KR192_HUMAN
ID KR192_HUMAN Reviewed; 52 AA.
AC Q3LHN2;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Keratin-associated protein 19-2;
GN Name=KRTAP19-2; Synonyms=KAP19.2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hair root;
RA Obayashi I., Shibuya K., Kudoh J., Shimizu N.;
RT "Identification of eight novel genes from keratin associated protein gene
RT cluster on human chromosome 21q22.11.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- INTERACTION:
CC Q3LHN2; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-12196745, EBI-10173507;
CC Q3LHN2; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-12196745, EBI-12224467;
CC Q3LHN2; Q86V38: ATN1; NbExp=3; IntAct=EBI-12196745, EBI-11954292;
CC Q3LHN2; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-12196745, EBI-947551;
CC Q3LHN2; P27658: COL8A1; NbExp=3; IntAct=EBI-12196745, EBI-747133;
CC Q3LHN2; Q02930-3: CREB5; NbExp=3; IntAct=EBI-12196745, EBI-10192698;
CC Q3LHN2; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-12196745, EBI-3867333;
CC Q3LHN2; Q12805: EFEMP1; NbExp=3; IntAct=EBI-12196745, EBI-536772;
CC Q3LHN2; O95571: ETHE1; NbExp=3; IntAct=EBI-12196745, EBI-715318;
CC Q3LHN2; P23142-4: FBLN1; NbExp=3; IntAct=EBI-12196745, EBI-11956479;
CC Q3LHN2; O60548: FOXD2; NbExp=3; IntAct=EBI-12196745, EBI-17282008;
CC Q3LHN2; O75593: FOXH1; NbExp=3; IntAct=EBI-12196745, EBI-1759806;
CC Q3LHN2; Q9Y223-2: GNE; NbExp=5; IntAct=EBI-12196745, EBI-11975289;
CC Q3LHN2; P31273: HOXC8; NbExp=3; IntAct=EBI-12196745, EBI-1752118;
CC Q3LHN2; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-12196745, EBI-3918847;
CC Q3LHN2; Q5T749: KPRP; NbExp=3; IntAct=EBI-12196745, EBI-10981970;
CC Q3LHN2; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-12196745, EBI-10176379;
CC Q3LHN2; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-12196745, EBI-10176396;
CC Q3LHN2; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-12196745, EBI-3957694;
CC Q3LHN2; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-12196745, EBI-739863;
CC Q3LHN2; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-12196745, EBI-1043191;
CC Q3LHN2; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-12196745, EBI-10246750;
CC Q3LHN2; O14770-4: MEIS2; NbExp=5; IntAct=EBI-12196745, EBI-8025850;
CC Q3LHN2; Q13064: MKRN3; NbExp=3; IntAct=EBI-12196745, EBI-2340269;
CC Q3LHN2; Q96HA8: NTAQ1; NbExp=5; IntAct=EBI-12196745, EBI-741158;
CC Q3LHN2; Q7RTU3: OLIG3; NbExp=3; IntAct=EBI-12196745, EBI-10225049;
CC Q3LHN2; P32242: OTX1; NbExp=5; IntAct=EBI-12196745, EBI-740446;
CC Q3LHN2; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-12196745, EBI-11956269;
CC Q3LHN2; Q96S52: PIGS; NbExp=3; IntAct=EBI-12196745, EBI-2908273;
CC Q3LHN2; Q12837: POU4F2; NbExp=3; IntAct=EBI-12196745, EBI-17236143;
CC Q3LHN2; Q9H310-3: RHBG; NbExp=3; IntAct=EBI-12196745, EBI-12006870;
CC Q3LHN2; Q9UP95: SLC12A4; NbExp=3; IntAct=EBI-12196745, EBI-7244836;
CC Q3LHN2; Q8IY34: SLC15A3; NbExp=3; IntAct=EBI-12196745, EBI-12179023;
CC Q3LHN2; Q92922: SMARCC1; NbExp=3; IntAct=EBI-12196745, EBI-355653;
CC Q3LHN2; P09234: SNRPC; NbExp=3; IntAct=EBI-12196745, EBI-766589;
CC Q3LHN2; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-12196745, EBI-11959123;
CC Q3LHN2; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-12196745, EBI-750487;
CC Q3LHN2; Q8NEK8: TENT5D; NbExp=3; IntAct=EBI-12196745, EBI-744726;
CC Q3LHN2; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-12196745, EBI-11952651;
CC Q3LHN2; O95231: VENTX; NbExp=3; IntAct=EBI-12196745, EBI-10191303;
CC Q3LHN2; A8MV65-2: VGLL3; NbExp=5; IntAct=EBI-12196745, EBI-11957216;
CC Q3LHN2; B2RUY7: VWC2L; NbExp=3; IntAct=EBI-12196745, EBI-11747707;
CC Q3LHN2; Q15915: ZIC1; NbExp=3; IntAct=EBI-12196745, EBI-11963196;
CC -!- SIMILARITY: Belongs to the KRTAP type 19 family. {ECO:0000305}.
