ID   KR194_HUMAN             Reviewed;          84 AA.
AC   Q3LI73; Q17RT4; Q17RT6;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Keratin-associated protein 19-4;
GN   Name=KRTAP19-4; Synonyms=KAP19.4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hair root;
RA   Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT   "Identification of complete keratin-associated protein (KAP) gene cluster
RT   spanning 800 kb region on human chromosome 21q22.11.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT CYS-48.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q3LI73; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-12958461, EBI-347538;
CC       Q3LI73; Q9P2K6: KLHL42; NbExp=3; IntAct=EBI-12958461, EBI-739890;
CC       Q3LI73; Q14847-2: LASP1; NbExp=3; IntAct=EBI-12958461, EBI-9088686;
CC       Q3LI73; Q86UR1-2: NOXA1; NbExp=3; IntAct=EBI-12958461, EBI-12025760;
CC   -!- SIMILARITY: Belongs to the KRTAP type 19 family. {ECO:0000305}.
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DR   EMBL; AB096945; BAE46360.1; -; mRNA.
DR   EMBL; BC117197; AAI17198.1; -; mRNA.
DR   EMBL; BC117199; AAI17200.1; -; mRNA.
DR   CCDS; CCDS33534.1; -.
DR   RefSeq; NP_853641.1; NM_181610.1.
DR   AlphaFoldDB; Q3LI73; -.
DR   BioGRID; 130654; 12.
DR   IntAct; Q3LI73; 4.
DR   STRING; 9606.ENSP00000335567; -.
DR   iPTMnet; Q3LI73; -.
DR   PhosphoSitePlus; Q3LI73; -.
DR   BioMuta; KRTAP19-4; -.
DR   DMDM; 88909170; -.
DR   MassIVE; Q3LI73; -.
DR   PaxDb; Q3LI73; -.
DR   PeptideAtlas; Q3LI73; -.
DR   PRIDE; Q3LI73; -.
DR   Antibodypedia; 34974; 7 antibodies from 3 providers.
DR   DNASU; 337971; -.
DR   Ensembl; ENST00000334058.3; ENSP00000335567.2; ENSG00000186967.7.
DR   GeneID; 337971; -.
DR   KEGG; hsa:337971; -.
DR   MANE-Select; ENST00000334058.3; ENSP00000335567.2; NM_181610.3; NP_853641.1.
DR   UCSC; uc011acz.3; human.
DR   CTD; 337971; -.
DR   GeneCards; KRTAP19-4; -.
DR   HGNC; HGNC:18939; KRTAP19-4.
DR   HPA; ENSG00000186967; Not detected.
DR   neXtProt; NX_Q3LI73; -.
DR   PharmGKB; PA134984740; -.
DR   VEuPathDB; HostDB:ENSG00000186967; -.
DR   eggNOG; ENOG502TDP7; Eukaryota.
DR   GeneTree; ENSGT01030000235953; -.
DR   HOGENOM; CLU_184630_1_0_1; -.
DR   OMA; CHLSSYY; -.
DR   OrthoDB; 1638225at2759; -.
DR   PathwayCommons; Q3LI73; -.
DR   Reactome; R-HSA-6805567; Keratinization.
DR   SignaLink; Q3LI73; -.
DR   BioGRID-ORCS; 337971; 8 hits in 993 CRISPR screens.
DR   GenomeRNAi; 337971; -.
DR   Pharos; Q3LI73; Tdark.
DR   PRO; PR:Q3LI73; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; Q3LI73; protein.
DR   Bgee; ENSG00000186967; Expressed in cell and 16 other tissues.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   InterPro; IPR021743; KRTAP_type6/8/16/19/20/21.
DR   Pfam; PF11759; KRTAP; 1.
PE   1: Evidence at protein level;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..84
FT                   /note="Keratin-associated protein 19-4"
FT                   /id="PRO_0000223906"
FT   VARIANT         48
FT                   /note="Y -> C (in dbSNP:rs2298437)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_053475"
SQ   SEQUENCE   84 AA;  9106 MW;  DEE899C59F81C419 CRC64;
     MSYYGSYYRG LGYGCGGFGG LGYGYGCGCG SFRRLGYGCG FGGNGYGYCR PSCYGGYGFS
     ILLKSYPEDT ISEVIRRSFN LTKY