KR171_HUMAN
ID KR171_HUMAN Reviewed; 105 AA.
AC Q9BYP8;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Keratin-associated protein 17-1;
DE AltName: Full=Keratin-associated protein 16.1;
GN Name=KRTAP17-1; Synonyms=KAP17.1, KRTAP16.1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Scalp;
RX PubMed=11279113; DOI=10.1074/jbc.m100657200;
RA Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B.,
RA Schweizer J.;
RT "Characterization of a cluster of human high/ultrahigh sulfur keratin-
RT associated protein genes embedded in the type I keratin gene domain on
RT chromosome 17q12-21.";
RL J. Biol. Chem. 276:19440-19451(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9BYP8; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-11988175, EBI-744545;
CC Q9BYP8; Q8N6W0: CELF5; NbExp=3; IntAct=EBI-11988175, EBI-12139335;
CC Q9BYP8; Q8NE01: CNNM3; NbExp=5; IntAct=EBI-11988175, EBI-741032;
CC Q9BYP8; Q92608: DOCK2; NbExp=3; IntAct=EBI-11988175, EBI-448771;
CC Q9BYP8; P43220: GLP1R; NbExp=3; IntAct=EBI-11988175, EBI-7466542;
CC Q9BYP8; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-11988175, EBI-11975289;
CC Q9BYP8; P17482: HOXB9; NbExp=3; IntAct=EBI-11988175, EBI-745290;
CC Q9BYP8; P37235: HPCAL1; NbExp=3; IntAct=EBI-11988175, EBI-749311;
CC Q9BYP8; P16144-2: ITGB4; NbExp=3; IntAct=EBI-11988175, EBI-11051601;
CC Q9BYP8; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11988175, EBI-10171774;
CC Q9BYP8; Q9BYQ6: KRTAP4-11; NbExp=5; IntAct=EBI-11988175, EBI-10302392;
CC Q9BYP8; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-11988175, EBI-11958132;
CC Q9BYP8; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-11988175, EBI-11993296;
CC Q9BYP8; Q6L8G9: KRTAP5-6; NbExp=5; IntAct=EBI-11988175, EBI-10250562;
CC Q9BYP8; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11988175, EBI-1044640;
CC Q9BYP8; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-11988175, EBI-11958364;
CC Q9BYP8; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-11988175, EBI-10245913;
CC Q9BYP8; Q5T753: LCE1E; NbExp=3; IntAct=EBI-11988175, EBI-11955335;
CC Q9BYP8; O14633: LCE2B; NbExp=4; IntAct=EBI-11988175, EBI-11478468;
CC Q9BYP8; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-11988175, EBI-11973993;
CC Q9BYP8; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-11988175, EBI-10246750;
CC Q9BYP8; Q5TA76: LCE3A; NbExp=5; IntAct=EBI-11988175, EBI-9394625;
CC Q9BYP8; Q5T5A8: LCE3C; NbExp=5; IntAct=EBI-11988175, EBI-10245291;
CC Q9BYP8; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-11988175, EBI-6658837;
CC Q9BYP8; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-11988175, EBI-10246358;
CC Q9BYP8; Q9NV56: MRGBP; NbExp=3; IntAct=EBI-11988175, EBI-399076;
CC Q9BYP8; P07438: MT1B; NbExp=3; IntAct=EBI-11988175, EBI-12015462;
CC Q9BYP8; Q8N339: MT1M; NbExp=3; IntAct=EBI-11988175, EBI-3911571;
CC Q9BYP8; P48645: NMU; NbExp=5; IntAct=EBI-11988175, EBI-10210351;
CC Q9BYP8; P32242: OTX1; NbExp=3; IntAct=EBI-11988175, EBI-740446;