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DR EMBL; AB180041; BAE46380.1; -; mRNA.
DR CCDS; CCDS13595.1; -.
DR RefSeq; NP_853639.1; NM_181608.1.
DR AlphaFoldDB; Q3LHN2; -.
DR BioGRID; 130652; 46.
DR IntAct; Q3LHN2; 43.
DR STRING; 9606.ENSP00000335660; -.
DR iPTMnet; Q3LHN2; -.
DR PhosphoSitePlus; Q3LHN2; -.
DR BioMuta; KRTAP19-2; -.
DR DMDM; 88909169; -.
DR PaxDb; Q3LHN2; -.
DR PRIDE; Q3LHN2; -.
DR DNASU; 337969; -.
DR Ensembl; ENST00000334055.5; ENSP00000335660.3; ENSG00000186965.5.
DR GeneID; 337969; -.
DR KEGG; hsa:337969; -.
DR MANE-Select; ENST00000334055.5; ENSP00000335660.3; NM_181608.2; NP_853639.1.
DR UCSC; uc011acy.3; human.
DR CTD; 337969; -.
DR GeneCards; KRTAP19-2; -.
DR HGNC; HGNC:18937; KRTAP19-2.
DR HPA; ENSG00000186965; Not detected.
DR neXtProt; NX_Q3LHN2; -.
DR PharmGKB; PA134969992; -.
DR VEuPathDB; HostDB:ENSG00000186965; -.
DR eggNOG; ENOG502TKV3; Eukaryota.
DR GeneTree; ENSGT00860000134229; -.
DR HOGENOM; CLU_184630_0_0_1; -.
DR InParanoid; Q3LHN2; -.
DR OMA; GYEGCRY; -.
DR PathwayCommons; Q3LHN2; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q3LHN2; -.
DR BioGRID-ORCS; 337969; 14 hits in 991 CRISPR screens.
DR GenomeRNAi; 337969; -.
DR Pharos; Q3LHN2; Tdark.
DR PRO; PR:Q3LHN2; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q3LHN2; protein.
DR Bgee; ENSG00000186965; Expressed in granulocyte and 12 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR021743; KRTAP_type6/8/16/19/20/21.
DR Pfam; PF11759; KRTAP; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..52
FT /note="Keratin-associated protein 19-2"
FT /id="PRO_0000223904"
FT VARIANT 5
FT /note="Y -> H (in dbSNP:rs7280687)"
FT /id="VAR_053473"
FT VARIANT 32
FT /note="G -> C (in dbSNP:rs8131735)"
FT /id="VAR_053474"
SQ SEQUENCE 52 AA; 5737 MW; 4693E518F766CE44 CRC64;
MCYGYGCGCG SFCRLGYGCG YEGCRYGCGH RGCGDGCCCP SCYRRYRFTG FY
