECO:0000305}.
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DR   EMBL; AL592545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS56804.1; -.
DR   RefSeq; NP_001242986.1; NM_001256057.1.
DR   AlphaFoldDB; A2A5X5; -.
DR   STRING; 10090.ENSMUSP00000100671; -.
DR   iPTMnet; A2A5X5; -.
DR   PhosphoSitePlus; A2A5X5; -.
DR   PaxDb; A2A5X5; -.
DR   PRIDE; A2A5X5; -.
DR   ProteomicsDB; 264797; -.
DR   Antibodypedia; 77982; 4 antibodies from 4 providers.
DR   Ensembl; ENSMUST00000105050; ENSMUSP00000100671; ENSMUSG00000078253.
DR   GeneID; 100504183; -.
DR   KEGG; mmu:100504183; -.
DR   UCSC; uc029rod.1; mouse.
DR   CTD; 100505753; -.
DR   MGI; MGI:3650326; Krtap16-1.
DR   VEuPathDB; HostDB:ENSMUSG00000078253; -.
DR   eggNOG; KOG4726; Eukaryota.
DR   GeneTree; ENSGT00940000163658; -.
DR   HOGENOM; CLU_573136_0_0_1; -.
DR   InParanoid; A2A5X5; -.
DR   OMA; TCEDSCG; -.
DR   OrthoDB; 1286075at2759; -.
DR   PhylomeDB; A2A5X5; -.
DR   Reactome; R-MMU-6805567; Keratinization.
DR   BioGRID-ORCS; 100504183; 2 hits in 70 CRISPR screens.
DR   PRO; PR:A2A5X5; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; A2A5X5; protein.
DR   Bgee; ENSMUSG00000078253; Expressed in lip and 3 other tissues.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   InterPro; IPR002494; KAP.
DR   PANTHER; PTHR23262; PTHR23262; 4.
DR   Pfam; PF13885; Keratin_B2_2; 2.
PE   3: Inferred from homology;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..502
FT                   /note="Keratin-associated protein 16-1"
FT                   /id="PRO_0000348960"
FT   REPEAT          4..8
FT                   /note="1"
FT   REPEAT          58..62
FT                   /note="2"
FT   REPEAT          73..77
FT                   /note="3"
FT   REPEAT          93..97
FT                   /note="4"
FT   REPEAT          108..112
FT                   /note="5"
FT   REPEAT          113..117
FT                   /note="6"
FT   REPEAT          133..137
FT                   /note="7"
FT   REPEAT          152..156
FT                   /note="8"
FT   REPEAT          177..181
FT                   /note="9"
FT   REPEAT          187..191
FT                   /note="10"
FT   REPEAT          212..216
FT                   /note="11"
FT   REPEAT          222..226
FT                   /note="12"
FT   REPEAT          272..276
FT                   /note="13"
FT   REPEAT          292..296
FT                   /note="14"
FT   REPEAT          347..351
FT                   /note="15"
FT   REGION          73..307
FT                   /note="15 X 5 AA repeats of C-C-X(3)"
FT   REGION          435..502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        452..473
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   502 AA;  52020 MW;  5C203CF3DAA808F2 CRC64;
     MSGCCCSRKC PSLPAISLCS TEVSCGGPVC LPSSCRSQTW QLVTCEDSCG SSGCGSQCCQ
     PSCSVSSCCQ PVCCEATICE PSCSVSSCAQ PVCCEATICE PSCSMGSCCQ PVCCEATICE
     PSCSVSTCAQ PVCCEATMCQ PSCSVSSCQP VCCETSSCQP VLCLPATCQP VICKPCCCQP
     VICEPSCCSA VCAVPASCQP MICEPVVCEP ACCQPVCPTP SCCPSVCSAA SSCQPVGCET
     SPCEPPCSEA SACQPSACMA LVCEPVCLRP VCCVQGPCEP PCVSSSCQDS SCCVSSICQP
     VCPEPSPCLP SVCVPTPCQP SCYIVKRCRS VSCEPISCPS PSCQPACCRP GSSASAICQP
     ACPPRTFYIP SSCKPPCSPV SCRPICRPIC SGPITFRQPY VTSITYRPAC YRSCYSILRR
     PTCLASYSYR PVCSRQPCTD SDNDKCDSKK PTSSQPDCAD STPVKTEVSD ETPCQPSEIK
     PASPITREAA APQPAASKPA DR
 
 
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