KR191_HUMAN
ID KR191_HUMAN Reviewed; 90 AA.
AC Q8IUB9; A4QN27; Q3LI75;
DT 03-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2006, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Keratin-associated protein 19-1;
DE AltName: Full=High tyrosine-glycine keratin-associated protein 19.1;
GN Name=KRTAP19-1; Synonyms=KAP19.1, KRTAP19.1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hair root;
RA Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT "Identification of complete keratin-associated protein (KAP) gene cluster
RT spanning 800 kb region on human chromosome 21q22.11.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 3-90.
RC TISSUE=Scalp;
RX PubMed=12359730; DOI=10.1074/jbc.m206422200;
RA Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Schweizer J.;
RT "Characterization of a first domain of human high glycine-tyrosine and high
RT sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1.";
RL J. Biol. Chem. 277:48993-49002(2002).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC Q8IUB9; Q92870-2: APBB2; NbExp=3; IntAct=EBI-12811111, EBI-21535880;
CC Q8IUB9; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-12811111, EBI-12006308;
CC Q8IUB9; P54253: ATXN1; NbExp=3; IntAct=EBI-12811111, EBI-930964;
CC Q8IUB9; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-12811111, EBI-742750;
CC Q8IUB9; P41182: BCL6; NbExp=3; IntAct=EBI-12811111, EBI-765407;
CC Q8IUB9; O14503: BHLHE40; NbExp=3; IntAct=EBI-12811111, EBI-711810;
CC Q8IUB9; Q6NUJ2: C11orf87; NbExp=3; IntAct=EBI-12811111, EBI-6660291;
CC Q8IUB9; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-12811111, EBI-744556;
CC Q8IUB9; Q8N4L8: CCDC24; NbExp=5; IntAct=EBI-12811111, EBI-1104933;
CC Q8IUB9; Q8TCT0: CERK; NbExp=3; IntAct=EBI-12811111, EBI-10274247;
CC Q8IUB9; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-12811111, EBI-3867333;
CC Q8IUB9; Q15038: DAZAP2; NbExp=3; IntAct=EBI-12811111, EBI-724310;
CC Q8IUB9; P50570-2: DNM2; NbExp=3; IntAct=EBI-12811111, EBI-10968534;
CC Q8IUB9; Q86UW9: DTX2; NbExp=3; IntAct=EBI-12811111, EBI-740376;
CC Q8IUB9; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-12811111, EBI-744099;
CC Q8IUB9; Q92567-2: FAM168A; NbExp=3; IntAct=EBI-12811111, EBI-11978259;
CC Q8IUB9; Q12951-2: FOXI1; NbExp=3; IntAct=EBI-12811111, EBI-12018822;
CC Q8IUB9; Q9Y5R4: HEMK1; NbExp=3; IntAct=EBI-12811111, EBI-10329202;
CC Q8IUB9; Q03014: HHEX; NbExp=3; IntAct=EBI-12811111, EBI-747421;
CC Q8IUB9; Q0VD86: INCA1; NbExp=3; IntAct=EBI-12811111, EBI-6509505;
CC Q8IUB9; Q9C086: INO80B; NbExp=3; IntAct=EBI-12811111, EBI-715611;
CC Q8IUB9; Q5T749: KPRP; NbExp=3; IntAct=EBI-12811111, EBI-10981970;
CC Q8IUB9; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-12811111, EBI-11992140;
CC Q8IUB9; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-12811111, EBI-11022007;
CC Q8IUB9; Q9UBV8: PEF1; NbExp=3; IntAct=EBI-12811111, EBI-724639;
CC Q8IUB9; Q7Z412: PEX26; NbExp=3; IntAct=EBI-12811111, EBI-752057;
CC Q8IUB9; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-12811111, EBI-769257;
CC Q8IUB9; D3DTS7: PMP22; NbExp=3; IntAct=EBI-12811111, EBI-25882629;
CC Q8IUB9; O75360: PROP1; NbExp=3; IntAct=EBI-12811111, EBI-9027467;
CC Q8IUB9; P86480: PRR20D; NbExp=3; IntAct=EBI-12811111, EBI-12754095;
CC Q8IUB9; P20618: PSMB1; NbExp=3; IntAct=EBI-12811111, EBI-372273;
CC Q8IUB9; P49721: PSMB2; NbExp=3; IntAct=EBI-12811111, EBI-359335;
