KR194_MOUSE
ID KR194_MOUSE Reviewed; 84 AA.
AC Q925H7;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Keratin-associated protein 19-4;
DE AltName: Full=Keratin-associated protein 16-4 {ECO:0000312|MGI:MGI:2157757};
DE AltName: Full=Keratin-associated protein 16.4 {ECO:0000312|EMBL:AAK52892.1};
GN Name=Krtap19-4;
GN Synonyms=Krtap16-4, Krtap16.4 {ECO:0000312|EMBL:AAK52892.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAK52892.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC STRAIN=FVB/NJ {ECO:0000312|EMBL:AAK52892.1};
RC TISSUE=Skin {ECO:0000269|PubMed:15385554};
RX PubMed=11290294; DOI=10.1242/dev.128.9.1547;
RA Tkatchenko A.V., Visconti R.P., Shang L., Papenbrock T., Pruett N.D.,
RA Ito T., Ogawa M., Awgulewitsch A.;
RT "Overexpression of Hoxc13 in differentiating keratinocytes results in
RT downregulation of a novel hair keratin gene cluster and alopecia.";
RL Development 128:1547-1558(2001).
RN [2] {ECO:0000312|EMBL:AAI16202.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=15385554; DOI=10.1074/jbc.m404331200;
RA Pruett N.D., Tkatchenko T.V., Jave-Suarez L., Jacobs D.F., Potter C.S.,
RA Tkatchenko A.V., Schweizer J., Awgulewitsch A.;
RT "Krtap16, characterization of a new hair keratin-associated protein (KAP)
RT gene complex on mouse chromosome 16 and evidence for regulation by
RT Hoxc13.";
RL J. Biol. Chem. 279:51524-51533(2004).
RN [4] {ECO:0000305}
RP INDUCTION.
RX PubMed=17151017; DOI=10.1242/dev.02721;
RA Kurek D., Garinis G.A., van Doorninck J.H., van der Wees J., Grosveld F.G.;
RT "Transcriptome and phenotypic analysis reveals Gata3-dependent signalling
RT pathways in murine hair follicles.";
RL Development 134:261-272(2007).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins. {ECO:0000305}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Strong expression in narrowly defined pattern
CC restricted to the lower and middle cortical regions of the hair shaft
CC in both developing and cycling hair. During hair follicle regression
CC (catagen), expression levels decrease until expression is no longer
CC detectable in follicles at resting stage (telogen).
CC {ECO:0000269|PubMed:15385554}.
CC -!- INDUCTION: Expression in skin and hair follicle is regulated by HOXC13
CC and by GATA3. {ECO:0000269|PubMed:11290294,
CC ECO:0000269|PubMed:17151017}.
CC -!- SIMILARITY: Belongs to the KRTAP type 19 family. {ECO:0000305}.
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DR EMBL; AF345294; AAK52892.1; -; mRNA.
DR EMBL; BC116200; AAI16201.1; -; mRNA.
DR EMBL; BC116201; AAI16202.1; -; mRNA.
DR CCDS; CCDS37387.1; -.
DR RefSeq; NP_570943.1; NM_130873.1.
DR AlphaFoldDB; Q925H7; -.
DR STRING; 10090.ENSMUSP00000056250; -.
DR PaxDb; Q925H7; -.
DR PRIDE; Q925H7; -.
DR Ensembl; ENSMUST00000051103; ENSMUSP00000056250; ENSMUSG00000043982.
DR GeneID; 170654; -.
DR KEGG; mmu:170654; -.
DR UCSC; uc007zvk.1; mouse.
DR CTD; 337971; -.
DR MGI; MGI:2157757; Krtap19-4.
DR VEuPathDB; HostDB:ENSMUSG00000043982; -.
DR eggNOG; ENOG502TDPC; Eukaryota.
DR GeneTree; ENSGT00860000136057; -.
DR HOGENOM; CLU_184630_0_0_1; -.
DR OMA; GRFRYCC; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR BioGRID-ORCS; 170654; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q925H7; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q925H7; protein.
DR Bgee; ENSMUSG00000043982; Expressed in lip and 17 other tissues.
DR Genevisible; Q925H7; MM.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR021743; KRTAP_type6/8/16/19/20/21.
DR Pfam; PF11759; KRTAP; 1.
PE 2: Evidence at transcript level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..84
FT /note="Keratin-associated protein 19-4"
FT /id="PRO_0000356214"
FT REGION 9..78
FT /note="24 X 2 AA repeats of G-[YCGS]"
FT /evidence="ECO:0000255"
SQ SEQUENCE 84 AA; 8626 MW; BAC53960E6B3D823 CRC64;
MSYYNSYYGG LGYGSGGYGG LGYGYGCGCG SFRRLGYGCG FGGYGGFGYG SGYGGFSSGS
GYGGFGYGYR RPLSYGGYGF STFY
