ID   KR191_MOUSE             Reviewed;          87 AA.
AC   Q925H2;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Keratin-associated protein 19-1;
DE   AltName: Full=Keratin-associated protein 16-9;
DE   AltName: Full=Keratin-associated protein 16.9 {ECO:0000312|EMBL:AAK52897.1};
GN   Name=Krtap19-1;
GN   Synonyms=Krtap16-9, Krtap16.9 {ECO:0000312|EMBL:AAK52897.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAK52897.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC   STRAIN=FVB/NJ {ECO:0000312|EMBL:AAK52897.1};
RC   TISSUE=Skin {ECO:0000269|PubMed:11290294};
RX   PubMed=11290294; DOI=10.1242/dev.128.9.1547;
RA   Tkatchenko A.V., Visconti R.P., Shang L., Papenbrock T., Pruett N.D.,
RA   Ito T., Ogawa M., Awgulewitsch A.;
RT   "Overexpression of Hoxc13 in differentiating keratinocytes results in
RT   downregulation of a novel hair keratin gene cluster and alopecia.";
RL   Development 128:1547-1558(2001).
RN   [2] {ECO:0000305}
RP   TISSUE SPECIFICITY.
RX   PubMed=15385554; DOI=10.1074/jbc.m404331200;
RA   Pruett N.D., Tkatchenko T.V., Jave-Suarez L., Jacobs D.F., Potter C.S.,
RA   Tkatchenko A.V., Schweizer J., Awgulewitsch A.;
RT   "Krtap16, characterization of a new hair keratin-associated protein (KAP)
RT   gene complex on mouse chromosome 16 and evidence for regulation by
RT   Hoxc13.";
RL   J. Biol. Chem. 279:51524-51533(2004).
RN   [3] {ECO:0000305}
RP   INDUCTION.
RX   PubMed=17151017; DOI=10.1242/dev.02721;
RA   Kurek D., Garinis G.A., van Doorninck J.H., van der Wees J., Grosveld F.G.;
RT   "Transcriptome and phenotypic analysis reveals Gata3-dependent signalling
RT   pathways in murine hair follicles.";
RL   Development 134:261-272(2007).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins. {ECO:0000305}.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Strong expression in narrowly defined pattern
CC       restricted to the lower and middle cortical regions of the hair shaft
CC       in both developing and cycling hair. During hair follicle regression
CC       (catagen), expression levels decrease until expression is no longer
CC       detectable in follicles at resting stage (telogen).
CC       {ECO:0000269|PubMed:15385554}.
CC   -!- INDUCTION: Expression in skin and hair follicle is regulated by HOXC13
CC       and by GATA3. {ECO:0000269|PubMed:11290294,
CC       ECO:0000269|PubMed:17151017}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 19 family. {ECO:0000305}.
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DR   EMBL; AF345299; AAK52897.1; -; mRNA.
DR   CCDS; CCDS49894.1; -.
DR   AlphaFoldDB; Q925H2; -.
DR   STRING; 10090.ENSMUSP00000132718; -.
DR   PaxDb; Q925H2; -.
DR   PRIDE; Q925H2; -.
DR   MGI; MGI:2157755; Krtap19-1.
DR   eggNOG; ENOG502TDPA; Eukaryota.
DR   Reactome; R-MMU-6805567; Keratinization.
DR   ChiTaRS; Krtap19-1; mouse.
DR   PRO; PR:Q925H2; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q925H2; protein.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   InterPro; IPR021743; KRTAP_type6/8/16/19/20/21.
DR   Pfam; PF11759; KRTAP; 1.
PE   2: Evidence at transcript level;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..87
FT                   /note="Keratin-associated protein 19-1"
FT                   /id="PRO_0000356218"
FT   REGION          6..72
FT                   /note="21 X 2 AA repeats of G-[YCGS]"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   87 AA;  8850 MW;  93936AD6E6177369 CRC64;
     MSYYSGYSGG LGYGYGSSFG GPGCGCNSIR RLGCGSGYGG FGYGSGYGGY GYGSDYGGYG
     YGSSYGGYGC GCRRPSCCGR YGFSNFY