CC Q8IUB9; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-12811111, EBI-740343;
CC Q8IUB9; Q9H310-3: RHBG; NbExp=3; IntAct=EBI-12811111, EBI-12006870;
CC Q8IUB9; Q7L0R7: RNF44; NbExp=3; IntAct=EBI-12811111, EBI-2845060;
CC Q8IUB9; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-12811111, EBI-6257312;
CC Q8IUB9; Q16637: SMN2; NbExp=3; IntAct=EBI-12811111, EBI-395421;
CC Q8IUB9; P14678-2: SNRPB; NbExp=3; IntAct=EBI-12811111, EBI-372475;
CC Q8IUB9; Q8WW24: TEKT4; NbExp=5; IntAct=EBI-12811111, EBI-750487;
CC Q8IUB9; O43711: TLX3; NbExp=3; IntAct=EBI-12811111, EBI-3939165;
CC Q8IUB9; O14656-2: TOR1A; NbExp=3; IntAct=EBI-12811111, EBI-25847109;
CC Q8IUB9; O95231: VENTX; NbExp=5; IntAct=EBI-12811111, EBI-10191303;
CC Q8IUB9; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-12811111, EBI-11957216;
CC Q8IUB9; Q96K80: ZC3H10; NbExp=3; IntAct=EBI-12811111, EBI-742550;
CC Q8IUB9; Q15915: ZIC1; NbExp=3; IntAct=EBI-12811111, EBI-11963196;
CC Q8IUB9; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-12811111, EBI-744257;
CC Q8IUB9; Q96F45: ZNF503; NbExp=3; IntAct=EBI-12811111, EBI-8832437;
CC Q8IUB9; Q96EJ4; NbExp=3; IntAct=EBI-12811111, EBI-750454;
CC -!- TISSUE SPECIFICITY: Detected in the upper portion of the hair cortex.
CC -!- SIMILARITY: Belongs to the KRTAP type 19 family. {ECO:0000305}.
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DR EMBL; AB096943; BAE46358.1; -; mRNA.
DR EMBL; AP000567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471079; EAX09898.1; -; Genomic_DNA.
DR EMBL; BC126284; AAI26285.1; -; mRNA.
DR EMBL; BC126286; AAI26287.1; -; mRNA.
DR EMBL; AJ457067; CAD29723.1; -; mRNA.
DR CCDS; CCDS13594.1; -.
DR RefSeq; NP_853638.1; NM_181607.1.
DR AlphaFoldDB; Q8IUB9; -.
DR BioGRID; 130627; 46.
DR IntAct; Q8IUB9; 48.
DR STRING; 9606.ENSP00000375108; -.
DR BioMuta; KRTAP19-1; -.
DR DMDM; 88984327; -.
DR MassIVE; Q8IUB9; -.
DR PaxDb; Q8IUB9; -.
DR PeptideAtlas; Q8IUB9; -.
DR PRIDE; Q8IUB9; -.
DR ProteomicsDB; 70538; -.
DR DNASU; 337882; -.
DR Ensembl; ENST00000390689.3; ENSP00000375108.2; ENSG00000184351.8.
DR GeneID; 337882; -.
DR KEGG; hsa:337882; -.
DR MANE-Select; ENST00000390689.3; ENSP00000375108.2; NM_181607.3; NP_853638.1.
DR UCSC; uc011acx.3; human.
DR CTD; 337882; -.
DR GeneCards; KRTAP19-1; -.
DR HGNC; HGNC:18936; KRTAP19-1.
DR HPA; ENSG00000184351; Tissue enriched (skin).
DR neXtProt; NX_Q8IUB9; -.
DR OpenTargets; ENSG00000184351; -.
DR PharmGKB; PA134956142; -.
DR VEuPathDB; HostDB:ENSG00000184351; -.
DR eggNOG; ENOG502TDP7; Eukaryota.
DR GeneTree; ENSGT00950000183970; -.
DR HOGENOM; CLU_184630_0_0_1; -.
DR OMA; FGCGSFC; -.
DR PathwayCommons; Q8IUB9; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q8IUB9; -.
DR BioGRID-ORCS; 337882; 5 hits in 1041 CRISPR screens.
DR GenomeRNAi; 337882; -.
DR Pharos; Q8IUB9; Tdark.
DR PRO; PR:Q8IUB9; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q8IUB9; protein.
DR Bgee; ENSG00000184351; Expressed in amniotic fluid and 14 other tissues.
DR Genevisible; Q8IUB9; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR021743; KRTAP_type6/8/16/19/20/21.
DR Pfam; PF11759; KRTAP; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..90
FT /note="Keratin-associated protein 19-1"
FT /id="PRO_0000185221"
FT REGION 5..84
FT /note="26 X 2 AA repeats of G-[YCGS]"
SQ SEQUENCE 90 AA; 9008 MW; C442DB474ACA47A5 CRC64;
MSHYGSYYGG LGYSCGGFGG LGYGYGCGCG SFCRRGSGCG YGGYGYGSGF GSYGYGSGFG
GYGYGSGFGG YGYGCCRPSY NGGYGFSGFY
