ID   KR193_HUMAN             Reviewed;          81 AA.
AC   Q7Z4W3;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Keratin-associated protein 19-3;
DE   AltName: Full=GTHRP;
DE   AltName: Full=Glycine/tyrosine-rich protein;
GN   Name=KRTAP19-3; Synonyms=KAP19.3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Zhou Y., Yu L., Zhao S.Y.;
RT   "Cloning of a new human cDNA homologous to mouse glycine/tyrosine-rich hair
RT   protein.";
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hair root;
RA   Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT   "Identification of complete keratin-associated protein (KAP) gene cluster
RT   spanning 800 kb region on human chromosome 21q22.11.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q7Z4W3; Q03989: ARID5A; NbExp=3; IntAct=EBI-12020132, EBI-948603;
CC       Q7Z4W3; Q8N9W6-4: BOLL; NbExp=3; IntAct=EBI-12020132, EBI-11983447;
CC       Q7Z4W3; Q9UQM7: CAMK2A; NbExp=3; IntAct=EBI-12020132, EBI-1383687;
CC       Q7Z4W3; Q13554-3: CAMK2B; NbExp=3; IntAct=EBI-12020132, EBI-11523526;
CC       Q7Z4W3; Q13555-5: CAMK2G; NbExp=3; IntAct=EBI-12020132, EBI-12020154;
CC       Q7Z4W3; Q02930-3: CREB5; NbExp=3; IntAct=EBI-12020132, EBI-10192698;
CC       Q7Z4W3; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-12020132, EBI-3867333;
CC       Q7Z4W3; Q15038: DAZAP2; NbExp=6; IntAct=EBI-12020132, EBI-724310;
CC       Q7Z4W3; Q9BZE0: GLIS2; NbExp=3; IntAct=EBI-12020132, EBI-7251368;
CC       Q7Z4W3; Q14847-2: LASP1; NbExp=3; IntAct=EBI-12020132, EBI-9088686;
CC       Q7Z4W3; Q96HR8: NAF1; NbExp=3; IntAct=EBI-12020132, EBI-2515597;
CC       Q7Z4W3; Q16633: POU2AF1; NbExp=3; IntAct=EBI-12020132, EBI-943588;
CC       Q7Z4W3; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-12020132, EBI-740343;
CC       Q7Z4W3; Q99954: SMR3A; NbExp=3; IntAct=EBI-12020132, EBI-12067698;
CC       Q7Z4W3; Q15025: TNIP1; NbExp=3; IntAct=EBI-12020132, EBI-357849;
CC       Q7Z4W3; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-12020132, EBI-947187;
CC       Q7Z4W3; Q08AM6: VAC14; NbExp=3; IntAct=EBI-12020132, EBI-2107455;
CC   -!- SIMILARITY: Belongs to the KRTAP type 19 family. {ECO:0000305}.
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DR   EMBL; AF139541; AAP97270.1; -; mRNA.
DR   EMBL; AB096944; BAE46359.1; -; mRNA.
DR   CCDS; CCDS13596.1; -.
DR   RefSeq; NP_853640.1; NM_181609.3.
DR   AlphaFoldDB; Q7Z4W3; -.
DR   BioGRID; 130653; 17.
DR   IntAct; Q7Z4W3; 17.
DR   STRING; 9606.ENSP00000386376; -.
DR   iPTMnet; Q7Z4W3; -.
DR   PhosphoSitePlus; Q7Z4W3; -.
DR   BioMuta; KRTAP19-3; -.
DR   DMDM; 74750108; -.
DR   PaxDb; Q7Z4W3; -.
DR   PRIDE; Q7Z4W3; -.
DR   DNASU; 337970; -.
DR   Ensembl; ENST00000334063.6; ENSP00000386376.2; ENSG00000244025.5.
DR   GeneID; 337970; -.
DR   KEGG; hsa:337970; -.
DR   MANE-Select; ENST00000334063.6; ENSP00000386376.2; NM_181609.4; NP_853640.1.
DR   UCSC; uc002yog.2; human.
DR   CTD; 337970; -.
DR   GeneCards; KRTAP19-3; -.
DR   HGNC; HGNC:18938; KRTAP19-3.
DR   HPA; ENSG00000244025; Group enriched (skeletal muscle, skin).
DR   neXtProt; NX_Q7Z4W3; -.
DR   OpenTargets; ENSG00000244025; -.
DR   PharmGKB; PA134977711; -.
DR   VEuPathDB; HostDB:ENSG00000244025; -.
DR   eggNOG; ENOG502TDP7; Eukaryota.
DR   GeneTree; ENSGT00950000183472; -.
DR   HOGENOM; CLU_184630_0_0_1; -.
DR   OMA; MSYYANY; -.
DR   PathwayCommons; Q7Z4W3; -.
DR   Reactome; R-HSA-6805567; Keratinization.
DR   SignaLink; Q7Z4W3; -.
DR   BioGRID-ORCS; 337970; 34 hits in 980 CRISPR screens.
DR   GenomeRNAi; 337970; -.
DR   Pharos; Q7Z4W3; Tdark.
DR   PRO; PR:Q7Z4W3; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; Q7Z4W3; protein.
DR   Bgee; ENSG00000244025; Expressed in tibialis anterior and 38 other tissues.
DR   Genevisible; Q7Z4W3; HS.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   InterPro; IPR021743; KRTAP_type6/8/16/19/20/21.
DR   Pfam; PF11759; KRTAP; 1.
PE   1: Evidence at protein level;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..81
FT                   /note="Keratin-associated protein 19-3"
FT                   /id="PRO_0000223905"
SQ   SEQUENCE   81 AA;  8247 MW;  D32EC93228804388 CRC64;
     MSYYGSYYGG LGYGCGGFGG LGYGYGCGCG SFRRLGSGCG YGGYGYGSGF GGYGYGSGFG
     GYGYGCYRPS YYGGYGFSGF Y