KR161_MOUSE
ID KR161_MOUSE Reviewed; 502 AA.
AC A2A5X5;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Keratin-associated protein 16-1;
GN Name=Krtap16-1; Synonyms=Gm11570;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the KRTAP type 16 family. {ECO:0000305}.
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DR EMBL; AL592545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS56804.1; -.
DR RefSeq; NP_001242986.1; NM_001256057.1.
DR AlphaFoldDB; A2A5X5; -.
DR STRING; 10090.ENSMUSP00000100671; -.
DR iPTMnet; A2A5X5; -.
DR PhosphoSitePlus; A2A5X5; -.
DR PaxDb; A2A5X5; -.
DR PRIDE; A2A5X5; -.
DR ProteomicsDB; 264797; -.
DR Antibodypedia; 77982; 4 antibodies from 4 providers.
DR Ensembl; ENSMUST00000105050; ENSMUSP00000100671; ENSMUSG00000078253.
DR GeneID; 100504183; -.
DR KEGG; mmu:100504183; -.
DR UCSC; uc029rod.1; mouse.
DR CTD; 100505753; -.
DR MGI; MGI:3650326; Krtap16-1.
DR VEuPathDB; HostDB:ENSMUSG00000078253; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000163658; -.
DR HOGENOM; CLU_573136_0_0_1; -.
DR InParanoid; A2A5X5; -.
DR OMA; TCEDSCG; -.
DR OrthoDB; 1286075at2759; -.
DR PhylomeDB; A2A5X5; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR BioGRID-ORCS; 100504183; 2 hits in 70 CRISPR screens.
DR PRO; PR:A2A5X5; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; A2A5X5; protein.
DR Bgee; ENSMUSG00000078253; Expressed in lip and 3 other tissues.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 4.
DR Pfam; PF13885; Keratin_B2_2; 2.
PE 3: Inferred from homology;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..502
FT /note="Keratin-associated protein 16-1"
FT /id="PRO_0000348960"
FT REPEAT 4..8
FT /note="1"
FT REPEAT 58..62
FT /note="2"
FT REPEAT 73..77
FT /note="3"
FT REPEAT 93..97
FT /note="4"
FT REPEAT 108..112
FT /note="5"
FT REPEAT 113..117
FT /note="6"
FT REPEAT 133..137
FT /note="7"
FT REPEAT 152..156
FT /note="8"
FT REPEAT 177..181
FT /note="9"
FT REPEAT 187..191
FT /note="10"
FT REPEAT 212..216
FT /note="11"
FT REPEAT 222..226
FT /note="12"
FT REPEAT 272..276
FT /note="13"
FT REPEAT 292..296
FT /note="14"
FT REPEAT 347..351
FT /note="15"
FT REGION 73..307
FT /note="15 X 5 AA repeats of C-C-X(3)"
FT REGION 435..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 502 AA; 52020 MW; 5C203CF3DAA808F2 CRC64;
MSGCCCSRKC PSLPAISLCS TEVSCGGPVC LPSSCRSQTW QLVTCEDSCG SSGCGSQCCQ
PSCSVSSCCQ PVCCEATICE PSCSVSSCAQ PVCCEATICE PSCSMGSCCQ PVCCEATICE
PSCSVSTCAQ PVCCEATMCQ PSCSVSSCQP VCCETSSCQP VLCLPATCQP VICKPCCCQP
VICEPSCCSA VCAVPASCQP MICEPVVCEP ACCQPVCPTP SCCPSVCSAA SSCQPVGCET
SPCEPPCSEA SACQPSACMA LVCEPVCLRP VCCVQGPCEP PCVSSSCQDS SCCVSSICQP
VCPEPSPCLP SVCVPTPCQP SCYIVKRCRS VSCEPISCPS PSCQPACCRP GSSASAICQP
ACPPRTFYIP SSCKPPCSPV SCRPICRPIC SGPITFRQPY VTSITYRPAC YRSCYSILRR
PTCLASYSYR PVCSRQPCTD SDNDKCDSKK PTSSQPDCAD STPVKTEVSD ETPCQPSEIK
PASPITREAA APQPAASKPA DR