CC Q9BYP8; O43741: PRKAB2; NbExp=3; IntAct=EBI-11988175, EBI-1053424;
CC Q9BYP8; P04554: PRM2; NbExp=3; IntAct=EBI-11988175, EBI-9681663;
CC Q9BYP8; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-11988175, EBI-11955083;
CC Q9BYP8; P0CI01: SPDYE6; NbExp=3; IntAct=EBI-11988175, EBI-11960469;
CC Q9BYP8; Q9BT49: THAP7; NbExp=3; IntAct=EBI-11988175, EBI-741350;
CC Q9BYP8; Q08117-2: TLE5; NbExp=3; IntAct=EBI-11988175, EBI-11741437;
CC Q9BYP8; Q6EMK4: VASN; NbExp=3; IntAct=EBI-11988175, EBI-10249550;
CC Q9BYP8; O96014: WNT11; NbExp=5; IntAct=EBI-11988175, EBI-8058160;
CC Q9BYP8; P25490: YY1; NbExp=3; IntAct=EBI-11988175, EBI-765538;
CC Q9BYP8; P24278: ZBTB25; NbExp=3; IntAct=EBI-11988175, EBI-739899;
CC Q9BYP8; Q8WTX9: ZDHHC1; NbExp=3; IntAct=EBI-11988175, EBI-2818796;
CC Q9BYP8; Q8IZC7: ZNF101; NbExp=3; IntAct=EBI-11988175, EBI-5278328;
CC Q9BYP8; Q86XF7: ZNF575; NbExp=3; IntAct=EBI-11988175, EBI-14069183;
CC Q9BYP8; Q96N58: ZNF578; NbExp=3; IntAct=EBI-11988175, EBI-11955189;
CC Q9BYP8; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-11988175, EBI-11090299;
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DR EMBL; AJ406952; CAC27591.1; -; mRNA.
DR EMBL; BC069297; AAH69297.1; -; mRNA.
DR EMBL; BC069078; AAH69078.1; -; mRNA.
DR CCDS; CCDS11387.1; -.
DR RefSeq; NP_114170.1; NM_031964.1.
DR AlphaFoldDB; Q9BYP8; -.
DR BioGRID; 123813; 47.
DR IntAct; Q9BYP8; 45.
DR STRING; 9606.ENSP00000333993; -.
DR BioMuta; KRTAP17-1; -.
DR PaxDb; Q9BYP8; -.
DR PeptideAtlas; Q9BYP8; -.
DR PRIDE; Q9BYP8; -.
DR DNASU; 83902; -.
DR Ensembl; ENST00000334202.5; ENSP00000333993.3; ENSG00000186860.5.
DR Ensembl; ENST00000574858.1; ENSP00000460320.1; ENSG00000263341.1.
DR GeneID; 83902; -.
DR KEGG; hsa:83902; -.
DR MANE-Select; ENST00000334202.5; ENSP00000333993.3; NM_031964.2; NP_114170.1.
DR UCSC; uc002hwj.3; human.
DR CTD; 83902; -.
DR GeneCards; KRTAP17-1; -.
DR HGNC; HGNC:18917; KRTAP17-1.
DR HPA; ENSG00000186860; Tissue enriched (skin).
DR neXtProt; NX_Q9BYP8; -.
DR OpenTargets; ENSG00000186860; -.
DR PharmGKB; PA38763; -.
DR VEuPathDB; HostDB:ENSG00000186860; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00950000183407; -.
DR HOGENOM; CLU_173435_0_0_1; -.
DR InParanoid; Q9BYP8; -.
DR OMA; QEQDCCE; -.
DR PathwayCommons; Q9BYP8; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q9BYP8; -.
DR BioGRID-ORCS; 83902; 12 hits in 1055 CRISPR screens.
DR GenomeRNAi; 83902; -.
DR Pharos; Q9BYP8; Tdark.
DR PRO; PR:Q9BYP8; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9BYP8; protein.
DR Bgee; ENSG00000186860; Expressed in skin of abdomen and 22 other tissues.
DR Genevisible; Q9BYP8; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..105
FT /note="Keratin-associated protein 17-1"
FT /id="PRO_0000223903"
SQ SEQUENCE 105 AA; 9504 MW; AA633F91BD800582 CRC64;
MGCCPGDCFT CCTQEQNCCE ECCCQPGCCG CCGSCCGCGG SGCGGSGCGG SCCGSSCCGS
GCGGCGGCGG CGGGCCGSSC CGSSCCGSGC CGPVCCQPTP ICDTK
